ATE455783T1 - Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung - Google Patents
Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendungInfo
- Publication number
- ATE455783T1 ATE455783T1 AT06753340T AT06753340T ATE455783T1 AT E455783 T1 ATE455783 T1 AT E455783T1 AT 06753340 T AT06753340 T AT 06753340T AT 06753340 T AT06753340 T AT 06753340T AT E455783 T1 ATE455783 T1 AT E455783T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- glucofuranose
- glucopyranose
- new
- fumaric acid
- Prior art date
Links
- AVVWPBAENSWJCB-IVMDWMLBSA-N D-glucofuranose Chemical class OC[C@@H](O)[C@H]1OC(O)[C@H](O)[C@H]1O AVVWPBAENSWJCB-IVMDWMLBSA-N 0.000 title abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical class OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 title 2
- 239000001530 fumaric acid Substances 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501002 | 2005-07-07 | ||
| PCT/DK2006/000403 WO2007006308A1 (en) | 2005-07-07 | 2006-07-07 | Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455783T1 true ATE455783T1 (de) | 2010-02-15 |
Family
ID=36840436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06753340T ATE455783T1 (de) | 2005-07-07 | 2006-07-07 | Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100144651A1 (de) |
| EP (2) | EP1915387B1 (de) |
| AT (1) | ATE455783T1 (de) |
| DE (1) | DE602006011910D1 (de) |
| WO (1) | WO2007006308A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005023241A1 (en) | 2003-09-09 | 2005-03-17 | Fumapharm Ag | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| SI2801354T1 (sl) * | 2004-10-08 | 2017-07-31 | Forward Pharma A/S | Farmacevtske sestave z nadzorovanim sproščanjem, ki zajemajo ester fumarne kisline |
| DK2653873T3 (da) | 2007-02-08 | 2022-07-25 | Biogen Ma Inc | Sammensætninger og anvendelser til behandling af multipel sklerose |
| DK2334378T3 (da) | 2008-08-19 | 2014-07-07 | Xenoport Inc | Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse |
| KR101699912B1 (ko) | 2009-01-09 | 2017-01-25 | 포워드 파마 에이/에스 | 1종 이상의 푸마르산 에스테르를 침식 매트릭스에 함유하는 제제 |
| EP3466420A1 (de) | 2009-04-29 | 2019-04-10 | Biogen MA Inc. | Dimethylfumarat zur behandlung von friedreich-ataxie |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US20130259856A1 (en) * | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| US20140348915A9 (en) | 2012-08-22 | 2014-11-27 | Xenoport, Inc. | Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof |
| JP2015527372A (ja) | 2012-08-22 | 2015-09-17 | ゼノポート，インコーポレイティド | 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法 |
| JP6506174B2 (ja) | 2012-12-21 | 2019-04-24 | バイオジェン エムエー インコーポレイテッド | 重水素置換されたフマル酸誘導体 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| CN105452213B (zh) | 2013-03-14 | 2017-09-22 | 阿尔克梅斯制药爱尔兰有限公司 | 富马酸酯前体药物及其在治疗多种疾病中的应用 |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| TW201516020A (zh) | 2013-09-06 | 2015-05-01 | Xenoport Inc | （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途 |
| EP3049074A1 (de) * | 2013-09-27 | 2016-08-03 | ratiopharm GmbH | Prodrugs aus monomethylfumarat (mmf) |
| CA2940845C (en) | 2014-02-24 | 2019-09-24 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| EP3273951B1 (de) | 2015-03-27 | 2020-07-29 | Symbionyx Pharmaceuticals Inc. | Zusammensetzungen und verfahren zur behandlung von schuppenflechte |
| CN112367987A (zh) | 2018-06-05 | 2021-02-12 | 旗舰创业创新五公司 | 活性剂和其用于治疗代谢障碍和非酒精性脂肪性肝病的方法 |
| MX2021006684A (es) | 2018-12-06 | 2021-09-10 | Flagship Pioneering Innovations V Inc | Conjugados portadores de monometil fumarato y métodos para su uso. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2530372A1 (de) * | 1975-07-08 | 1977-01-13 | Walter Dr Schweckendiek | Pharmazeutische zubereitungen zur behandlung von psoriasis |
| WO1989001830A1 (en) | 1987-08-24 | 1989-03-09 | Leningradsky Tekhnologichesky Institut Tselljulozn | Method of obtaining a relief image on a carrier |
| US4959389A (en) * | 1987-10-19 | 1990-09-25 | Speiser Peter P | Pharmaceutical preparation for the treatment of psoriatic arthritis |
| US5424332A (en) * | 1987-10-19 | 1995-06-13 | Speiser; Peter P. | Pharmaceutical composition and process for the production thereof |
| US5484610A (en) * | 1991-01-02 | 1996-01-16 | Macromed, Inc. | pH and temperature sensitive terpolymers for oral drug delivery |
| DE19814358C2 (de) * | 1998-03-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
| DE19839566C2 (de) | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
| DE19848260C2 (de) * | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
| DE19853487A1 (de) * | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| US6537584B1 (en) | 1999-11-12 | 2003-03-25 | Macromed, Inc. | Polymer blends that swell in an acidic environment and deswell in a basic environment |
| DE10000577A1 (de) * | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| AU2002219236B2 (en) | 2001-01-12 | 2006-02-09 | Biogen International Gmbh | Fumaric acid amides |
| CN101961317A (zh) | 2001-07-06 | 2011-02-02 | 生命周期药物公司 | 受控制的凝聚 |
| DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
-
2006
- 2006-07-07 US US11/993,369 patent/US20100144651A1/en not_active Abandoned
- 2006-07-07 EP EP06753340A patent/EP1915387B1/de active Active
- 2006-07-07 EP EP10151082A patent/EP2186819A1/de not_active Withdrawn
- 2006-07-07 AT AT06753340T patent/ATE455783T1/de not_active IP Right Cessation
- 2006-07-07 DE DE602006011910T patent/DE602006011910D1/de active Active
- 2006-07-07 WO PCT/DK2006/000403 patent/WO2007006308A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1915387A1 (de) | 2008-04-30 |
| WO2007006308A1 (en) | 2007-01-18 |
| DE602006011910D1 (de) | 2010-03-11 |
| EP2186819A1 (de) | 2010-05-19 |
| EP1915387B1 (de) | 2010-01-20 |
| US20100144651A1 (en) | 2010-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |