ATE445010T1 - Stellenspezifisches system zur erstellung vielfältiger proteinsequenzen - Google Patents

Stellenspezifisches system zur erstellung vielfältiger proteinsequenzen

Info

Publication number
ATE445010T1
ATE445010T1 AT05804058T AT05804058T ATE445010T1 AT E445010 T1 ATE445010 T1 AT E445010T1 AT 05804058 T AT05804058 T AT 05804058T AT 05804058 T AT05804058 T AT 05804058T AT E445010 T1 ATE445010 T1 AT E445010T1
Authority
AT
Austria
Prior art keywords
site
nucleic acid
protein sequences
specific system
diverse protein
Prior art date
Application number
AT05804058T
Other languages
English (en)
Inventor
Jeffery Miller
Sergei Doulatov
Asher Hodes
Min Xu
Mari Gingery
David Martin
Original Assignee
Univ California
Avidbiotics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Avidbiotics Corp filed Critical Univ California
Application granted granted Critical
Publication of ATE445010T1 publication Critical patent/ATE445010T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Ecology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT05804058T 2004-08-03 2005-08-03 Stellenspezifisches system zur erstellung vielfältiger proteinsequenzen ATE445010T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59861704P 2004-08-03 2004-08-03
PCT/US2005/027625 WO2006015370A2 (en) 2004-08-03 2005-08-03 Site specific system for generating diversity protein sequences

Publications (1)

Publication Number Publication Date
ATE445010T1 true ATE445010T1 (de) 2009-10-15

Family

ID=35787926

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05804058T ATE445010T1 (de) 2004-08-03 2005-08-03 Stellenspezifisches system zur erstellung vielfältiger proteinsequenzen

Country Status (9)

Country Link
US (1) US7585957B2 (de)
EP (1) EP1773995B1 (de)
JP (1) JP2008508879A (de)
CN (1) CN101090967A (de)
AT (1) ATE445010T1 (de)
AU (1) AU2005267719B2 (de)
CA (1) CA2575533C (de)
DE (1) DE602005017042D1 (de)
WO (1) WO2006015370A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7749694B2 (en) * 2004-12-31 2010-07-06 The Regents Of The University Of California C-type lectin fold as a scaffold for massive sequence variation
US7700729B2 (en) 2006-05-15 2010-04-20 Avidbiotics Corporation Modified bacteriocins and methods for their use
ES2387722T3 (es) * 2006-05-15 2012-09-28 Avidbiotics Corporation Bacteriocinas modificadas y métodos para su uso
US8445639B2 (en) 2006-05-15 2013-05-21 Avidbiotics Corporation Recombinant bacteriophage and methods for their use
US9476032B2 (en) 2007-03-30 2016-10-25 The Research Foundation For The State University Of New York Attenuated viruses useful for vaccines
WO2009094006A2 (en) 2007-10-25 2009-07-30 Wake Forest University Health Sciences Bordetella outer-membrane protein antigens and methods of making and using the same
WO2012091756A1 (en) 2010-12-30 2012-07-05 Avidbiotics Corp. Non-natural mic proteins
US9115354B2 (en) 2010-05-27 2015-08-25 Avidbiotics Corp. Diffocins and methods of use thereof
WO2011150342A1 (en) 2010-05-27 2011-12-01 Avidbiotics Corp. Diffocins and methods of use thereof
CN105473608A (zh) 2013-03-14 2016-04-06 阿维德百奥提克斯股份有限公司 艰难梭菌素及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165718A (en) * 1996-01-10 2000-12-26 Novo Nordisk A/S Novo Alle Method for in vivo production of a mutant library in cells
US20030148352A1 (en) * 2001-12-14 2003-08-07 Yale University Intracellular generation of single-stranded DNA
CA2488328C (en) 2002-06-05 2017-03-07 Kevin L. Rozwadowski Retrons for gene targeting
AU2003258658A1 (en) 2002-08-29 2004-03-19 Andreas Beck Improved dna and proteins

Also Published As

Publication number Publication date
EP1773995A2 (de) 2007-04-18
CA2575533A1 (en) 2006-02-09
CN101090967A (zh) 2007-12-19
WO2006015370A3 (en) 2006-08-17
CA2575533C (en) 2014-11-18
EP1773995B1 (de) 2009-10-07
US7585957B2 (en) 2009-09-08
US20060121450A1 (en) 2006-06-08
JP2008508879A (ja) 2008-03-27
AU2005267719B2 (en) 2010-12-23
AU2005267719A1 (en) 2006-02-09
WO2006015370A2 (en) 2006-02-09
DE602005017042D1 (de) 2009-11-19

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