ATE448197T1 - Malonamid- und malonsäureamid-ester-derivate mit antithrombotischer wirkung, deren herstellung und verwendung - Google Patents

Malonamid- und malonsäureamid-ester-derivate mit antithrombotischer wirkung, deren herstellung und verwendung

Info

Publication number: ATE448197T1
Authority: AT; Austria
Prior art keywords: malonamid; production; acid amide; malonic acid; ester derivatives
Prior art date: 2000-09-30

Application number

AT01974267T

Other languages

English (en)

Inventor

Manfred Schudok

Otmar Klingler

Hans-Peter Nestler

Hans Matter

Herman Schreuder

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-30

Filing date

2001-09-20

Publication date

2009-11-15

2001-09-20 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2009-11-15 Application granted granted Critical

2009-11-15 Publication of ATE448197T1 publication Critical patent/ATE448197T1/de

Links

-1 MALONIC ACID AMIDE ESTER Chemical class 0.000 title 1
230000002785 anti-thrombosis Effects 0.000 title 1
WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/20—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups acylated

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Furan Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT01974267T 2000-09-30 2001-09-20 Malonamid- und malonsäureamid-ester-derivate mit antithrombotischer wirkung, deren herstellung und verwendung ATE448197T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00121551A EP1193248A1 (de)	2000-09-30	2000-09-30	Malonamid- und Malonsäureamid-ester-Derivate mit antithrombotischer Wirkung, deren Herstellung und Verwendung
PCT/EP2001/010845 WO2002028823A1 (en)	2000-09-30	2001-09-20	Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use

Publications (1)

Publication Number	Publication Date
ATE448197T1 true ATE448197T1 (de)	2009-11-15

Family

ID=8169996

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01974267T ATE448197T1 (de)	2000-09-30	2001-09-20	Malonamid- und malonsäureamid-ester-derivate mit antithrombotischer wirkung, deren herstellung und verwendung

Country Status (12)

Country	Link
US (2)	US6645992B2 (de)
EP (2)	EP1193248A1 (de)
JP (1)	JP5016178B2 (de)
AR (1)	AR033399A1 (de)
AT (1)	ATE448197T1 (de)
AU (2)	AU9382401A (de)
CA (1)	CA2423857C (de)
DE (1)	DE60140478D1 (de)
IL (2)	IL155099A0 (de)
MX (1)	MXPA03002133A (de)
TW (1)	TWI288130B (de)
WO (1)	WO2002028823A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1193248A1 (de) *	2000-09-30	2002-04-03	Aventis Pharma Deutschland GmbH	Malonamid- und Malonsäureamid-ester-Derivate mit antithrombotischer Wirkung, deren Herstellung und Verwendung
US20040147503A1 (en) *	2002-06-04	2004-07-29	Sheila Zipfeil	Novel compounds and compositions as cathepsin inhibitors
TW200410921A (en) *	2002-11-25	2004-07-01	Hoffmann La Roche	Mandelic acid derivatives
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1797068B1 (de) *	2004-09-03	2013-10-09	Celgene Corporation	Verfahren zur herstellung substituierter 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline
US7662824B2 (en)	2005-03-18	2010-02-16	Janssen Pharmaceutica Nv	Acylhydrazones as kinase modulators
WO2008107335A1 (en) *	2007-03-05	2008-09-12	F. Hoffmann-La Roche Ag	Aminoamides as orexin antagonists
CN101636378A (zh)	2007-03-15	2010-01-27	弗·哈夫曼-拉罗切有限公司	作为食欲肽拮抗剂的丙二酰胺类
KR20100031732A (ko) *	2007-07-10	2010-03-24	사노피-아벤티스	항혈전 활성을 갖는 말론아미드 유도체
US8906647B2 (en) *	2008-02-21	2014-12-09	Sequoia Pharmaceuticals, Inc.	Diamide inhibitors of cytochrome P450
GB201601301D0 (en) *	2016-01-25	2016-03-09	Takeda Pharmaceutical	Novel compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2037153A1 (en) *	1990-03-09	1991-09-10	Leo Alig	Acetic acid derivatives
AU3232597A (en) *	1996-06-18	1998-01-07	Warner-Lambert Company	Pyrrolo{1,2-a}pyrazine-1,4-dione serine protease inhibitors
WO1997049684A1 (en) *	1996-06-24	1997-12-31	Novo Nordisk A/S	Factor vii-binding reagent
TWI248435B (en) *	1998-07-04	2006-02-01	Boehringer Ingelheim Pharma	Benzimidazoles, the preparation thereof and their use as pharmaceutical compositions
EP1193248A1 (de)	2000-09-30	2002-04-03	Aventis Pharma Deutschland GmbH	Malonamid- und Malonsäureamid-ester-Derivate mit antithrombotischer Wirkung, deren Herstellung und Verwendung

2000
- 2000-09-30 EP EP00121551A patent/EP1193248A1/de not_active Withdrawn
2001
- 2001-09-20 AU AU9382401A patent/AU9382401A/xx active Pending
- 2001-09-20 CA CA2423857A patent/CA2423857C/en not_active Expired - Fee Related
- 2001-09-20 IL IL15509901A patent/IL155099A0/xx unknown
- 2001-09-20 DE DE60140478T patent/DE60140478D1/de not_active Expired - Lifetime
- 2001-09-20 EP EP01974267A patent/EP1339673B1/de not_active Expired - Lifetime
- 2001-09-20 AT AT01974267T patent/ATE448197T1/de not_active IP Right Cessation
- 2001-09-20 JP JP2002532409A patent/JP5016178B2/ja not_active Expired - Fee Related
- 2001-09-20 MX MXPA03002133A patent/MXPA03002133A/es active IP Right Grant
- 2001-09-20 AU AU2001293824A patent/AU2001293824B2/en not_active Ceased
- 2001-09-20 WO PCT/EP2001/010845 patent/WO2002028823A1/en not_active Ceased
- 2001-09-27 AR ARP010104562A patent/AR033399A1/es not_active Application Discontinuation
- 2001-10-01 US US09/965,790 patent/US6645992B2/en not_active Expired - Lifetime
- 2001-10-23 TW TW090126095A patent/TWI288130B/zh not_active IP Right Cessation
2003
- 2003-03-26 IL IL155099A patent/IL155099A/en not_active IP Right Cessation
- 2003-08-06 US US10/634,827 patent/US7153876B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1339673A1 (de)	2003-09-03
AU9382401A (en)	2002-04-15
AU2001293824B2 (en)	2006-01-12
AR033399A1 (es)	2003-12-17
DE60140478D1 (de)	2009-12-24
TWI288130B (en)	2007-10-11
WO2002028823A1 (en)	2002-04-11
US7153876B2 (en)	2006-12-26
MXPA03002133A (es)	2003-08-19
IL155099A (en)	2008-12-29
JP5016178B2 (ja)	2012-09-05
EP1339673B1 (de)	2009-11-11
JP2004512280A (ja)	2004-04-22
EP1193248A1 (de)	2002-04-03
US6645992B2 (en)	2003-11-11
CA2423857A1 (en)	2002-04-11
CA2423857C (en)	2010-07-20
IL155099A0 (en)	2003-10-31
US20040034027A1 (en)	2004-02-19
US20030027828A1 (en)	2003-02-06

Legal Events

Date	Code	Title	Description
2010-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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