ATE452641T1 - Orale pharmazeutische zusammensetzung enthaltend 15-hydroxytestosteron und seine derivate - Google Patents

Orale pharmazeutische zusammensetzung enthaltend 15-hydroxytestosteron und seine derivate

Info

Publication number: ATE452641T1
Authority: AT; Austria
Prior art keywords: hydroxytestosterone; hydroxytestosterones; androsten; dihydroxy; derivatives
Prior art date: 2002-09-05

Application number

AT03794351T

Other languages

English (en)

Inventor

Evert Bunschoten

Bennink Herman Coelingh

Der Linden Rene Van

Original Assignee

Pantarhei Bioscience Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-05

Filing date

2003-09-05

Publication date

2010-01-15

2003-09-05 Application filed by Pantarhei Bioscience Bv filed Critical Pantarhei Bioscience Bv

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE452641T1 publication Critical patent/ATE452641T1/de

Links

KYGUQDTWUBBBSD-MJVYMRHDSA-N 15alpha-hydroxytestosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](C[C@@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 KYGUQDTWUBBBSD-MJVYMRHDSA-N 0.000 title abstract 2
239000008203 oral pharmaceutical composition Substances 0.000 title 1
KYGUQDTWUBBBSD-YIJWYKPTSA-N (8r,9s,10r,13s,14s,17s)-15,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4O)O)[C@@H]4[C@@H]3CCC2=C1 KYGUQDTWUBBBSD-YIJWYKPTSA-N 0.000 abstract 3
YMCWOAZGWMZGQT-FPNLOETNSA-N 16alpha-hydroxytestosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 YMCWOAZGWMZGQT-FPNLOETNSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000002243 precursor Substances 0.000 abstract 2
150000003515 testosterones Chemical class 0.000 abstract 2
YMCWOAZGWMZGQT-UHFFFAOYSA-N (16alpha,17beta)-16,17-Dihydroxyandrost-4-en-3-one Natural products O=C1CCC2(C)C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 YMCWOAZGWMZGQT-UHFFFAOYSA-N 0.000 abstract 1
KYGUQDTWUBBBSD-XJBBOAPUSA-N (8r,9s,10r,13s,14s,15r,17s)-15,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](C[C@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 KYGUQDTWUBBBSD-XJBBOAPUSA-N 0.000 abstract 1
YMCWOAZGWMZGQT-QFSSQGEMSA-N (8r,9s,10r,13s,14s,17r)-16,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](C(O)C4)O)[C@@H]4[C@@H]3CCC2=C1 YMCWOAZGWMZGQT-QFSSQGEMSA-N 0.000 abstract 1
KYGUQDTWUBBBSD-UHFFFAOYSA-N 15alpha-hydroxymethyltestosterone Natural products O=C1CCC2(C)C3CCC(C)(C(CC4O)O)C4C3CCC2=C1 KYGUQDTWUBBBSD-UHFFFAOYSA-N 0.000 abstract 1
YMCWOAZGWMZGQT-KYQPOWKGSA-N 16beta-hydroxytestosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H]([C@@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 YMCWOAZGWMZGQT-KYQPOWKGSA-N 0.000 abstract 1
206010002261 Androgen deficiency Diseases 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
230000001548 androgenic effect Effects 0.000 abstract 1
230000003054 hormonal effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03794351T 2002-09-05 2003-09-05 Orale pharmazeutische zusammensetzung enthaltend 15-hydroxytestosteron und seine derivate ATE452641T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02078643		2002-09-05
PCT/NL2003/000621 WO2004022065A1 (en)	2002-09-05	2003-09-05	Pharmaceutical application of 15- or 16- substituted testosterone analogues

Publications (1)

Publication Number	Publication Date
ATE452641T1 true ATE452641T1 (de)	2010-01-15

Family

ID=31970390

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03794351T ATE452641T1 (de)	2002-09-05	2003-09-05	Orale pharmazeutische zusammensetzung enthaltend 15-hydroxytestosteron und seine derivate

Country Status (9)

Country	Link
US (1)	US7943602B2 (de)
EP (1)	EP1551415B1 (de)
CN (2)	CN101785775B (de)
AT (1)	ATE452641T1 (de)
AU (1)	AU2003263663A1 (de)
CA (1)	CA2497838C (de)
DE (1)	DE60330695D1 (de)
ES (1)	ES2338782T3 (de)
WO (1)	WO2004022065A1 (de)

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KR20060130723A (ko)	2004-03-10	2006-12-19	쉐링 악티엔게젤샤프트	분자 분산된 드로스피레논을 포함하는 조성물
MY142989A (en)	2004-03-10	2011-02-14	Bayer Schering Pharma Ag	Stabilised supersaturated solids of lipophilic drugs
US7401307B2 (en) *	2004-11-03	2008-07-15	International Business Machines Corporation	Slack sensitivity to parameter variation based timing analysis
US9375437B2 (en) *	2010-06-18	2016-06-28	Lipocine Inc.	Progesterone containing oral dosage forms and kits
US8951996B2 (en)	2011-07-28	2015-02-10	Lipocine Inc.	17-hydroxyprogesterone ester-containing oral compositions and related methods
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
ES2885523T3 (es)	2011-11-23	2021-12-14	Therapeuticsmd Inc	Formulaciones y terapias de reposición hormonal de combinación naturales
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
WO2014078576A2 (en)	2012-11-14	2014-05-22	Abon Pharmaceuticals, Llc	Oral transmucosal drug delivery system
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
MX2016014281A (es)	2014-05-22	2017-02-22	Therapeuticsmd Inc	Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
JP2018522854A (ja)	2015-06-22	2018-08-16	リポカインインコーポレーテッド	１７−ヒドロキシプロゲステロンエステル含有経口組成物及び関連方法
US10328087B2 (en)	2015-07-23	2019-06-25	Therapeuticsmd, Inc.	Formulations for solubilizing hormones
US10286077B2 (en)	2016-04-01	2019-05-14	Therapeuticsmd, Inc.	Steroid hormone compositions in medium chain oils
AU2017239645A1 (en)	2016-04-01	2018-10-18	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
US11633405B2 (en)	2020-02-07	2023-04-25	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical formulations
CN119157100A (zh) *	2024-08-15	2024-12-20	北京星辉再生科技有限责任公司	用于模拟人类雄性激素型脱发的无创动物模型的构建方法及其模型和应用

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US2793216A (en) *	1954-08-17	1957-05-21	Upjohn Co	15-oxy-androstenes and 15-oxy-19-norandrostenes
GB774064A (en) *	1954-08-17	1957-05-01	Upjohn Co	Steroids
FR2035786A1 (en) *	1969-03-28	1970-12-24	Squibb & Sons Inc	A-d-glucosides of steroids contng 16a-and 17-oh gps
US6117446A (en) *	1999-01-26	2000-09-12	Place; Virgil A.	Drug dosage unit for buccal administration of steroidal active agents
WO2000074684A1 (en)	1999-06-04	2000-12-14	The General Hospital Corporation	Pharmaceutical formulations for treating postmenopausal and perimenopausal women, and their use
CA2669753C (en) *	1999-09-30	2012-06-26	Hollis-Eden Pharmaceuticals, Inc.	Therapeutic treatment of androgen receptor driven conditions

2003
- 2003-09-05 WO PCT/NL2003/000621 patent/WO2004022065A1/en not_active Ceased
- 2003-09-05 CN CN200910221753.4A patent/CN101785775B/zh not_active Expired - Fee Related
- 2003-09-05 CA CA2497838A patent/CA2497838C/en not_active Expired - Fee Related
- 2003-09-05 AT AT03794351T patent/ATE452641T1/de not_active IP Right Cessation
- 2003-09-05 EP EP03794351A patent/EP1551415B1/de not_active Expired - Lifetime
- 2003-09-05 CN CN038248905A patent/CN1694710B/zh not_active Expired - Fee Related
- 2003-09-05 US US10/526,730 patent/US7943602B2/en not_active Expired - Fee Related
- 2003-09-05 DE DE60330695T patent/DE60330695D1/de not_active Expired - Lifetime
- 2003-09-05 ES ES03794351T patent/ES2338782T3/es not_active Expired - Lifetime
- 2003-09-05 AU AU2003263663A patent/AU2003263663A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2338782T3 (es)	2010-05-12
CN1694710B (zh)	2012-09-05
AU2003263663A1 (en)	2004-03-29
US20060122158A1 (en)	2006-06-08
EP1551415B1 (de)	2009-12-23
CA2497838A1 (en)	2004-03-18
CN101785775A (zh)	2010-07-28
WO2004022065A1 (en)	2004-03-18
EP1551415A1 (de)	2005-07-13
CA2497838C (en)	2012-07-17
US7943602B2 (en)	2011-05-17
CN101785775B (zh)	2015-03-25
CN1694710A (zh)	2005-11-09
DE60330695D1 (de)	2010-02-04

Legal Events

Date	Code	Title	Description
2010-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60330695D1 (de)	2010-02-04	Orale pharmazeutische zusammensetzung enthaltend 15-hydroxytestosteron und seine derivate
JP6740497B2 (ja)	2020-08-12	癌を治療するための方法及び組成物
Malini et al.	2000	Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates
YU54602A (sh)	2006-01-16	Drospirenon za terapiju zamene hormona
US20150290221A1 (en)	2015-10-15	Methods and compositions for treating cancer
CA2467222A1 (en)	2003-05-22	Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
SE463074B (sv)	1990-10-08	Anvaendning av aromatashaemmare och antiandrogener foer framstaellning av laekemedel foer profylax och terapi av benign prostatahyperplasi
KR20090080989A (ko)	2009-07-27	여성 리비도의 유지 및/또는 증가를 위한 경구 치료요법을 위한 디에노게스트와 조합된 에스트라디올 발레레이트 또는 17β-에스트라디올의 용도
CA2467237A1 (en)	2003-05-22	Method of preventing or treating benign gynaecological disorders
WO2001003687A3 (en)	2001-08-09	Method and compositions for inhibiting biosynthesis or bioactivity of endogenous steroid sex hormones in humans
MY128482A (en)	2007-02-28	New hormonal composition and its use
NO955085L (no)	1996-02-14	Androstansteroider som nevrokjemiske initiatorer for forandring i menneskets hypotalamiske funksjon og beslektede farmasöytiske blandinger og metoder
HUP9903747A2 (hu)	2001-05-28	Új eljárás mometazon-furoát előállítására
HUP0101005A2 (hu)	2001-08-28	Szteroid aromatáz gátlót tartalmazó gyógyszer emlőrák megelőzésére és/vagy kezelésére
BR9307866A (pt)	1996-07-30	Esteróides estreno como iniciadores neuroquímicos de mudança em funçao hipotalamica humana e composiçoes farmaceuticas relacionadas e processos
RU2004116082A (ru)	2005-05-10	Применение (11бета, 17 бета)-11-(1,3-бензодиоксол-5-ил)-17-гидрокси-17-(1-пропинил) эстра-4,9-диен-3-она при лечении большого депрессивного расстройства
Nishino et al.	1989	Antitumor effect of a specific aromatase inhibitor, 1-methyl-androsta-1, 4-diene-3, 17-dione (atamestane), in female rats bearing DMBA-induced mammary tumors
MX9700881A (es)	1997-04-30	Pregnanos y colanos como indicadores neuroquimicos del cambio en la funcion hipotalamica.
YU16403A (sh)	2006-05-25	4-halogenovani 17-metilen steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenja
BR9816142A (pt)	2002-06-25	Esteróides de 19-nor-colano como iniciadores neuroquìmicos de mudança na função hipotalâmica humana
AR033260A1 (es)	2003-12-10	Nueva composicion hormonal y su utilizacion
JO2334B1 (en)	2006-06-28	Drospirenone for hormone replacement therapy
HK1173966A (en)	2013-05-31	Compositions for treating cancer