ATE455783T1 - Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung - Google Patents
Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendungInfo
- Publication number
- ATE455783T1 ATE455783T1 AT06753340T AT06753340T ATE455783T1 AT E455783 T1 ATE455783 T1 AT E455783T1 AT 06753340 T AT06753340 T AT 06753340T AT 06753340 T AT06753340 T AT 06753340T AT E455783 T1 ATE455783 T1 AT E455783T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- glucofuranose
- glucopyranose
- new
- fumaric acid
- Prior art date
Links
- AVVWPBAENSWJCB-IVMDWMLBSA-N D-glucofuranose Chemical class OC[C@@H](O)[C@H]1OC(O)[C@H](O)[C@H]1O AVVWPBAENSWJCB-IVMDWMLBSA-N 0.000 title abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical class OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 title 2
- 239000001530 fumaric acid Substances 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501002 | 2005-07-07 | ||
| PCT/DK2006/000403 WO2007006308A1 (en) | 2005-07-07 | 2006-07-07 | Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455783T1 true ATE455783T1 (de) | 2010-02-15 |
Family
ID=36840436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06753340T ATE455783T1 (de) | 2005-07-07 | 2006-07-07 | Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100144651A1 (de) |
| EP (2) | EP2186819A1 (de) |
| AT (1) | ATE455783T1 (de) |
| DE (1) | DE602006011910D1 (de) |
| WO (1) | WO2007006308A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004010531T2 (de) | 2003-09-09 | 2008-07-03 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| PT2316430E (pt) | 2004-10-08 | 2012-06-26 | Forward Pharma As | Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico |
| HRP20220902T3 (hr) | 2007-02-08 | 2022-10-14 | Biogen Ma Inc. | Pripravci i njihova upotreba u liječenju multiple skleroze |
| PL2334378T3 (pl) | 2008-08-19 | 2014-09-30 | Xenoport Inc | Proleki wodorofumaranu metylu, ich kompozycje farmaceutyczne i sposoby zastosowania |
| UA112975C2 (uk) | 2009-01-09 | 2016-11-25 | Форвард Фарма А/С | Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти |
| AU2010242064A1 (en) | 2009-04-29 | 2011-11-17 | Biogen Ma Inc. | Treatment of neurodegeneration and neuroinflammation |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US20130259856A1 (en) * | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| ES2733961T3 (es) | 2012-12-21 | 2019-12-03 | Biogen Ma Inc | Derivados de fumarato sustituidos con deuterio |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| KR101814474B1 (ko) | 2013-03-14 | 2018-01-12 | 엘커메스 파마 아일랜드 리미티드 | 푸마레이트의 프로드럭 및 다양한 질환을 치료하는데 있어서의 이들의 용도 |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| EP3041467A1 (de) | 2013-09-06 | 2016-07-13 | XenoPort, Inc. | Kristalline formen von (n,n-diethylcarbamoyl) methyl-methyl(2e)but-2-en-1,4-dioat, syntheseverfahren und verwendung |
| EP3049074A1 (de) * | 2013-09-27 | 2016-08-03 | ratiopharm GmbH | Prodrugs aus monomethylfumarat (mmf) |
| WO2015127450A1 (en) | 2014-02-24 | 2015-08-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| DK3273951T3 (da) | 2015-03-27 | 2020-11-02 | Symbionyx Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til behandling af psoriasis |
| KR20210016407A (ko) | 2018-06-05 | 2021-02-15 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 대사 장애 및 비알코올성 지방 간 질환의 치료를 위한 활성제 및 그 사용 방법 |
| WO2020118178A1 (en) | 2018-12-06 | 2020-06-11 | Flagship Pioneering Innovations V, Inc. | Monomethyl fumarate-carrier conjugates and methods of their use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2530372A1 (de) * | 1975-07-08 | 1977-01-13 | Walter Dr Schweckendiek | Pharmazeutische zubereitungen zur behandlung von psoriasis |
| FI891911A0 (fi) | 1987-08-24 | 1989-04-21 | Leningr T I T Tselljulozno Bum | Foerfarande foer bildande av en relief pao ett underlag. |
| US5424332A (en) | 1987-10-19 | 1995-06-13 | Speiser; Peter P. | Pharmaceutical composition and process for the production thereof |
| US4959389A (en) * | 1987-10-19 | 1990-09-25 | Speiser Peter P | Pharmaceutical preparation for the treatment of psoriatic arthritis |
| US5484610A (en) | 1991-01-02 | 1996-01-16 | Macromed, Inc. | pH and temperature sensitive terpolymers for oral drug delivery |
| DE19814358C2 (de) * | 1998-03-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
| DE19839566C2 (de) * | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
| DE19848260C2 (de) | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
| DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| US6537584B1 (en) * | 1999-11-12 | 2003-03-25 | Macromed, Inc. | Polymer blends that swell in an acidic environment and deswell in a basic environment |
| DE10000577A1 (de) * | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| AU2002219236B2 (en) * | 2001-01-12 | 2006-02-09 | Biogen International Gmbh | Fumaric acid amides |
| JP4570357B2 (ja) | 2001-07-06 | 2010-10-27 | ライフサイクル ファーマ エー／エス | 制御された凝集 |
| DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
-
2006
- 2006-07-07 AT AT06753340T patent/ATE455783T1/de not_active IP Right Cessation
- 2006-07-07 WO PCT/DK2006/000403 patent/WO2007006308A1/en not_active Ceased
- 2006-07-07 DE DE602006011910T patent/DE602006011910D1/de active Active
- 2006-07-07 EP EP10151082A patent/EP2186819A1/de not_active Withdrawn
- 2006-07-07 US US11/993,369 patent/US20100144651A1/en not_active Abandoned
- 2006-07-07 EP EP06753340A patent/EP1915387B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1915387A1 (de) | 2008-04-30 |
| EP1915387B1 (de) | 2010-01-20 |
| DE602006011910D1 (de) | 2010-03-11 |
| WO2007006308A1 (en) | 2007-01-18 |
| EP2186819A1 (de) | 2010-05-19 |
| US20100144651A1 (en) | 2010-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |