ATE453611T1 - Vitamin-d-analoga - Google Patents

Vitamin-d-analoga

Info

Publication number: ATE453611T1
Authority: AT; Austria
Prior art keywords: bis; phenyl; trifluoro; carbon atoms; radical
Prior art date: 2001-05-22

Application number

AT02735556T

Other languages

English (en)

Inventor

Jean-Michel Bernardon

Original Assignee

Galderma Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-22

Filing date

2002-05-22

Publication date

2010-01-15

2002-05-22 Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE453611T1 publication Critical patent/ATE453611T1/de

Links

229940088594 vitamin Drugs 0.000 title 1
229930003231 vitamin Natural products 0.000 title 1
235000013343 vitamin Nutrition 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000003722 vitamin derivatives Chemical class 0.000 title 1
-1 alkyl radical Chemical class 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
150000005840 aryl radicals Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
GTLCUSKTPJNTRH-YNXPHOCQSA-N (3e,5e)-6-[3-[[3,4-bis(hydroxymethyl)phenyl]methoxy]phenyl]-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol Chemical compound FC(F)(F)C(O)(C(F)(F)F)\C=C\C=C(/CC)C1=CC=CC(OCC=2C=C(CO)C(CO)=CC=2)=C1 GTLCUSKTPJNTRH-YNXPHOCQSA-N 0.000 abstract 1
MQVQVTPMLKHAJK-HFWUGNDSSA-N (4e,6e)-7-[3-[2-[3,4-bis(hydroxymethyl)phenyl]ethyl]phenyl]-3-ethylnona-4,6-dien-3-ol Chemical compound CCC(O)(CC)\C=C\C=C(/CC)C1=CC=CC(CCC=2C=C(CO)C(CO)=CC=2)=C1 MQVQVTPMLKHAJK-HFWUGNDSSA-N 0.000 abstract 1
JRQYVUBDUOPEJR-FBCYGCLPSA-N (e)-6-[3-[2-[3,4-bis(hydroxymethyl)phenyl]ethyl]phenyl]-1,1,1-trifluoro-2-(trifluoromethyl)oct-5-en-3-yn-2-ol Chemical compound FC(F)(F)C(O)(C(F)(F)F)C#C\C=C(/CC)C1=CC=CC(CCC=2C=C(CO)C(CO)=CC=2)=C1 JRQYVUBDUOPEJR-FBCYGCLPSA-N 0.000 abstract 1
LJLDWEAGJAEIGO-UBKPWBPPSA-N (e)-6-[3-[[3,4-bis(hydroxymethyl)phenyl]methoxy]phenyl]-1,1,1-trifluoro-2-(trifluoromethyl)oct-5-en-3-yn-2-ol Chemical compound FC(F)(F)C(O)(C(F)(F)F)C#C\C=C(/CC)C1=CC=CC(OCC=2C=C(CO)C(CO)=CC=2)=C1 LJLDWEAGJAEIGO-UBKPWBPPSA-N 0.000 abstract 1
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/486—Polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Immunology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Emergency Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Virology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02735556T 2001-05-22 2002-05-22 Vitamin-d-analoga ATE453611T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0106731A FR2825087B1 (fr)	2001-05-22	2001-05-22	Analogues de la vitamine d
PCT/FR2002/001726 WO2002094754A1 (fr)	2001-05-22	2002-05-22	Analogues de la vitamine d

Publications (1)

Publication Number	Publication Date
ATE453611T1 true ATE453611T1 (de)	2010-01-15

Family

ID=8863543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02735556T ATE453611T1 (de)	2001-05-22	2002-05-22	Vitamin-d-analoga

Country Status (20)

Country	Link
US (1)	US7700657B2 (de)
EP (1)	EP1395538B1 (de)
JP (1)	JP4629309B2 (de)
KR (1)	KR100878728B1 (de)
CN (1)	CN1267394C (de)
AT (1)	ATE453611T1 (de)
AU (1)	AU2002310684B2 (de)
BR (1)	BR0205517A (de)
CA (1)	CA2446149C (de)
CY (1)	CY1109843T1 (de)
DE (1)	DE60234920D1 (de)
DK (1)	DK1395538T3 (de)
ES (1)	ES2338995T3 (de)
FR (1)	FR2825087B1 (de)
MX (1)	MXPA03010628A (de)
PL (1)	PL215582B1 (de)
PT (1)	PT1395538E (de)
RU (1)	RU2266274C2 (de)
WO (1)	WO2002094754A1 (de)
ZA (1)	ZA200300668B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004069134A2 (en) *	2003-02-05	2004-08-19	Galderma Research & Development, S.N.C.	Invert emulsion type composition containing at least one active agent sensitive to the presence of water, and its uses in cosmetics and in dermatology
US20050124591A1 (en) *	2003-07-29	2005-06-09	Jin Tian	Use of vitamin Ds to treat kidney disease
US20050148557A1 (en) *	2003-07-29	2005-07-07	Jin Tian	Use of Vitamin Ds to treat kidney disease
US20050192255A1 (en) *	2003-07-30	2005-09-01	Jin Tian	Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease
US20060171983A1 (en) *	2003-07-30	2006-08-03	Jin Tian	Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
DK1686972T3 (da)	2003-11-21	2008-06-30	Galderma Res & Dev	Spröjtbart præparat til indgivelse af D-vitaminderivater
FR2892936A1 (fr) *	2005-11-10	2007-05-11	Galderma Res & Dev	Composition pharmaceutique ou cosmetique, et procede de solubilisation mixte pour preparer la composition.
US8470304B2 (en)	2009-08-04	2013-06-25	Avidas Pharmaceuticals Llc	Therapeutic vitamin D sun-protecting formulations and methods for their use
MX366076B (es) *	2009-08-14	2019-06-27	Berg Llc	Vitamina d3 y analogos de la misma para tratar alopecia.
WO2017102792A1 (en) *	2015-12-18	2017-06-22	Dsm Ip Assets B.V.	Biaromatic vitamin d analogs
EP3389607B1 (de) *	2015-12-18	2020-07-15	DSM IP Assets B.V.	Biaromatische vitamin d analoge
US10336675B2 (en)	2015-12-18	2019-07-02	Dsm Ip Assets B.V.	Biaromatic vitamin D analogs
CN108366941B (zh) *	2015-12-18	2021-06-18	帝斯曼知识产权资产管理有限公司	新颖的化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2713635B1 (fr) *	1993-12-15	1996-01-05	Cird Galderma	Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US5650420A (en)	1994-12-15	1997-07-22	Pharmacia & Upjohn Company	Pramipexole as a neuroprotective agent
FR2741876B1 (fr) *	1995-12-01	1998-01-09	Cird Galderma	Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations
FR2757852B1 (fr)	1996-12-31	1999-02-19	Cird Galderma	Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
FR2785284B1 (fr) *	1998-11-02	2000-12-01	Galderma Res & Dev	Analogues de la vitamine d
US6659922B1 (en)	2003-04-21	2003-12-09	Jao-Hsing Tsai	Resistance adjustment mechanism for easy pull exerciser

2001
- 2001-05-22 FR FR0106731A patent/FR2825087B1/fr not_active Expired - Fee Related
2002
- 2002-05-22 DE DE60234920T patent/DE60234920D1/de not_active Expired - Lifetime
- 2002-05-22 ES ES02735556T patent/ES2338995T3/es not_active Expired - Lifetime
- 2002-05-22 AU AU2002310684A patent/AU2002310684B2/en not_active Ceased
- 2002-05-22 PT PT02735556T patent/PT1395538E/pt unknown
- 2002-05-22 BR BR0205517-1A patent/BR0205517A/pt not_active IP Right Cessation
- 2002-05-22 RU RU2003136744/04A patent/RU2266274C2/ru not_active IP Right Cessation
- 2002-05-22 KR KR1020037000956A patent/KR100878728B1/ko not_active Expired - Fee Related
- 2002-05-22 CA CA2446149A patent/CA2446149C/fr not_active Expired - Fee Related
- 2002-05-22 MX MXPA03010628A patent/MXPA03010628A/es active IP Right Grant
- 2002-05-22 CN CNB028104579A patent/CN1267394C/zh not_active Expired - Fee Related
- 2002-05-22 AT AT02735556T patent/ATE453611T1/de active
- 2002-05-22 DK DK02735556.9T patent/DK1395538T3/da active
- 2002-05-22 EP EP02735556A patent/EP1395538B1/de not_active Expired - Lifetime
- 2002-05-22 JP JP2002591429A patent/JP4629309B2/ja not_active Expired - Fee Related
- 2002-05-22 WO PCT/FR2002/001726 patent/WO2002094754A1/fr not_active Ceased
- 2002-05-22 PL PL363872A patent/PL215582B1/pl unknown
2003
- 2003-01-24 ZA ZA200300668A patent/ZA200300668B/en unknown
- 2003-11-24 US US10/718,538 patent/US7700657B2/en not_active Expired - Fee Related
2010
- 2010-02-25 CY CY20101100185T patent/CY1109843T1/el unknown

Also Published As

Publication number	Publication date
CN1549803A (zh)	2004-11-24
CA2446149A1 (fr)	2002-11-28
US7700657B2 (en)	2010-04-20
DK1395538T3 (da)	2010-03-15
RU2003136744A (ru)	2005-04-10
BR0205517A (pt)	2003-07-01
EP1395538A1 (de)	2004-03-10
ZA200300668B (en)	2004-06-22
FR2825087A1 (fr)	2002-11-29
ES2338995T3 (es)	2010-05-14
FR2825087B1 (fr)	2005-01-14
DE60234920D1 (de)	2010-02-11
JP4629309B2 (ja)	2011-02-09
CY1109843T1 (el)	2014-09-10
RU2266274C2 (ru)	2005-12-20
PL215582B1 (pl)	2013-12-31
KR20030019601A (ko)	2003-03-06
PT1395538E (pt)	2010-02-12
PL363872A1 (en)	2004-11-29
EP1395538B1 (de)	2009-12-30
CA2446149C (fr)	2010-07-06
CN1267394C (zh)	2006-08-02
AU2002310684B2 (en)	2005-07-21
MXPA03010628A (es)	2004-04-02
KR100878728B1 (ko)	2009-01-14
WO2002094754A1 (fr)	2002-11-28
JP2004534038A (ja)	2004-11-11
US20040224929A1 (en)	2004-11-11

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DE69500542D1 (de)	1997-09-18	11,21-Bisphenyl-19-nor-pregnan Derivate
IL196754A0 (en)	2009-11-18	Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof
HUP0003614A2 (hu)	2001-10-28	Indolil-(pirrolilidén-metil)-pirrol-származékok és eljárás előállításukra
WO2000027337A3 (fr)	2000-08-17	Procede de photostabilisation de derives de d,3,5-triazine
EA200100639A1 (ru)	2002-06-27	Производные тиомочевины, содержащие гетероциклический карбоксамид и защитную группу фенилэтиленамина, в качестве ингибиторов вирусов герпеса
BR0214139A (pt)	2004-10-19	Derivados de fenil-propargil éter
AU558461B2 (en)	1987-01-29	Carbamyloxybenzhyrol derivatives
IT1255207B (it)	1995-10-20	Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatrice
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