ATE450795T1 - Arrays in zufallsanordnung und herstellungs- und verwendungsverfahren - Google Patents

Arrays in zufallsanordnung und herstellungs- und verwendungsverfahren

Info

Publication number
ATE450795T1
ATE450795T1 AT02800906T AT02800906T ATE450795T1 AT E450795 T1 ATE450795 T1 AT E450795T1 AT 02800906 T AT02800906 T AT 02800906T AT 02800906 T AT02800906 T AT 02800906T AT E450795 T1 ATE450795 T1 AT E450795T1
Authority
AT
Austria
Prior art keywords
arrays
manufacturing
random arrangement
probe
microparticles
Prior art date
Application number
AT02800906T
Other languages
English (en)
Inventor
Patrick Guire
Kristin Taton
John Wall
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Application granted granted Critical
Publication of ATE450795T1 publication Critical patent/ATE450795T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00466—Beads in a slurry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Cell Biology (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02800906T 2001-10-05 2002-10-04 Arrays in zufallsanordnung und herstellungs- und verwendungsverfahren ATE450795T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/972,687 US7195913B2 (en) 2001-10-05 2001-10-05 Randomly ordered arrays and methods of making and using
PCT/US2002/031740 WO2003031979A1 (en) 2001-10-05 2002-10-04 Randomly ordered arrays and methods of making and using

Publications (1)

Publication Number Publication Date
ATE450795T1 true ATE450795T1 (de) 2009-12-15

Family

ID=25520000

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02800906T ATE450795T1 (de) 2001-10-05 2002-10-04 Arrays in zufallsanordnung und herstellungs- und verwendungsverfahren

Country Status (8)

Country Link
US (2) US7195913B2 (de)
EP (1) EP1432989B1 (de)
JP (1) JP4464132B2 (de)
AT (1) ATE450795T1 (de)
CA (1) CA2462736A1 (de)
DE (1) DE60234614D1 (de)
MX (1) MXPA04003184A (de)
WO (1) WO2003031979A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
AU2001272993B2 (en) 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
ATE295155T1 (de) * 2001-10-05 2005-05-15 Surmodics Inc Beschichtungen mit immobilisierten partikeln sowie verwendungen derselben
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US7108891B2 (en) * 2002-03-07 2006-09-19 Eastman Kodak Company Random array of microspheres
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
CN1514243A (zh) * 2003-04-30 2004-07-21 成都夸常科技有限公司 对目标物进行定性和/或定量分析的方法、装置和标记物及检测试剂盒
DE10319155B4 (de) * 2003-04-29 2008-02-14 Bruker Daltonik Gmbh Elektrisch auslesbare Bindungen von Analytmolekülen an immobilisierten Sondenmolekülen
US20050019745A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Random array of microspheres
JP4363935B2 (ja) * 2003-09-17 2009-11-11 株式会社豊田中央研究所 生体物質の光固定化・回収方法及び表面プラズモン共鳴センサー
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
NZ547495A (en) 2003-10-29 2008-05-30 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20080200575A1 (en) * 2004-03-31 2008-08-21 Universal Bio Research Co., Ltd. Immobilization Vehicle, Method of Treating Vehicle and Continuous Vehicle Treating Apparatus
US20050239112A1 (en) * 2004-04-01 2005-10-27 Migenix, Inc. Methods and processes for attaching compounds to matrices
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CN103951595B (zh) 2004-10-12 2015-10-14 卢米尼克斯股份有限公司 形成染色的微球体和染色的微球体群的方法
JP2006118920A (ja) * 2004-10-20 2006-05-11 Institute Of Physical & Chemical Research 相互作用観察方法
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070161124A1 (en) * 2006-01-09 2007-07-12 Sigma-Aldrich Co. Compositions for separation of a plurality of distinct targets from a sample
US20070161121A1 (en) * 2006-01-09 2007-07-12 Sigma Aldrich Compositions for separation of a plurality of distinct targets from a sample
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
DE102006029032A1 (de) * 2006-02-17 2007-08-23 Poly-An Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Vorrichtung, Verfahren und Kit zum Nachweis von Analyten in einer Probe
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
AT503573B1 (de) * 2006-04-13 2007-11-15 Arc Seibersdorf Res Gmbh Vorrichtung zur steigerung der reaktions-, insbesondere der anbindungseffizienz zwischen molekülen bzw. molekülteilen
DE102006056949B4 (de) * 2006-11-30 2011-12-22 Ruprecht-Karls-Universität Heidelberg Verfahren und Vorrichtung zur Detektion mindestens einer Eigenschaft von mindestens einem Objekt mit einem Mikrochip
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
CA2682826C (en) 2007-04-02 2013-08-13 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
EP2162486A4 (de) 2007-06-22 2014-03-12 Fio Corp System und verfahren zur herstellung von quantenpunkt-dotierten polymermikrokügelchen
JP5507454B2 (ja) * 2007-07-09 2014-05-28 フィオ コーポレイション 試験サンプル中の標的分子の蛍光検出の向上のためのシステムおよび方法
RU2010106248A (ru) * 2007-07-23 2011-08-27 Эф-Ай-Оу Корпорейшн (Ca) Способ и система систематизации, хранения, анализа и предоставления доступа к собранным и проанализированным данным, касающимся исследований биологических объектов и окружающей среды
EP2209549A4 (de) * 2007-10-12 2014-03-05 Fio Corp Strömungsfokussierungsverfahren und system zur bildung von konzentrierten volumina von mikrokügelchen und weiterhin gebildete mikrokügelchen
CA2729023C (en) 2008-06-25 2013-02-26 Fio Corporation Bio-threat alert system
MX2011002235A (es) 2008-08-29 2011-04-05 Fio Corp Dispositivo de prueba de diagnostico portatil de un solo uso, y un sistema y metodo asociado para probar muestras de prueba biologicas y ambientales.
KR101065078B1 (ko) * 2008-11-05 2011-09-15 삼성전자주식회사 바이오칩용 기판 및 그 제조 방법
CN104374932A (zh) 2009-01-13 2015-02-25 Fio公司 与电子设备和快速诊断测试中的测试盒结合使用的手持诊断测试设备
US8574835B2 (en) * 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US20110105990A1 (en) * 2009-11-04 2011-05-05 Silvestrini Thomas A Zonal drug delivery device and method
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
EP2542890B1 (de) 2010-03-01 2015-05-06 Quanterix Corporation Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US8541498B2 (en) 2010-09-08 2013-09-24 Biointeractions Ltd. Lubricious coatings for medical devices
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9512397B2 (en) 2012-03-21 2016-12-06 Shengyuan Yang Micro and nano scale structures disposed in a material so as to present micrometer and nanometer scale curvature and stiffness patterns for use in cell and tissue culturing and in other surface and interface applications
US20130252337A1 (en) * 2012-03-21 2013-09-26 Shengyuan Yang Substrates with micrometer and nanometer scale stiffness patterns for use in cell and tissue culturing and a method for making same
JP5998217B2 (ja) 2012-07-06 2016-09-28 株式会社日立ハイテクノロジーズ 分析装置及び分析方法
US9810688B2 (en) 2013-03-15 2017-11-07 Robert Bosch Gmbh Smart glass slide for microarrays
US9874538B2 (en) 2012-07-06 2018-01-23 Robert Bosch Gmbh Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US9910008B2 (en) 2012-07-06 2018-03-06 Robert Bosch Gmbh Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
GB201212902D0 (en) 2012-07-20 2012-09-05 Univ Singapore Combinatoric encoding methods for microarrays
JP6037701B2 (ja) * 2012-08-03 2016-12-07 株式会社日立ハイテクノロジーズ 免疫分析装置
WO2014060483A1 (en) 2012-10-17 2014-04-24 Spatial Transcriptomics Ab Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
EP3105572B1 (de) 2014-02-13 2019-04-10 Robert Bosch GmbH Kapazitive luftblasenerkennung
WO2016015037A1 (en) * 2014-07-25 2016-01-28 Microscale Devices Llc Apparatus and methods for detecting multiple labelled biopolymers
US20180003703A1 (en) * 2015-01-13 2018-01-04 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
EP4282977B1 (de) 2015-04-10 2024-06-05 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
US10011549B2 (en) 2015-07-06 2018-07-03 Robert Bosch Gmbh Electrochemically active agents for pH modulation in biological buffers
US11867660B2 (en) 2015-07-06 2024-01-09 Robert Bosch Gmbh Electronic control of the pH of a solution close to an electrode surface
US10379080B2 (en) 2015-07-06 2019-08-13 Robert Bosch Gmbh Electronic control of the pH of a solution close to an electrode surfaces
JP7130919B2 (ja) * 2016-03-11 2022-09-06 三菱瓦斯化学株式会社 生体物質固定化方法
US10667923B2 (en) 2016-10-31 2020-06-02 Warsaw Orthopedic, Inc. Sacro-iliac joint implant system and method
WO2018176262A1 (zh) * 2017-03-27 2018-10-04 武汉优视科技有限公司 一种免疫印迹的自动检测系统
CN106932596A (zh) * 2017-03-27 2017-07-07 武汉优视科技有限公司 一种免疫印迹薄膜及其制备方法
CN107045066A (zh) * 2017-03-27 2017-08-15 武汉优视科技有限公司 一种免疫印迹卷轴
US10871435B2 (en) 2017-07-18 2020-12-22 Shengyuan Yang Methods and kits for cell sorting
DE102018115391A1 (de) * 2018-06-26 2020-01-02 Brandenburgische Technische Universität Cottbus-Senftenberg Assay, Verfahren zu seiner Herstellung sowie seine Verwendung
WO2020123311A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Resolving spatial arrays using deconvolution
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
GB201905181D0 (en) * 2019-04-11 2019-05-29 Arrayjet Ltd Method and apparatus for substrate handling and printing
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
CN115375604B (zh) * 2021-05-18 2024-07-26 南京大学 一种基于量子化自编码器的无监督缺陷检测方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
DE69032425T2 (de) 1990-05-11 1998-11-26 Microprobe Corp., Bothell, Wash. Teststreifen zum Eintauchen für Nukleinsäure-Hybridisierungsassays und Verfahren zur kovalenten Immobilisierung von Oligonucleotiden
US5993935A (en) 1991-10-11 1999-11-30 3M Innovative Properties Company Covalently reactive particles incorporated in a continous porous matrix
DE69328523T2 (de) * 1992-02-13 2000-09-21 Surmodics, Inc. Immobilisierung eines chemischen spezies in einer vernetzten matrix
US5900921A (en) * 1994-07-06 1999-05-04 Jong-Deok Park Lens for diplopia and amblyopia and glasses using the same
DE69520044T2 (de) * 1994-10-12 2001-06-13 Focal, Inc. Zielgerichte verabreichung mittels biologisch abbaubarer polymere
US5736257A (en) 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US5714360A (en) 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US5700921A (en) * 1995-11-27 1997-12-23 Vector Laboratories Labeling nucleic acids
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
DE19823660C1 (de) 1998-05-20 1999-10-07 Nanomont Ges Fuer Nanotechnolo Verfahren und Vorrichtung zur Fixierung fester Mikro- und/oder Nanoobjekte
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
AU770146B2 (en) 1999-02-09 2004-02-12 Illumina, Inc. Intrabead screening methods and compositions
US6503556B2 (en) * 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
CA2399908A1 (en) 2000-02-10 2001-08-16 Todd Dickinson Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6673385B1 (en) * 2000-05-31 2004-01-06 Advanced Cardiovascular Systems, Inc. Methods for polymeric coatings stents
US6669980B2 (en) * 2001-09-18 2003-12-30 Scimed Life Systems, Inc. Method for spray-coating medical devices

