ATE452908T1 - Il-10 mutante - Google Patents

Il-10 mutante

Info

Publication number
ATE452908T1
ATE452908T1 AT06771553T AT06771553T ATE452908T1 AT E452908 T1 ATE452908 T1 AT E452908T1 AT 06771553 T AT06771553 T AT 06771553T AT 06771553 T AT06771553 T AT 06771553T AT E452908 T1 ATE452908 T1 AT E452908T1
Authority
AT
Austria
Prior art keywords
retain
mutant
hemoatopoeitic
polypeptides
wild
Prior art date
Application number
AT06771553T
Other languages
English (en)
Inventor
Jurg M Sommer
Raymond A Chavez
Kirk W Johnson
Linda May Rothblum Watkins
Original Assignee
Univ Colorado
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado filed Critical Univ Colorado
Application granted granted Critical
Publication of ATE452908T1 publication Critical patent/ATE452908T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
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AT06771553T 2005-05-31 2006-05-26 Il-10 mutante ATE452908T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68627205P 2005-05-31 2005-05-31
PCT/US2006/020863 WO2006130580A2 (en) 2005-05-31 2006-05-26 Mutant il-10

Publications (1)

Publication Number Publication Date
ATE452908T1 true ATE452908T1 (de) 2010-01-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT06771553T ATE452908T1 (de) 2005-05-31 2006-05-26 Il-10 mutante

Country Status (7)

Country Link
US (1) US7749490B2 (de)
EP (1) EP1891103B1 (de)
JP (2) JP4992025B2 (de)
AT (1) ATE452908T1 (de)
CA (1) CA2609543C (de)
DE (1) DE602006011311D1 (de)
WO (1) WO2006130580A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7052686B2 (en) 2000-09-29 2006-05-30 Schering Corporation Pegylated interleukin-10
US7261882B2 (en) * 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
PL2816118T3 (pl) * 2005-05-31 2019-03-29 The Regents Of The University Of Colorado, A Body Corporate Sposoby dostarczania genów
NZ597098A (en) 2006-09-28 2013-05-31 Merck Sharp & Dohme Use of pegylated il-10 to treat cancer
ES2957546T3 (es) 2008-12-17 2024-01-22 Merck Sharp & Dohme Producción de mono- y di-PEG-IL10; y usos
US20140314712A1 (en) 2011-11-08 2014-10-23 Umc Utrecht Holding B.V. Fusion protein comprising an interleukin 4 and interleukin
WO2013103966A1 (en) * 2012-01-06 2013-07-11 The Regents Of The University Of Colorado, A Body Corporate Methods for the treatment of multiple sclerosis and other demyelinating disorders
EP2986306A4 (de) 2013-04-18 2016-12-07 Armo Biosciences Inc Verfahren zur verwendung von interleukin-10 zur behandlung von erkrankungen und leiden
JP2016526014A (ja) * 2013-04-24 2016-09-01 アルモ・バイオサイエンシーズ・インコーポレイテッド インターロイキン−１０組成物及びその使用
CA2914837A1 (en) 2013-06-17 2014-12-24 Armo Biosciences, Inc. Method for assessing protein identity and stability
SI3021873T1 (sl) * 2013-07-18 2018-12-31 Xalud Therapeutics, Inc. Sestavek za zdravljenje vnetne sklepne bolezni
US10010588B2 (en) 2013-08-30 2018-07-03 Armo Biosciences, Inc. Methods of using pegylated interleukin-10 for treating hyperlipidemia
KR20160079114A (ko) 2013-11-11 2016-07-05 아르모 바이오사이언시스 인코포레이티드 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법
WO2015187295A2 (en) 2014-06-02 2015-12-10 Armo Biosciences, Inc. Methods of lowering serum cholesterol
EP3206713A4 (de) 2014-10-14 2018-06-27 Armo Biosciences, Inc. Interleukin-15-zusammensetzungen und verwendungen davon
AU2015336101A1 (en) 2014-10-22 2017-04-20 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
US10618970B2 (en) 2015-02-03 2020-04-14 Armo Biosciences, Inc. Method of treating cancer with IL-10 and antibodies that induce ADCC
WO2016191587A1 (en) 2015-05-28 2016-12-01 Armo Biosciences, Inc. Pegylated interleukin-10 for use in treating cancer
CA2995120A1 (en) 2015-08-25 2017-03-02 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
WO2017160599A1 (en) 2016-03-14 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of cd300b antagonists to treat sepsis and septic shock
RU2731160C2 (ru) * 2016-04-22 2020-08-31 Ксалюд Терапьютикс, Инк. Способы и композиции для усиления противовоспалительных эффектов интерлейкина 10
TW202033766A (zh) * 2018-11-26 2020-09-16 大陸商江蘇恆瑞醫藥股份有限公司 一種人白細胞介素１０變體及其衍生物
JP2022519586A (ja) * 2019-02-04 2022-03-24 ゼネティック バイオサイエンシーズ インコーポレイテッド 糖ポリシアル酸化治療用タンパク質を使用する方法
CN113811549A (zh) 2019-02-21 2021-12-17 Xencor股份有限公司 非靶向和靶向性il-10 fc融合蛋白
JP7641912B2 (ja) 2019-04-19 2025-03-07 シナーキン・ファーマ・ベスローテン・フエンノートシャップ Ｉｌ１３を含む融合タンパク質
JP2023527359A (ja) * 2020-05-28 2023-06-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 改変インターロイキン－１０ポリペプチド及びその使用
IL330191A (en) 2020-06-26 2026-08-01 Amgen Inc IL-10 mutants and their fusion proteins
EP4306124A4 (de) * 2021-03-12 2025-03-12 Kolon Life Science, Inc. Zusammensetzung zur prävention oder behandlung von degenerativen hirnerkrankungen
WO2023114958A1 (en) * 2021-12-16 2023-06-22 Xalud Therapeutics, Inc. Dosing regimen for il-10 encoding expression construct

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6428985B1 (en) * 1998-12-02 2002-08-06 The Regents Of The University Of Michigan Immunosuppressive structural definition of IL-10
AU2001231532A1 (en) * 2000-02-11 2001-08-20 Maxygen Aps Improved interleukin 10

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CA2609543C (en) 2015-03-24
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WO2006130580A3 (en) 2007-04-19
CA2609543A1 (en) 2006-12-07
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