ATE44530T1 - BENZOPYRAN DERIVATIVES, COMPOSITIONS CONTAINING THEM, AND METHOD OF MANUFACTURE THEREOF. - Google Patents

BENZOPYRAN DERIVATIVES, COMPOSITIONS CONTAINING THEM, AND METHOD OF MANUFACTURE THEREOF.

Info

Publication number
ATE44530T1
ATE44530T1 AT85300381T AT85300381T ATE44530T1 AT E44530 T1 ATE44530 T1 AT E44530T1 AT 85300381 T AT85300381 T AT 85300381T AT 85300381 T AT85300381 T AT 85300381T AT E44530 T1 ATE44530 T1 AT E44530T1
Authority
AT
Austria
Prior art keywords
bond
alkyl
aryl
manufacture
compositions containing
Prior art date
Application number
AT85300381T
Other languages
German (de)
Inventor
Ian Douglas Dicker
Kenneth John Gould
John Louis Suschitzky
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848402047A external-priority patent/GB8402047D0/en
Priority claimed from GB848402577A external-priority patent/GB8402577D0/en
Application filed by Fisons Plc filed Critical Fisons Plc
Priority claimed from EP85300381A external-priority patent/EP0150966B1/en
Application granted granted Critical
Publication of ATE44530T1 publication Critical patent/ATE44530T1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Benzopyran derivs. of formula (I) and their derivs. are new. In (I) an adjacent pair of R5-R8 = -X-CR12R13-CR14R15-Y-substd. by A1E1; the remainder = H, OH, alkoxy, NH2, halo, NO2, CN, alkyl, aryl or aralkyl; X = CR10R11 or a bond; Y = O, S, NR20 or CR16R17; either (a) R14+R20 = a bond and opt. R10+R12 = a bond; (b) R12+R14 = a bond; or (c) R10=R12=R14=H; and R11, R13, R15-R17 = H, alkyl, NR21COR22, CN or CnHxF(2n+1-x); or a geminal pair of R10-R17, together with the C to which they are attached, form CO or C=NOR23; or a vicinal pair of R11,R13,R15 and R17 may form -CH=CH-CH=CH- substd. by A1E1; R20 = H, alkyl, aryl or aralkyl, when not linked with R14; A and A1 = a bond, (CH2)m or arylene; n = 1-10; x = 0 or 1 to 2n; m = 1-10; R21-R23=H, alkyl or aryl; E and E1 = COOH or 5H-tetrazolyl; provided that when -X-CR12R13-CR14R15-Y (i) is CO-CR13=CR15-Y, Y = O or S and A = A1 = a bond, then Y is bonded to R7, R5 = R13 = H, R8 = propyl and R15 = E1 which is 5H-tetrazolyl or CONR24R25 (R24 and R25 = H, alkyl or aryl); (ii) is CO-CR13 = CR15-NR20 in which one of R13 and R15 is E1, then E1 = H; and (iii) is CR11=CR13-CR15=N, then at least one of R11, R13 and R15 is NR21COR22, CN or CnHxF(2n+1-x).
AT85300381T 1984-01-26 1985-01-21 BENZOPYRAN DERIVATIVES, COMPOSITIONS CONTAINING THEM, AND METHOD OF MANUFACTURE THEREOF. ATE44530T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB848402047A GB8402047D0 (en) 1984-01-26 1984-01-26 Nitrogen heterocycles
GB848402577A GB8402577D0 (en) 1984-02-01 1984-02-01 Nitrogen heterocyclic compounds
EP85300381A EP0150966B1 (en) 1984-01-26 1985-01-21 Benzopyran derivatives, compositions containing them and processes for their preparation

Publications (1)

Publication Number Publication Date
ATE44530T1 true ATE44530T1 (en) 1989-07-15

Family

ID=27227946

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85300381T ATE44530T1 (en) 1984-01-26 1985-01-21 BENZOPYRAN DERIVATIVES, COMPOSITIONS CONTAINING THEM, AND METHOD OF MANUFACTURE THEREOF.

Country Status (2)

Country Link
AT (1) ATE44530T1 (en)
ES (1) ES8706658A1 (en)

Also Published As

Publication number Publication date
ES8706658A1 (en) 1987-07-01
ES554962A0 (en) 1987-07-01

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