ATE448795T1 - Methode zur behandlung von wundheilung in diabetikern - Google Patents
Methode zur behandlung von wundheilung in diabetikernInfo
- Publication number
- ATE448795T1 ATE448795T1 AT97947592T AT97947592T ATE448795T1 AT E448795 T1 ATE448795 T1 AT E448795T1 AT 97947592 T AT97947592 T AT 97947592T AT 97947592 T AT97947592 T AT 97947592T AT E448795 T1 ATE448795 T1 AT E448795T1
- Authority
- AT
- Austria
- Prior art keywords
- wound healing
- treating wound
- subject
- diabetic persons
- diabetic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Marine Sciences & Fisheries (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/755,235 US6790443B2 (en) | 1996-11-22 | 1996-11-22 | Method for treating symptoms of diabetes |
| PCT/US1997/021197 WO1998022138A1 (en) | 1996-11-22 | 1997-11-12 | Method for treating symptoms of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE448795T1 true ATE448795T1 (de) | 2009-12-15 |
Family
ID=25038266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947592T ATE448795T1 (de) | 1996-11-22 | 1997-11-12 | Methode zur behandlung von wundheilung in diabetikern |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6790443B2 (de) |
| EP (1) | EP0946196B1 (de) |
| JP (1) | JP4754660B2 (de) |
| AT (1) | ATE448795T1 (de) |
| AU (1) | AU745241B2 (de) |
| CA (2) | CA2633660A1 (de) |
| DE (1) | DE69739662D1 (de) |
| ES (1) | ES2336978T3 (de) |
| WO (1) | WO1998022138A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US7101838B2 (en) | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| US6465422B1 (en) * | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| US6753150B2 (en) * | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
| ES2299267T3 (es) * | 1998-10-06 | 2008-05-16 | The Trustees Of Columbia University In The City Of New York | Nueva proteina extracelular ligante de rage (en-rage) y sus usos. |
| EP1307219A4 (de) * | 1999-08-13 | 2005-04-06 | Univ Columbia | Verfahren zur hemmung der bindung von beta-faltblattfibrillen an rage( advanced glycation endproduct receptor ) |
| US20050170382A1 (en) * | 1999-10-06 | 2005-08-04 | The Trustees Of Columbia University In The City Of New York. | RAGE-related compositions |
| US6908741B1 (en) | 2000-05-30 | 2005-06-21 | Transtech Pharma, Inc. | Methods to identify compounds that modulate RAGE |
| US6613801B2 (en) | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US7919670B1 (en) | 2000-08-14 | 2011-04-05 | The Trustees Of Columbia University In The City Of New York | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereof |
| AU2002213192A1 (en) | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| WO2002070473A2 (en) | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
| WO2002070667A2 (en) * | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | High level insect expression of rage proteins |
| JP2004523565A (ja) | 2001-03-05 | 2004-08-05 | トランス テック ファーマ,インコーポレイテッド | 治療因子としてのベンゾイミダゾール誘導体 |
| US7754217B2 (en) | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| EP1482931B1 (de) | 2002-03-05 | 2011-10-19 | TransTech Pharma, Inc. | Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen |
| WO2004016229A2 (en) * | 2002-08-16 | 2004-02-26 | Wyeth | Compositions and methods for treating rage-associated disorders |
| WO2004100890A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of Columbia University In The City Of New York | Rage g82s-related methods and compositions for treating inflammatory disorders |
| DE10335420A1 (de) * | 2003-08-02 | 2005-02-17 | ITW Oberflächentechnik GmbH & Co. KG | Spritzbeschichtungseinrichtung |
| WO2005023191A2 (en) * | 2003-09-05 | 2005-03-17 | The Trustees Of Columbia University In The City Of New York | Rage-related methods and compositions for treating glomerular injury |
| WO2006008779A1 (en) | 2004-07-20 | 2006-01-26 | Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione-Istituto Dermopatico Dell'immacolata | Use of hmgb1 for wound healing |
| CN1993378A (zh) * | 2004-08-03 | 2007-07-04 | 转化技术制药公司 | Rage融合蛋白及使用方法 |
| AP2007003893A0 (en) * | 2004-08-03 | 2007-02-28 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| EP1799700A4 (de) * | 2004-09-27 | 2009-02-11 | Centocor Inc | Srage-mimetikörper, -zusammensetzungen, -verfahren und -verwendungen |
