ATE442387T1 - Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung - Google Patents

Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung

Info

Publication number: ATE442387T1
Authority: AT; Austria
Prior art keywords: interleukin; cell receptor; following infection; progression; aids
Prior art date: 2001-05-18

Application number

AT02730429T

Other languages

English (en)

Inventor

John Marchalonis

Ronald Watson

Original Assignee

Univ Arizona

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-17

Publication date

2009-09-15

2002-05-17 Application filed by Univ Arizona filed Critical Univ Arizona

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE442387T1 publication Critical patent/ATE442387T1/de

Links

108091008874 T cell receptors Proteins 0.000 title abstract 3
102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 3
239000012634 fragment Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
208000015181 infectious disease Diseases 0.000 abstract 3
238000010171 animal model Methods 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
208000010648 susceptibility to HIV infection Diseases 0.000 abstract 2
XMVZMBGFIOQONW-GARJFASQSA-N Cys-Lys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CS)N)C(=O)O XMVZMBGFIOQONW-GARJFASQSA-N 0.000 abstract 1
HRGGKHFHRSFSDE-CIUDSAMLSA-N His-Asn-Ser Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O)N HRGGKHFHRSFSDE-CIUDSAMLSA-N 0.000 abstract 1
ZLFNNVATRMCAKN-ZKWXMUAHSA-N Ile-Ser-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)NCC(=O)O)N ZLFNNVATRMCAKN-ZKWXMUAHSA-N 0.000 abstract 1
102000008070 Interferon-gamma Human genes 0.000 abstract 1
108010074328 Interferon-gamma Proteins 0.000 abstract 1
102000003814 Interleukin-10 Human genes 0.000 abstract 1
108090000174 Interleukin-10 Proteins 0.000 abstract 1
102000000588 Interleukin-2 Human genes 0.000 abstract 1
108010002350 Interleukin-2 Proteins 0.000 abstract 1
102000000743 Interleukin-5 Human genes 0.000 abstract 1
108010002616 Interleukin-5 Proteins 0.000 abstract 1
102000004889 Interleukin-6 Human genes 0.000 abstract 1
108090001005 Interleukin-6 Proteins 0.000 abstract 1
TYYLDKGBCJGJGW-UHFFFAOYSA-N L-tryptophan-L-tyrosine Natural products C=1NC2=CC=CC=C2C=1CC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 TYYLDKGBCJGJGW-UHFFFAOYSA-N 0.000 abstract 1
MAXILRZVORNXBE-PMVMPFDFSA-N Leu-Phe-Trp Chemical compound C([C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CC=CC=C1 MAXILRZVORNXBE-PMVMPFDFSA-N 0.000 abstract 1
HKIUVWMZYFBIHG-KKUMJFAQSA-N Tyr-Arg-Gln Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)N)O HKIUVWMZYFBIHG-KKUMJFAQSA-N 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
108010020688 glycylhistidine Proteins 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
229940027941 immunoglobulin g Drugs 0.000 abstract 1
229960003130 interferon gamma Drugs 0.000 abstract 1
229940076144 interleukin-10 Drugs 0.000 abstract 1
229940100601 interleukin-6 Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Cell Biology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Confectionery (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT02730429T 2001-05-18 2002-05-17 Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung ATE442387T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0112126.8A GB0112126D0 (en)	2001-05-18	2001-05-18	Composition
PCT/GB2002/002323 WO2002094860A2 (en)	2001-05-18	2002-05-17	Dimerized t-cell receptor fragment, its compositions and use

Publications (1)

Publication Number	Publication Date
ATE442387T1 true ATE442387T1 (de)	2009-09-15

Family

ID=9914850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02730429T ATE442387T1 (de)	2001-05-18	2002-05-17	Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung

Country Status (7)

