ATE453655T1 - Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten - Google Patents

Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten

Info

Publication number
ATE453655T1
ATE453655T1 AT01947909T AT01947909T ATE453655T1 AT E453655 T1 ATE453655 T1 AT E453655T1 AT 01947909 T AT01947909 T AT 01947909T AT 01947909 T AT01947909 T AT 01947909T AT E453655 T1 ATE453655 T1 AT E453655T1
Authority
AT
Austria
Prior art keywords
hyaluronic acid
agent
acid oligosaccharides
inhibitor
cell
Prior art date
Application number
AT01947909T
Other languages
English (en)
Inventor
Akira Asari
Hitoshi Kurihara
Tomomi Ito
Yuka Miyazaki
Hiroko Yamanokuchi
Akira Tawada
Takahiro Masa
Yuji Matsuzaki
Original Assignee
Seikagaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd
Application granted granted Critical
Publication of ATE453655T1 publication Critical patent/ATE453655T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01947909T 2000-07-07 2001-07-06 Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten ATE453655T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000206404 2000-07-07
JP2000247840 2000-08-17
PCT/JP2001/005918 WO2002004471A1 (fr) 2000-07-07 2001-07-06 Fractions oligosaccharidiques d'acide hyaluronique et medicament les contenant

Publications (1)

Publication Number Publication Date
ATE453655T1 true ATE453655T1 (de) 2010-01-15

Family

ID=26595584

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01947909T ATE453655T1 (de) 2000-07-07 2001-07-06 Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten

Country Status (9)

Country Link
US (5) US7507723B2 (de)
EP (1) EP1300412B1 (de)
JP (1) JP4861596B2 (de)
CN (1) CN100369925C (de)
AT (1) ATE453655T1 (de)
AU (3) AU6947801A (de)
CA (2) CA2414211C (de)
DE (1) DE60140941D1 (de)
WO (1) WO2002004471A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7511026B2 (en) * 2003-03-25 2009-03-31 Seikagaku Corporation Therapeutic agent for nerve damage
JP4576583B2 (ja) * 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
JP2007084509A (ja) * 2005-09-26 2007-04-05 Toshitsu Kagaku Kenkyusho:Kk 細胞賦活剤
JP2007153761A (ja) * 2005-12-01 2007-06-21 Toshitsu Kagaku Kenkyusho:Kk シナプス伝達促進剤及びシナプス保護剤
US20070099867A1 (en) * 2005-05-24 2007-05-03 Glycoscience Laboratories, Inc. Pharmaceutical agent containing hyaluronan as an active ingredient
NO20064337L (no) * 2005-09-26 2007-03-27 Glycoscience Lab Inc Farmasoytisk middel inneholdende hyaluronan som en aktiv ingrediens
JP2009091248A (ja) * 2006-01-17 2009-04-30 Toshitsu Kagaku Kenkyusho:Kk 外傷性神経障害および／または運動機能障害の治療薬
KR101482800B1 (ko) * 2006-02-24 2015-01-14 큐피가부시키가이샤 신규한 저분자량 히알루론산 및/또는 이의 염, 및 이를 이용한 화장료, 의약 조성물 및 식품 조성물
WO2008047779A1 (fr) * 2006-10-17 2008-04-24 Glycoscience Laboratories, Inc. Agent thérapeutique ou prophylactique pour la dermatite atopique
RU2385157C1 (ru) * 2006-12-05 2010-03-27 Гликосайенс Лабораториз, Инк. Лечение остеоартрита
EP1994934A4 (de) * 2006-12-05 2010-03-10 Glycoscience Lab Inc Therapeutisches mittel gegen degenerative arthritis
WO2009046530A1 (en) * 2007-10-12 2009-04-16 London Health Sciences Centre Research Inc. Compositions affecting hyaluronic acid mediated activity
CN101326963B (zh) * 2008-03-03 2011-06-22 北京神州圣业科技有限公司 一种碱性阳离子饲料免疫增强剂溶液、生产方法及其用途
JPWO2009113512A1 (ja) * 2008-03-11 2011-07-21 キユーピー株式会社 Ｓｏｃｓ３発現促進剤、これを含有する医薬品および食品、ならびにｓｏｃｓ３の発現を促進する方法
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
JP5587637B2 (ja) * 2009-04-10 2014-09-10 生化学工業株式会社 マトリックスメタロプロテアーゼ阻害剤及びその用途
EP2818172A4 (de) * 2012-02-22 2016-02-17 Hyaluronan Res Inst Inc Tlr4-mittel, gewebehomöostatikum, hepatozytenwachstumsfaktorinduktor, gewebereparierendes mittel und sirtuininduktor mit hyaluronsäurefragmenten als wirkstoffe davon
EP2698636A1 (de) * 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Verfahren und Reagenzien zur Vorbeugung und/oder Behandlung von Transplantatabstoßung
WO2015120223A1 (en) * 2014-02-06 2015-08-13 New York University Method for separating hyaluronan and quantifying its molecular mass distribution in biological samples
KR20180028787A (ko) * 2016-09-09 2018-03-19 삼성전자주식회사 디펙 검사 시스템과 방법, 및 그 검사 방법을 이용한 반도체 소자 제조방법
CN116622006B (zh) 2017-03-10 2025-05-30 北卡罗来纳大学查珀尔希尔分校 短效的基于肝素的抗凝血剂化合物和方法
JP7285048B2 (ja) * 2017-03-31 2023-06-01 ロート製薬株式会社 ヒアルロン酸オリゴ糖含有組成物の製造方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
JP7495061B2 (ja) 2017-11-03 2024-06-04 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 抗炎症作用を有する硫酸化オリゴ糖
CN112437667B (zh) 2018-06-20 2024-05-28 北卡罗来纳大学查珀尔希尔分校 细胞保护方法和组合物
CN109517012B (zh) * 2018-11-13 2020-05-22 华熙生物科技股份有限公司 一种透明质酸寡糖的制备方法
CN109528753B (zh) * 2018-12-20 2021-01-22 四川大学华西医院 寡聚透明质酸或其盐在制备治疗心肌梗死的药物中的用途
JP7801217B2 (ja) 2019-11-13 2026-01-16 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果
CN113876623B (zh) * 2021-09-24 2024-06-14 华熙生物科技股份有限公司 一种透明质酸寡糖组合物在抗皮肤衰老、促进胶原蛋白生成中的用途
CN115774066B (zh) * 2022-11-16 2024-08-27 南京乐韬生物科技有限公司 一种分析超低分子量透明质酸组分比例的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPH06107538A (ja) * 1992-03-31 1994-04-19 Shiseido Co Ltd 角膜移植用眼球保存液
US5902795A (en) * 1992-06-16 1999-05-11 Trustees Of Tufts College Oligosaccharides reactive with hyaluronan-binding protein and their methods of use
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
JP4195107B2 (ja) 1996-02-16 2008-12-10 生化学工業株式会社 ストレス蛋白質発現増強剤
IT1287227B1 (it) * 1996-04-04 1998-08-04 Fidia Spa In Amministrazione S Acido ialuronico quale componente del liquido di conservazione della cornea
JPH11246301A (ja) * 1998-02-27 1999-09-14 Denki Kagaku Kogyo Kk 臓器保存溶液
AU758575C (en) * 1998-04-30 2003-11-20 Maruha Corporation Compounds having glucuronic acid derivative and glucosamine derivative in structure thereof, method for producing the compounds, and uses of the compounds
JP4301591B2 (ja) * 1998-04-30 2009-07-22 株式会社マルハニチロ水産 新規な血小板粘着凝集抑制物質、その製造法およびその用途
JP4301602B2 (ja) * 1998-09-28 2009-07-22 株式会社マルハニチロ水産 血管内皮細胞増殖促進剤
US7511026B2 (en) * 2003-03-25 2009-03-31 Seikagaku Corporation Therapeutic agent for nerve damage

Also Published As

Publication number Publication date
US20050090661A1 (en) 2005-04-28
US20070134646A1 (en) 2007-06-14
US7601488B2 (en) 2009-10-13
US20090291914A1 (en) 2009-11-26
CA2414211A1 (en) 2003-01-06
JP4861596B2 (ja) 2012-01-25
CA2414211C (en) 2011-08-02
CN1440418A (zh) 2003-09-03
AU2006252178A1 (en) 2007-01-18
EP1300412A1 (de) 2003-04-09
WO2002004471A1 (fr) 2002-01-17
AU2006252178B2 (en) 2010-05-27
AU6947801A (en) 2002-01-21
JPWO2002004471A1 (ja) 2004-01-15
AU2001269478B2 (en) 2006-09-21
CA2698561C (en) 2012-07-10
US20110224169A1 (en) 2011-09-15
US8314079B2 (en) 2012-11-20
CA2698561A1 (en) 2002-01-17
US7507723B2 (en) 2009-03-24
EP1300412A4 (de) 2004-08-18
DE60140941D1 (de) 2010-02-11
EP1300412B1 (de) 2009-12-30
US20080182983A1 (en) 2008-07-31
CN100369925C (zh) 2008-02-20

Similar Documents

Publication Publication Date Title
ATE453655T1 (de) Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten
AR023939A1 (es) COMPUESTOS DERIVADOS DE PIPERIDINA uTILES COMO ANTAGONISTAS DE CCR5, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN, EL USO DE LOS MISMOS SOLOS O EN COMBINACIoN CON OTRO AGENTE ANTIVIRAL PARA LA PREPARACIoN DE UN MEDICAMENTO Y UN KIT
SE0102764D0 (sv) Compounds
AR012820A1 (es) Un proceso para la preparacion de microparticulas biodegradables y biocompatibles
ECSP034883A (es) Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como preparados farmaceuticos que las contienen
KR960700742A (ko) 아토피성질환 치료약(atopic disease remedy)
NO304795B1 (no) Tetrazolderivater av gallesyrer, legemidler inneholdende dem og deres anvendelse som legemiddel
BR0210711A (pt) Uso de um composto, composição farmacêutica, composto, e, processo para a preparação de um composto
UA26455C2 (uk) Лікарський препарат у формі таблеток із сповільhеhим вивільhеhhям активhого іhгредієhта
WO2005072343A3 (en) Aqueous pharmaceutical compositions 2,6-diisopropylphenol (propofol) and their use
ATE245429T1 (de) Antitrombotische mitteln
RU94044456A (ru) Средство для подавления дисфункционального маточного кровотечения
MX9501849A (es) Nuevos compuestos biciclicos-aromaticos, composiciones farmaceuticas y cosmeticas que los contienen y sus usos.
KR970032872A (ko) 아세틸살리실산을 함유하는 피부 손상 처치용 약물
EP2050442A4 (de) Pharmazeutische zusammensetzung zur prävention und/oder behandlung von knochenerkrankungen, diese zusammensetzung enthaltendes funktionales nahrungsmittel oder gesundheitsnahrungsmittel und pharmazeutische zubereitung mit der zusammensetzung als wirkstoff
BRPI0208367B8 (pt) composição farmacêutica para o tratamento de infecções oculares, para aplicação local, processo para a preparação de uma composição farmacêutica de colírio, adequada para aplicação local em oftalmologia, e, utilização de azitromicina
NO20010940D0 (no) TAN-1057 derivater
JPH04266826A (ja) 局所的抗侵入剤外用水薬ニクロサミド
RU2007129266A (ru) Фармацевтический состав для профилактики рака и для борьбы с ним
WO2002064552A8 (en) 1g(a)-AMINO-N-HYDROXY-ACETAMIDE DERIVATIVES
BR0308576A (pt) Compostos: composições farmacêuticas para administração em um mamìfero e métodos para inibir a enzima citocroma p450rai em um mamìfero
FR2413090A1 (fr) Preparation pharmaceutique a base d'ethylsuccinate d'erythromycine et son application contre les infections sensibles a l'erythromycine
AR022338A1 (es) Un compuesto de benzamida, medicamento que lo contiene, y uso para la manufactura de un medicamento para el tratamiento o prevencion de una enfermedad digestiva o para mejorar la movilidad del tracto gastrointestinal.
BRPI9912125B8 (pt) benzenossulfoniluréias e - tiouréias 2,5-substituídas, processos para a sua preparação, sua aplicação e preparados farmacêuticos contendo as mesmas
TR200003451T2 (tr) Pirimidin-Aminometil-Piridin Türevleri, Hazırlanmaları ve helikobakter bakterinin kontrolünde kullanımları

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties