ATE449168T1 - Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür - Google Patents

Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür

Info

Publication number: ATE449168T1
Authority: AT; Austria
Prior art keywords: reconstituted complex; reconstituted; histone methyltransferase; complex; methods
Prior art date: 2004-06-01

Application number

AT05804853T

Other languages

English (en)

Inventor

Yi Zhang

Ru Cao

Original Assignee

Univ North Carolina

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-01

Filing date

2005-05-27

Publication date

2009-12-15

2005-05-27 Application filed by Univ North Carolina filed Critical Univ North Carolina

2009-12-15 Application granted granted Critical

2009-12-15 Publication of ATE449168T1 publication Critical patent/ATE449168T1/de

Links

108010036115 Histone Methyltransferases Proteins 0.000 title abstract 3
102000011787 Histone Methyltransferases Human genes 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
102100033636 Histone H3.2 Human genes 0.000 abstract 1
102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 abstract 1
108010033040 Histones Proteins 0.000 abstract 1
101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 abstract 1
101000866766 Homo sapiens Polycomb protein EED Proteins 0.000 abstract 1
101000584499 Homo sapiens Polycomb protein SUZ12 Proteins 0.000 abstract 1
101000833157 Homo sapiens Zinc finger protein AEBP2 Proteins 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
102100031338 Polycomb protein EED Human genes 0.000 abstract 1
102100030702 Polycomb protein SUZ12 Human genes 0.000 abstract 1
102000007508 Retinoblastoma-Binding Protein 4 Human genes 0.000 abstract 1
108010071034 Retinoblastoma-Binding Protein 4 Proteins 0.000 abstract 1
102100024389 Zinc finger protein AEBP2 Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01043—Histone-lysine N-methyltransferase (2.1.1.43)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)

AT05804853T 2004-06-01 2005-05-27 Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür ATE449168T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57588004P	2004-06-01	2004-06-01
PCT/US2005/018840 WO2005118796A2 (en)	2004-06-01	2005-05-27	Reconstituted histone methyltransferase complex and methods of identifying modulators thereof

Publications (1)

Publication Number	Publication Date
ATE449168T1 true ATE449168T1 (de)	2009-12-15

Family

ID=35463449

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05804853T ATE449168T1 (de)	2004-06-01	2005-05-27	Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür

Country Status (6)

Country	Link
US (3)	US7563589B2 (de)
EP (1)	EP1765994B1 (de)
JP (1)	JP5160885B2 (de)
AT (1)	ATE449168T1 (de)
DE (1)	DE602005017781D1 (de)
WO (1)	WO2005118796A2 (de)

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WO2008103761A2 (en) *	2007-02-20	2008-08-28	Sequenom, Inc.	Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
WO2009114543A2 (en)	2008-03-11	2009-09-17	Sequenom, Inc.	Nucleic acid-based tests for prenatal gender determination
US8962247B2 (en)	2008-09-16	2015-02-24	Sequenom, Inc.	Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en)	2008-09-16	2013-07-02	Sequenom, Inc.	Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
GB0822248D0 (en) *	2008-12-05	2009-01-14	Medical Res Council	Crystal meths
WO2011011366A2 (en) *	2009-07-20	2011-01-27	Constellation Pharmaceuticals	Agents for stimulating activity of methyl modifying enzymes and methods of use thereof
DK2516680T3 (en)	2009-12-22	2016-05-02	Sequenom Inc	Method and kits to identify aneuploidy
WO2011082098A1 (en) *	2009-12-30	2011-07-07	The Rockefeller University	Lysine and arginine methyltransferase inhibitors for treating cancer
CA2841142C (en)	2010-06-23	2020-12-15	Ryan D. Morin	Biomarkers for non-hodgkin lymphomas and uses thereof
BR112013005806B1 (pt) *	2010-09-10	2022-05-10	Epizyme, Inc	Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
US9175331B2 (en)	2010-09-10	2015-11-03	Epizyme, Inc.	Inhibitors of human EZH2, and methods of use thereof
WO2012118812A2 (en)	2011-02-28	2012-09-07	Epizyme, Inc.	Substituted 6,5-fused bicyclic heteroaryl compounds
TW201733984A (zh)	2011-04-13	2017-10-01	雅酶股份有限公司	經取代之苯化合物
JO3363B1 (ar)	2011-04-13	2019-03-13	Epizyme Inc	مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
WO2013075084A1 (en)	2011-11-18	2013-05-23	Constellation Pharmaceuticals	Modulators of methyl modifying enzymes, compositions and uses thereof
US9206128B2 (en)	2011-11-18	2015-12-08	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
WO2013078320A1 (en) *	2011-11-21	2013-05-30	Constellation Pharmaceuticals	Modulators of methyl modifying enzymes, compositions and uses thereof
US9085583B2 (en)	2012-02-10	2015-07-21	Constellation—Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
EP4155401A1 (de)	2012-03-02	2023-03-29	Sequenom, Inc.	Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
CA3177515A1 (en) *	2012-03-12	2013-09-19	Epizyme, Inc.	Inhibitors of human ezh2, and methods of use thereof
ES2617379T3 (es)	2012-04-13	2017-06-16	Epizyme, Inc.	Forma de sal de un inhibidor de histona metiltransferasa EZH2 humana
US10504613B2 (en)	2012-12-20	2019-12-10	Sequenom, Inc.	Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en)	2012-05-21	2018-03-20	Sequenom, Inc.	Methods and compositions for analyzing nucleic acid
US20140093873A1 (en)	2012-07-13	2014-04-03	Sequenom, Inc.	Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
BR112015008480A2 (pt)	2012-10-15	2017-07-04	Epizyme Inc	compostos de benzeno substituído
EP3597774A1 (de)	2013-03-13	2020-01-22	Sequenom, Inc.	Primer zur analyse der dna-methylierung
US9745305B2 (en)	2013-03-15	2017-08-29	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
US9969716B2 (en)	2013-08-15	2018-05-15	Constellation Pharmaceuticals, Inc.	Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
PE20161273A1 (es)	2013-10-16	2016-12-18	Epizyme Inc	Forma salina de hidrocloruro para la inhibicion de ezh2
WO2015138774A1 (en)	2014-03-13	2015-09-17	Sequenom, Inc.	Methods and processes for non-invasive assessment of genetic variations
MX375970B (es)	2014-12-23	2025-03-06	Novartis Ag	Compuestos de triazolopirimidina y usos de los mismos.
WO2017040190A1 (en)	2015-08-28	2017-03-09	Constellation Pharmaceuticals, Inc.	Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide
JP2019524872A (ja)	2016-06-20	2019-09-05	ノバルティスアーゲー	癌の治療に有用なイミダゾピリミジン化合物
JP7042812B2 (ja)	2016-06-20	2022-03-28	ノバルティスアーゲー	トリアゾロピリミジン化合物の結晶形態
US10689378B2 (en)	2016-06-20	2020-06-23	Novartis Ag	Triazolopyridine compounds and uses thereof
WO2018075598A1 (en)	2016-10-19	2018-04-26	Constellation Pharmaceuticals, Inc.	Synthesis of inhibitors of ezh2
CN108314677B (zh)	2017-01-17	2020-06-30	安徽中科拓苒药物科学研究有限公司	一种ezh2抑制剂及其用途
US20230100105A1 (en) *	2020-02-23	2023-03-30	The Jackson Laboratory	Regulatory elements in the genome
CN113549603A (zh) *	2021-06-29	2021-10-26	洛阳职业技术学院	一种鸡ezh2蛋白的原核表达与纯化方法的研究方法

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DE19516776A1 (de) *	1995-05-10	1996-11-14	Boehringer Ingelheim Int	Chromatin-Regulatorgene
US20050059682A1 (en)	2003-09-12	2005-03-17	Supergen, Inc., A Delaware Corporation	Compositions and methods for treatment of cancer

2005
- 2005-05-27 JP JP2007515421A patent/JP5160885B2/ja not_active Expired - Fee Related
- 2005-05-27 AT AT05804853T patent/ATE449168T1/de not_active IP Right Cessation
- 2005-05-27 WO PCT/US2005/018840 patent/WO2005118796A2/en not_active Ceased
- 2005-05-27 US US11/140,659 patent/US7563589B2/en not_active Expired - Fee Related
- 2005-05-27 DE DE602005017781T patent/DE602005017781D1/de not_active Expired - Lifetime
- 2005-05-27 EP EP05804853A patent/EP1765994B1/de not_active Expired - Lifetime
2009
- 2009-07-02 US US12/497,211 patent/US20090298105A1/en not_active Abandoned
2016
- 2016-02-26 US US15/054,712 patent/US20160168546A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2005118796A2 (en)	2005-12-15
EP1765994B1 (de)	2009-11-18
WO2005118796A3 (en)	2006-06-01
US7563589B2 (en)	2009-07-21
US20090298105A1 (en)	2009-12-03
JP5160885B2 (ja)	2013-03-13
DE602005017781D1 (de)	2009-12-31
US20160168546A1 (en)	2016-06-16
US20050266473A1 (en)	2005-12-01
JP2008506367A (ja)	2008-03-06
EP1765994A2 (de)	2007-03-28

Legal Events

Date	Code	Title	Description
2010-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602005017781D1 (de)	2009-12-31	Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür
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BRPI0408238A (pt)	2006-03-01	anticorpo, método de detectar cáncer, conjunto para detecção de cáncer, e, composição farmacêutica para tratar cáncer
AU2003211040A8 (en)	2003-09-09	The eaat2 promoter and uses thereof
EP1255110A3 (de)	2004-02-04	Verfahren und Produkten zur Identifizierung von Modulatoren der P2X7-Rezeptorwirkzamkeit, und ihre Verwendung zur Behandlung von Skelettstörungen
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