ATE455086T1 - Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation - Google Patents

Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation

Info

Publication number: ATE455086T1
Authority: AT; Austria
Prior art keywords: reduced coenzyme; acid; crystalization; stabilizing reduced; stabilizing
Prior art date: 2001-07-16

Application number

AT02746041T

Other languages

English (en)

Inventor

Takahiro Ueda

Shiro Kitamura

Yasuyoshi Ueda

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-16

Filing date

2002-07-15

Publication date

2010-01-15

2002-07-15 Application filed by Kaneka Corp filed Critical Kaneka Corp

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE455086T1 publication Critical patent/ATE455086T1/de

Links

QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 title abstract 4
239000002253 acid Substances 0.000 title abstract 3
230000000087 stabilizing effect Effects 0.000 title abstract 2
239000000463 material Substances 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
229910001882 dioxygen Inorganic materials 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/46—Use of additives, e.g. for stabilisation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

AT02746041T 2001-07-16 2002-07-15 Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation ATE455086T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001215804		2001-07-16
JP2002114878		2002-04-17
PCT/JP2002/007148 WO2003008363A1 (fr)	2001-07-16	2002-07-15	Procede de stabilisation d'une coenzyme q10 reduite et technique de cristallisation en presence d'acide

Publications (1)

Publication Number	Publication Date
ATE455086T1 true ATE455086T1 (de)	2010-01-15

Family

ID=26618815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02746041T ATE455086T1 (de)	2001-07-16	2002-07-15	Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation

Country Status (11)

Country	Link
US (1)	US7169590B2 (de)
EP (1)	EP1415973B1 (de)
JP (1)	JP4149917B2 (de)
KR (1)	KR20040018464A (de)
CN (1)	CN1254462C (de)
AT (1)	ATE455086T1 (de)
AU (1)	AU2002318516B2 (de)
CA (1)	CA2453135A1 (de)
DE (1)	DE60235089D1 (de)
TW (1)	TWI235146B (de)
WO (1)	WO2003008363A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI305547B (en)	2001-12-27	2009-01-21	Kaneka Corp	Processes for producing coenzyme q10
TW200302056A (en) *	2002-01-18	2003-08-01	Kaneka Corp	Method for stabilizing reduced coenzyme Q10 and composition therefor
US7358402B2 (en) *	2003-09-10	2008-04-15	Kaneka Corporation	Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
KR101395370B1 (ko)	2004-01-22	2014-05-14	유니버시티 오브 마이애미	국소용 코-엔자임 큐10 제형 및 그의 사용 방법
US20060147542A1 (en) *	2004-12-24	2006-07-06	Tadao Ono	Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en)	2004-12-28	2011-11-29	Kaneka Corporation	Method for preserving reduced coenzyme Q10
WO2007126086A1 (ja) *	2006-04-28	2007-11-08	Kaneka Corporation	還元型補酵素ｑ10の精製方法
MX337408B (es)	2007-03-22	2016-03-03	Berg Llc	Formulaciones topicas que tienen biodisponibilidad aumentada.
MX2010011032A (es)	2008-04-11	2011-03-01	Cytotech Labs Llc Star	Metodos y uso de induccion de apoptosis en celulas cancerigenas.
CN101307338B (zh) *	2008-07-17	2012-04-25	任雷	还原型辅酶q10的制备方法
CN102481271A (zh)	2009-05-11	2012-05-30	博格生物系统有限责任公司	利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法
SG10202010355PA (en)	2010-03-12	2020-11-27	Berg Llc	Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
KR101038916B1 (ko) *	2011-03-17	2011-06-07	노새미	콘크리트 저수조의 짜임공법식 내벽 마감구조
CA2832324C (en)	2011-04-04	2022-03-15	Berg Llc	Methods of treating central nervous system tumors
EP2720680B1 (de)	2011-06-17	2020-02-12	Berg LLC	Inhalbierbare pharmazeutische zusammensetzungen
DK2725004T3 (en) *	2011-06-24	2018-04-16	Kaneka Corp	REDUCED COENZYM Q10 CRYSTAL WITH EXCELLENT STABILITY
NZ713868A (en)	2013-04-08	2021-12-24	Berg Llc	Treatment of cancer using coenzyme q10 combination therapies
KR102370843B1 (ko)	2013-09-04	2022-03-04	버그 엘엘씨	코엔자임 q10의 연속주입에 의한 암치료 방법
WO2017087576A1 (en)	2015-11-16	2017-05-26	Berg Llc	Methods of treatment of temozolomide-resistant glioma using coenzyme q10
CN105833793B (zh) *	2015-12-21	2019-04-02	神舟生物科技有限责任公司	一种工业生产辅酶q10的工艺方法
US11498893B2 (en) *	2018-09-28	2022-11-15	Kaneka Corporation	Production method for crystal of reduced coenzyme Q10 having excellent stability
CN113024362B (zh) *	2021-03-10	2022-02-15	中国科学院上海药物研究所	一种辅酶qh与烟酰胺的共晶及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6712642A (de) *	1966-09-17	1968-03-18
JPS5915894B2 (ja)	1975-12-15	1984-04-12	ニツシンセイフンカブシキガイシヤ	ホコウソｑノセイゾウホウホウ
JPS609796B2 (ja)	1977-04-21	1985-03-13	日清製粉株式会社	補酵素ｑの製造法
JPS56140947A (en) *	1980-04-03	1981-11-04	Sekisui Chem Co Ltd	Production of coenzyme q
CA2207093A1 (en)	1994-12-06	1996-06-13	National Research Council Of Canada	Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
JP3889481B2 (ja)	1996-08-16	2007-03-07	株式会社カネカ	医薬組成物
US8753675B1 (en)	2000-01-20	2014-06-17	Raj K. Chopra	Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications

2002
- 2002-07-12 TW TW091115494A patent/TWI235146B/zh not_active IP Right Cessation
- 2002-07-15 CA CA002453135A patent/CA2453135A1/en not_active Abandoned
- 2002-07-15 EP EP02746041A patent/EP1415973B1/de not_active Expired - Lifetime
- 2002-07-15 WO PCT/JP2002/007148 patent/WO2003008363A1/ja not_active Ceased
- 2002-07-15 US US10/484,227 patent/US7169590B2/en not_active Expired - Lifetime
- 2002-07-15 AT AT02746041T patent/ATE455086T1/de not_active IP Right Cessation
- 2002-07-15 KR KR10-2004-7000608A patent/KR20040018464A/ko not_active Ceased
- 2002-07-15 DE DE60235089T patent/DE60235089D1/de not_active Expired - Lifetime
- 2002-07-15 JP JP2003513924A patent/JP4149917B2/ja not_active Expired - Fee Related
- 2002-07-15 AU AU2002318516A patent/AU2002318516B2/en not_active Ceased
- 2002-07-15 CN CNB028137051A patent/CN1254462C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60235089D1 (de)	2010-03-04
EP1415973A4 (de)	2006-02-01
CA2453135A1 (en)	2003-01-30
TWI235146B (en)	2005-07-01
JPWO2003008363A1 (ja)	2004-11-04
WO2003008363A1 (fr)	2003-01-30
EP1415973A1 (de)	2004-05-06
EP1415973B1 (de)	2010-01-13
US20040197418A1 (en)	2004-10-07
CN1254462C (zh)	2006-05-03
JP4149917B2 (ja)	2008-09-17
US7169590B2 (en)	2007-01-30
AU2002318516B2 (en)	2007-12-06
CN1525951A (zh)	2004-09-01
AU2002318516A2 (en)	2003-03-03
KR20040018464A (ko)	2004-03-03

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Legal Events

Date	Code	Title	Description
2010-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties