ATE442380T1 - Verfahren zur reiningung von vancomycin- hydrochlorid - Google Patents

Verfahren zur reiningung von vancomycin- hydrochlorid

Info

Publication number: ATE442380T1
Authority: AT; Austria
Prior art keywords: vancomycin hydrochloride; purifying; vancomycin; fermentation broth; exchange resin
Prior art date: 2004-06-30

Application number

AT04356158T

Other languages

English (en)

Inventor

Ju Won Lee

Yun Taek Jung

Jung Woo Suh

Kwang Seob Lee

Original Assignee

Samyang Genex Corp

Genotech Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-30

Filing date

2004-09-24

Publication date

2009-09-15

2004-09-24 Application filed by Samyang Genex Corp, Genotech Co Ltd filed Critical Samyang Genex Corp

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE442380T1 publication Critical patent/ATE442380T1/de

Links

108010059993 Vancomycin Proteins 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
229960001572 vancomycin hydrochloride Drugs 0.000 title 1
LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 title 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 3
229960003165 vancomycin Drugs 0.000 abstract 3
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 abstract 3
238000000855 fermentation Methods 0.000 abstract 2
230000004151 fermentation Effects 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
230000002745 absorbent Effects 0.000 abstract 1
239000002250 absorbent Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
239000003957 anion exchange resin Substances 0.000 abstract 1
239000003729 cation exchange resin Substances 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT04356158T 2004-06-30 2004-09-24 Verfahren zur reiningung von vancomycin- hydrochlorid ATE442380T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
KR1020040050429A KR100554481B1 (ko)	2004-06-30	2004-06-30	반코마이신 염산염의 정제방법

Publications (1)

Publication Number	Publication Date
ATE442380T1 true ATE442380T1 (de)	2009-09-15

Family

ID=34931759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04356158T ATE442380T1 (de)	2004-06-30	2004-09-24	Verfahren zur reiningung von vancomycin- hydrochlorid

Country Status (8)

Country	Link
US (1)	US7018814B2 (de)
EP (1)	EP1612216B1 (de)
JP (1)	JP4173124B2 (de)
KR (1)	KR100554481B1 (de)
AT (1)	ATE442380T1 (de)
DE (1)	DE602004023065D1 (de)
TW (1)	TWI270575B (de)
WO (1)	WO2006004238A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI21924A (sl) *	2004-12-07	2006-06-30	Lek Farmacevtska Druzba D.D.	Cist vankomicin hidroklorid
DE102006028817A1 (de) *	2006-06-21	2007-12-27	Evonik Degussa Gmbh	Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen
US20080161536A1 (en) *	2006-12-29	2008-07-03	Abbott Laboratories	Vancomycin b hydrochloride crystalline form 1
KR20080075979A (ko) *	2007-02-14	2008-08-20	주식회사 바이오앤진	아미코라톱시스 오리엔탈리스 변이주 및 이를 이용한반코마이신 염산염의 제조방법
KR101101663B1 (ko) *	2009-01-13	2011-12-30	(주) 제노텍	반코마이신 습체의 정제방법
EP2686334B2 (de) *	2011-03-16	2020-07-01	F.Hoffmann-La Roche Ag	Ionenaustausch-chromatografie mit verbesserter selektivität zur trennung von polypeptidmonomeren, -aggregaten und -fragmenten durch modulierung der mobilen phase
EP2592090A1 (de) *	2011-11-11	2013-05-15	LEK Pharmaceuticals d.d.	Verfahren zur Reinigung von Teicoplanin
CN102603872A (zh) *	2012-04-11	2012-07-25	苏州纳微生物科技有限公司	单分散聚甲基丙烯酸酯混合型阳离子交换层析介质在万古霉素柱层析纯化中的应用
US10405588B2 (en) *	2012-06-18	2019-09-10	Rayma Charlene Wright	Electro illuminating wire lighted safety vests
CN104043104B (zh) *	2013-03-15	2018-07-10	浙江创新生物有限公司	含盐酸万古霉素的喷雾干粉及其工业化制备方法
IT201600127655A1 (it) *	2016-12-16	2018-06-16	Gnosis Spa	Processo per la purificazione di antibiotici lipopolipeptidici
CN107641149B (zh) *	2017-09-29	2020-11-10	华北制药华胜有限公司	一种利用离子交换树脂提高盐酸万古霉素纯度的方法
CN111388652B (zh) *	2020-03-10	2020-11-13	华北制药股份有限公司	一种注射用盐酸去甲万古霉素制剂及其制备方法
CN113666987A (zh) *	2020-05-14	2021-11-19	博瑞生物医药泰兴市有限公司	一种达巴万星的纯化方法
KR102405920B1 (ko) *	2021-10-14	2022-06-07	주식회사 휴피트	항생제 중화능이 있는 미생물 생장배지
CN115010792A (zh) *	2022-06-23	2022-09-06	丽珠集团新北江制药股份有限公司	一种盐酸万古霉素的纯化方法
KR102595909B1 (ko) *	2023-02-13	2023-10-31	주식회사 휴피트	이산화탄소 비색 센서와 혐기성 미생물 생장 배지를 포함하는 혈액 배양 시약
KR102595908B1 (ko) *	2023-02-13	2023-10-31	주식회사 휴피트	이산화탄소 비색 센서와 호기성 미생물 생장 배지를 포함하는 혈액 배양 시약

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4440753A (en) *	1982-03-15	1984-04-03	Eli Lilly And Company	Purification of glycopeptide antibiotics using non-functional resins
AU579120B2 (en) *	1983-12-16	1988-11-17	Gruppo Lepetit S.P.A.	Chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts
GB8608798D0 (en) *	1986-04-11	1986-05-14	Lepetit Spa	Recovery of glycopeptide antibiotics from aqueous solutions
US4845194A (en) *	1987-02-27	1989-07-04	Eli Lilly And Company	Glycopeptide recovery process
US5037652A (en) *	1987-12-28	1991-08-06	Eli Lilly And Company	Vancomycin precipitation process
JP2577133B2 (ja) *	1989-11-27	1997-01-29	スティフティングフォールドテフニスヘウェッテンスハッペン	船舶のプロペラ
US5258495A (en) *	1990-07-10	1993-11-02	Abbott Laboratories	Process for making vancomycin HC1
US5574135A (en) *	1990-07-10	1996-11-12	Abbott Laboratories	Process for making vancomycin
US5149784A (en) *	1990-07-10	1992-09-22	Abbott Laboratories	Process for making vancomycin
US5235037A (en) *	1991-08-15	1993-08-10	American Cyanamid Company	Vancomycin precipitation process
DK0640095T3 (da) *	1992-04-20	1999-04-12	Abbott Lab	Fremgangsmåde til fremstilling af vancomycin
SI9500039B (sl) *	1995-02-07	2002-02-28	Lek,	Nov kombiniran postopek čiščenja Vankomicin hidroklorida
US6696412B1 (en) *	2000-01-20	2004-02-24	Cubist Pharmaceuticals, Inc.	High purity lipopeptides, Lipopeptide micelles and processes for preparing same

2004
- 2004-06-30 KR KR1020040050429A patent/KR100554481B1/ko not_active Expired - Fee Related
- 2004-09-17 US US10/943,404 patent/US7018814B2/en not_active Expired - Fee Related
- 2004-09-17 JP JP2004270625A patent/JP4173124B2/ja not_active Expired - Fee Related
- 2004-09-21 WO PCT/KR2004/002419 patent/WO2006004238A1/en not_active Ceased
- 2004-09-24 DE DE602004023065T patent/DE602004023065D1/de not_active Expired - Lifetime
- 2004-09-24 EP EP04356158A patent/EP1612216B1/de not_active Expired - Lifetime
- 2004-09-24 AT AT04356158T patent/ATE442380T1/de not_active IP Right Cessation
2005
- 2005-04-27 TW TW094113386A patent/TWI270575B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100554481B1 (ko)	2006-03-03
TWI270575B (en)	2007-01-11
US20060003406A1 (en)	2006-01-05
EP1612216B1 (de)	2009-09-09
JP4173124B2 (ja)	2008-10-29
JP2006014720A (ja)	2006-01-19
WO2006004238A1 (en)	2006-01-12
US7018814B2 (en)	2006-03-28
KR20060001329A (ko)	2006-01-06
TW200600576A (en)	2006-01-01
EP1612216A1 (de)	2006-01-04
DE602004023065D1 (de)	2009-10-22

Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE442380T1 (de)	2009-09-15	Verfahren zur reiningung von vancomycin- hydrochlorid
ATE445587T1 (de)	2009-10-15	Verfahren zur herstellung von cinacalcet hydrochlorid kristallform i
DE60232120D1 (de)	2009-06-10	Verfahren zur Herstellung von L-Lysin oder L-Arginin unter Verwendung methanolassimilierender Bakterien
DE60332163D1 (de)	2010-05-27	Zusammensetzung zur hautaufhellung
EP1669459A4 (de)	2011-10-05	Verfahren zur aufreinigung von bernsteinsäure aus fermentationsflüssigkeit
ATE474847T1 (de)	2010-08-15	Verfahren zur herstellung von dipeptiden
EP1510570A3 (de)	2006-04-19	Verfahren zur Herstellung der L-Histidine durch die Verwendung von Bakterien aus der Familie Enterobacteriaceae
DE602006017995D1 (de)	2010-12-16	Verfahren zur herstellung von pregabalin und salzen daraus
DE50208306D1 (de)	2006-11-16	Verfahren zur Herstellung von nicht-proteinogenen L-Aminosäuren
DE60207490D1 (de)	2005-12-29	Verfahren zur Herstellung von (Meth)Acrylsäureanhydrid
DE502004001216D1 (de)	2006-09-28	Verfahren zur aufreinigung von blausäure
DE50207455D1 (de)	2006-08-17	Verfahren ZUR HERSTELLUNG VON CARBONSÄURESALZEN
ATE380862T1 (de)	2007-12-15	Verfahren zur entgiftung von mykotoxinen
ATE246692T1 (de)	2003-08-15	Verfahren zur reinigung von phosphatidylserin
DE60237436D1 (de)	2010-10-07	Verfahren zur herstellung von acrylamid mittels eines mit wässriger acrylsäurelösung gewaschenen mikrobiellen katasylators
DE60239286D1 (de)	2011-04-07	Verfahren zur herstellung von trans-1,4-cyclohexandicarbonsäure
ATE340634T1 (de)	2006-10-15	Verfahren zur verringerung einer adsorptionsneigung von molekülen oder biologischen zellen an einer materialoberfläche
DE50306876D1 (de)	2007-05-03	Verfahren zur herstellung von alkylarylsulfonaten mittels modifizierter, dimerisierter olefine
DE60130970D1 (de)	2007-11-29	Reagenziensatz zur detektion von mikroorganismen, vorrichtung zur quantifizierungvon mikroorganismen und verfahren zur quantifizierung von mikroorganismen
DE60301019D1 (de)	2005-08-25	Verfahren zur Stabilierung sauerer Milchgetränke
DE60331527D1 (de)	2010-04-15	Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren
DE60129547D1 (de)	2007-09-06	Verfahren zur kultivierung von mikroorganismen
ATE271561T1 (de)	2004-08-15	Verfahren zur herstellung von einer amid verbindung
DE602004022076D1 (de)	2009-08-27	Verfahren zur reduzierung von stickoxidemissionen toranordnung
DE60108990D1 (de)	2005-03-24	Verfahren zur erzeugung von feinteiligem calciumkarbonat aus calciumkarbonatreichen industriellen nebenprodukten