ATE448249T1 - Neue cyclodextrindimere und derivate davon, herstellungsverfahren dafür und verwendung davon, insbesondere zur solubilisierung von pharmakologischen wirkstoffen - Google Patents

Neue cyclodextrindimere und derivate davon, herstellungsverfahren dafür und verwendung davon, insbesondere zur solubilisierung von pharmakologischen wirkstoffen

Info

Publication number: ATE448249T1
Authority: AT; Austria
Prior art keywords: integer; image; compound; alkyl; formula
Prior art date: 2003-11-26

Application number

AT04805527T

Other languages

English (en)

Inventor

Jacques Defaye

Carmen Ortiz-Mellet

Jose Manuel Garcia-Fernandez

Juan Benito

Marta Gomez-Garcia

Jian-Xin Yu

Original Assignee

Centre Nat Rech Scient

Univ Joseph Fourier

Consejo Superior Investigacion

Univ Sevilla

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-26

Filing date

2004-11-24

Publication date

2009-11-15

2004-11-24 Application filed by Centre Nat Rech Scient, Univ Joseph Fourier, Consejo Superior Investigacion, Univ Sevilla filed Critical Centre Nat Rech Scient

2009-11-15 Application granted granted Critical

2009-11-15 Publication of ATE448249T1 publication Critical patent/ATE448249T1/de

Links

229920000858 Cyclodextrin Polymers 0.000 title abstract 2
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000000144 pharmacologic effect Effects 0.000 title 1
230000007928 solubilization Effects 0.000 title 1
238000005063 solubilization Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
-1 9-fluorenylmethyl Chemical group 0.000 abstract 1
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
229940125773 compound 10 Drugs 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
150000002540 isothiocyanates Chemical class 0.000 abstract 1
ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000002772 monosaccharides Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
150000002482 oligosaccharides Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003138 primary alcohols Chemical group 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
230000002285 radioactive effect Effects 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1
125000004964 sulfoalkyl group Chemical group 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
238000012800 visualization Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Polymers & Plastics (AREA)
Nanotechnology (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medical Informatics (AREA)
Crystallography & Structural Chemistry (AREA)
Inorganic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT04805527T 2003-11-26 2004-11-24 Neue cyclodextrindimere und derivate davon, herstellungsverfahren dafür und verwendung davon, insbesondere zur solubilisierung von pharmakologischen wirkstoffen ATE448249T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0313873A FR2862649B1 (fr)	2003-11-26	2003-11-26	Nouveaux dimeres de cyclodextrines et leurs derives, leurs procedes de preparation et leur utilisation notamment pour la solubilisation de substances pharmacologiquement actives
PCT/FR2004/002998 WO2005054303A2 (fr)	2003-11-26	2004-11-24	Dimères de cyclodextrines et leurs dérivés, leurs procédés de préparation et leur utilisation notamment pour la solubilisation de substances pharmacologiquement actives

Publications (1)

Publication Number	Publication Date
ATE448249T1 true ATE448249T1 (de)	2009-11-15

Family

ID=34531291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04805527T ATE448249T1 (de)	2003-11-26	2004-11-24	Neue cyclodextrindimere und derivate davon, herstellungsverfahren dafür und verwendung davon, insbesondere zur solubilisierung von pharmakologischen wirkstoffen

Country Status (8)

Country	Link
US (1)	US7781417B2 (de)
EP (1)	EP1689789B1 (de)
AT (1)	ATE448249T1 (de)
CA (1)	CA2547545A1 (de)
DE (1)	DE602004024110D1 (de)
ES (1)	ES2336003T3 (de)
FR (1)	FR2862649B1 (de)
WO (1)	WO2005054303A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2907456B1 (fr) *	2006-10-20	2009-01-16	Biocydex Soc Par Actions Simpl	Procede de preparation d'oligomeres ou polymeres de cyclodestrines.
CZ301772B6 (cs) *	2006-11-23	2010-06-16	Ústav organické chemie a biochemie AV CR	Alfa-cyklodextrinový dimer, zpusob jeho prípravy a jeho použití
US7680553B2 (en)	2007-03-08	2010-03-16	Smp Logic Systems Llc	Methods of interfacing nanomaterials for the monitoring and execution of pharmaceutical manufacturing processes
DE102009054962A1 (de) *	2009-12-18	2011-06-22	Hilti Aktiengesellschaft	Vorrichtung und Verfahren zur Aufbereitung einer Kühl- und Spülflüssigkeit
CN110451599A (zh) *	2019-08-30	2019-11-15	东南大学	一种通过紫外光活化甲酸去除水体中硝态氮的方法
CN112553162B (zh) *	2020-12-15	2023-01-13	湖北盛齐安生物科技股份有限公司	细胞凋亡诱导剂和载药囊泡及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY106598A (en) *	1988-08-31	1995-06-30	Australian Commercial Res & Development Ltd	Compositions and methods for drug delivery and chromatography.
US5684169A (en) *	1992-11-27	1997-11-04	Ensuiko Sugar Refining Co., Ltd.	Cyclodextrin inclusion complex of taxol, and method for its production and its use
JPH0753396A (ja) *	1993-08-19	1995-02-28	Ensuiko Sugar Refining Co Ltd	タキソールのサイクロデキストリン包接物，その製造法および用途
FR2716200B1 (fr) *	1994-02-11	1996-04-26	Commissariat Energie Atomique	Procédé de préparation de cyclomaltooligosaccharides ramifiés, en particulier de cyclodextrines ramifiées.
FR2746103B1 (fr) *	1996-03-14	1998-07-24		Thioureido-cyclodextrines, utilisables en particulier pour solubiliser des agents antitumoraux et antiparasitaires et leurs procedes de preparation
JP2001522901A (ja) *	1997-11-11	2001-11-20	セラモプテックインコーポレイティド	医薬活性物質のシクロデキストリンオリゴマーによる非毒化
DE10018617A1 (de) *	2000-01-13	2001-10-31	Joerg G Moser	Cyclodextrin-Dimere mit Peptid-Spacerstrukturen zur Entgiftung von pharmazeutischen Wirkstoffen hohen Nebenwirkungspotentials
US20030134824A1 (en) *	2001-11-12	2003-07-17	Ronald Breslow	Beta-cyclodextrin dimers and phthalocyanines and uses thereof

2003
- 2003-11-26 FR FR0313873A patent/FR2862649B1/fr not_active Expired - Fee Related
2004
- 2004-11-24 EP EP04805527A patent/EP1689789B1/de not_active Expired - Lifetime
- 2004-11-24 ES ES04805527T patent/ES2336003T3/es not_active Expired - Lifetime
- 2004-11-24 CA CA002547545A patent/CA2547545A1/fr not_active Abandoned
- 2004-11-24 WO PCT/FR2004/002998 patent/WO2005054303A2/fr not_active Ceased
- 2004-11-24 AT AT04805527T patent/ATE448249T1/de not_active IP Right Cessation
- 2004-11-24 US US10/580,856 patent/US7781417B2/en not_active Expired - Fee Related
- 2004-11-24 DE DE602004024110T patent/DE602004024110D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FR2862649B1 (fr)	2006-01-27
EP1689789A2 (de)	2006-08-16
US7781417B2 (en)	2010-08-24
DE602004024110D1 (de)	2009-12-24
US20070082867A1 (en)	2007-04-12
CA2547545A1 (fr)	2005-06-16
FR2862649A1 (fr)	2005-05-27
WO2005054303A2 (fr)	2005-06-16
ES2336003T3 (es)	2010-04-07
WO2005054303A8 (fr)	2006-09-28
WO2005054303A3 (fr)	2005-08-04
EP1689789B1 (de)	2009-11-11

Legal Events

Date	Code	Title	Description
2010-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EP0380559B1 (de)	1993-12-22	Oligonukleotidfunktionierungsmittel und -verfahren
RU2005110412A (ru)	2006-01-20	Производные гидроксиалкилкрахмала
US20100303754A1 (en)	2010-12-02	Process for preparation of cyclodextrin oligomers or polymers, products obtained and uses
CA2492775A1 (en)	2004-02-12	Polyalkylene glycol acid additives
TWI230162B (en)	2005-04-01	Geranyl group-containing compounds
JPS61191675A (ja)	1986-08-26	巨大分子物質
JP2006518704A (ja)	2006-08-17	チューブライシン、その製造方法、及び、チューブライシン製剤
HU204506B (en)	1992-01-28	Process for producing phenyl-hydrazine derivatives
NZ592917A (en)	2012-12-21	Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates
US20040030142A1 (en)	2004-02-12	Method for producing n-alkoxy-n-alkylamides
ATE448249T1 (de)	2009-11-15	Neue cyclodextrindimere und derivate davon, herstellungsverfahren dafür und verwendung davon, insbesondere zur solubilisierung von pharmakologischen wirkstoffen
CA2619036A1 (en)	2007-03-22	Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
CA2539975A1 (en)	2005-04-07	9,10-.alpha.,.alpha.-oh-taxane analogs and methods for production thereof
DE502005000198D1 (de)	2007-01-04	Verfahren zur Herstellung von Alkylglycosiden
Bakulev et al.	1993	Study of polyfunctional diazo compounds reactivity in heterocyclization by the method of intramolecular competitive reactions
US6080733A (en)	2000-06-27	Thioureido-cyclodextrins, utilized in particular to solubilize anti-tumor, and antiparasitic agents and their preparation processes
JP2002128889A (ja)	2002-05-09	メルカプト脂肪酸とポリオキシアルキレン化合物とのエステルおよびその製造方法
US5990278A (en)	1999-11-23	Protective or anchor groups and their use
KR960029312A (ko)	1996-08-17	N-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
AU746588B2 (en)	2002-05-02	Stereoisomeric indole compounds, process for the preparation of the same, and use thereof
EA199900528A1 (ru)	1999-12-29	Новые производные эритромицина, способ их получения и применения в качетве медикаментов
EP4310094A1 (de)	2024-01-24	Verfahren zur herstellung von aminosäure oder peptid, reagenz zur bildung einer schutzgruppe und verbindung
FR2497800A1 (fr)	1982-07-16	Nouveaux derives de nitrosouree
KR840002807A (ko)	1984-07-21	4-시아노-2-아제티디논 유도체의 제조방법
PT1101756E (pt)	2003-06-30	Novos compostos de aminopirrolina processo para a sua preparacao e as composicoes farmaceuticas que os contem