Country	Link
US (1)	US7998926B2 (de)
EP (1)	EP1389219B1 (de)
AT (1)	ATE442387T1 (de)
AU (1)	AU2002302751A1 (de)
DE (1)	DE60233654D1 (de)
GB (1)	GB0112126D0 (de)
WO (1)	WO2002094860A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7323174B1 (en) *	2000-06-12	2008-01-29	Arizona Board Of Regents On Behalf Of The University Of Arizona	Modulation of immune response and methods based thereon
WO2005087793A2 (en) *	2004-02-05	2005-09-22	The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University	Immunostimulatory compositions and uses thereof
AU2005229411B2 (en)	2004-03-30	2010-11-18	Centre National De La Recherche Scientifique	Polypeptide sequence involved in the modulation of the immunosuppressive effect of viral proteins
JP2008500289A (ja) *	2004-05-27	2008-01-10	ノヴォザイムズグロペップリミテッド	炎症性気道疾患の治療
US8178649B2 (en) *	2004-12-07	2012-05-15	Arizona Biomedical Research Commission	Immunostimulatory compositions and uses thereof
US7811995B2 (en) *	2006-12-13	2010-10-12	Susavion Biosciences, Inc.	Therapeutic and diagnostic peptides
US8496942B2 (en) *	2006-12-13	2013-07-30	Susavion Biosciences, Inc.	Therapeutic peptides and uses thereof
EP3288576A4 (de)	2015-04-27	2019-01-16	Susavion Biosciences, Inc.	Zusammensetzungen und verfahren zur behandlung von krebs und persistenten virusinfektionen
EP3773633A4 (de)	2018-04-06	2022-01-26	The Regents of The University of California	Verfahren zur behandlung von glioblastomen
CA3096202A1 (en)	2018-04-06	2019-10-10	The Regents Of The University Of California	Methods of treating egfrviii expressing glioblastomas

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* Cited by examiner, † Cited by third party
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SE8205892D0 (sv)	1982-10-18	1982-10-18	Bror Morein	Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE8405493D0 (sv)	1984-11-01	1984-11-01	Bror Morein	Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
ES2039229T3 (es)	1986-01-14	1993-09-16	De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur	Procedimiento para la preparacion de complejos inmunogenicos y composiciones farmaceuticas que contienen estos complejos.
US4806352A (en)	1986-04-15	1989-02-21	Ribi Immunochem Research Inc.	Immunological lipid emulsion adjuvant
WO1991010736A2 (en)	1990-01-19	1991-07-25	Dana Farber Cancer Institute	CLONING AND CHARACTERIZATION OF THE CD3θ SUBUNIT
CA2087545A1 (en) *	1990-07-19	1992-01-20	The Board Of Trustees Of The Leland Stanford Junior University	Soluble cell-surface dimeric proteins
HUT73101A (en) *	1993-02-12	1996-06-28	Harvard College	Method for regulating transcription of targeted genes and other biological events
AUPM322393A0 (en)	1993-12-24	1994-01-27	Austin Research Institute, The	Mucin carbohydrate compounds and their use in immunotherapy
WO1996021028A2 (en) *	1995-01-03	1996-07-11	Procept, Inc.	Soluble heterodimeric t cell receptors and their antibodies
US6150337A (en)	1996-01-23	2000-11-21	Icn Pharmaceuticals, Inc.	Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes
US5714577A (en) *	1996-01-26	1998-02-03	University Of Pittsburgh	Antimicrobial peptides
JPH11507843A (ja) *	1996-03-28	1999-07-13	ザ・ジョンズ・ホプキンス・ユニバーシティー	タンパク質の可溶性二価および多価ヘテロ二量体類縁体
US5962319A (en)	1997-05-19	1999-10-05	Bml, Inc.	Human-Th1-specific protein, gene encoding the protein, transformants, recombinant vectors, and antibodies related to the gene
US5911990A (en)	1996-08-13	1999-06-15	Arizona Board Of Regents On Behalf Of The University Of Arizona	T-cell receptor peptides and methods for preventing the progression to AIDS in an animal model
IL119938A (en) *	1996-12-30	2005-08-31	Yissum Res Dev Co	Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells
US7323174B1 (en) *	2000-06-12	2008-01-29	Arizona Board Of Regents On Behalf Of The University Of Arizona	Modulation of immune response and methods based thereon

2001
- 2001-05-18 GB GBGB0112126.8A patent/GB0112126D0/en not_active Ceased
2002
- 2002-05-17 WO PCT/GB2002/002323 patent/WO2002094860A2/en not_active Ceased
- 2002-05-17 US US10/478,194 patent/US7998926B2/en active Active
- 2002-05-17 AU AU2002302751A patent/AU2002302751A1/en not_active Abandoned
- 2002-05-17 AT AT02730429T patent/ATE442387T1/de not_active IP Right Cessation
- 2002-05-17 DE DE60233654T patent/DE60233654D1/de not_active Expired - Lifetime
- 2002-05-17 EP EP02730429A patent/EP1389219B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20040248192A1 (en)	2004-12-09
EP1389219A2 (de)	2004-02-18
AU2002302751A1 (en)	2002-12-03
DE60233654D1 (de)	2009-10-22
WO2002094860A3 (en)	2003-06-26
WO2002094860A2 (en)	2002-11-28
EP1389219B1 (de)	2009-09-09
US7998926B2 (en)	2011-08-16
GB0112126D0 (en)	2001-07-11

Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
RU2010116278A (ru)	2011-11-10	Модифицированная константная область антитела
NL300013I1 (nl)	2000-10-02	Nieuwe protein met TNF-remmende werking en hun ber
PL363071A1 (pl)	2004-11-15	Sposoby i kompozycje dla zmniejszenia replikacji HIV-1
AU6285694A (en)	1994-10-11	Therapeutical compositions for use in humans, characterised by a combination of a muramyl peptide and a cytokine
JP2004518624A5 (de)	2008-11-06
DE60233654D1 (de)	2009-10-22	Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung
WO2006034334A3 (en)	2006-09-14	Peptide analogs capable of enhancing stimulation of a glioma-specific ctl response
WO2006023665A3 (en)	2006-08-03	Il-1 antagonist formulations
AU1873992A (en)	1992-11-17	Bradykinin antagonist peptides
DK1447414T3 (da)	2007-09-10	Antagonistpeptider af carcinoembronisk antigen (CEA)
PT996726E (pt)	2004-04-30	Proteina de membrana de celulas t (tirc7) peptidos e anticorpos dela derivados e suas utilizacoes
ES2123556T3 (es)	1999-01-16	Peptidos de tipo bradiquinina.
TR200003498T2 (tr)	2001-10-22	Amino asit sekansından oluşan bir polipetit, bunun aşıları ve kullanımları
EP1250358B1 (de)	2005-03-16	Therapeutische peptide
NO975565L (no)	1998-01-19	Benstimulerende faktor
ES2180781T3 (es)	2003-02-16	Nuevos ligandos del receptor opiaceo mu: agonistas y antagonistas.
EP1578772A4 (de)	2007-05-09	Cytokine und cytokinrezeptoren mit reduzierter immunogenität
EP1908781A3 (de)	2008-04-16	Modulation der Immunreaktion und darauf basierende Verfahren
WO2001051512A3 (en)	2002-03-14	Human and parasite orphan receptor proteins
ATE420890T1 (de)	2009-01-15	Isoleucyl-valyl-threonyl-asparaginyl-threonyl- threonin (ivtntt) enthaltende biologisch wirksame peptide
IL154777A0 (en)	2003-10-31	Il-6 receptor/il-6 chimera in huntington's disease
EP0717752A4 (de)	1997-08-20	Therapeitische inhaltsstoffe
EP1372691A4 (de)	2005-11-09	Mucinpeptid mit immunstärkenden eigenschaften
DE60325227D1 (de)	2009-01-22
Hamaoka	1985	T-cell-replacing factor and its acceptor site on B cells: molecular properties and immunogenetic aspects