ATE445227T1 - Methoden und apparat für die massenspektrometrie - Google Patents

Methoden und apparat für die massenspektrometrie

Info

Publication number
ATE445227T1
ATE445227T1 AT05025116T AT05025116T ATE445227T1 AT E445227 T1 ATE445227 T1 AT E445227T1 AT 05025116 T AT05025116 T AT 05025116T AT 05025116 T AT05025116 T AT 05025116T AT E445227 T1 ATE445227 T1 AT E445227T1
Authority
AT
Austria
Prior art keywords
ions
parent
daughter
mode
mass spectra
Prior art date
Application number
AT05025116T
Other languages
English (en)
Inventor
Robert Harold Bateman
Edward James Clayton
John Brian Hoyes
Original Assignee
Micromass Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0014062A external-priority patent/GB0014062D0/en
Priority claimed from GB0101048A external-priority patent/GB0101048D0/en
Application filed by Micromass Ltd filed Critical Micromass Ltd
Application granted granted Critical
Publication of ATE445227T1 publication Critical patent/ATE445227T1/de

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/26Mass spectrometers or separator tubes
    • H01J49/34Dynamic spectrometers
    • H01J49/42Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205Device types
    • H01J49/421Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215Quadrupole mass filters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
AT05025116T 2000-06-09 2001-06-11 Methoden und apparat für die massenspektrometrie ATE445227T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0014062A GB0014062D0 (en) 2000-06-09 2000-06-09 Methods and apparatus for tandem mass spectrometry
GB0101048A GB0101048D0 (en) 2001-01-15 2001-01-15 Methods and apparatus for tandem mass spectrometry
GB0105227A GB2364168B (en) 2000-06-09 2001-03-02 Methods and apparatus for mass spectrometry

Publications (1)

Publication Number Publication Date
ATE445227T1 true ATE445227T1 (de) 2009-10-15

Family

ID=26244455

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05025116T ATE445227T1 (de) 2000-06-09 2001-06-11 Methoden und apparat für die massenspektrometrie

Country Status (6)

