ATE444080T1 - Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien - Google Patents

Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien

Info

Publication number: ATE444080T1
Authority: AT; Austria
Prior art keywords: substituted; alkyls; cycloalkyls; aryls; heteroalkyls
Prior art date: 1997-12-17

Application number

AT98963173T

Other languages

English (en)

Inventor

Richard Greenwald

Annapurna Pendri

Yun Choe

Samuel Zalipsky

Original Assignee

Enzon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-17

Filing date

1998-12-14

Publication date

2009-10-15

1998-12-14 Application filed by Enzon Inc filed Critical Enzon Inc

1998-12-14 Priority claimed from PCT/US1998/026565 external-priority patent/WO1999030727A1/en

2009-10-15 Application granted granted Critical

2009-10-15 Publication of ATE444080T1 publication Critical patent/ATE444080T1/de

Links

239000012867 bioactive agent Substances 0.000 title 1
239000012704 polymeric precursor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229940002612 prodrug Drugs 0.000 abstract 4
239000000651 prodrug Substances 0.000 abstract 4
-1 nitro- Chemical class 0.000 abstract 3
125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 abstract 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 2
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000890 antigenic effect Effects 0.000 abstract 1
150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004405 heteroalkoxy group Chemical group 0.000 abstract 1
125000004404 heteroalkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polyamides (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT98963173T 1997-12-17 1998-12-14 Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien ATE444080T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US99243597A	1997-12-17	1997-12-17
US09/183,557 US6180095B1 (en)	1997-12-17	1998-10-30	Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
PCT/US1998/026565 WO1999030727A1 (en)	1997-12-17	1998-12-14	Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents

Publications (1)

Publication Number	Publication Date
ATE444080T1 true ATE444080T1 (de)	2009-10-15

Family

ID=25538340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98963173T ATE444080T1 (de)	1997-12-17	1998-12-14	Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien

Country Status (4)

Country	Link
US (1)	US6180095B1 (de)
EP (1)	EP1897561A1 (de)
AT (1)	ATE444080T1 (de)
DE (1)	DE69841206D1 (de)

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1998
- 1998-10-30 US US09/183,557 patent/US6180095B1/en not_active Expired - Lifetime
- 1998-12-14 DE DE69841206T patent/DE69841206D1/de not_active Expired - Lifetime
- 1998-12-14 EP EP07117973A patent/EP1897561A1/de not_active Ceased
- 1998-12-14 AT AT98963173T patent/ATE444080T1/de not_active IP Right Cessation

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Publication number	Publication date
US6180095B1 (en)	2001-01-30
EP1897561A1 (de)	2008-03-12
DE69841206D1 (de)	2009-11-12

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Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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