ATE457973T1 - Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle - Google Patents

Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle

Info

Publication number
ATE457973T1
ATE457973T1 AT02740788T AT02740788T ATE457973T1 AT E457973 T1 ATE457973 T1 AT E457973T1 AT 02740788 T AT02740788 T AT 02740788T AT 02740788 T AT02740788 T AT 02740788T AT E457973 T1 ATE457973 T1 AT E457973T1
Authority
AT
Austria
Prior art keywords
reagents
biological molecules
alkyl
linking arm
aryl
Prior art date
Application number
AT02740788T
Other languages
English (en)
Inventor
Cecile Bourget
Jean Lhomme
Ali Laayoun
Mitsuharu Kotera
Emmanuelle Trevisiol
Lionel Menou
Mendez Eloy Bernal
Original Assignee
Bio Merieux
Univ Grenoble 1
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Merieux, Univ Grenoble 1, Centre Nat Rech Scient filed Critical Bio Merieux
Application granted granted Critical
Publication of ATE457973T1 publication Critical patent/ATE457973T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02740788T 2001-05-04 2002-05-03 Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle ATE457973T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0106040A FR2824323B1 (fr) 2001-05-04 2001-05-04 Reactif de marquage et procede de detection de molecules biologiques
PCT/FR2002/001543 WO2002090319A1 (fr) 2001-05-04 2002-05-03 Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques

Publications (1)

Publication Number Publication Date
ATE457973T1 true ATE457973T1 (de) 2010-03-15

Family

ID=8863021

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740788T ATE457973T1 (de) 2001-05-04 2002-05-03 Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle

Country Status (10)

Country Link
EP (1) EP1383732B1 (de)
JP (2) JP4494717B2 (de)
CN (1) CN100509761C (de)
AT (1) ATE457973T1 (de)
AU (1) AU2002314227B2 (de)
CA (1) CA2444918C (de)
DE (1) DE60235354D1 (de)
ES (1) ES2339337T3 (de)
FR (1) FR2824323B1 (de)
WO (1) WO2002090319A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2824323B1 (fr) * 2001-05-04 2008-04-25 Bio Merieux Reactif de marquage et procede de detection de molecules biologiques
FR2824335A1 (fr) * 2001-05-04 2002-11-08 Bio Merieux Procede de marquage et de fragmentation d'adn
US20050153371A1 (en) * 2004-01-07 2005-07-14 Ambit Biosciences Corporation Conjugated small molecules
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
GB0616724D0 (en) 2006-08-23 2006-10-04 Isis Innovation Surface adhesion using arylcarbene reactive intermediates
FR2917090B1 (fr) * 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
KR101753917B1 (ko) 2009-03-02 2017-07-04 옥스포드 어드밴스드 서패이시즈 리미티드 공유결합 3차원 네트워크를 형성할 수 있는 화학제
WO2011150976A1 (en) 2010-06-04 2011-12-08 bioMérieux Method and kit for the prognosis of colorectal cancer
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
KR101953819B1 (ko) * 2017-12-22 2019-03-06 (주)바이오액츠 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
CN113636931B (zh) * 2021-08-05 2024-02-13 康龙化成(宁波)科技发展有限公司 基因编码化合物库起始头片段化合物及其在基因编码化合物库合成上的应用
CN115772174A (zh) * 2022-12-02 2023-03-10 中国科学院生态环境研究中心 生物素标记的全氟磺酸类化合物及制备方法
CN115873012A (zh) * 2022-12-02 2023-03-31 中国科学院生态环境研究中心 生物素连全氟羧酸类化合物及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007431A1 (en) * 1989-01-10 1990-07-10 Larry W. Mclauglin Labeling of nucleic acids with fluorescent markers
FR2780059B1 (fr) * 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
FR2824323B1 (fr) * 2001-05-04 2008-04-25 Bio Merieux Reactif de marquage et procede de detection de molecules biologiques

Also Published As

Publication number Publication date
JP2009137954A (ja) 2009-06-25
FR2824323B1 (fr) 2008-04-25
CA2444918C (fr) 2012-01-10
EP1383732B1 (de) 2010-02-17
CN100509761C (zh) 2009-07-08
WO2002090319A1 (fr) 2002-11-14
CN1518536A (zh) 2004-08-04
JP4494717B2 (ja) 2010-06-30
CA2444918A1 (fr) 2002-11-14
AU2002314227B2 (en) 2008-03-20
EP1383732A1 (de) 2004-01-28
JP2005502027A (ja) 2005-01-20
DE60235354D1 (de) 2010-04-01
HK1062014A1 (zh) 2004-10-15
FR2824323A1 (fr) 2002-11-08
ES2339337T3 (es) 2010-05-19

Similar Documents

Publication Publication Date Title
ATE457973T1 (de) Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle
ATE256658T1 (de) Funktionelle vitamin-d-derivate und verfahren zur bestimmung von 25-hydroxy- und 1alpha,25- dihydroxy-vitamin-d
ATE302286T1 (de) Sequenzierungsverfahren mit signalverstärkern
ATE208827T1 (de) Konjugate von dns und pns und verfahren zu deren herstellung
ATE522580T1 (de) Cyaninfarbstoffe als markieragenzien
ATE127923T1 (de) Elektrochemilumineszenz-testverfahren.
CA2380395A1 (en) Conditional-selex
DK1086179T3 (da) Energioverførselsassaymetode og reagens
Schafmeister et al. Shape-programmable macromolecules
DE60238940D1 (de) Verfahren zur isolierung und markierung von probenmolekülen
IL159981A0 (en) Direct binding assay for identifying inhibitors of hcv polymerase
DE602006018317D1 (de) Massenmarkierungen
ATE208828T1 (de) Ein screeningverfahren, basierend auf fluoreszenzpolarisation
ATE496917T1 (de) Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd
ATE458816T1 (de) Fluoreszierendes protein aus aequorea coerulescens und ihre verwendungen
ATE464566T1 (de) Verfahren zur markierung phosphorylierten peptiden, komplexverbindunger, verfahren zu deren herstellung und zwischenprodukte
DE60315343D1 (de) Neuartige verwendungen von durch ble-gene kodierten proteinen und antibiotika aus der bleomycin-familie
BR0213779A (pt) Molécula de ácido nucleico isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina
FR2868071A1 (fr) Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
DE602004019047D1 (de) Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)-1,1-bisphosphonsäuren und deren salzen
EP1310490A4 (de) Gpr14-antagonisten
DE60313157D1 (de) Ein verfahren zur herstellung von clopidogrel
DE60043618D1 (de) Verfahren zum nachweis einer reaktion zur molekularen erkennung
ES2512615T3 (es) Reactivos de marcado que llevan funciones diazo y nitro, procedimientos de síntesis de tales reactivos y procedimientos de detección de moléculas biológicas
Satam et al. Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)• pyrrole and Hx• imidazole pairings

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties