ATE456678T1 - Nukleinsäurenachweisverfahren mit erhöhter empfindlichkeit - Google Patents

Nukleinsäurenachweisverfahren mit erhöhter empfindlichkeit

Info

Publication number
ATE456678T1
ATE456678T1 AT04818676T AT04818676T ATE456678T1 AT E456678 T1 ATE456678 T1 AT E456678T1 AT 04818676 T AT04818676 T AT 04818676T AT 04818676 T AT04818676 T AT 04818676T AT E456678 T1 ATE456678 T1 AT E456678T1
Authority
AT
Austria
Prior art keywords
nucleic acid
detection method
acid detection
increased sensitivity
technique involves
Prior art date
Application number
AT04818676T
Other languages
English (en)
Inventor
Donald Crothers
R Holmlin
Honghua Zhang
Chunnian Shi
Original Assignee
Geneohm Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneohm Sciences Inc filed Critical Geneohm Sciences Inc
Application granted granted Critical
Publication of ATE456678T1 publication Critical patent/ATE456678T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT04818676T 2003-11-10 2004-11-10 Nukleinsäurenachweisverfahren mit erhöhter empfindlichkeit ATE456678T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51881603P 2003-11-10 2003-11-10
PCT/US2004/037407 WO2005047474A2 (en) 2003-11-10 2004-11-10 Nucleic acid detection method having increased sensitivity

Publications (1)

Publication Number Publication Date
ATE456678T1 true ATE456678T1 (de) 2010-02-15

Family

ID=34590306

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04818676T ATE456678T1 (de) 2003-11-10 2004-11-10 Nukleinsäurenachweisverfahren mit erhöhter empfindlichkeit

Country Status (8)

Country Link
US (1) US20050186590A1 (de)
EP (2) EP1687406B1 (de)
JP (1) JP4947355B2 (de)
AT (1) ATE456678T1 (de)
AU (1) AU2004290036B2 (de)
CA (1) CA2545356A1 (de)
DE (1) DE602004025371D1 (de)
WO (1) WO2005047474A2 (de)

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US7258978B2 (en) * 2002-11-06 2007-08-21 Geneohm Sciences Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen
WO2006065598A2 (en) * 2004-12-13 2006-06-22 Geneohm Sciences, Inc. Fluidic cartridges for electrochemical detection of dna
US7910719B2 (en) * 2005-12-08 2011-03-22 Kabushiki Kaisha Toshiba Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier
CN101466848B (zh) * 2006-06-08 2017-08-25 皇家飞利浦电子股份有限公司 用于dna检测的微电子传感器装置
DE102006027675B4 (de) 2006-06-14 2011-05-12 Siemens Ag Verfahren zur Bestimmung der Konzentration von Nukleinsäuren
EP2677309B9 (de) 2006-12-14 2014-11-19 Life Technologies Corporation Verfahren zur Sequenzierung einer Nukleinsäure mittels grosser FET-Arrays, geeignet zur Messung in einem begrenzten pH-Bereich
EP2171097A2 (de) * 2007-06-29 2010-04-07 Population Genetics Technologies LTD. Verfahren und zusammensetzungen zur isolierung der varianten von nukleinsäuresequenzen
US9551026B2 (en) * 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
US8888969B2 (en) 2008-09-02 2014-11-18 The Governing Council Of The University Of Toronto Nanostructured microelectrodes and biosensing devices incorporating the same
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010047804A1 (en) * 2008-10-22 2010-04-29 Ion Torrent Systems Incorporated Integrated sensor arrays for biological and chemical analysis
WO2010060060A1 (en) * 2008-11-24 2010-05-27 Adnavance Technologies, Inc. Electrochemical methods of detecting nucleic acid hybridization
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
EP3467487A1 (de) 2011-01-11 2019-04-10 The Governing Council Of The University Of Toronto Proteinnachweisverfahren
EP2683822B1 (de) 2011-03-10 2020-04-22 General Atomics Vorrichtungen und verfahren zur diagnose und probenherstellung
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
EP2843047B1 (de) * 2012-02-27 2019-10-30 Toray Industries, Inc. Nucleinsäuredetektionsverfahren
US10174366B2 (en) 2012-11-14 2019-01-08 Olink Bioscience Ab Localised RCA-based amplification method
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
EP3030678A4 (de) * 2013-08-07 2017-05-10 Xagenic, Inc. Systeme, verfahren und vorrichtungen für elektrochemische detektion mithilfe von helper-oligonukleotiden
WO2015060417A1 (ja) * 2013-10-25 2015-04-30 一般財団法人生産技術研究奨励会 Ｄｎａの検出方法
TWI756167B (zh) 2014-12-18 2022-03-01 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
CN112400016A (zh) * 2018-06-26 2021-02-23 Tdk株式会社 用于检测dna的试剂盒与方法
JP7333928B2 (ja) * 2018-10-05 2023-08-28 国立大学法人山形大学 電気化学式非標識核酸検出の測定方法

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DE3310337A1 (de) * 1983-03-22 1984-09-27 Europäisches Laboratorium für Molekularbiologie (EMBL), 6900 Heidelberg Verfahren zur durchfuehrung von hybridisierungsreaktionen
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4840893A (en) * 1983-12-16 1989-06-20 Medisense, Inc. Electrochemical assay for nucleic acids and nucleic acid probes
US5019496A (en) * 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
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US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
WO2000004193A1 (en) * 1998-07-20 2000-01-27 Yale University Method for detecting nucleic acids using target-mediated ligation of bipartite primers
US6638716B2 (en) * 1998-08-24 2003-10-28 Therasense, Inc. Rapid amperometric verification of PCR amplification of DNA
US6261782B1 (en) * 1999-04-06 2001-07-17 Yale University Fixed address analysis of sequence tags
ATE318932T1 (de) * 1999-08-13 2006-03-15 Univ Yale Binär kodierte sequenzmarker
US6448004B1 (en) * 1999-10-05 2002-09-10 Aventis Pharmaceuticals Inc. Electrochemiluminescence helicase assay
FR2805545B1 (fr) * 2000-02-24 2002-05-17 Argene Sa Procede electrochimique de detection d'acides nucleiques
US6291187B1 (en) * 2000-05-12 2001-09-18 Molecular Staging, Inc. Poly-primed amplification of nucleic acid sequences
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AU2003303395A1 (en) * 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
CN1617936A (zh) * 2002-01-29 2005-05-18 美国大西洋生物实验室 在单一样本中检测和定量多种靶核酸
EP1478783A4 (de) * 2002-02-06 2006-12-27 Ge Healthcare Bio Sciences Ab Zusammensetzungen und verfahren für rolling circle-amplifikation
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
US20040086895A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Method of electrochemical detection of somatic cell mutations
US7258978B2 (en) * 2002-11-06 2007-08-21 Geneohm Sciences Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen
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US7531306B2 (en) * 2003-11-12 2009-05-12 Geneohm Sciences, Inc. Nucleic acid hybridization methods

Also Published As

Publication number Publication date
JP4947355B2 (ja) 2012-06-06
CA2545356A1 (en) 2005-05-26
DE602004025371D1 (de) 2010-03-18
WO2005047474A3 (en) 2006-09-14
JP2007512810A (ja) 2007-05-24
AU2004290036B2 (en) 2011-08-04
AU2004290036A1 (en) 2005-05-26
EP1687406A4 (de) 2008-05-21
US20050186590A1 (en) 2005-08-25
WO2005047474A2 (en) 2005-05-26
EP1687406A2 (de) 2006-08-09
EP1687406B1 (de) 2010-01-27
EP2163653B1 (de) 2013-03-27
EP2163653A3 (de) 2010-05-26
EP2163653A2 (de) 2010-03-17

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