ATE446971T1 - Verfahren zur synthese von insulinpolypeptid- oligomer-konjugaten und proinsulinpolypeptid- oligomer-konjugaten und verfahren zu deren synthese - Google Patents
Verfahren zur synthese von insulinpolypeptid- oligomer-konjugaten und proinsulinpolypeptid- oligomer-konjugaten und verfahren zu deren syntheseInfo
- Publication number
- ATE446971T1 ATE446971T1 AT02766246T AT02766246T ATE446971T1 AT E446971 T1 ATE446971 T1 AT E446971T1 AT 02766246 T AT02766246 T AT 02766246T AT 02766246 T AT02766246 T AT 02766246T AT E446971 T1 ATE446971 T1 AT E446971T1
- Authority
- AT
- Austria
- Prior art keywords
- synthesis
- oligomer conjugates
- polypeptide
- proinsulin
- insulin
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 238000000034 method Methods 0.000 title 2
- 238000003786 synthesis reaction Methods 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 108010076181 Proinsulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31819701P | 2001-09-07 | 2001-09-07 | |
| US10/036,744 US6913903B2 (en) | 2001-09-07 | 2001-12-21 | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US34946202P | 2002-01-18 | 2002-01-18 | |
| PCT/US2002/028428 WO2003022996A2 (en) | 2001-09-07 | 2002-09-06 | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446971T1 true ATE446971T1 (de) | 2009-11-15 |
Family
ID=27365090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02766246T ATE446971T1 (de) | 2001-09-07 | 2002-09-06 | Verfahren zur synthese von insulinpolypeptid- oligomer-konjugaten und proinsulinpolypeptid- oligomer-konjugaten und verfahren zu deren synthese |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1430082B1 (de) |
| JP (1) | JP4318546B2 (de) |
| AR (1) | AR036449A1 (de) |
| AT (1) | ATE446971T1 (de) |
| AU (1) | AU2002329989A1 (de) |
| CY (1) | CY1110640T1 (de) |
| DE (1) | DE60234198D1 (de) |
| DK (1) | DK1430082T3 (de) |
| ES (1) | ES2333781T3 (de) |
| MY (1) | MY127575A (de) |
| PE (1) | PE20030536A1 (de) |
| PT (1) | PT1430082E (de) |
| SA (1) | SA02230453B1 (de) |
| SI (1) | SI1430082T1 (de) |
| UY (1) | UY27439A1 (de) |
| WO (1) | WO2003022996A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| EP1569683B1 (de) | 2002-11-26 | 2010-03-03 | Biocon Limited | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
| US7648962B2 (en) | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| MX2007000883A (es) * | 2004-07-19 | 2007-04-02 | Biocon Ltd | Conjugados de insulina-oligomero, formulaciones y usos de los mismos. |
| EP1893240A2 (de) * | 2005-06-13 | 2008-03-05 | Nastech Pharmaceutical Company Inc. | Transmukosale abgabe von peptid-derivaten |
| CN101291952B (zh) | 2005-10-13 | 2016-02-03 | 拜奥康有限公司 | 制备胰岛素缀合物的方法 |
| EP2049149B1 (de) | 2006-07-31 | 2015-04-15 | Novo Nordisk A/S | Pegylierte verlängerte insuline |
| EP2404934A1 (de) | 2006-09-22 | 2012-01-11 | Novo Nordisk A/S | Proteaseresistente Insulinanaloga |
| ES2563038T3 (es) | 2007-04-30 | 2016-03-10 | Novo Nordisk A/S | Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca |
| ES2618073T3 (es) | 2008-03-14 | 2017-06-20 | Novo Nordisk A/S | Análogos de insulina estabilizados frente a proteasas |
| MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| CA2798518A1 (en) | 2010-05-17 | 2011-11-24 | Cebix, Inc. | Pegylated c-peptide |
| KR20150002777A (ko) | 2012-04-11 | 2015-01-07 | 노보 노르디스크 에이/에스 | 인슐린 제제 |
| AU2014333979B2 (en) | 2013-10-07 | 2018-02-15 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| MA49116A (fr) | 2016-12-16 | 2020-03-25 | Novo Nordisk As | Compositions pharmaceutiques contenant de l'insuline |
| BR112020025924A2 (pt) * | 2018-06-18 | 2021-03-23 | Biocon Limited | método e uso de controle de níveis de glicose pós-prandial em um indivíduo |
| CN113087623A (zh) * | 2021-04-13 | 2021-07-09 | 苏州昊帆生物股份有限公司 | 一种8-溴辛酸乙酯的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4431740A (en) * | 1979-09-12 | 1984-02-14 | The Regents Of The University Of California | DNA Transfer vector and transformed microorganism containing human proinsulin and pre-proinsulin genes |
| US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| SI0792290T1 (en) | 1993-09-17 | 2001-12-31 | Novo Nordisk As | Acylated insulin |
| US5646242A (en) | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
| US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| US6323311B1 (en) * | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
-
2002
- 2002-09-06 PT PT02766246T patent/PT1430082E/pt unknown
- 2002-09-06 JP JP2003527061A patent/JP4318546B2/ja not_active Expired - Fee Related
- 2002-09-06 MY MYPI20023348A patent/MY127575A/en unknown
- 2002-09-06 AU AU2002329989A patent/AU2002329989A1/en not_active Abandoned
- 2002-09-06 UY UY27439A patent/UY27439A1/es not_active IP Right Cessation
- 2002-09-06 ES ES02766246T patent/ES2333781T3/es not_active Expired - Lifetime
- 2002-09-06 WO PCT/US2002/028428 patent/WO2003022996A2/en not_active Ceased
- 2002-09-06 AT AT02766246T patent/ATE446971T1/de active
- 2002-09-06 EP EP02766246A patent/EP1430082B1/de not_active Expired - Lifetime
- 2002-09-06 PE PE2002000884A patent/PE20030536A1/es active IP Right Grant
- 2002-09-06 AR ARP020103388A patent/AR036449A1/es unknown
- 2002-09-06 SI SI200230878T patent/SI1430082T1/sl unknown
- 2002-09-06 DE DE60234198T patent/DE60234198D1/de not_active Expired - Lifetime
- 2002-09-06 DK DK02766246.9T patent/DK1430082T3/da active
- 2002-11-25 SA SA02230453A patent/SA02230453B1/ar unknown
-
2010
- 2010-01-22 CY CY20101100072T patent/CY1110640T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002329989A1 (en) | 2003-03-24 |
| EP1430082A2 (de) | 2004-06-23 |
| PT1430082E (pt) | 2010-01-15 |
| SI1430082T1 (sl) | 2010-02-26 |
| SA02230453B1 (ar) | 2008-02-05 |
| DK1430082T3 (da) | 2010-01-18 |
| JP2005502353A (ja) | 2005-01-27 |
| WO2003022996A3 (en) | 2003-12-31 |
| WO2003022996A2 (en) | 2003-03-20 |
| CY1110640T1 (el) | 2015-04-29 |
| DE60234198D1 (de) | 2009-12-10 |
| MY127575A (en) | 2006-12-29 |
| EP1430082A4 (de) | 2004-11-24 |
| PE20030536A1 (es) | 2003-07-03 |
| JP4318546B2 (ja) | 2009-08-26 |
| AR036449A1 (es) | 2004-09-08 |
| EP1430082B1 (de) | 2009-10-28 |
| ES2333781T3 (es) | 2010-03-01 |
| UY27439A1 (es) | 2003-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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