Also Published As

Publication number Publication date
JP4464132B2 (ja) 2010-05-19
EP1432989A1 (de) 2004-06-30
US20080039343A1 (en) 2008-02-14
EP1432989B1 (de) 2009-12-02
US7195913B2 (en) 2007-03-27
DE60234614D1 (de) 2010-01-14
US20030073086A1 (en) 2003-04-17
MXPA04003184A (es) 2004-07-27
JP2005506527A (ja) 2005-03-03
CA2462736A1 (en) 2003-04-17
WO2003031979A1 (en) 2003-04-17

Similar Documents

Publication Publication Date Title
ATE450795T1 (de) Arrays in zufallsanordnung und herstellungs- und verwendungsverfahren
ATE268902T1 (de) Biosensor und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor
ATE432361T1 (de) Vorrichtung mit integrierter mikromatrize
ATE330038T1 (de) Nukleinsäure-biosensor
FR2890665B1 (fr) Article securise, notamment un document de securite et/ou de valeur.
WO2003067504A3 (en) Drug discovery methods
ATE376587T1 (de) Granulat mit hoher schlagfestigkeit
EP1436429A4 (de) Zielnukleinsäurekonstrukte und damit verbundene verwendungen
WO2004000094A8 (en) Predictive markers in cancer therapy
TW200729462A (en) Phase-change random access memory device and method of operating the same
FR13C0003I2 (fr) Inhibiteurs cycliques de proteine tyrosine kinase
NO20020348L (no) Peptid acceptor ligeringsmetoder
ITRM20020529A1 (it) Polimeri sterilizzanti, processo di loro preparazione ed uso.
BR0115715A (pt) Análise de expressão de ácidos nucleìcos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata
DE60027910D1 (de) Hochsensitiver zeitaufgelöster immunofluoreszenzassay zum nachweis von chemokinen
DE60139544D1 (de) Veränderte, fluoreszierende proteine
BR0305312B1 (pt) processo e dispositivo para testar objetos em forma de bastço, ou seja, cigarros.
BR0105065B1 (pt) sistema de injetor de gÁs e mÉtodo para fabricÁ-lo.
BR0015594B1 (pt) processo para produzir polietileno e/ou interpolìmeros de etileno e um, ou mais, outros monÈmeros interpolimerizáveis com etileno, e/ou misturas de ditos interpolìmeros.
WO2005024378A3 (en) Ion detection using a pillar chip
DE69943134D1 (de) Nukleinsäureamplifizierung und detektion von mykobacterium-spezies
WO2001075149A3 (de) Biosensor, biosensor-array und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor
WO2001061038A3 (en) Method for detecting a biological entity in a sample
DE60203393D1 (de) Verfahren und vorrichtung zur unterwasserzersetzung organischer substanzen in elektrisch leitenden, wässrigen abfalllösungen
DE602004027014D1 (de) Ttel und synergistischer kombinationen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties