ATE443717T1 - Metastin derivate und ihre verwendung - Google Patents

Metastin derivate und ihre verwendung

Info

Publication number: ATE443717T1
Authority: AT; Austria
Prior art keywords: metastin derivatives; derivatives; relates; suppressing activity; metastin
Prior art date: 2003-01-06

Application number

AT04700164T

Other languages

English (en)

Inventor

Nobutaka Fujii

Ryuichiro Doi

Shinya Oishi

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-06

Filing date

2004-01-05

Publication date

2009-10-15

2004-01-05 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2009-10-15 Application granted granted Critical

2009-10-15 Publication of ATE443717T1 publication Critical patent/ATE443717T1/de

Links

KAHDONZOCXSKII-NJVVDGNHSA-N kisspeptin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C1=CN=CN1 KAHDONZOCXSKII-NJVVDGNHSA-N 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 3
201000011510 cancer Diseases 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Obesity (AREA)
Oncology (AREA)
Hematology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT04700164T 2003-01-06 2004-01-05 Metastin derivate und ihre verwendung ATE443717T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/337,105 US6800611B2 (en)	2003-01-06	2003-01-06	Metastin derivatives and their use
PCT/IB2004/000606 WO2004060264A2 (en)	2003-01-06	2004-01-05	Metastin derivatives and their use

Publications (1)

Publication Number	Publication Date
ATE443717T1 true ATE443717T1 (de)	2009-10-15

Family

ID=32710947

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04700164T ATE443717T1 (de)	2003-01-06	2004-01-05	Metastin derivate und ihre verwendung

Country Status (8)

Country	Link
US (1)	US6800611B2 (de)
EP (1)	EP1581557B1 (de)
JP (1)	JP4335910B2 (de)
CN (1)	CN1756765A (de)
AT (1)	ATE443717T1 (de)
CA (1)	CA2512553A1 (de)
DE (1)	DE602004023271D1 (de)
WO (1)	WO2004060264A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004063221A1 (ja)	2002-12-26	2004-07-29	Takeda Pharmaceutical Company Limited	メタスチン誘導体およびその用途
US7754220B2 (en)	2003-03-12	2010-07-13	Takeda Pharmaceutical Company Limited	Methods of inhibiting secretion of follicle-stimulating hormone and testosterone
WO2006001499A2 (en)	2004-06-25	2006-01-05	Takeda Pharmaceutical Company Limited	Metastin derivatives and use thereof
UA97236C2 (en) *	2005-12-22	2012-01-25	Такеда Фармасьютикал Компани Лимитед	Metastin derivatives and use thereof
AR058584A1 (es) *	2005-12-22	2008-02-13	Takeda Pharmaceutical	Derivados de metastina y uso de los mismos
US8404643B2 (en) *	2005-12-22	2013-03-26	Takeda Pharmaceutical Company Limited	Metastin derivatives and use thereof
JP5279021B2 (ja) *	2006-04-26	2013-09-04	国立大学法人京都大学	Ｇｐｒ５４アゴニスト活性を有する新規化合物
UA94774C2 (en) *	2006-10-25	2011-06-10	Такеда Фармасьютикал Компани Лимитед	Metastin derivatives and use thereof
JO3048B1 (ar) *	2006-10-25	2016-09-05	Takeda Pharmaceuticals Co	مشتقات متاستين واستخدامها
GB0719592D0 (en)	2007-10-08	2007-11-14	Medical Res Council	Compound, use and method
US20110118172A1 (en) *	2008-04-24	2011-05-19	Takeda Pharmaceutical Company Limited	Metastin derivative and use thereof
EP2275433B1 (de) *	2008-04-30	2017-06-07	Kyoto University	Metastinderivat und verwendung davon
WO2010013762A1 (ja)	2008-07-30	2010-02-04	武田薬品工業株式会社	メタスチン誘導体およびその用途
EP2350118B1 (de)	2008-09-19	2016-03-30	Nektar Therapeutics	Kohlenhydratbasisierte polymere zur wirkstoffabgabe und konjugate davon
EP2340047A1 (de) *	2008-09-19	2011-07-06	Nektar Therapeutics	Polymerkonjugate von kiss1-peptiden
GEP20146001B (en) *	2008-12-29	2014-01-10	Takeda Pharmaceuticals Co	Cancer prophylactic/therapeutic agent
US8716228B2 (en)	2009-05-27	2014-05-06	Yeda Research And Development Co. Ltd.	GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities
WO2013136338A1 (en)	2012-03-14	2013-09-19	Yeda Research And Development Co. Ltd At The Weizmann Institute Of Science	Modified kisspeptin peptides and uses thereof
US20180116849A1 (en) *	2015-04-23	2018-05-03	Obalon Therapeutics, Inc.	Systems and methods for determining failure of intragastric devices
CN116813705A (zh)	2017-07-05	2023-09-29	凯惠科技发展(上海)有限公司	一种肽类化合物、其应用及含其的组合物
WO2025217074A1 (en)	2024-04-08	2025-10-16	Radionetics Oncology, Inc.	Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4486187B2 (ja)	1998-10-27	2010-06-23	武田薬品工業株式会社	新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド
WO2001075104A1 (fr)	2000-03-30	2001-10-11	Takeda Chemical Industries, Ltd.	Nouvelle proteine, adn codant pour celle-ci, et son procede de production
WO2002085399A1 (fr)	2001-04-20	2002-10-31	Takeda Chemical Industries, Ltd.	Preparations contenant un peptide
WO2004063221A1 (ja) *	2002-12-26	2004-07-29	Takeda Pharmaceutical Company Limited	メタスチン誘導体およびその用途

2003
- 2003-01-06 US US10/337,105 patent/US6800611B2/en not_active Expired - Lifetime
2004
- 2004-01-05 JP JP2006500328A patent/JP4335910B2/ja not_active Expired - Lifetime
- 2004-01-05 CN CNA2004800060897A patent/CN1756765A/zh active Pending
- 2004-01-05 CA CA002512553A patent/CA2512553A1/en not_active Abandoned
- 2004-01-05 AT AT04700164T patent/ATE443717T1/de not_active IP Right Cessation
- 2004-01-05 DE DE602004023271T patent/DE602004023271D1/de not_active Expired - Lifetime
- 2004-01-05 EP EP04700164A patent/EP1581557B1/de not_active Expired - Lifetime
- 2004-01-05 WO PCT/IB2004/000606 patent/WO2004060264A2/en not_active Ceased

Also Published As

Publication number	Publication date
US6800611B2 (en)	2004-10-05
WO2004060264A2 (en)	2004-07-22
JP4335910B2 (ja)	2009-09-30
US20040142875A1 (en)	2004-07-22
CN1756765A (zh)	2006-04-05
EP1581557B1 (de)	2009-09-23
CA2512553A1 (en)	2004-07-22
EP1581557A2 (de)	2005-10-05
DE602004023271D1 (de)	2009-11-05
WO2004060264A3 (en)	2004-12-02
JP2006517922A (ja)	2006-08-03

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Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties