ATE453611T1 - Vitamin-d-analoga - Google Patents

Vitamin-d-analoga

Info

Publication number: ATE453611T1
Authority: AT; Austria
Prior art keywords: bis; phenyl; trifluoro; carbon atoms; radical
Prior art date: 2001-05-22

Application number

AT02735556T

Other languages

English (en)

Inventor

Jean-Michel Bernardon

Original Assignee

Galderma Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-22

Filing date

2002-05-22

Publication date

2010-01-15

2002-05-22 Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE453611T1 publication Critical patent/ATE453611T1/de

Links

229940088594 vitamin Drugs 0.000 title 1
229930003231 vitamin Natural products 0.000 title 1
235000013343 vitamin Nutrition 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000003722 vitamin derivatives Chemical class 0.000 title 1
-1 alkyl radical Chemical class 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
150000005840 aryl radicals Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
GTLCUSKTPJNTRH-YNXPHOCQSA-N (3e,5e)-6-[3-[[3,4-bis(hydroxymethyl)phenyl]methoxy]phenyl]-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol Chemical compound FC(F)(F)C(O)(C(F)(F)F)\C=C\C=C(/CC)C1=CC=CC(OCC=2C=C(CO)C(CO)=CC=2)=C1 GTLCUSKTPJNTRH-YNXPHOCQSA-N 0.000 abstract 1
MQVQVTPMLKHAJK-HFWUGNDSSA-N (4e,6e)-7-[3-[2-[3,4-bis(hydroxymethyl)phenyl]ethyl]phenyl]-3-ethylnona-4,6-dien-3-ol Chemical compound CCC(O)(CC)\C=C\C=C(/CC)C1=CC=CC(CCC=2C=C(CO)C(CO)=CC=2)=C1 MQVQVTPMLKHAJK-HFWUGNDSSA-N 0.000 abstract 1
JRQYVUBDUOPEJR-FBCYGCLPSA-N (e)-6-[3-[2-[3,4-bis(hydroxymethyl)phenyl]ethyl]phenyl]-1,1,1-trifluoro-2-(trifluoromethyl)oct-5-en-3-yn-2-ol Chemical compound FC(F)(F)C(O)(C(F)(F)F)C#C\C=C(/CC)C1=CC=CC(CCC=2C=C(CO)C(CO)=CC=2)=C1 JRQYVUBDUOPEJR-FBCYGCLPSA-N 0.000 abstract 1
LJLDWEAGJAEIGO-UBKPWBPPSA-N (e)-6-[3-[[3,4-bis(hydroxymethyl)phenyl]methoxy]phenyl]-1,1,1-trifluoro-2-(trifluoromethyl)oct-5-en-3-yn-2-ol Chemical compound FC(F)(F)C(O)(C(F)(F)F)C#C\C=C(/CC)C1=CC=CC(OCC=2C=C(CO)C(CO)=CC=2)=C1 LJLDWEAGJAEIGO-UBKPWBPPSA-N 0.000 abstract 1
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/486—Polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Obesity (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02735556T 2001-05-22 2002-05-22 Vitamin-d-analoga ATE453611T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0106731A FR2825087B1 (fr)	2001-05-22	2001-05-22	Analogues de la vitamine d
PCT/FR2002/001726 WO2002094754A1 (fr)	2001-05-22	2002-05-22	Analogues de la vitamine d

Publications (1)

Publication Number	Publication Date
ATE453611T1 true ATE453611T1 (de)	2010-01-15

Family

ID=8863543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02735556T ATE453611T1 (de)	2001-05-22	2002-05-22	Vitamin-d-analoga

Country Status (20)

Country	Link
US (1)	US7700657B2 (de)
EP (1)	EP1395538B1 (de)
JP (1)	JP4629309B2 (de)
KR (1)	KR100878728B1 (de)
CN (1)	CN1267394C (de)
AT (1)	ATE453611T1 (de)
AU (1)	AU2002310684B2 (de)
BR (1)	BR0205517A (de)
CA (1)	CA2446149C (de)
CY (1)	CY1109843T1 (de)
DE (1)	DE60234920D1 (de)
DK (1)	DK1395538T3 (de)
ES (1)	ES2338995T3 (de)
FR (1)	FR2825087B1 (de)
MX (1)	MXPA03010628A (de)
PL (1)	PL215582B1 (de)
PT (1)	PT1395538E (de)
RU (1)	RU2266274C2 (de)
WO (1)	WO2002094754A1 (de)
ZA (1)	ZA200300668B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0406490A (pt) *	2003-02-05	2005-12-06	Galderma Res & Dev	Composições, composição cosmética ou dermatológica e uso de uma composição
US20050124591A1 (en) *	2003-07-29	2005-06-09	Jin Tian	Use of vitamin Ds to treat kidney disease
US20050148557A1 (en) *	2003-07-29	2005-07-07	Jin Tian	Use of Vitamin Ds to treat kidney disease
US20050192255A1 (en) *	2003-07-30	2005-09-01	Jin Tian	Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease
US20060171983A1 (en) *	2003-07-30	2006-08-03	Jin Tian	Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
JP2007511578A (ja)	2003-11-21	2007-05-10	ガルデルマ・リサーチ・アンド・デヴェロップメント・エス・エヌ・セ	ビタミンｄの投与のためのスプレー可能な組成物
FR2892936A1 (fr) *	2005-11-10	2007-05-11	Galderma Res & Dev	Composition pharmaceutique ou cosmetique, et procede de solubilisation mixte pour preparer la composition.
US8470304B2 (en) *	2009-08-04	2013-06-25	Avidas Pharmaceuticals Llc	Therapeutic vitamin D sun-protecting formulations and methods for their use
CN102655869B (zh)	2009-08-14	2016-08-10	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
KR20180095882A (ko) *	2015-12-18	2018-08-28	디에스엠 아이피 어셋츠 비.브이.	이중방향족 비타민 d 유사체
JP6972464B2 (ja) *	2015-12-18	2021-11-24	ディーエスエムアイピーアセッツビー.ブイ.Dsm Ip Assets B.V.	二芳香族ビタミンｄアナログ
EP3389607B1 (de) *	2015-12-18	2020-07-15	DSM IP Assets B.V.	Biaromatische vitamin d analoge
JP6632006B2 (ja) *	2015-12-18	2020-01-15	ディーエスエムアイピーアセッツビー．ブイ．ＤｓｍＩｐＡｓｓｅｔｓＢ．Ｖ．	新規化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2713635B1 (fr) *	1993-12-15	1996-01-05	Cird Galderma	Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US5650420A (en)	1994-12-15	1997-07-22	Pharmacia & Upjohn Company	Pramipexole as a neuroprotective agent
FR2741876B1 (fr) *	1995-12-01	1998-01-09	Cird Galderma	Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations
FR2757852B1 (fr)	1996-12-31	1999-02-19	Cird Galderma	Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
FR2785284B1 (fr) *	1998-11-02	2000-12-01	Galderma Res & Dev	Analogues de la vitamine d
US6659922B1 (en)	2003-04-21	2003-12-09	Jao-Hsing Tsai	Resistance adjustment mechanism for easy pull exerciser

2001
- 2001-05-22 FR FR0106731A patent/FR2825087B1/fr not_active Expired - Fee Related
2002
- 2002-05-22 CN CNB028104579A patent/CN1267394C/zh not_active Expired - Fee Related
- 2002-05-22 MX MXPA03010628A patent/MXPA03010628A/es active IP Right Grant
- 2002-05-22 RU RU2003136744/04A patent/RU2266274C2/ru not_active IP Right Cessation
- 2002-05-22 BR BR0205517-1A patent/BR0205517A/pt not_active IP Right Cessation
- 2002-05-22 JP JP2002591429A patent/JP4629309B2/ja not_active Expired - Fee Related
- 2002-05-22 DK DK02735556.9T patent/DK1395538T3/da active
- 2002-05-22 DE DE60234920T patent/DE60234920D1/de not_active Expired - Lifetime
- 2002-05-22 AU AU2002310684A patent/AU2002310684B2/en not_active Ceased
- 2002-05-22 KR KR1020037000956A patent/KR100878728B1/ko not_active Expired - Fee Related
- 2002-05-22 AT AT02735556T patent/ATE453611T1/de active
- 2002-05-22 CA CA2446149A patent/CA2446149C/fr not_active Expired - Fee Related
- 2002-05-22 PL PL363872A patent/PL215582B1/pl unknown
- 2002-05-22 ES ES02735556T patent/ES2338995T3/es not_active Expired - Lifetime
- 2002-05-22 PT PT02735556T patent/PT1395538E/pt unknown
- 2002-05-22 WO PCT/FR2002/001726 patent/WO2002094754A1/fr not_active Ceased
- 2002-05-22 EP EP02735556A patent/EP1395538B1/de not_active Expired - Lifetime
2003
- 2003-01-24 ZA ZA200300668A patent/ZA200300668B/en unknown
- 2003-11-24 US US10/718,538 patent/US7700657B2/en not_active Expired - Fee Related
2010
- 2010-02-25 CY CY20101100185T patent/CY1109843T1/el unknown

Also Published As

Publication number	Publication date
BR0205517A (pt)	2003-07-01
KR20030019601A (ko)	2003-03-06
KR100878728B1 (ko)	2009-01-14
US7700657B2 (en)	2010-04-20
AU2002310684B2 (en)	2005-07-21
US20040224929A1 (en)	2004-11-11
DE60234920D1 (de)	2010-02-11
CA2446149C (fr)	2010-07-06
RU2003136744A (ru)	2005-04-10
EP1395538B1 (de)	2009-12-30
DK1395538T3 (da)	2010-03-15
WO2002094754A1 (fr)	2002-11-28
FR2825087B1 (fr)	2005-01-14
PL363872A1 (en)	2004-11-29
ZA200300668B (en)	2004-06-22
JP2004534038A (ja)	2004-11-11
EP1395538A1 (de)	2004-03-10
PT1395538E (pt)	2010-02-12
CN1549803A (zh)	2004-11-24
RU2266274C2 (ru)	2005-12-20
CA2446149A1 (fr)	2002-11-28
CY1109843T1 (el)	2014-09-10
PL215582B1 (pl)	2013-12-31
ES2338995T3 (es)	2010-05-14
JP4629309B2 (ja)	2011-02-09
MXPA03010628A (es)	2004-04-02
CN1267394C (zh)	2006-08-02
FR2825087A1 (fr)	2002-11-29

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2010-05-15

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Publication	Publication Date	Title
ATE453611T1 (de)	2010-01-15	Vitamin-d-analoga
IL105481A0 (en)	1993-08-18	Phenyl sulfonamide derivatives and pharmaceutical compositions containing the same
MEP24608A (en)	2010-10-10	Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
DE69410092D1 (en)	1998-06-10	Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
ES2106685A1 (es)	1997-11-01	Bis-resorciniltriazinas.
HU9203016D0 (en)	1992-12-28	New taxane compounds substituted with alkoxy and pharmaceutical preparatives containing these compounds
YU3902A (sh)	2006-01-16	Imidazoimidazoli i triazoli kao anti-inflamatorna sredstva
BR0306292A (pt)	2004-08-24	Composto de éster e uso medicinal do mesmo
BR9703447A (pt)	1998-11-10	Novos compostos 3-(piperid-4-il)-1,2-benzisoxazol e 3-(piperazin-4-il) 1,2-benzisoxazol processos para a preparação dos mesmos e composições farmacêuticas contendo os mesmo
ATE286027T1 (de)	2005-01-15	Fluorpyrazol-biphenylamide als fungizide
BR0207846A (pt)	2005-09-13	Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
ATE156836T1 (de)	1997-08-15	11,21-bisphenyl-19-nor-pregnan derivate
IL196754A0 (en)	2009-11-18	Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof
DE69724646D1 (de)	2003-10-09	16-ene-vitamin d derivate
TW200744589A (en)	2007-12-16	Pharmaceutical composition
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