| CA2601630A1 (en) * | 2005-03-17 | 2006-09-21 | The Trustees Of Columbia University In The City Of New York | Rage/diaphanous interaction and related compositions and methods |
| WO2006119510A2 (en) * | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same |
| WO2007073272A1 (en) * | 2005-12-23 | 2007-06-28 | Gcoder Systems Ab | Positioning pattern |
| CN101410411A (zh) * | 2006-02-09 | 2009-04-15 | 转化技术制药公司 | Rage融合蛋白及使用方法 |
| BRPI0711193A2 (pt) | 2006-05-05 | 2013-06-18 | Transtech Pharma Inc | proteÍnas de fusço rage, formulaÇÕes e mÉtodos de uso dos mesmos |
| US20080199467A1 (en) * | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
| WO2008153957A1 (en) * | 2007-06-07 | 2008-12-18 | The Trustees Of Columbia University In The City Of New York | Uses of rage antagonists for treating obesity and related diseases |
| EP2158210B1 (de) * | 2007-06-14 | 2015-12-09 | Galactica Pharmaceuticals, Inc. | Rage-fusionsproteine |
| CN101903775A (zh) * | 2007-10-19 | 2010-12-01 | Erac股份有限公司 | 抗edta的s100a12c复合物(erac) |
| RU2518351C2 (ru) * | 2008-05-09 | 2014-06-10 | Эббви Дойчланд Гмбх Унд Ко.Кг, | Антитела к рецептору конечных продуктов глубокого гликирования (rage) и их применения |
| WO2010058517A1 (ja) * | 2008-11-20 | 2010-05-27 | 明治乳業株式会社 | IgGおよび/またはIgGのFc断片を含む神経細胞刺激剤 |
| CN102803292A (zh) | 2009-04-20 | 2012-11-28 | 辉瑞公司 | 蛋白质糖基化的控制及其相关组合物和方法 |
| CA2772797C (en) | 2009-09-30 | 2018-09-25 | Transtech Pharma, Inc. | Substituted imidazole derivatives |
| TWI510241B (zh) | 2010-02-18 | 2015-12-01 | Vtv Therapeutice Llc | 苯基-雜芳基衍生物及其使用方法 |
| US9717710B2 (en) | 2012-10-05 | 2017-08-01 | Vtv Therapeutics Llc | Treatment of mild and moderate Alzheimer's disease |
| WO2019190823A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| WO2019190822A1 (en) | 2018-03-28 | 2019-10-03 | Vtv Therapeutics Llc | Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine |
| JP7464591B2 (ja) | 2018-10-10 | 2024-04-09 | ブイティーブイ・セラピューティクス・エルエルシー | [3-(4-{2-ブチル-1-[4-(4-クロロ-フェノキシ)-フェニル]-1h-イミダゾール-4-イル}-フェノキシ)-プロピル]-ジエチル-アミンの代謝産物 |
| CN113995833B (zh) * | 2021-11-10 | 2023-12-26 | 南京南方元生物科技有限公司 | 腺苷脱氨酶及其修饰物在制备糖尿病伤口修复药物中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585344A (en) * | 1984-03-19 | 1996-12-17 | The Rockefeller University | Liver-derived receptors for advanced glycosylation endproducts and uses thereof |
| US5165938A (en) * | 1984-11-29 | 1992-11-24 | Regents Of The University Of Minnesota | Wound healing agents derived from platelets |
| US4975421A (en) * | 1985-08-19 | 1990-12-04 | Bioglucan, Lp. | Soluble phosphorylated glucan: methods and compositions for wound healing |
| US5436228A (en) * | 1990-12-12 | 1995-07-25 | Postlethwaite; Arnold E. | Chemotactic wound healing peptides |
| JPH07500580A (ja) * | 1991-09-09 | 1995-01-19 | ペプテック リミテッド | 糖尿病の合併症及び病因の処理方法 |
| US5453514A (en) * | 1992-12-25 | 1995-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrazole derivatives and compositions and methods of use as maillard reaction inhibitors |
| US5561107A (en) * | 1993-06-04 | 1996-10-01 | Demeter Biotechnologies, Ltd. | Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides |
| US6410322B1 (en) * | 1993-07-27 | 2002-06-25 | Hybridon Inc | Antisense oligonucleotide inhibition of vascular endothelial growth factor expression |
| US5532275A (en) * | 1994-12-07 | 1996-07-02 | Andrx Pharmaceuticals, Inc. | Method of promoting wound healing and scar regression |
| AU1832797A (en) | 1996-01-26 | 1997-08-20 | Trustees Of Columbia University In The City Of New York, The | A polypeptide from lung extract which binds amyloid-beta peptide |
| AU2696097A (en) | 1996-04-16 | 1997-11-07 | Schering Aktiengesellschaft | Advanced glycosylation end-product receptor peptides and uses therefor |
| US5864018A (en) | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| GB9621214D0 (en) | 1996-10-11 | 1996-11-27 | Johnson Matthey Plc | Improvements in catalytic processes |
| US7081241B1 (en) * | 1998-10-06 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Extracellular rage binding protein (EN-RAGE) and uses thereof |
| US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US6555651B2 (en) * | 1997-10-09 | 2003-04-29 | The Trustees Of Columbia University In The City Of New York | Ligand binding site of rage and uses thereof |
| US6790443B2 (en) * | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US7101838B2 (en) | 1997-08-05 | 2006-09-05 | The Trustees Of Columbia University In The City Of New York | Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts |
| US6465422B1 (en) | 1998-04-17 | 2002-10-15 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting tumor invasion or spreading in a subject |
| US6753150B2 (en) * | 1998-10-05 | 2004-06-22 | The Trustees Of Columbia University In The City Of New York | Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage |
| ES2299267T3 (es) * | 1998-10-06 | 2008-05-16 | The Trustees Of Columbia University In The City Of New York | Nueva proteina extracelular ligante de rage (en-rage) y sus usos. |
| US6605642B2 (en) * | 1999-04-05 | 2003-08-12 | City Of Hope | Inhibitors of formation of advanced glycation endproducts (AGES) |
| AU5170400A (en) * | 1999-05-27 | 2000-12-18 | George F. El Khoury | Topical application of muscarinic and opioid agents for treatment of tinnitus |
| EP1307219A4 (de) * | 1999-08-13 | 2005-04-06 | Univ Columbia | Verfahren zur hemmung der bindung von beta-faltblattfibrillen an rage( advanced glycation endproduct receptor ) |
| US6825164B1 (en) * | 2000-08-14 | 2004-11-30 | The Trustees Of Columbia University In The City Of New York | Method to increase cerebral blood flow in amyloid angiopathy |
| US6563015B1 (en) * | 2000-08-14 | 2003-05-13 | The Trustees Of Columbia University In The City Of New York | Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) and mutant APP in brain and uses thereof |
| AU2002213192A1 (en) * | 2000-10-13 | 2002-04-22 | The Trustees Of Columbia University In The City Of New York | A method for inhibiting new tissue growth in blood vessels in a patient subjected to blood vessel injury |
| WO2004100890A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of Columbia University In The City Of New York | Rage g82s-related methods and compositions for treating inflammatory disorders |
| AP2007003893A0 (en) * | 2004-08-03 | 2007-02-28 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
| US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
| WO2008153957A1 (en) * | 2007-06-07 | 2008-12-18 | The Trustees Of Columbia University In The City Of New York | Uses of rage antagonists for treating obesity and related diseases |
-
1996
- 1996-11-22 US US08/755,235 patent/US6790443B2/en not_active Expired - Fee Related
-
1997
- 1997-11-12 JP JP52386098A patent/JP4754660B2/ja not_active Expired - Fee Related
- 1997-11-12 CA CA002633660A patent/CA2633660A1/en not_active Abandoned
- 1997-11-12 WO PCT/US1997/021197 patent/WO1998022138A1/en not_active Ceased
- 1997-11-12 ES ES97947592T patent/ES2336978T3/es not_active Expired - Lifetime
- 1997-11-12 DE DE69739662T patent/DE69739662D1/de not_active Expired - Lifetime
- 1997-11-12 CA CA002271857A patent/CA2271857C/en not_active Expired - Fee Related
- 1997-11-12 EP EP97947592A patent/EP0946196B1/de not_active Expired - Lifetime
- 1997-11-12 AU AU52639/98A patent/AU745241B2/en not_active Ceased
- 1997-11-12 AT AT97947592T patent/ATE448795T1/de not_active IP Right Cessation
-
2004
- 2004-05-20 US US10/850,861 patent/US7700085B2/en not_active Expired - Fee Related
-
2010
- 2010-04-20 US US12/799,204 patent/US20100255081A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030059423A1 (en) | 2003-03-27 |
| AU745241B2 (en) | 2002-03-14 |
| CA2633660A1 (en) | 1998-05-28 |
| US20040228855A1 (en) | 2004-11-18 |
| ES2336978T3 (es) | 2010-04-19 |
| DE69739662D1 (de) | 2009-12-31 |
| AU5263998A (en) | 1998-06-10 |
| EP0946196A4 (de) | 2005-01-12 |
| CA2271857A1 (en) | 1998-05-28 |
| US7700085B2 (en) | 2010-04-20 |
| US6790443B2 (en) | 2004-09-14 |
| JP4754660B2 (ja) | 2011-08-24 |
| US20100255081A1 (en) | 2010-10-07 |
| EP0946196A1 (de) | 1999-10-06 |
| EP0946196B1 (de) | 2009-11-18 |
| CA2271857C (en) | 2008-07-15 |
| WO1998022138A1 (en) | 1998-05-28 |
| JP2001504493A (ja) | 2001-04-03 |
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