ATE449596T1 - Verfahren zur herstellung von mikropartikeln - Google Patents

Verfahren zur herstellung von mikropartikeln

Info

Publication number
ATE449596T1
ATE449596T1 AT01964090T AT01964090T ATE449596T1 AT E449596 T1 ATE449596 T1 AT E449596T1 AT 01964090 T AT01964090 T AT 01964090T AT 01964090 T AT01964090 T AT 01964090T AT E449596 T1 ATE449596 T1 AT E449596T1
Authority
AT
Austria
Prior art keywords
stream
producing microparticles
diameter
particle
vibrating
Prior art date
Application number
AT01964090T
Other languages
English (en)
Inventor
Kyekyoon Kim
Daniel Pack
Cory Berkland
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of ATE449596T1 publication Critical patent/ATE449596T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing & Machinery (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AT01964090T 2000-08-15 2001-08-15 Verfahren zur herstellung von mikropartikeln ATE449596T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22562000P 2000-08-15 2000-08-15
US22552500P 2000-08-15 2000-08-15
PCT/US2001/025674 WO2002013786A2 (en) 2000-08-15 2001-08-15 Method of forming microparticles

Publications (1)

Publication Number Publication Date
ATE449596T1 true ATE449596T1 (de) 2009-12-15

Family

ID=26919678

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01964090T ATE449596T1 (de) 2000-08-15 2001-08-15 Verfahren zur herstellung von mikropartikeln

Country Status (9)

Country Link
US (3) US6669961B2 (de)
EP (1) EP1355630B1 (de)
JP (1) JP2004505761A (de)
KR (2) KR100867392B1 (de)
AT (1) ATE449596T1 (de)
AU (1) AU2001284982A1 (de)
CA (1) CA2419115C (de)
DE (1) DE60140625D1 (de)
WO (1) WO2002013786A2 (de)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101460240B1 (ko) * 2008-06-13 2014-11-21 삼성전자주식회사 메모리 기반 저장 장치 및 그것의 블록 관리 기법
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
KR100867392B1 (ko) * 2000-08-15 2008-11-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로입자
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6518330B2 (en) * 2001-02-13 2003-02-11 Board Of Trustees Of University Of Illinois Multifunctional autonomically healing composite material
US6610223B2 (en) * 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
US7306752B2 (en) * 2001-06-22 2007-12-11 Sekisui Chemical Co., Ltd. Method for preparing resin particles, resin particles and apparatus for preparing resin particles
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
CN1555253A (zh) * 2001-09-13 2004-12-15 ������ѧ�����о�Ժ 化疗栓塞用紫杉醇的油性组合物、制剂及它们的制造方法
CN1558755A (zh) * 2001-09-26 2004-12-29 ���ع��ʹ�˾ 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
BR0311693A (pt) * 2002-06-10 2005-03-22 Wyeth Corp Sal de formato de o-desmetil-venlafaxina
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7623908B2 (en) 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
US20050074611A1 (en) * 2003-02-25 2005-04-07 Manfred R. Kuehnle Encapsulated nanoparticles for the absorption of electromagnetic energy
US20080199701A1 (en) * 2003-02-25 2008-08-21 Kuehnle Manfred R Encapsulated nanoparticles for the absorption of electromagnetic energy
CN1780728A (zh) * 2003-02-25 2006-05-31 曼弗雷德·R·库赫奈利 吸收紫外频段的电磁能量的包覆纳米颗粒
US7511079B2 (en) * 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
JP4305729B2 (ja) * 2003-03-28 2009-07-29 セイコーエプソン株式会社 液体吐出装置及びマイクロカプセルの製造方法
EP2127736A1 (de) 2003-04-10 2009-12-02 The President and Fellows of Harvard College Erzeugung und Kontrolle von Fluiden
US7285306B1 (en) 2003-04-18 2007-10-23 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Process for self-repair of insulation material
US7883031B2 (en) 2003-05-20 2011-02-08 James F. Collins, Jr. Ophthalmic drug delivery system
US8012136B2 (en) 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US7217410B2 (en) * 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
US7198777B2 (en) * 2003-06-17 2007-04-03 The Board Of Trustees Of The University Of Illinois Optical contrast agents for optically modifying incident radiation
EP1659094B1 (de) * 2003-07-31 2019-05-15 SIJTechnology, Inc. Verfahren zur herstellung einer dreidimensionalen struktur
BRPI0414004A (pt) 2003-08-27 2006-10-24 Harvard College controle eletrÈnico de espécies fluìdicas
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20070158450A1 (en) * 2003-09-09 2007-07-12 John Scattergood Systems and methods for producing fine particles
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20050175836A1 (en) * 2003-11-12 2005-08-11 Xmx Corporation Physical color new concepts for color pigments
US20070141342A1 (en) * 2003-11-12 2007-06-21 Kuehnle Manfred R Physical color new concepts for color pigments
US7309500B2 (en) 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
EP3242318A1 (de) 2003-12-19 2017-11-08 The University of North Carolina at Chapel Hill Monodisperses produkt von mikrostrukturen oder nanostrukturen
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
US20050196416A1 (en) * 2004-02-05 2005-09-08 Kipp James E. Dispersions prepared by use of self-stabilizing agents
ES2334238T3 (es) 2004-02-23 2010-03-08 Eyesense Ag Procedimiento para la produccion de microesferas de polisacarido reticulado ionicamente.
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7566747B2 (en) * 2004-05-07 2009-07-28 The Board Of Trustees Of The University Of Illinois Wax particles for protection of activators, and multifunctional autonomically healing composite materials
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
DK1765292T3 (en) 2004-06-12 2018-01-02 Collegium Pharmaceutical Inc ABUSE PREVENTIONAL PHARMACEUTICAL FORMULATIONS
JP4762517B2 (ja) 2004-09-09 2011-08-31 株式会社オプトニクス精密 プリンター用トナーの製造方法
US8043480B2 (en) * 2004-11-10 2011-10-25 The Regents Of The University Of Michigan Methods for forming biodegradable nanocomponents with controlled shapes and sizes via electrified jetting
US7767017B2 (en) * 2004-11-10 2010-08-03 The Regents Of The University Of Michigan Multi-phasic nanoparticles
US7947772B2 (en) 2004-11-10 2011-05-24 The Regents Of The University Of Michigan Multiphasic nano-components comprising colorants
US7748343B2 (en) 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system
US20060140843A1 (en) * 2004-12-23 2006-06-29 In-Kyung Sung Macroporous structures for heterogeneous catalyst support
US20060147536A1 (en) * 2004-12-30 2006-07-06 Fiore Robert A Method for removing fluids containing dissolved or suspended carbohydrates, lipids, metals, salts, and/or toxins from biological systems
ES2257968B1 (es) * 2005-01-28 2007-07-01 Universidad De Sevilla Procedimiento y dispositivo para la obtencion de particulas de tamaño micro y nanometrico.
US20090104269A1 (en) * 2005-02-11 2009-04-23 Brian Graham Nanoformulations
WO2006086654A2 (en) * 2005-02-11 2006-08-17 Battelle Memorial Institute Nanoformulations
US7586618B2 (en) * 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US7612152B2 (en) * 2005-05-06 2009-11-03 The Board Of Trustees Of The University Of Illinois Self-healing polymers
US8961586B2 (en) 2005-05-24 2015-02-24 Inspiremd Ltd. Bifurcated stent assemblies
WO2006126182A2 (en) 2005-05-24 2006-11-30 Inspire M.D Ltd. Stent apparatuses for treatment via body lumens and methods of use
US8043323B2 (en) 2006-10-18 2011-10-25 Inspiremd Ltd. In vivo filter assembly
US20060280786A1 (en) * 2005-06-14 2006-12-14 Rabinow Barrett E Pharmaceutical formulations for minimizing drug-drug interactions
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
JP4854240B2 (ja) * 2005-09-09 2012-01-18 株式会社オプトニクス精密 加圧振動及び噴射造粒による超微粒子
US20070059370A1 (en) * 2005-09-15 2007-03-15 Industrial Technology Research Institute Method and apparatus for fabricating nanoparticles
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
JP2009509535A (ja) * 2005-09-27 2009-03-12 アムニクス， インコーポレイテッド タンパク様薬剤およびその使用
US7709544B2 (en) * 2005-10-25 2010-05-04 Massachusetts Institute Of Technology Microstructure synthesis by flow lithography and polymerization
CA2628630A1 (en) * 2005-11-15 2007-05-24 Baxter International Inc. Compositions of lipoxygenase inhibitors
CN1785153B (zh) * 2005-12-06 2010-04-21 青岛大学 纳米级材料制备装置及纳米抗氧化活性多肽药物的制备方法
US7993749B2 (en) * 2005-12-16 2011-08-09 University Of Kansas Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof
JP4823675B2 (ja) * 2005-12-16 2011-11-24 花王株式会社 ハイドロゲル粒子の製造方法、並びに、それによって製造されるハイドロゲル粒子及びそれを用いた分散体
WO2007076295A2 (en) * 2005-12-16 2007-07-05 University Of Kansas Nanoclusters for delivery of therapeutics
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
AU2006332340B2 (en) 2005-12-30 2013-09-26 Zensun (Shanghai) Science & Technology, Co., Ltd. Extended release of neuregulin for improved cardiac function
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
WO2007082153A2 (en) 2006-01-05 2007-07-19 The Board Of Trustees Of The University Of Illinois Self-healing coating system
AU2007211061B2 (en) 2006-01-31 2013-04-18 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US7569625B2 (en) * 2006-06-02 2009-08-04 The Board Of Trustees Of The University Of Illinois Self-healing elastomer system
WO2007149310A2 (en) 2006-06-16 2007-12-27 The Regents Of The University Of Michigan Multiphasic biofunctional nano-components and methods for use thereof
US8465775B2 (en) 2006-07-27 2013-06-18 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
EP2054537A2 (de) * 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothese mit dreidimensionaler desintegrationssteuerung
ATE517590T1 (de) 2006-09-15 2011-08-15 Boston Scient Ltd Biologisch erodierbare endoprothesen
WO2008034047A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis with adjustable surface features
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
ES2357661T3 (es) * 2006-09-15 2011-04-28 Boston Scientific Scimed, Inc. Endoprótesis bioerosionables con capas inorgánicas bioestables.
WO2008034031A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503482A (ja) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド 内部人工器官
US20110165236A1 (en) * 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
US20080075785A1 (en) * 2006-09-22 2008-03-27 San-Laung Chow Controlled release hydrogel formulation
EP2076212B1 (de) 2006-10-18 2017-03-29 Inspiremd Ltd. Gewirkte stentmäntel
US20100324664A1 (en) * 2006-10-18 2010-12-23 Asher Holzer Bifurcated Stent Assemblies
US20080097577A1 (en) * 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
WO2008053988A1 (fr) * 2006-11-02 2008-05-08 National University Corporation Nagoya University Procédé de production de microcapsules
EP1958622A1 (de) * 2006-11-07 2008-08-20 Royal College of Surgeons in Ireland Verfahren zur Herstellung von Mikrokapseln
CA3013758C (en) 2006-11-22 2021-09-14 Inspiremd Ltd. Intravascular aneurysm treatment device and methods
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
JP5355418B2 (ja) 2006-12-28 2013-11-27 ボストン サイエンティフィック リミテッド 生侵食性内部人工器官、及び該生侵食性内部人工器官を製造する方法
US20080182019A1 (en) * 2007-01-30 2008-07-31 Robert Retter Hollow Microsphere Particle Generator
US20080182056A1 (en) * 2007-01-30 2008-07-31 Eric Bakker Hollow Microsphere Particles
US8222988B2 (en) * 2007-04-09 2012-07-17 The Board Of Trustees Of The University Of Illinois Porous device for optical and electronic applications and method of fabricating the porous device
US7872563B2 (en) * 2007-04-09 2011-01-18 The Board Of Trustees Of The University Of Illinois Variably porous structures
US8237538B2 (en) * 2007-04-09 2012-08-07 The Board Of Trustees Of The University Of Illinois Porous battery electrode for a rechargeable battery and method of making the electrode
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US20080299391A1 (en) * 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
CN103298935A (zh) 2007-08-15 2013-09-11 阿穆尼克斯公司 用于改善生物活性多肽性能的组合物和方法
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
WO2009053885A2 (en) * 2007-10-23 2009-04-30 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
EP2055299A1 (de) * 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Verfahren zur Herstellung von Polymermikropartikeln
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
EP2172264A1 (de) * 2008-01-02 2010-04-07 Ziel Biopharma Ltd Verfahren und Gerät zur Herstellung von Mikrokapseln
US20090181254A1 (en) * 2008-01-15 2009-07-16 The Board Of Trustees Of The University Of Illinois Multi-capsule system and its use for encapsulating active agents
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8983580B2 (en) * 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
EP2085080A1 (de) * 2008-01-30 2009-08-05 LEK Pharmaceuticals D.D. Herstellung von Nanoteilchen durch Verwendung einer vibrierenden Düsenvorrichtung
JP4656167B2 (ja) * 2008-03-03 2011-03-23 株式会社日立プラントテクノロジー 流体機器装置
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US20090297621A1 (en) * 2008-06-03 2009-12-03 Abbott Cardiovascular Systems Inc. Microparticles For The Treatment Of Disease
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
ES2770273T3 (es) 2008-06-27 2020-07-01 Tepha Inc Administración inyectable de micropartículas y composiciones para ello
CA2729101A1 (en) * 2008-07-21 2010-01-28 Dixie Consumer Products Llc Paper cup manufacture with microencapsulated adhesive
WO2010011641A2 (en) * 2008-07-21 2010-01-28 The Regents Of The University Of Michigan Microphasic micro-components and methods for controlling morphology via electrified jetting
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2010033452A2 (en) * 2008-09-19 2010-03-25 Delaware State University Foundation, Inc. Mono-and multi-element coded libs assays and methods
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
SI2393828T1 (sl) 2009-02-03 2017-01-31 Amunix Operating Inc. Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo
US20110046060A1 (en) 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
EP2408369A1 (de) 2009-03-02 2012-01-25 Seventh Sense Biosystems, Inc. Vorrichtungen und verfahren zur analyse eines extrahierbaren mediums
US20120277629A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
EP2403546A2 (de) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Selbstpufferende medizinische implantate
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US20120045487A1 (en) * 2009-04-29 2012-02-23 The Regents Of The University Of Michigan Multiphasic microfibers for spatially guided cell growth
US20120123355A1 (en) * 2009-07-30 2012-05-17 Cook Medical Technologied Erodible embolization material
CA2778678A1 (en) 2009-10-30 2011-05-05 Cns Therapeutics, Inc. Improved neurturin molecules
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
EP2512522A4 (de) * 2009-12-16 2013-09-25 Brigham & Womens Hospital Partikel zur abgabe mehrerer wirkstoffe
JP5432767B2 (ja) * 2010-02-25 2014-03-05 日本光電工業株式会社 リモートメンテナンスシステム及び中継ユニット
EA015780B1 (ru) * 2010-03-11 2011-12-30 Общество С Ограниченной Ответственностью "Цэм" (Ооо "Цэм") Фармацевтическая композиция пролонгированного действия для снижения аппетита
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
KR101545413B1 (ko) 2010-07-15 2015-08-18 아이노비아 인코포레이티드 점적 발생 디바이스
US9087145B2 (en) 2010-07-15 2015-07-21 Eyenovia, Inc. Ophthalmic drug delivery
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
CN103068308B (zh) 2010-07-16 2016-03-16 第七感生物系统有限公司 用于流体传输装置的低压环境
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
US9482861B2 (en) 2010-10-22 2016-11-01 The Regents Of The University Of Michigan Optical devices with switchable particles
EP2637562B1 (de) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systeme und schnittstellen zur blutabnahme
GB201102148D0 (en) * 2011-02-08 2011-03-23 Ucl Business Plc Layered bodies, compositions containing them and processes for producing them
CN103874460B (zh) 2011-04-29 2016-06-22 第七感生物系统有限公司 一种用于从受验者的皮肤接收血液或其它物质的装置
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3106092A3 (de) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systeme und verfahren zur flüssigkeitsentnahme aus einer person
WO2013090452A1 (en) 2011-12-12 2013-06-20 Orbis Biosciences, Inc. Sustained release particle formulations
US20130172830A1 (en) 2011-12-12 2013-07-04 Corinthian Ophthalmic, Inc. Ejector mechanism, ejector device, and methods of use
NZ628014A (en) 2012-02-15 2016-09-30 Biogen Ma Inc Recombinant factor viii proteins
CN111548418A (zh) 2012-02-15 2020-08-18 比奥贝拉蒂治疗公司 因子viii组合物及其制备和使用方法
US9163169B2 (en) 2012-03-13 2015-10-20 Georgia-Pacific Chemicals Llc Adhesive compositions having a reduced cure time and methods for making and using same
NZ701271A (en) 2012-04-27 2016-10-28 Georgia Pacific Chemicals Llc Composite products made with lewis acid catalyzed binder compositions that include tannins and multifunctional aldehydes
EP2866847B1 (de) 2012-07-02 2018-08-22 Boston Scientific Scimed, Inc. Herstellung einer herzklappenprothese
US20140294944A1 (en) 2013-03-28 2014-10-02 Kimberly-Clark Worldwide, Inc. Microencapsulation of oxygen liberating reactants
UY35548A (es) 2013-05-02 2014-11-28 Glaxosmithkline Ip No 2 Ltd Péptidos terapéuticos para el tratamiento de trastornos metabólicos.
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
WO2015130760A1 (en) 2014-02-25 2015-09-03 Orbis Biosciences, Inc. Taste masking drug formulations
US9617427B2 (en) 2014-04-02 2017-04-11 Georgia-Pacific Chemicals Llc Methods for making lignocellulose composite products with oxidative binders and encapsulated catalyst
US20150359804A1 (en) 2014-06-12 2015-12-17 Orbis Biosciences, Inc. Extended-release drug delivery compositions
US10784498B2 (en) * 2014-06-26 2020-09-22 Murata Manufacturing Co., Ltd. Positive electrode, battery, battery pack, electronic device, electric vehicle, electricity storage device, and electric power system
US10149826B2 (en) * 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres
WO2016154509A1 (en) 2015-03-26 2016-09-29 Dover Photonics Llc Preparation of fluid samples for laser induced breakdown spectroscopy and/or imaging analysis
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10299915B2 (en) 2015-04-09 2019-05-28 Boston Scientific Scimed, Inc. Synthetic heart valves composed of zwitterionic polymers
US10426609B2 (en) 2015-04-09 2019-10-01 Boston Scientific Scimed, Inc. Fiber reinforced prosthetic heart valve having undulating fibers
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
US10413403B2 (en) 2015-07-14 2019-09-17 Boston Scientific Scimed, Inc. Prosthetic heart valve including self-reinforced composite leaflets
AU2016301303B2 (en) 2015-08-03 2021-10-07 Bioverativ Therapeutics Inc. Factor IX fusion proteins and methods of making and using same
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US10987735B2 (en) 2015-12-16 2021-04-27 6K Inc. Spheroidal titanium metallic powders with custom microstructures
CN108883407A (zh) 2015-12-16 2018-11-23 阿马斯坦技术有限责任公司 球状脱氢金属和金属合金颗粒
GB2551944B (en) * 2015-12-18 2021-09-01 Midatech Pharma Wales Ltd Microparticle production process and apparatus
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN109414401B (zh) 2016-04-26 2023-06-13 阿代尔制药股份有限公司 用于胃肠外给药的生物可降解聚合物微球组合物
CN109475409B (zh) 2016-05-19 2021-02-19 波士顿科学国际有限公司 人工瓣膜、瓣膜小叶和相关方法
ES2899399T3 (es) * 2016-06-23 2022-03-11 6K Inc Materiales de batería de iones litio
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
US20180000744A1 (en) * 2016-06-30 2018-01-04 Georgia Southern Research and Service Foundation, Inc. Nanoencapsulated compositions
US10654040B2 (en) 2016-08-18 2020-05-19 Northeastern University Platform for liquid droplet formation and isolation
US10707531B1 (en) 2016-09-27 2020-07-07 New Dominion Enterprises Inc. All-inorganic solvents for electrolytes
US10967102B2 (en) 2016-09-28 2021-04-06 Boston Scientific Limited Cell encapsulation membranes, devices and methods
US11471419B2 (en) 2016-09-30 2022-10-18 The Board Of Trustees Of The University Of Illinois Capsules with intracapsular microspheres for improved survival and function of encapsulated cells
TWI631985B (zh) * 2016-10-26 2018-08-11 財團法人金屬工業研究發展中心 微粒製造方法
WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
EP3615097B1 (de) 2017-04-25 2026-03-11 Boston Scientific Scimed, Inc. Biokompatible polyisobutylenfaserverbundstoffe und verfahren
KR102643190B1 (ko) 2017-06-10 2024-03-04 아이노비아 인코포레이티드 유체를 취급하기 위한, 그리고 눈에 유체를 전달하기 위한 디바이스들
US11173461B2 (en) 2018-03-22 2021-11-16 Lawrence Livermore National Security, Llc Fabricating structured particles through rapid hardening and tailored collection methods
JP7763589B2 (ja) 2018-05-18 2025-11-04 バイオベラティブ セラピューティクス インコーポレイテッド 血友病ａを処置する方法
WO2019246257A1 (en) 2018-06-19 2019-12-26 Amastan Technologies Inc. Process for producing spheroidized powder from feedstock materials
US11684498B2 (en) 2018-10-19 2023-06-27 Inspire M.D Ltd. Methods of using a self-adjusting stent assembly and kits including same
TR201818352A2 (tr) * 2018-12-02 2020-06-22 Bursa Teknik Ueniversitesi Mi̇kroenkapsülasyon yöntemleri̇nde parti̇kül boyutunu küçülten damlatma düzeneği̇
FR3089391A1 (fr) 2018-12-05 2020-06-12 V. Mane Fils Méthode d’amelioration de l’expérience sensorielle d’un arome
KR20220002998A (ko) 2019-04-30 2022-01-07 6케이 인크. 기계적으로 합금된 분말 공급원료
KR102644961B1 (ko) 2019-04-30 2024-03-11 6케이 인크. 리튬 란타넘 지르코늄 산화물(llzo) 분말
EP4414470A3 (de) 2019-11-18 2024-10-23 6K Inc. Einzigartige ausgangsstoffe für sphärische pulver und herstellungsverfahren
US12245935B2 (en) 2019-11-26 2025-03-11 Boston Scientific Limited Composite web-polymer heart valve
CN115038414A (zh) 2019-12-11 2022-09-09 艾诺维亚股份有限公司 用于向眼睛输送流体的系统和装置及使用方法
US11590568B2 (en) 2019-12-19 2023-02-28 6K Inc. Process for producing spheroidized powder from feedstock materials
KR20230029836A (ko) 2020-06-25 2023-03-03 6케이 인크. 마이크로복합 합금 구조
NL2025932B1 (en) 2020-06-26 2022-02-21 Iamfluidics Holding B V Micro-fluidic system and method
US11351514B2 (en) 2020-07-02 2022-06-07 Lawrence Livermore National Security, Llc Parallelized multiple nozzle system and method to produce layered droplets and fibers for microencapsulation
MX2023000479A (es) 2020-07-10 2023-02-13 Adare Pharmaceuticals Inc Composiciones farmaceuticas orales hinchables.
US11963287B2 (en) 2020-09-24 2024-04-16 6K Inc. Systems, devices, and methods for starting plasma
US11919071B2 (en) 2020-10-30 2024-03-05 6K Inc. Systems and methods for synthesis of spheroidized metal powders
NL2027229B1 (en) * 2020-12-24 2022-07-20 Medspray B V Device and method to aerosolize nanoparticle formulations
CA3197544A1 (en) 2021-01-11 2022-07-14 6K Inc. Methods and systems for reclamation of li-ion cathode materials using microwave plasma processing
KR20230164699A (ko) 2021-03-31 2023-12-04 6케이 인크. 질화금속 세라믹의 적층 제조를 위한 시스템 및 방법
CA3218457A1 (en) 2021-05-20 2022-11-24 Jason C. Cole Flavor beads and method of making and using same
WO2022246285A1 (en) * 2021-05-21 2022-11-24 The Trustees Of Columbia University In The City Of New York Bio-microbur therapeutic delivery platform
GB202205123D0 (en) * 2022-04-07 2022-05-25 Univ Oxford Innovation Ltd Encapsulation method and particle
US12261023B2 (en) 2022-05-23 2025-03-25 6K Inc. Microwave plasma apparatus and methods for processing materials using an interior liner
US12040162B2 (en) 2022-06-09 2024-07-16 6K Inc. Plasma apparatus and methods for processing feed material utilizing an upstream swirl module and composite gas flows
US12094688B2 (en) 2022-08-25 2024-09-17 6K Inc. Plasma apparatus and methods for processing feed material utilizing a powder ingress preventor (PIP)
US12195338B2 (en) 2022-12-15 2025-01-14 6K Inc. Systems, methods, and device for pyrolysis of methane in a microwave plasma for hydrogen and structured carbon powder production
US12435622B2 (en) 2023-08-22 2025-10-07 Saudi Arabian Oil Company Identifying drill cuttings with tracer pills

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US617469A (en) * 1899-01-10 Isaac moore
US2766064A (en) * 1955-08-22 1956-10-09 Howard V Schweitzer Paint gun
US3579245A (en) * 1967-12-07 1971-05-18 Teletype Corp Method of transferring liquid
IE45426B1 (en) * 1976-07-15 1982-08-25 Ici Ltd Atomisation of liquids
DE2725849C3 (de) 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
US4313403A (en) * 1979-09-07 1982-02-02 Bie Jr Norman Internal combustion engine
CA1166413A (en) * 1980-10-30 1984-05-01 Edward E. Timm Process and apparatus for preparing uniform size polymer beads
US4748043A (en) * 1986-08-29 1988-05-31 Minnesota Mining And Manufacturing Company Electrospray coating process
DE3787700T3 (de) * 1986-10-29 1998-12-24 Kanegafuchi Kagaku Kogyo K.K., Osaka Gleichförmige Polymerteilchen.
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US5985354A (en) * 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
CH675370A5 (en) 1988-06-03 1990-09-28 Ciba Geigy Ag Filled pill mfr. - by concentric nozzles receiving ingredients from oscillating diaphragms
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5226948A (en) * 1990-08-30 1993-07-13 University Of Southern California Method and apparatus for droplet stream manufacturing
US5260002A (en) * 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
DE69324280T2 (de) * 1992-01-13 1999-08-12 Hercules Inc., Wilmington, Del. Wärmeverbindbare Fasern für wiederstandsfähige Vliesstoffe
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US5344676A (en) 1992-10-23 1994-09-06 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing nanodrops and nanoparticles and thin film deposits therefrom
JPH08503950A (ja) 1992-12-02 1996-04-30 アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド 徐放性成長ホルモン含有マイクロスフェア
DE4242645C2 (de) * 1992-12-17 1997-12-18 Deutsche Forsch Luft Raumfahrt Verfahren und Einrichtung zur Herstellung von Metallkügelchen annähernd gleichen Durchmessers
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
CN1074923C (zh) 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
EP2275089A1 (de) 1993-11-19 2011-01-19 Alkermes Controlled Therapeutics, Inc. Herstellung biologisch abbaubarer Mikropartikel, die einen biologisch aktiven Stoff enthalten
GB9324250D0 (en) * 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
GB9406255D0 (en) * 1994-03-29 1994-05-18 Electrosols Ltd Dispensing device
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
AU710347B2 (en) 1995-08-31 1999-09-16 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
WO1997031691A1 (en) * 1996-03-01 1997-09-04 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
US6197835B1 (en) * 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for creating spherical particles of uniform size
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6254854B1 (en) * 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US5874111A (en) * 1997-01-07 1999-02-23 Maitra; Amarnath Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
US5948483A (en) * 1997-03-25 1999-09-07 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing thin film and nanoparticle deposits
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US5954907A (en) * 1997-10-07 1999-09-21 Avery Dennison Corporation Process using electrostatic spraying for coating substrates with release coating compositions, pressure sensitive adhesives, and combinations thereof
ATE262976T1 (de) * 1998-03-07 2004-04-15 Inotech Ag Verfahren und vorrichtung zum verkapseln von mikrobiellen, pflanzlichen und tierischen zellen bzw. von biologischen und chemischen substanzen
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
JP4677102B2 (ja) * 1999-04-23 2011-04-27 バテル・メモリアル・インスティテュート エーロゾル給送装置及びエーロゾル小滴を給送する方法
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
KR100867392B1 (ko) * 2000-08-15 2008-11-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로입자
US6599627B2 (en) * 2000-12-13 2003-07-29 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US7748343B2 (en) * 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system

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US6669961B2 (en) 2003-12-30
JP2004505761A (ja) 2004-02-26
DE60140625D1 (de) 2010-01-07
US20080175915A1 (en) 2008-07-24
US20040022939A1 (en) 2004-02-05
CA2419115A1 (en) 2002-02-21
WO2002013786A3 (en) 2003-08-28
KR100867392B1 (ko) 2008-11-06
US7368130B2 (en) 2008-05-06
WO2002013786A2 (en) 2002-02-21
US20020054912A1 (en) 2002-05-09
EP1355630B1 (de) 2009-11-25
KR100902625B1 (ko) 2009-06-15
CA2419115C (en) 2011-03-08
KR20030067660A (ko) 2003-08-14
AU2001284982A1 (en) 2002-02-25
EP1355630A2 (de) 2003-10-29

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