ATE451357T1 - Inhibitoren der nicht-nukleotidischen reversen transkriptase - Google Patents
Inhibitoren der nicht-nukleotidischen reversen transkriptaseInfo
- Publication number
- ATE451357T1 ATE451357T1 AT04809207T AT04809207T ATE451357T1 AT E451357 T1 ATE451357 T1 AT E451357T1 AT 04809207 T AT04809207 T AT 04809207T AT 04809207 T AT04809207 T AT 04809207T AT E451357 T1 ATE451357 T1 AT E451357T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- orx
- nrxrx
- reverse transcriptase
- transcriptase inhibitors
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940121357 antivirals Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400021A SE0400021D0 (sv) | 2004-01-08 | 2004-01-08 | Non-nucleoside reverse transcriptase inhibitors |
| SE0400585A SE0400585D0 (sv) | 2004-03-09 | 2004-03-09 | NNRTI Antivirals |
| PCT/SE2004/002034 WO2005066131A1 (en) | 2004-01-08 | 2004-12-30 | Non-nucleotide reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451357T1 true ATE451357T1 (de) | 2009-12-15 |
Family
ID=34752289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04809207T ATE451357T1 (de) | 2004-01-08 | 2004-12-30 | Inhibitoren der nicht-nukleotidischen reversen transkriptase |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7915295B2 (de) |
| EP (1) | EP1701942B1 (de) |
| JP (1) | JP4762917B2 (de) |
| AT (1) | ATE451357T1 (de) |
| AU (1) | AU2004312284B2 (de) |
| BR (1) | BRPI0418306B8 (de) |
| CA (1) | CA2550187C (de) |
| DE (1) | DE602004024584D1 (de) |
| DK (1) | DK1701942T3 (de) |
| EA (1) | EA009700B1 (de) |
| ES (1) | ES2337794T3 (de) |
| IL (1) | IL176740A (de) |
| NZ (1) | NZ548367A (de) |
| SG (1) | SG149070A1 (de) |
| WO (1) | WO2005066131A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003260492B2 (en) * | 2002-09-05 | 2007-03-01 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| ES2539527T3 (es) * | 2005-04-27 | 2015-07-01 | Taimed Biologics, Inc. | Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas |
| CA2632095A1 (en) | 2005-11-30 | 2007-06-07 | Ambrilia Biopharma Inc. | Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation |
| GB0608876D0 (en) * | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
| WO2007136572A2 (en) * | 2006-05-15 | 2007-11-29 | Merck & Co., Inc. | Antidiabetic bicyclic compounds |
| EP2064177B1 (de) | 2006-09-21 | 2017-04-05 | TaiMed Biologics, Inc. | Proteasehemmer |
| JP6636031B2 (ja) * | 2015-01-30 | 2020-01-29 | ジェネンテック， インコーポレイテッド | 治療用化合物およびその使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR016169A1 (es) * | 1998-01-16 | 2001-06-20 | Medivir Ab | Compuesto, composicion farmaceutica que lo comprende y uso del mismo en la fabricacion de un medicamento para el tratamiento o profilaxis del vih. |
| WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| SE0100733D0 (sv) * | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| SE0102867D0 (sv) * | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| AU2003260492B2 (en) * | 2002-09-05 | 2007-03-01 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
-
2004
- 2004-12-30 JP JP2006549182A patent/JP4762917B2/ja not_active Expired - Fee Related
- 2004-12-30 AU AU2004312284A patent/AU2004312284B2/en not_active Ceased
- 2004-12-30 BR BRPI0418306A patent/BRPI0418306B8/pt not_active IP Right Cessation
- 2004-12-30 NZ NZ548367A patent/NZ548367A/en not_active IP Right Cessation
- 2004-12-30 EA EA200601289A patent/EA009700B1/ru not_active IP Right Cessation
- 2004-12-30 ES ES04809207T patent/ES2337794T3/es not_active Expired - Lifetime
- 2004-12-30 SG SG200809639-8A patent/SG149070A1/en unknown
- 2004-12-30 WO PCT/SE2004/002034 patent/WO2005066131A1/en not_active Ceased
- 2004-12-30 DE DE602004024584T patent/DE602004024584D1/de not_active Expired - Lifetime
- 2004-12-30 CA CA2550187A patent/CA2550187C/en not_active Expired - Fee Related
- 2004-12-30 AT AT04809207T patent/ATE451357T1/de not_active IP Right Cessation
- 2004-12-30 US US10/584,933 patent/US7915295B2/en not_active Expired - Fee Related
- 2004-12-30 DK DK04809207.6T patent/DK1701942T3/da active
- 2004-12-30 EP EP04809207A patent/EP1701942B1/de not_active Expired - Lifetime
-
2006
- 2006-07-06 IL IL176740A patent/IL176740A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG149070A1 (en) | 2009-01-29 |
| AU2004312284A1 (en) | 2005-07-21 |
| US20080070951A1 (en) | 2008-03-20 |
| IL176740A0 (en) | 2006-10-31 |
| BRPI0418306B1 (pt) | 2018-09-18 |
| EA009700B1 (ru) | 2008-02-28 |
| CA2550187A1 (en) | 2005-07-21 |
| BRPI0418306B8 (pt) | 2021-05-25 |
| AU2004312284A2 (en) | 2005-07-21 |
| BRPI0418306A (pt) | 2007-05-02 |
| AU2004312284B2 (en) | 2010-08-05 |
| EP1701942B1 (de) | 2009-12-09 |
| JP4762917B2 (ja) | 2011-08-31 |
| EP1701942A1 (de) | 2006-09-20 |
| ES2337794T3 (es) | 2010-04-29 |
| DK1701942T3 (da) | 2010-04-06 |
| DE602004024584D1 (de) | 2010-01-21 |
| CA2550187C (en) | 2012-08-07 |
| EA200601289A1 (ru) | 2006-12-29 |
| HK1101400A1 (en) | 2007-10-18 |
| NZ548367A (en) | 2010-06-25 |
| WO2005066131A1 (en) | 2005-07-21 |
| IL176740A (en) | 2011-09-27 |
| JP2007519640A (ja) | 2007-07-19 |
| US7915295B2 (en) | 2011-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |