ATE452967T1 - Verfahren zur herstellung menschlicher beta- zelllinien - Google Patents

Verfahren zur herstellung menschlicher beta- zelllinien

Info

Publication number
ATE452967T1
ATE452967T1 AT02785716T AT02785716T ATE452967T1 AT E452967 T1 ATE452967 T1 AT E452967T1 AT 02785716 T AT02785716 T AT 02785716T AT 02785716 T AT02785716 T AT 02785716T AT E452967 T1 ATE452967 T1 AT E452967T1
Authority
AT
Austria
Prior art keywords
human beta
pancreatic
beta cell
cell lines
producing human
Prior art date
Application number
AT02785716T
Other languages
English (en)
Inventor
Paul Czernichov
Raphael Scharfmann
Philippe Ravassard
Jacques Mallet
Original Assignee
Univ Paris 7 Denis Diderot
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Paris 7 Denis Diderot, Centre Nat Rech Scient filed Critical Univ Paris 7 Denis Diderot
Application granted granted Critical
Publication of ATE452967T1 publication Critical patent/ATE452967T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT02785716T 2001-10-19 2002-10-18 Verfahren zur herstellung menschlicher beta- zelllinien ATE452967T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/981,750 US20030077256A1 (en) 2001-10-19 2001-10-19 Pancreas regeneration using embryonic pancreatic cells
PCT/IB2002/004599 WO2003033685A2 (en) 2001-10-19 2002-10-18 Method of producing human beta cell lines

Publications (1)

Publication Number Publication Date
ATE452967T1 true ATE452967T1 (de) 2010-01-15

Family

ID=25528625

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02785716T ATE452967T1 (de) 2001-10-19 2002-10-18 Verfahren zur herstellung menschlicher beta- zelllinien

Country Status (18)

Country Link
US (2) US20030077256A1 (de)
EP (1) EP1456356B1 (de)
JP (1) JP2005505635A (de)
KR (1) KR20040080430A (de)
CN (1) CN1662644A (de)
AT (1) ATE452967T1 (de)
BR (1) BR0213429A (de)
CA (1) CA2463979A1 (de)
DE (1) DE60234862D1 (de)
GB (1) GB2397825B (de)
HR (1) HRP20040446A2 (de)
HU (1) HUP0600102A2 (de)
IL (1) IL161468A0 (de)
NZ (1) NZ532965A (de)
PL (1) PL370167A1 (de)
RU (1) RU2004115108A (de)
WO (1) WO2003033685A2 (de)
ZA (1) ZA200403646B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009508492A (ja) * 2005-09-15 2009-03-05 バーンハム インスティトゥート フォー メディカル リサーチ インスリンプロモーター活性を調節する化合物のスクリーニング方法
US10167450B2 (en) * 2007-02-21 2019-01-01 Sarl Endocells Human pancreatic beta cell lines for diagnostic of diabetes
US8859286B2 (en) * 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
KR102580225B1 (ko) 2013-06-11 2023-09-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
WO2016100930A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Methods for generating stem cell-derived b cells and methods of use thereof
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
CN118497104A (zh) 2017-11-15 2024-08-16 沃泰克斯药物股份有限公司 胰岛细胞制备性组合物和使用方法
EP3833365A4 (de) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Aus stammzellen gewonnene inseldifferenzierung
CN110029130A (zh) * 2019-04-24 2019-07-19 皖南医学院第一附属医院（皖南医学院弋矶山医院） 基于CRISPR/Cas9系统在Beta-TC-6细胞株中剔除Sidt2基因方法
CN120813682A (zh) * 2024-02-09 2025-10-17 智新浩正(上海)医药科技有限公司 用于制备内胚层干细胞和由其衍生的胰岛的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723333A (en) * 1995-02-10 1998-03-03 Regents Of The University Of California Human pancreatic cell lines: developments and uses

Also Published As

Publication number Publication date
GB2397825A (en) 2004-08-04
DE60234862D1 (de) 2010-02-04
EP1456356B1 (de) 2009-12-23
CN1662644A (zh) 2005-08-31
ZA200403646B (en) 2005-01-26
IL161468A0 (en) 2004-09-27
BR0213429A (pt) 2004-11-09
US20030077256A1 (en) 2003-04-24
GB2397825B (en) 2006-02-22
WO2003033685A3 (en) 2004-05-27
RU2004115108A (ru) 2005-02-10
CA2463979A1 (en) 2003-04-24
PL370167A1 (en) 2005-05-16
NZ532965A (en) 2006-04-28
EP1456356A2 (de) 2004-09-15
KR20040080430A (ko) 2004-09-18
US20030219418A1 (en) 2003-11-27
HRP20040446A2 (en) 2005-04-30
HUP0600102A2 (en) 2006-05-29
GB0411052D0 (en) 2004-06-23
WO2003033685A2 (en) 2003-04-24
JP2005505635A (ja) 2005-02-24

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