ATE455174T1 - CELLS THAT COEXPRESS VITAMIN K REDUCTASE AND VITAMIN K DEPENDENT PROTEIN AND THEIR APPLICATION TO IMPROVE THE PRODUCTIVITY OF THIS VITAMIN K DEPENDENT PROTEIN - Google Patents

CELLS THAT COEXPRESS VITAMIN K REDUCTASE AND VITAMIN K DEPENDENT PROTEIN AND THEIR APPLICATION TO IMPROVE THE PRODUCTIVITY OF THIS VITAMIN K DEPENDENT PROTEIN

Info

Publication number
ATE455174T1
ATE455174T1 AT07109353T AT07109353T ATE455174T1 AT E455174 T1 ATE455174 T1 AT E455174T1 AT 07109353 T AT07109353 T AT 07109353T AT 07109353 T AT07109353 T AT 07109353T AT E455174 T1 ATE455174 T1 AT E455174T1
Authority
AT
Austria
Prior art keywords
vitamin
dependent protein
coexpress
reductase
productivity
Prior art date
Application number
AT07109353T
Other languages
German (de)
Inventor
Darrel Stafford
Tao Li
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34393028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE455174(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE455174T1 publication Critical patent/ATE455174T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying the subject having increased or decreased sensitivity to warfarin.
AT07109353T 2003-09-23 2004-09-23 CELLS THAT COEXPRESS VITAMIN K REDUCTASE AND VITAMIN K DEPENDENT PROTEIN AND THEIR APPLICATION TO IMPROVE THE PRODUCTIVITY OF THIS VITAMIN K DEPENDENT PROTEIN ATE455174T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50552703P 2003-09-23 2003-09-23

Publications (1)

Publication Number Publication Date
ATE455174T1 true ATE455174T1 (en) 2010-01-15

Family

ID=34393028

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07109353T ATE455174T1 (en) 2003-09-23 2004-09-23 CELLS THAT COEXPRESS VITAMIN K REDUCTASE AND VITAMIN K DEPENDENT PROTEIN AND THEIR APPLICATION TO IMPROVE THE PRODUCTIVITY OF THIS VITAMIN K DEPENDENT PROTEIN

Country Status (12)

Country Link
US (6) US7687233B2 (en)
EP (4) EP2380985B1 (en)
JP (4) JP2007506433A (en)
AT (1) ATE455174T1 (en)
AU (2) AU2004275828B2 (en)
CA (1) CA2539434C (en)
DE (1) DE602004025157D1 (en)
DK (2) DK1842920T4 (en)
ES (2) ES2453895T3 (en)
PL (1) PL1842920T5 (en)
PT (1) PT2380985E (en)
WO (1) WO2005030039A2 (en)

Families Citing this family (25)

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Publication number Priority date Publication date Assignee Title
EP2380985B1 (en) 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Cells expressing vitamin K epoxide reductase and use thereof
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
ATE466074T1 (en) * 2003-10-14 2010-05-15 Baxter Int VKORC1 (VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE), A THERAPEUTIC TARGET FOR COUMARIN AND THEIR DERIVATIVES
WO2006012902A2 (en) * 2004-08-02 2006-02-09 Novozymes A/S Creation of diversity in polypeptides
US7445896B2 (en) 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
JP4997113B2 (en) * 2004-10-18 2012-08-08 ユニヴァーシティ オブ ワシントン Methods and compositions for predicting drug response
MX2007007568A (en) * 2004-12-21 2008-03-11 Academia Sinica Genetic variants of vkorci predicting warfarin sensitivity.
ES2397530T3 (en) * 2005-02-28 2013-03-07 Baxter International Inc. Recombinant coexpression of vitamin K epoxy reductase subunit 1 to improve vitamin K-dependent protein expression
AU2005329450A1 (en) * 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
NZ561925A (en) * 2005-04-13 2010-04-30 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation
US8500720B2 (en) * 2005-05-09 2013-08-06 Medtronic, Inc Method and apparatus for treatment of cardiac disorders
EP1969127B8 (en) * 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Method of producing biologically active vitamin k dependent proteins by recombinant methods
TW200808976A (en) * 2006-06-02 2008-02-16 Pharmigene Inc Warfarin dosage prediction
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
WO2009130602A2 (en) 2008-04-24 2009-10-29 Celtic Pharma Peg Ltd. Factor ix conjugates with extended half-lives
WO2010045381A2 (en) * 2008-10-15 2010-04-22 President And Fellows Of Harvard College Antimicrobial agents that target bacterial vkor
DK2451963T3 (en) 2009-07-10 2014-08-04 Csl Ltd METHOD OF INCREASING EXPRESSION PERFORMANCE PERFORMANCE OF VITAMIN-K-DEPENDENT PROTEINS
EP2655607A4 (en) 2010-12-21 2014-05-14 Univ North Carolina METHODS AND COMPOSITIONS FOR THE PRODUCTION OF ACTIVE PROTEINS DEPENDENT ON VITAMIN K
JP2012139232A (en) * 2012-03-15 2012-07-26 Univ Of North Carolina At Chapel Hill Method and composition for producing active vitamin k-dependent protein
JP2014221048A (en) * 2014-06-16 2014-11-27 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル Method and composition for producing active vitamin k-dependent protein
BR102015012334A2 (en) * 2015-05-27 2016-11-29 Fundação Hemoct De Ribeirão Preto Fundherp production process of blood coagulation factor vii and blood coagulation factor vii
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
CN121197633A (en) 2019-12-13 2025-12-26 比特比德科有限责任公司 Ingestible device for delivering therapeutic agents to the gastrointestinal tract

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ATE466074T1 (en) * 2003-10-14 2010-05-15 Baxter Int VKORC1 (VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE), A THERAPEUTIC TARGET FOR COUMARIN AND THEIR DERIVATIVES
US7445896B2 (en) * 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
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AU2005329450A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
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Also Published As

Publication number Publication date
US20060240440A1 (en) 2006-10-26
DK2380985T3 (en) 2014-03-17
EP1842920A1 (en) 2007-10-10
EP2380985B1 (en) 2014-01-01
US20070009950A1 (en) 2007-01-11
US20090215061A1 (en) 2009-08-27
DK1842920T3 (en) 2010-05-03
EP1842920B1 (en) 2010-01-13
WO2005030039A2 (en) 2005-04-07
JP2015180205A (en) 2015-10-15
US20090215045A1 (en) 2009-08-27
EP1670947B1 (en) 2015-04-01
JP2007506433A (en) 2007-03-22
US20110124000A1 (en) 2011-05-26
EP2380985A1 (en) 2011-10-26
US7858318B2 (en) 2010-12-28
US7482141B2 (en) 2009-01-27
JP2012161315A (en) 2012-08-30
AU2010203318A1 (en) 2010-08-12
AU2010203318B2 (en) 2012-07-12
JP2010268803A (en) 2010-12-02
AU2004275828B2 (en) 2010-04-29
WO2005030039A3 (en) 2005-07-21
CA2539434C (en) 2014-03-18
US20070190614A1 (en) 2007-08-16
US8097410B2 (en) 2012-01-17
PL1842920T3 (en) 2010-06-30
EP1670947A2 (en) 2006-06-21
PL1842920T5 (en) 2018-04-30
EP1842920B2 (en) 2017-06-21
PT2380985E (en) 2014-03-26
US7687233B2 (en) 2010-03-30
CA2539434A1 (en) 2005-04-07
EP2336360A1 (en) 2011-06-22
DE602004025157D1 (en) 2010-03-04
ES2339710T3 (en) 2010-05-24
EP1670947A4 (en) 2008-11-05
DK1842920T4 (en) 2017-08-21
AU2004275828A1 (en) 2005-04-07
JP5840539B2 (en) 2016-01-06
JP5094920B2 (en) 2012-12-12
ES2339710T5 (en) 2017-10-05
HK1093223A1 (en) 2007-02-23
US7524665B2 (en) 2009-04-28
US8426128B2 (en) 2013-04-23
ES2453895T3 (en) 2014-04-08

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