Country Link
US (1) US6586727B2 (de)
EP (2) EP2299469B1 (de)
JP (1) JP5154511B2 (de)
AT (1) ATE445227T1 (de)
DE (2) DE60140150D1 (de)
GB (1) GB2364168B (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US7038197B2 (en) * 2001-04-03 2006-05-02 Micromass Limited Mass spectrometer and method of mass spectrometry
US6777671B2 (en) * 2001-04-10 2004-08-17 Science & Engineering Services, Inc. Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same
US7196323B2 (en) * 2002-02-28 2007-03-27 Metanomics Gmbh & Co. Kgaa Mass spectrometry method for analyzing mixtures of substances
AU2003213945A1 (en) * 2002-04-29 2003-11-17 Mds Inc., Doing Business As Mds Sciex Broad ion fragmentation coverage in mass spectrometry by varying the collision energy
US6770871B1 (en) * 2002-05-31 2004-08-03 Michrom Bioresources, Inc. Two-dimensional tandem mass spectrometry
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
JP3816883B2 (ja) * 2003-03-06 2006-08-30 株式会社日立ハイテクノロジーズ 液体クロマトグラフ質量分析装置
US7041968B2 (en) * 2003-03-20 2006-05-09 Science & Technology Corporation @ Unm Distance of flight spectrometer for MS and simultaneous scanless MS/MS
WO2004090933A2 (en) * 2003-04-09 2004-10-21 Mds Inc. Doing Business Through Its Mds Sciex Division Dynamic signal selection in chromatography/mass spectrometry/mass spectrometry system
US20050227251A1 (en) 2003-10-23 2005-10-13 Robert Darnell Method of purifying RNA binding protein-RNA complexes
US20060186028A1 (en) * 2004-02-06 2006-08-24 Micromass Uk Limited Mass spectrometer
US20070258861A1 (en) * 2004-06-15 2007-11-08 Barket Dennis Jr Analytical Instruments, Assemblies, and Methods
GB0416288D0 (en) 2004-07-21 2004-08-25 Micromass Ltd Mass spectrometer
WO2006116564A2 (en) 2005-04-25 2006-11-02 Griffin Analytical Technologies, L.L.C. Analytical instrumentation, appartuses, and methods
US7417223B2 (en) * 2005-10-28 2008-08-26 Mds Inc. Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences
GB2432712B (en) * 2005-11-23 2007-12-27 Micromass Ltd Mass spectrometer
CA2636822C (en) * 2006-01-11 2015-03-03 Mds Inc., Doing Business Through Its Mds Sciex Division Fragmenting ions in mass spectrometry
GB0607542D0 (en) * 2006-04-13 2006-05-24 Thermo Finnigan Llc Mass spectrometer
WO2007122383A2 (en) 2006-04-13 2007-11-01 Thermo Fisher Scientific (Bremen) Gmbh Ion energy spread reduction for mass spectrometer
GB0609253D0 (en) 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
US8180576B2 (en) * 2006-05-11 2012-05-15 Shimadzu Corporation Data processor for mass spectrometer
US7992424B1 (en) 2006-09-14 2011-08-09 Griffin Analytical Technologies, L.L.C. Analytical instrumentation and sample analysis methods
US7511267B2 (en) * 2006-11-10 2009-03-31 Thermo Finnigan Llc Data-dependent accurate mass neutral loss analysis
EP1933366B1 (de) * 2006-12-14 2019-06-12 Tofwerk AG Vorrichtung zur Massenanalyse von Ionen
EP1933365A1 (de) * 2006-12-14 2008-06-18 Tofwerk AG Vorrichtung zur Massenanalyse von Ionen
EP1968100B1 (de) * 2007-03-08 2014-04-30 Tofwerk AG Ionenführungskammer
WO2009114932A1 (en) * 2008-03-20 2009-09-24 Mds Analytical Technologies, A Business Unit Of Mds Inc., Systems and methods for analyzing substances using a mass spectrometer
DE102008025972B4 (de) * 2008-05-30 2018-11-29 Bruker Daltonik Gmbh Verfahren zur Messung der Mobilität massenspektrometrisch ausgewählter Ionensorten
WO2010032276A1 (ja) * 2008-09-16 2010-03-25 株式会社島津製作所 飛行時間型質量分析装置
US8581176B2 (en) * 2009-05-27 2013-11-12 Dh Technologies Development Pte. Ltd. Method for high efficiency tandem mass spectrometry
GB0915474D0 (en) 2009-09-04 2009-10-07 Micromass Ltd Multiple reaction monitoring with a time-of-flight based mass spectrometer
GB0919870D0 (en) * 2009-11-13 2009-12-30 Micromass Ltd A method to detect and quantitatively profile organic species using a mass spectrometer
JP5314603B2 (ja) * 2010-01-15 2013-10-16 日本電子株式会社 飛行時間型質量分析装置
DE102011017084B4 (de) 2010-04-14 2020-07-09 Wisconsin Alumni Research Foundation Massenspektrometriedaten-Erfassungsmodus zur Erzielung einer zuverlässigeren Proteinquantifizierung
CN103109345B (zh) * 2010-09-15 2016-06-22 Dh科技发展私人贸易有限公司 产物离子光谱的数据独立获取及参考光谱库匹配
DE102011053684B4 (de) 2010-09-17 2019-03-28 Wisconsin Alumni Research Foundation Verfahren zur Durchführung von strahlformstossaktivierter Dissoziation im bereits bestehenden Ioneninjektionspfad eines Massenspektrometers
US9513232B2 (en) * 2010-12-29 2016-12-06 Dh Technologies Development Pte. Ltd. Method for triggering dependent spectra for data acquisition
GB201104225D0 (en) * 2011-03-14 2011-04-27 Micromass Ltd Pre scan for mass to charge ratio range
US8975575B2 (en) * 2011-04-04 2015-03-10 Shimadzu Corporation Mass spectrometer and mass spectrometric method
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
GB201106689D0 (en) * 2011-04-20 2011-06-01 Micromass Ltd Function switching with fast asynchronous acquisition
WO2012164378A2 (en) * 2011-06-03 2012-12-06 Dh Technologies Development Pte. Ltd. Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range
GB201116065D0 (en) 2011-09-16 2011-11-02 Micromass Ltd Encoding of precursor ion beam to aid product ion assignment
EP2786399B1 (de) * 2011-11-29 2019-10-09 Thermo Finnigan LLC Verfahren zur automatisierten prüfung und einstellung einer massenspektrometer-kalibrierung
GB201122178D0 (en) 2011-12-22 2012-02-01 Thermo Fisher Scient Bremen Method of tandem mass spectrometry
GB2497948A (en) 2011-12-22 2013-07-03 Thermo Fisher Scient Bremen Collision cell for tandem mass spectrometry
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
GB2503538B (en) * 2012-03-27 2015-09-09 Micromass Ltd A method of mass spectrometry and a mass spectrometer
CA2868705A1 (en) * 2012-04-05 2013-10-10 Micromass Uk Limited Ms/ms analysis using ecd or etd fragmentation
EP2741224A1 (de) * 2012-11-20 2014-06-11 Thermo Finnigan LLC Verfahren zur Erzeugung von lokalen massenspektrometrischen Bibliotheken zur Interpretation überlagerter Massenspektren
US10615014B2 (en) * 2013-11-12 2020-04-07 Micromass Uk Limited Data dependent MS/MS analysis
EP3283877B1 (de) 2015-04-14 2024-10-09 Waters Technologies Corporation Strukturaufklärung von isotopisch markierten analyten
WO2016196181A1 (en) * 2015-05-29 2016-12-08 Waters Technologies Corporation Mass spectrometry with quadrupole and ion mobility separation capabilities
GB2544834A (en) 2015-06-09 2017-05-31 Waters Technologies Corp Profile diagnositcs in personalized dermatology, dermatopathology and cosmetics
GB2565238A (en) 2015-06-09 2019-02-06 Waters Technologies Corp Molecular diagnostics in personalized dermatology, dermatopathology and cosmetics
WO2017060991A1 (ja) * 2015-10-07 2017-04-13 株式会社島津製作所 タンデム型質量分析装置
US20180088094A1 (en) 2016-09-27 2018-03-29 Waters Technologies Corporation Multiple attribute monitoring methodologies for complex samples
GB2585372B (en) 2019-07-04 2022-03-02 Thermo Fisher Scient Bremen Gmbh Methods and apparatus for mass spectrometry
CN110455907B (zh) * 2019-07-04 2022-04-19 昆山禾信质谱技术有限公司 基于飞行时间质量分析器的串联质谱数据分析方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1205211A (en) * 1982-04-16 1986-05-27 Universite De Sherbrooke Process for the determination of isotopes by mass spectrometry
US5073713A (en) * 1990-05-29 1991-12-17 Battelle Memorial Institute Detection method for dissociation of multiple-charged ions
GB2250632B (en) * 1990-10-18 1994-11-23 Unisearch Ltd Tandem mass spectrometry systems based on time-of-flight analyser
US5182451A (en) * 1991-04-30 1993-01-26 Finnigan Corporation Method of operating an ion trap mass spectrometer in a high resolution mode
GB9510052D0 (en) * 1995-05-18 1995-07-12 Fisons Plc Mass spectrometer
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
CA2227806C (en) * 1998-01-23 2006-07-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
AU2334199A (en) * 1998-01-23 1999-08-09 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guide
JP3405919B2 (ja) * 1998-04-01 2003-05-12 株式会社日立製作所 大気圧イオン化質量分析計
DE69942124D1 (de) * 1998-09-25 2010-04-22 Oregon State Tandemflugzeitmassenspektrometer
CA2255122C (en) 1998-12-04 2007-10-09 Mds Inc. Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry

Also Published As

Publication number Publication date
EP2299469A1 (de) 2011-03-23
JP2009258116A (ja) 2009-11-05
GB2364168A (en) 2002-01-16
GB2364168B (en) 2002-06-26
EP2056334B1 (de) 2016-02-24
DE60140150D1 (de) 2009-11-19
US6586727B2 (en) 2003-07-01
GB0105227D0 (en) 2001-04-18
DE20122885U1 (de) 2008-12-24
EP2056334A3 (de) 2009-12-02
JP5154511B2 (ja) 2013-02-27
US20010052569A1 (en) 2001-12-20
EP2299469B1 (de) 2016-01-06
EP2056334A2 (de) 2009-05-06

Similar Documents

Publication Publication Date Title
ATE445227T1 (de) Methoden und apparat für die massenspektrometrie
CA2350041A1 (en) Methods and apparatus for mass spectrometry
ATE419643T1 (de) Verfahren und vorrichtung zur anwendung in der tandemmassenspektrometrie
ATE488024T1 (de) Verfahren zur massenspektrometrie und massenspektrometer
EP1006559A3 (de) MS/MS Massenabtastungsvorrichtung für ein Quadrupol-Flugzeit-tandemmassenspektrometer
WO2002009144A3 (en) Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
WO1999040610A3 (en) A tandem time-of-flight mass spectrometer with delayed extraction and method for use
CA2601707A1 (en) Improvements relating to a mass spectrometer
WO2006103412A3 (en) Improvements relating to mass spectrometry
SE0000754D0 (sv) Mass spectral peak identification
DK0750747T3 (da) Identifikation af aminosyrer ved massespektrometri
WO2006014285A3 (en) Pulsed ion source for quadrupole mass spectrometer and method
WO2004011905A8 (en) Quality assurance/quality control for electrospray ionization processes
CA2480295A1 (en) Apparatus and method for mobility separation of ions utilizing an ion guide with an axial field and counterflow of gas
WO2006115686A3 (en) Method for controlling space charge-driven ion instabilities in electron impact ion sources
ATE274235T1 (de) Vorrichtung und verfahren zur stoss-induzierten dissoziation von ionen in einem quadrupol- ionenleiter
WO2006064280A3 (en) Mass spectrometer
GB0312483D0 (en) Mass spectrometer
WO2002058106A3 (de) Verfahren und vorrichtung zur beurteilung des zustandes von organismen und naturprodukten sowie zur analyse einer gasförmigen mischung mit haupt- und nebenkomponenten
WO2004112074A3 (en) Laser desorption ion source
WO2004108257A3 (en) Mass spectrometer and related ionizer and methods
WO2005114703A3 (en) Tandem-in-time and tandem-in-space mass and ion mobility spectrometer and method
WO2003102033A3 (en) Methods and apparatus for the characterization and analysis of the shape of molecules and molecular clusters, and for the separation of desired isomers, based on rydberg states
WO2003010794A3 (de) Massenspektrometrie-vorrichtung
EP1406091A4 (de) Verfahren zur analyse eines in der zelle auftretenden proteins oder einer mit dem protein wechselwirkenden substanz

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties