ATE454140T1 - Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität - Google Patents
Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualitätInfo
- Publication number
- ATE454140T1 ATE454140T1 AT05732660T AT05732660T ATE454140T1 AT E454140 T1 ATE454140 T1 AT E454140T1 AT 05732660 T AT05732660 T AT 05732660T AT 05732660 T AT05732660 T AT 05732660T AT E454140 T1 ATE454140 T1 AT E454140T1
- Authority
- AT
- Austria
- Prior art keywords
- optically pure
- dopamine agonist
- preferred
- sedative agent
- desmethylzopiclone
- Prior art date
Links
- 239000003136 dopamine receptor stimulating agent Substances 0.000 title abstract 7
- 239000000932 sedative agent Substances 0.000 title abstract 7
- 229940125723 sedative agent Drugs 0.000 title abstract 7
- 238000002648 combination therapy Methods 0.000 title 1
- 230000003860 sleep quality Effects 0.000 title 1
- WQSACWZKKZPCHN-AWEZNQCLSA-N (1s)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Chemical compound C=1C=C(Cl)C=CC=1C1([C@@H](N)CC(C)C)CCC1 WQSACWZKKZPCHN-AWEZNQCLSA-N 0.000 abstract 4
- GBBSUAFBMRNDJC-INIZCTEOSA-N eszopiclone Chemical compound C1CN(C)CCN1C(=O)O[C@H]1C2=NC=CN=C2C(=O)N1C1=CC=C(Cl)C=N1 GBBSUAFBMRNDJC-INIZCTEOSA-N 0.000 abstract 4
- 208000008705 Nocturnal Myoclonus Syndrome Diseases 0.000 abstract 2
- 208000005793 Restless legs syndrome Diseases 0.000 abstract 2
- 208000023515 periodic limb movement disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 206010022437 insomnia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54541304P | 2004-02-18 | 2004-02-18 | |
| PCT/US2005/003937 WO2005079851A2 (en) | 2004-02-18 | 2005-02-07 | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454140T1 true ATE454140T1 (de) | 2010-01-15 |
Family
ID=34886149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05732660T ATE454140T1 (de) | 2004-02-18 | 2005-02-07 | Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20050267176A1 (de) |
| EP (1) | EP1742624B1 (de) |
| JP (1) | JP2007523165A (de) |
| AT (1) | ATE454140T1 (de) |
| AU (2) | AU2005215376B2 (de) |
| CA (1) | CA2556870C (de) |
| DE (1) | DE602005018763D1 (de) |
| DK (1) | DK1742624T3 (de) |
| ES (1) | ES2337700T3 (de) |
| WO (1) | WO2005079851A2 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1691811T3 (pl) * | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| WO2005079851A2 (en) | 2004-02-18 | 2005-09-01 | Sepracor, Inc. | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
| WO2005097132A2 (en) | 2004-04-05 | 2005-10-20 | Sepracor Inc. | Methods of treatment using eszopiclone |
| EP1844047A1 (de) * | 2004-10-18 | 2007-10-17 | Neurocrine Biosciences, Inc. | Hydrat von n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamid und verfahren zur herstellung davon |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| EP2243475B1 (de) | 2005-04-06 | 2016-01-13 | Adamas Pharmaceuticals, Inc. | Kombination von Memantin und Donepezil zur Behandlung von Erkrankungen des ZNS |
| WO2007006003A2 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| JP2008543953A (ja) * | 2006-04-20 | 2008-12-04 | テバ ファーマシューティカル インダストリーズ リミティド | エスゾピクロン結晶形態a、実質的に純粋なエスゾピクロン及び光学的に豊富なエスゾピクロンを調製するための方法 |
| US20080045547A1 (en) * | 2006-07-07 | 2008-02-21 | Lippa Arnold S | Salts And Co-Crystals of Pyrazolopyrimidine Compounds, Compositions Thereof And Methods For Their Production And Use |
| EP1987815A1 (de) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Im Mund-Nasen-Rachenraum verabreichbare pharmazeutische Zusammensetzungen enthaltend Dopaminagonisten zur Vorbeugung und/oder Behandlung von unruhigen Gliedmassen |
| WO2008150741A1 (en) * | 2007-06-04 | 2008-12-11 | Drugtech Corporation | Controlled release dopamine agonist compositions |
| EP2020403A1 (de) | 2007-08-02 | 2009-02-04 | Esteve Quimica, S.A. | Verfahren zur Auflösung von Zopiclon und Zwischenprodukten |
| US8212036B2 (en) | 2007-12-19 | 2012-07-03 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8198278B2 (en) | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8268832B2 (en) | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8198277B2 (en) | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8269005B2 (en) | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| BRPI0921431A2 (pt) * | 2008-11-06 | 2017-06-06 | Biotie Therapies Ag | método para tratar ou prevenir síndrome das pernas inquietas, composição farmacêutica, e, métodos para tratar ou prevenir distúrbios do sono, e para melhorar a quantidade do sono ou adequação do sono |
| DK3006024T3 (da) * | 2009-01-20 | 2019-06-03 | Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct | Benzoesyre eller salte deraf til forstærkning af aktiviteten af et neurofarmaceutisk lægemiddel |
| EP3632417A1 (de) * | 2009-01-30 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | Dragees mit 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrolo [3,4-b] pyrazin |
| CA2782556C (en) | 2009-12-02 | 2018-03-27 | Adamas Pharma, Llc | Amantadine compositions and methods of use |
| EP2563347B1 (de) | 2010-04-30 | 2016-10-12 | Teikoku Pharma USA, Inc. | Transdermale propynylaminoindanzusammensetzungen |
| US9119799B2 (en) | 2011-03-24 | 2015-09-01 | Teikoku Pharma Usa, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
| JP5913614B2 (ja) | 2011-11-09 | 2016-04-27 | テイコク ファーマ ユーエスエー インコーポレーテッド | 皮膚新生物の処置方法 |
| US9616123B1 (en) * | 2012-03-05 | 2017-04-11 | Robert L. Knobler | Method and compound for treatment of menopausal symptoms |
| US9205061B2 (en) | 2012-11-02 | 2015-12-08 | Teikoku Pharma Usa, Inc. | Propynylaminoindan transdermal compositions |
| WO2014204933A1 (en) | 2013-06-17 | 2014-12-24 | Adamas Pharmaceuticals, Inc. | Amantadine compositions and methods of use |
| CA2994952A1 (en) * | 2015-08-11 | 2017-02-16 | Ovid Therapeutics Inc. | Methods of sedation and parenteral formulation for use during critical care treatment |
| WO2017027249A1 (en) * | 2015-08-11 | 2017-02-16 | Ovid Therapeutics Inc. | Methods of sedation and parenteral formulation for use during critical care treatment |
| EP3468946A4 (de) | 2016-06-13 | 2020-02-12 | Syneurx International (Taiwan) Corp. | Co-kristalle von lithium-benzoat und verwendungen davon |
| MX2018015397A (es) | 2016-06-13 | 2019-08-16 | Syneurx Int Taiwan Corp | Co-cristales de benzoato de sodio y sus usos. |
| EP3506906A4 (de) * | 2016-08-31 | 2020-08-12 | Taro Pharmaceutical Industries Ltd. | Topische fenoldopam-formulierungen zur behandlung von hautkrankheiten |
| CA3072764A1 (en) | 2017-08-24 | 2019-02-28 | Adamas Pharma, Llc | Amantadine compositions, preparations thereof, and methods of use |
| US10213393B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Feleõsségû Társaság | Composition and method for treating neurological disease |
| US20190247331A1 (en) | 2018-02-15 | 2019-08-15 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
| US10213394B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
| CN113543773B (zh) | 2019-03-08 | 2023-07-14 | 塔罗制药工业有限公司 | 稳定的局部用非诺多泮组合物 |
| KR20220010721A (ko) * | 2019-04-22 | 2022-01-26 | 로버트 엘. 노블러 | 안면 홍조의 비-호르몬 치료 |
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-
2005
- 2005-02-07 WO PCT/US2005/003937 patent/WO2005079851A2/en not_active Ceased
- 2005-02-07 ES ES05732660T patent/ES2337700T3/es not_active Expired - Lifetime
- 2005-02-07 JP JP2006554124A patent/JP2007523165A/ja active Pending
- 2005-02-07 EP EP05732660A patent/EP1742624B1/de not_active Expired - Lifetime
- 2005-02-07 AU AU2005215376A patent/AU2005215376B2/en not_active Ceased
- 2005-02-07 AT AT05732660T patent/ATE454140T1/de not_active IP Right Cessation
- 2005-02-07 US US11/052,719 patent/US20050267176A1/en not_active Abandoned
- 2005-02-07 DE DE602005018763T patent/DE602005018763D1/de not_active Expired - Lifetime
- 2005-02-07 DK DK05732660.5T patent/DK1742624T3/da active
- 2005-02-07 CA CA2556870A patent/CA2556870C/en not_active Expired - Fee Related
-
2009
- 2009-08-14 US US12/541,686 patent/US8877755B2/en active Active
-
2011
- 2011-04-15 AU AU2011201703A patent/AU2011201703A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005018763D1 (de) | 2010-02-25 |
| AU2005215376A1 (en) | 2005-09-01 |
| US20050267176A1 (en) | 2005-12-01 |
| WO2005079851A2 (en) | 2005-09-01 |
| AU2005215376B2 (en) | 2011-01-20 |
| US20100004251A1 (en) | 2010-01-07 |
| US8877755B2 (en) | 2014-11-04 |
| ES2337700T3 (es) | 2010-04-28 |
| WO2005079851A3 (en) | 2006-06-22 |
| EP1742624A2 (de) | 2007-01-17 |
| AU2011201703A1 (en) | 2011-05-12 |
| JP2007523165A (ja) | 2007-08-16 |
| CA2556870A1 (en) | 2005-09-01 |
| DK1742624T3 (da) | 2010-03-08 |
| EP1742624B1 (de) | 2010-01-06 |
| CA2556870C (en) | 2014-01-28 |
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