ATE457198T1 - Well-einheit zum nachweis der chemotaxis von zellen und zur trennung chemotaktischer zellen - Google Patents

Well-einheit zum nachweis der chemotaxis von zellen und zur trennung chemotaktischer zellen

Info

Publication number
ATE457198T1
ATE457198T1 AT01999630T AT01999630T ATE457198T1 AT E457198 T1 ATE457198 T1 AT E457198T1 AT 01999630 T AT01999630 T AT 01999630T AT 01999630 T AT01999630 T AT 01999630T AT E457198 T1 ATE457198 T1 AT E457198T1
Authority
AT
Austria
Prior art keywords
cells
chemotaxis
well unit
detecting
deformability
Prior art date
Application number
AT01999630T
Other languages
English (en)
Inventor
Shiro Kanegasaki
Yuji Kikuchi
Hiroko Kikuchi
Original Assignee
Eci Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eci Inc filed Critical Eci Inc
Application granted granted Critical
Publication of ATE457198T1 publication Critical patent/ATE457198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01999630T 2000-12-07 2001-12-06 Well-einheit zum nachweis der chemotaxis von zellen und zur trennung chemotaktischer zellen ATE457198T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2000372467 2000-12-07
JP2000377120 2000-12-12
JP2001209743 2001-07-10
JP2001258526 2001-08-28
JP2001313205 2001-10-10
PCT/JP2001/010683 WO2002046355A1 (en) 2000-12-07 2001-12-06 Well unit for detecting cell chemotaxis and separating chemotactic cells

Publications (1)

Publication Number Publication Date
ATE457198T1 true ATE457198T1 (de) 2010-02-15

Family

ID=27531737

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01999630T ATE457198T1 (de) 2000-12-07 2001-12-06 Well-einheit zum nachweis der chemotaxis von zellen und zur trennung chemotaktischer zellen

Country Status (10)

Country Link
US (1) US7022516B2 (de)
EP (1) EP1340809B1 (de)
KR (1) KR100445131B1 (de)
CN (1) CN1236046C (de)
AT (1) ATE457198T1 (de)
AU (1) AU2002221072A1 (de)
CA (1) CA2400738A1 (de)
DE (1) DE60141287D1 (de)
TW (1) TWI241343B (de)
WO (1) WO2002046355A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3738899B2 (ja) * 2000-12-07 2006-01-25 株式会社 エフェクター細胞研究所 微量試料処理装置
ATE429482T1 (de) * 2001-12-31 2009-05-15 Trinity College Dublin Vorrichtung zur durchführung von auf zellen basierende analyseverfahren
US7977089B2 (en) 2002-08-27 2011-07-12 Vanderbilt University Bioreactors with multiple chambers
JP4434649B2 (ja) * 2003-03-27 2010-03-17 株式会社Ｅｃｉ 観察器具及びそれを用いた観察方法
US20070177255A1 (en) * 2003-03-27 2007-08-02 Shiro Kanegasaki Observing tool and observing method using the same
TW200506364A (en) * 2003-04-09 2005-02-16 Effector Cell Inst Inc Apparatus for detecting cell chemo-taxis
CA2522410A1 (en) * 2003-05-19 2004-11-25 Japan Science And Technology Agency Micro chamber for cell culture
KR100573621B1 (ko) * 2003-07-18 2006-04-25 주식회사 디지탈바이오테크놀러지 세포 개체수 계수용 장치 및 그 제조방법
JP2006006166A (ja) * 2004-06-24 2006-01-12 Univ Of Tokyo 細胞分離装置、及び細胞分離方法
US20080257735A1 (en) * 2004-09-24 2008-10-23 Regents Of The University Of California Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same
US7276367B2 (en) * 2004-10-14 2007-10-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of etching islands of cells in a grid pattern
EP1821094A1 (de) * 2004-12-07 2007-08-22 Effector Cell Institute, Inc. Zellmessverfahren
US9354156B2 (en) * 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
EP1764409A1 (de) * 2005-09-12 2007-03-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vorrichtung und Verfahren zum Beobachten der Organisation von zu untersuchenden Zellen in Gegenwart eines Gradient von chemotaktischen Molekülen
US20070084706A1 (en) * 2005-10-18 2007-04-19 Shuichi Takayama Microfluidic cell culture device and method for using same
US20070090166A1 (en) 2005-10-18 2007-04-26 Shuichi Takayama Microfluidic cell culture device
US20100247384A1 (en) * 2005-10-18 2010-09-30 Shuichi Takayama Microfluidic cell culture device and method for using same
US8603806B2 (en) * 2005-11-02 2013-12-10 The Ohio State Universtiy Research Foundation Materials and methods for cell-based assays
KR100848811B1 (ko) 2006-09-29 2008-07-28 전자부품연구원 세포 배양 환경 및 주화성 측정 장치
JP5170239B2 (ja) * 2007-05-15 2013-03-27 和光純薬工業株式会社 集積化ｐｃｒ−ｃｅマイクロ流体デバイスにおける圧力を均一化するための圧力マニホールド
EP2163880A1 (de) * 2008-09-10 2010-03-17 Koninklijke Philips Electronics N.V. Verfahren und Verwendung für die Trennung von biologischem Material aus einer Probenflüssigkeit
FR2937050A1 (fr) * 2008-10-10 2010-04-16 Inst Curie Dispositif de culture cellulaire
US9157550B2 (en) * 2009-01-05 2015-10-13 The Board Of Trustees Of The University Of Illinois Microfluidic systems and methods
EP2599548B1 (de) * 2009-05-13 2018-07-04 ibidi GmbH Probenträger zum Positionieren einer organischen, biologischen und/oder medizinischen Probe
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
KR101126547B1 (ko) 2009-12-01 2012-03-22 한국생산기술연구원 세포 주화성 검사용 마이크로 플루이딕 칩 및 제조방법
KR101160188B1 (ko) * 2010-01-14 2012-06-26 김영호 자력을 이용한 세포분리기
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
WO2013019491A1 (en) * 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
CN102925356A (zh) * 2011-08-09 2013-02-13 华中科技大学同济医学院附属协和医院 一种细胞培养池
WO2015009688A1 (en) * 2013-07-17 2015-01-22 The Johns Hopkins University Microfluidic chip for analysis of cell motility and methods for using same
US10077420B2 (en) * 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN104792750B (zh) * 2015-03-27 2017-11-28 南方医科大学 细胞极性模型的构建方法
US20160354781A1 (en) * 2015-06-08 2016-12-08 National Taiwan University Microfluidic plate for sample processing
CN107226453B (zh) * 2016-03-24 2021-08-13 中芯国际集成电路制造(上海)有限公司 一种mems器件及其制备方法、电子装置
KR101895776B1 (ko) * 2016-04-07 2018-09-07 영남대학교 산학협력단 실리콘 마이크로칩 및 그 제조방법
WO2018037788A1 (ja) * 2016-08-23 2018-03-01 ソニー株式会社 単一粒子捕捉用装置、単一粒子捕捉システム及び単一粒子の捕捉方法
KR102088102B1 (ko) * 2017-07-05 2020-03-11 가부시키가이샤 스크린 홀딩스 시료 용기
CN109706076A (zh) * 2019-01-14 2019-05-03 上海市肿瘤研究所 观察细胞迁移极化分子分布的方法
CN113899659A (zh) * 2020-06-22 2022-01-07 苏州中加康美科技有限公司 一种载玻片及血细胞分析仪
AU2022396279A1 (en) * 2021-11-24 2024-05-23 Purigen Biosystems, Inc. Fluidic device with capillary barrier
CN114164078A (zh) * 2021-11-30 2022-03-11 齐齐哈尔大学 一种细菌趋化物质筛选载玻片及其应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888770A (en) 1971-10-21 1975-06-10 Shlomo Avital Plural-sample filter device
US3929583A (en) 1975-08-14 1975-12-30 Canadian Patents Dev Apparatus for enumerating microorganisms
US4317726A (en) 1981-02-12 1982-03-02 The United States Of America As Represented By The Secretary Of The Army Microbial filter assembly
IL68507A (en) 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US4514495A (en) 1982-05-18 1985-04-30 Spiral Systems Instruments, Inc. Method for testing microbial interaction with growth affecting substances
US4493815A (en) 1983-07-28 1985-01-15 Bio-Rad Laboratories, Inc. Supporting and filtering biochemical test plate assembly
US4714674A (en) 1985-02-28 1987-12-22 Genentech, Inc. Chemotactic assay for immunogenicity
US4833382A (en) * 1986-06-06 1989-05-23 Gibbs David L Method and apparatus for use in microscope investigations
US5023173A (en) 1986-10-14 1991-06-11 Xoma Corporation Device for assessing nematode vitality and method for using same
JP2559760B2 (ja) 1987-08-31 1996-12-04 株式会社日立製作所 細胞搬送方法
JP2685544B2 (ja) 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
US4912057A (en) 1989-06-13 1990-03-27 Cancer Diagnostics, Inc. Cell chamber for chemotaxis assay
JP2532707B2 (ja) * 1990-03-08 1996-09-11 佑二 菊池 血液回路及びこれを用いた血液測定装置及び血液測定方法
US5284753A (en) 1991-03-20 1994-02-08 Neuro Probe, Inc. Multiple-site chemotactic test apparatus and method
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5302515A (en) * 1992-08-20 1994-04-12 Neuro Probe, Inc. Chemotactic test apparatus and method
JP2685119B2 (ja) 1994-07-15 1997-12-03 浜松ホトニクス株式会社 細胞分画方法及び細胞分画装置
US5595712A (en) 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
JP3089285B2 (ja) 1997-12-02 2000-09-18 農林水産省食品総合研究所長 積層マイクロチャネルアレイ装置並びに同装置を用いた濾過・分級方法及びエマルションの製造方法
JP2002521690A (ja) 1998-07-28 2002-07-16 バイオメトリック イメージング インコーポレイテッド 細胞運動性アッセイのための装置および方法
US6329164B1 (en) * 1999-03-18 2001-12-11 Neuro Probe, Incorporated Method for using a cell activity assay apparatus
GB9925904D0 (en) 1999-11-03 1999-12-29 Univ Belfast Cell migration and chemotaxis chamber
JP2002159287A (ja) * 2000-09-12 2002-06-04 Effector Cell Institute Inc 細胞走化性検出及び走化細胞分離装置
WO2002042766A2 (en) 2000-10-26 2002-05-30 University Of Connecticut A system and method for investigating the effect of chemical and other factors on cell movement
JP3738899B2 (ja) * 2000-12-07 2006-01-25 株式会社 エフェクター細胞研究所 微量試料処理装置

Also Published As

Publication number Publication date
KR20020075786A (ko) 2002-10-05
CA2400738A1 (en) 2002-06-13
AU2002221072A1 (en) 2002-06-18
US7022516B2 (en) 2006-04-04
EP1340809A4 (de) 2007-04-04
CN1236046C (zh) 2006-01-11
WO2002046355A1 (en) 2002-06-13
DE60141287D1 (de) 2010-03-25
EP1340809B1 (de) 2010-02-10
KR100445131B1 (ko) 2004-08-21
TWI241343B (en) 2005-10-11
US20030003571A1 (en) 2003-01-02
CN1398296A (zh) 2003-02-19
EP1340809A1 (de) 2003-09-03

Similar Documents

Publication Publication Date Title
ATE457198T1 (de) Well-einheit zum nachweis der chemotaxis von zellen und zur trennung chemotaktischer zellen
EP1809173A4 (de) Langzeitüberwachung zum nachweis von vorhofflimmern
DE602004019406D1 (de) Sensoreinrichtung zum nachweis von sacchariden
ATE268902T1 (de) Biosensor und verfahren zum ermitteln makromolekularer biopolymere mit einem biosensor
DE60126756D1 (de) Verfahren zur erkennung eines analyten durch fluoreszenz
EA200702232A1 (ru) Способ и устройство для усовершенствованной фокусировки тока в приборах каротажа сопротивлений контактным методом
ATE476659T1 (de) Sensor für mehrere analyte
ATE348336T1 (de) Mikrokavitätsbiosensor, herstellungsverfahren und verwendungen davon
CR7966A (es) Metodo y sistema mejorado pata detectar y/o predecir anomalias biologicas, tales como desordenes cerebrales
ATE526580T1 (de) Methode zum sichten von mutierten zellen
DE60239940D1 (de) Verfahren, vorrichtungen und computerprogramme zum verifizieren der integrität einer sonde
DE102005052713A1 (de) Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE60301801D1 (de) Elektrochemischer Sensor zum Nachweis von Kohlenmonoxid
ATE376674T1 (de) Verwendung von transthyretin als biomarker zum nachweis von kolorektalen adenomen; verfahren und nachweis-system
DE69930404D1 (de) Methode zum nachweis von analyten
ATE420211T1 (de) Vorrichtung und verfahren zum nachweis von geladenen makromolekülen
DE60328055D1 (de) Verfahren zum nachweis von pathogenen mykobakterien in klinischen proben
ATE540609T1 (de) Vorrichtung und gerät zum nachweis von feuchtigkeit
DE60306865D1 (de) Detektion von Vancomycin-resistenten Enterococcus-Subspezies
EP1893967A4 (de) Verfahren und vorrichtung zur erhöhung der empfindlichkeit einer kapillarbereichselektrophorese
WO2007002132A3 (en) High frequency or multifrequency resistivity tool
SE0702207L (sv) Förfarande vid och en anordning för opåverkad materialundersökning
DE50207850D1 (de) Biosensor und verfahren zum erfassen von nukleinsäuren mittels mindestens zwei einheiten zum immobilisieren von nukleinsäuren
SE0201023D0 (sv) Förfarande och anordning för mätning av kraftpåkänningar hos raffinörer
DE60327776D1 (de) Sonden zum nachweis von tumorzellen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties