ATE449168T1 - Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür - Google Patents
Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafürInfo
- Publication number
- ATE449168T1 ATE449168T1 AT05804853T AT05804853T ATE449168T1 AT E449168 T1 ATE449168 T1 AT E449168T1 AT 05804853 T AT05804853 T AT 05804853T AT 05804853 T AT05804853 T AT 05804853T AT E449168 T1 ATE449168 T1 AT E449168T1
- Authority
- AT
- Austria
- Prior art keywords
- reconstituted complex
- reconstituted
- histone methyltransferase
- complex
- methods
- Prior art date
Links
- 108010036115 Histone Methyltransferases Proteins 0.000 title abstract 3
- 102000011787 Histone Methyltransferases Human genes 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100033636 Histone H3.2 Human genes 0.000 abstract 1
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 abstract 1
- 108010033040 Histones Proteins 0.000 abstract 1
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 abstract 1
- 101000866766 Homo sapiens Polycomb protein EED Proteins 0.000 abstract 1
- 101000584499 Homo sapiens Polycomb protein SUZ12 Proteins 0.000 abstract 1
- 101000833157 Homo sapiens Zinc finger protein AEBP2 Proteins 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100031338 Polycomb protein EED Human genes 0.000 abstract 1
- 102100030702 Polycomb protein SUZ12 Human genes 0.000 abstract 1
- 102000007508 Retinoblastoma-Binding Protein 4 Human genes 0.000 abstract 1
- 108010071034 Retinoblastoma-Binding Protein 4 Proteins 0.000 abstract 1
- 102100024389 Zinc finger protein AEBP2 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01043—Histone-lysine N-methyltransferase (2.1.1.43)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57588004P | 2004-06-01 | 2004-06-01 | |
| PCT/US2005/018840 WO2005118796A2 (en) | 2004-06-01 | 2005-05-27 | Reconstituted histone methyltransferase complex and methods of identifying modulators thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE449168T1 true ATE449168T1 (de) | 2009-12-15 |
Family
ID=35463449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05804853T ATE449168T1 (de) | 2004-06-01 | 2005-05-27 | Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7563589B2 (de) |
| EP (1) | EP1765994B1 (de) |
| JP (1) | JP5160885B2 (de) |
| AT (1) | ATE449168T1 (de) |
| DE (1) | DE602005017781D1 (de) |
| WO (1) | WO2005118796A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008103761A2 (en) * | 2007-02-20 | 2008-08-28 | Sequenom, Inc. | Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation |
| US8709726B2 (en) | 2008-03-11 | 2014-04-29 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| GB0822248D0 (en) * | 2008-12-05 | 2009-01-14 | Medical Res Council | Crystal meths |
| WO2011011366A2 (en) * | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
| US9926593B2 (en) | 2009-12-22 | 2018-03-27 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| WO2011082098A1 (en) * | 2009-12-30 | 2011-07-07 | The Rockefeller University | Lysine and arginine methyltransferase inhibitors for treating cancer |
| CA2841142C (en) | 2010-06-23 | 2020-12-15 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| BR112013005806B1 (pt) | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| EP3323820B1 (de) | 2011-02-28 | 2023-05-10 | Epizyme, Inc. | Substituierte 6,5-kondensierte bicyclische heteroarylverbindungen |
| TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| US9206128B2 (en) | 2011-11-18 | 2015-12-08 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2013075084A1 (en) | 2011-11-18 | 2013-05-23 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2013078320A1 (en) * | 2011-11-21 | 2013-05-30 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2013120104A2 (en) | 2012-02-10 | 2013-08-15 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP2820129A1 (de) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| KR102587175B1 (ko) * | 2012-03-12 | 2023-10-06 | 에피자임, 인코포레이티드 | 인간 ｅｚｈ2의 억제제 및 이의 사용 방법 |
| IL296199B2 (en) | 2012-04-13 | 2024-12-01 | Eisai R&D Man Co Ltd | Salt form of a human hi stone methyltransf erase ezh2 inhibitor |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2014011928A1 (en) | 2012-07-13 | 2014-01-16 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| AU2013331380B2 (en) | 2012-10-15 | 2018-03-22 | Epizyme, Inc. | Substituted benzene compounds |
| EP2971100A1 (de) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primer zur analyse der dna-methylierung |
| US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3033334A1 (de) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Indolderivate als modulatoren methylmodifizierender enzyme, zusammensetzungen daraus und verwendungen davon |
| AU2014337300B2 (en) | 2013-10-16 | 2019-01-03 | Eisai R&D Management Co., Ltd. | Hydrochloride salt form for EZH2 inhibition |
| EP3736344A1 (de) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| EA032416B1 (ru) | 2014-12-23 | 2019-05-31 | Новартис Аг | Соединения триазолопиримидина и их применения |
| US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| WO2017221092A1 (en) | 2016-06-20 | 2017-12-28 | Novartis Ag | Triazolopyridine compounds and uses thereof |
| US10676479B2 (en) | 2016-06-20 | 2020-06-09 | Novartis Ag | Imidazolepyridine compounds and uses thereof |
| EP3472168B1 (de) | 2016-06-20 | 2024-01-10 | Novartis AG | Kristalline formen einer triazolopyrimidinverbindung |
| CA3039059A1 (en) | 2016-10-19 | 2018-04-26 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
| CN108314677B (zh) | 2017-01-17 | 2020-06-30 | 安徽中科拓苒药物科学研究有限公司 | 一种ezh2抑制剂及其用途 |
| US20230100105A1 (en) * | 2020-02-23 | 2023-03-30 | The Jackson Laboratory | Regulatory elements in the genome |
| CN113549603A (zh) * | 2021-06-29 | 2021-10-26 | 洛阳职业技术学院 | 一种鸡ezh2蛋白的原核表达与纯化方法的研究方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19516776A1 (de) | 1995-05-10 | 1996-11-14 | Boehringer Ingelheim Int | Chromatin-Regulatorgene |
| US20050059682A1 (en) | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
-
2005
- 2005-05-27 WO PCT/US2005/018840 patent/WO2005118796A2/en not_active Ceased
- 2005-05-27 US US11/140,659 patent/US7563589B2/en not_active Expired - Fee Related
- 2005-05-27 EP EP05804853A patent/EP1765994B1/de not_active Expired - Lifetime
- 2005-05-27 AT AT05804853T patent/ATE449168T1/de not_active IP Right Cessation
- 2005-05-27 JP JP2007515421A patent/JP5160885B2/ja not_active Expired - Fee Related
- 2005-05-27 DE DE602005017781T patent/DE602005017781D1/de not_active Expired - Lifetime
-
2009
- 2009-07-02 US US12/497,211 patent/US20090298105A1/en not_active Abandoned
-
2016
- 2016-02-26 US US15/054,712 patent/US20160168546A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005118796A3 (en) | 2006-06-01 |
| DE602005017781D1 (de) | 2009-12-31 |
| US20090298105A1 (en) | 2009-12-03 |
| US7563589B2 (en) | 2009-07-21 |
| US20050266473A1 (en) | 2005-12-01 |
| WO2005118796A2 (en) | 2005-12-15 |
| EP1765994B1 (de) | 2009-11-18 |
| JP5160885B2 (ja) | 2013-03-13 |
| EP1765994A2 (de) | 2007-03-28 |
| JP2008506367A (ja) | 2008-03-06 |
| US20160168546A1 (en) | 2016-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE449168T1 (de) | Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür | |
| WO2004037159A3 (en) | Compounds, compositions and methods for modulating fat metabolism | |
| WO2003089904A3 (en) | Aib1 as a prognostic marker and predictor of resistance to encocrine therapy | |
| DE69918089D1 (de) | Btk inhibitoren und verfahren zur identifizierung und verwendung | |
| ATE340593T1 (de) | Ermittlung der auswirkung von einem clostridial toxin auf muskeln | |
| EP1700120A4 (de) | Marker für neuromyelitis optica | |
| WO2003079020A3 (en) | Methods and compositions for the identification, assessment, and therapy of small cell lung cancer | |
| ATE504836T1 (de) | Verfahren zur identifizierung von trpv2- modulatoren | |
| ATE431426T1 (de) | Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2 | |
| DE60321356D1 (de) | Verfahren zur diagnostik von eierstock endometriose | |
| WO2004033666A3 (en) | Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases | |
| ATE494548T1 (de) | Reinigung, charakterisierung und wiederherstellung einer ubiquitin-e3-ligase | |
| ATE403864T1 (de) | Verfahren zur identifizierung von substanzen, die die aktivität von hyperpolarisations-aktivierten kationen-kanälen modulieren | |
| WO2004070025A3 (en) | Novel goodpasture antigen-binding protein isoforms and protein misfolded-mediated disorders | |
| WO2003030725A3 (en) | Pancreatic cancer diagnosis and therapies | |
| ATE426039T1 (de) | Verfahren fur den nachweis von streptococcus agalactiae mittels alpha-glucosidase-aktivitat | |
| MXPA05001690A (es) | Estrategia de deteccion para farmacos anticancer. | |
| WO2004087069A3 (en) | METHODS OF IDENTIFYING COMPOUNDS THAT TARGET tRNA SPLICING ENDONUCLEASE AND USES OF SAID COMPOUNDS AS ANTI-PROLIFERATIVE AGENTS | |
| BRPI0408238A (pt) | anticorpo, método de detectar cáncer, conjunto para detecção de cáncer, e, composição farmacêutica para tratar cáncer | |
| AU2003211040A8 (en) | The eaat2 promoter and uses thereof | |
| TW200517910A (en) | Order analysis system, order analysis method and order analysis program | |
| EP1255110A3 (de) | Verfahren und Produkten zur Identifizierung von Modulatoren der P2X7-Rezeptorwirkzamkeit, und ihre Verwendung zur Behandlung von Skelettstörungen | |
| ATE479778T1 (de) | Verfahren zur diagnose nicht-kleinzelliger lungenkarzinome über die trna-dihydrouridin- synthaseaktivität von urlc8 | |
| GB0201754D0 (en) | Method for binding site identification | |
| WO2006017748A3 (en) | Materials and methods for identifying anti-schizophrenic agents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |