ATE456T1 - SELECTIVELY PROTECTED 4,6-D I-O-(AMINOGLYCOSYL)-1,3-DIAMINO-CYCLITOLS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS INTERMEDIATE PRODUCTS. - Google Patents

SELECTIVELY PROTECTED 4,6-D I-O-(AMINOGLYCOSYL)-1,3-DIAMINO-CYCLITOLS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS INTERMEDIATE PRODUCTS.

Info

Publication number
ATE456T1
ATE456T1 AT79103385T AT79103385T ATE456T1 AT E456 T1 ATE456 T1 AT E456T1 AT 79103385 T AT79103385 T AT 79103385T AT 79103385 T AT79103385 T AT 79103385T AT E456 T1 ATE456 T1 AT E456T1
Authority
AT
Austria
Prior art keywords
aminoglycosyl
cyclitols
diamino
production
selectively protected
Prior art date
Application number
AT79103385T
Other languages
German (de)
Inventor
Eckart Dr. Voss
Uwe Dr. Petersen
Peter Dr. Stadler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE456T1 publication Critical patent/ATE456T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diamino cyclitols (and methods for their preparation) useful as intermediates for the synthesis of antibiotics, such as those of the sisomycin type.
AT79103385T 1978-09-20 1979-09-11 SELECTIVELY PROTECTED 4,6-D I-O-(AMINOGLYCOSYL)-1,3-DIAMINO-CYCLITOLS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS INTERMEDIATE PRODUCTS. ATE456T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782840907 DE2840907A1 (en) 1978-09-20 1978-09-20 SELECTIVELY PROTECTED 4,6-DI-O- (AMINOGLYKOSYL) -1,3-DIAMINOCYCLITOLE
EP79103385A EP0009201B1 (en) 1978-09-20 1979-09-11 Selectively protected 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitols, method for their preparation and their use as intermediates

Publications (1)

Publication Number Publication Date
ATE456T1 true ATE456T1 (en) 1981-12-15

Family

ID=6049947

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79103385T ATE456T1 (en) 1978-09-20 1979-09-11 SELECTIVELY PROTECTED 4,6-D I-O-(AMINOGLYCOSYL)-1,3-DIAMINO-CYCLITOLS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS INTERMEDIATE PRODUCTS.

Country Status (5)

Country Link
US (1) US4294959A (en)
EP (1) EP0009201B1 (en)
JP (1) JPS5543095A (en)
AT (1) ATE456T1 (en)
DE (2) DE2840907A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177454B1 (en) * 1984-10-04 1988-12-21 Ciba-Geigy Ag Silanes, process for their preparation and their use
US4831123A (en) * 1985-10-15 1989-05-16 Schering Corporation Process for preparing netilmicin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE402777C (en) * 1972-12-29 1979-02-05 Takeda Chemical Industries Ltd METHODS OF PRODUCING AMINOGLYCOSIDE ANTIBIOTICS OF 3 'AND / OR 5' '- DIOXINEOMYCIN TYPE, 3'- AND / OR 2' '- DIOXICANAMYCIN TYPE OR 3' '- DIOXISTRYPTOMYCINTYPE
CH606076A5 (en) * 1973-08-06 1978-10-13 Scherico Ltd
US4063015A (en) * 1973-08-27 1977-12-13 Schering Corporation Garamine and derivatives thereof
PH12960A (en) * 1974-03-19 1979-10-19 Scherico Ltd Derivatives of 4,6-di-(aminoglycosyl)-1,3-diaminocy-clitols and pharmaceutical compositions thereof
CH630644A5 (en) * 1974-04-10 1982-06-30 Takeda Chemical Industries Ltd METHOD FOR PRODUCING DESOXYAMINOGLYCOSIDE ANTIBIOTICS.
US4000261A (en) * 1974-11-29 1976-12-28 Schering Corporation 5-epi-4,6-di-o-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor
MX3676E (en) * 1975-07-15 1981-04-23 Abbott Lab PROCEDURE FOR OBTAINING DERIVATIVES FROM ANTIBIOTIC XK-62-2
US4062947A (en) * 1975-11-04 1977-12-13 Schering Corporation Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor
EP0000057B1 (en) * 1977-06-10 1982-07-14 Bayer Ag Selectively protected 4,6-di-o-(aminoglycosyl)-1,3-diamino-cyclitols
US4282350A (en) * 1977-08-05 1981-08-04 Schering Corporation Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols
DE2753769A1 (en) * 1977-12-02 1979-06-13 Bayer Ag 1-N-4,6-DI-O- (AMINOGLYCOSYL) -1,3-DIAMINO-CYCLITOL DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE

Also Published As

Publication number Publication date
JPS5543095A (en) 1980-03-26
EP0009201B1 (en) 1981-12-02
DE2961512D1 (en) 1982-01-28
EP0009201A1 (en) 1980-04-02
DE2840907A1 (en) 1980-04-03
US4294959A (en) 1981-10-13

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Legal Events

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