ATE458054T1 - Menschliches parathyroidhormon, modifikationen, herstellung und verwendung - Google Patents

Menschliches parathyroidhormon, modifikationen, herstellung und verwendung

Info

Publication number
ATE458054T1
ATE458054T1 AT99959086T AT99959086T ATE458054T1 AT E458054 T1 ATE458054 T1 AT E458054T1 AT 99959086 T AT99959086 T AT 99959086T AT 99959086 T AT99959086 T AT 99959086T AT E458054 T1 ATE458054 T1 AT E458054T1
Authority
AT
Austria
Prior art keywords
preparation
modifications
parathyroid hormone
human parathyroid
asnleuglylyshisleuasnser
Prior art date
Application number
AT99959086T
Other languages
English (en)
Inventor
F Bringhurst
Hisashi Takasu
Thomas Gardella
John Potts
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Application granted granted Critical
Publication of ATE458054T1 publication Critical patent/ATE458054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99959086T 1998-11-25 1999-11-24 Menschliches parathyroidhormon, modifikationen, herstellung und verwendung ATE458054T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10993898P 1998-11-25 1998-11-25
PCT/US1999/027863 WO2000031266A1 (en) 1998-11-25 1999-11-24 Human parathyroid hormone modifications, preparation and use

Publications (1)

Publication Number Publication Date
ATE458054T1 true ATE458054T1 (de) 2010-03-15

Family

ID=22330386

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99959086T ATE458054T1 (de) 1998-11-25 1999-11-24 Menschliches parathyroidhormon, modifikationen, herstellung und verwendung

Country Status (7)

Country Link
US (3) US6417333B1 (de)
EP (1) EP1133560B1 (de)
JP (1) JP4486258B2 (de)
AT (1) ATE458054T1 (de)
AU (1) AU1633200A (de)
DE (1) DE69942035D1 (de)
WO (1) WO2000031266A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417133B1 (en) * 1998-02-25 2002-07-09 Monsanto Technology Llc Deeply reduced oxidation catalyst and its use for catalyzing liquid phase oxidation reactions
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
DE69938064T2 (de) * 1998-11-25 2009-01-15 The General Hospital Corp., Boston Aminoterminal modifizierte parathyroidhormon (pth) analoge
WO2000031266A1 (en) * 1998-11-25 2000-06-02 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
AU4217299A (en) * 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
ATE308609T1 (de) * 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
DE69939275D1 (de) * 1998-12-31 2008-09-18 Gen Hospital Corp Peptide, bestehend aus zwei funktionellen PTH-Domänen, die durch ein Linkermolekül verknüpft sind, und Derivate davon
US7057012B1 (en) * 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
ATE412670T1 (de) * 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7354597B2 (en) 2001-12-03 2008-04-08 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
AU2003278766A1 (en) 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
AU2002951372A0 (en) * 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
CA2511966A1 (en) * 2002-11-01 2004-07-22 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US7795220B2 (en) * 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) * 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ
WO2006081279A2 (en) 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
CN104072606B (zh) * 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
MX358161B (es) 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
AR086400A1 (es) 2011-05-13 2013-12-11 Trimel Pharmaceuticals Corp Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event
US11975050B2 (en) 2018-03-16 2024-05-07 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6448990A (en) 1989-09-29 1991-04-28 Her Majesty in Right of Canada, as represented by National Research Council Canada Synthesis of mature human parathyroid hormone
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
AU672790B2 (en) 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
DK0915911T3 (da) 1996-08-02 2004-03-08 Ca Nat Research Council Analoger til parathyreoideahormon til behandling af osteoporose
EP1030658A1 (de) * 1997-10-14 2000-08-30 Eli Lilly And Company Verfahren zum aufbau und zur erhaltung von knochen
JP4486256B2 (ja) 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
DE69938064T2 (de) * 1998-11-25 2009-01-15 The General Hospital Corp., Boston Aminoterminal modifizierte parathyroidhormon (pth) analoge
WO2000031266A1 (en) 1998-11-25 2000-06-02 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
AU4217299A (en) * 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
DE69939275D1 (de) 1998-12-31 2008-09-18 Gen Hospital Corp Peptide, bestehend aus zwei funktionellen PTH-Domänen, die durch ein Linkermolekül verknüpft sind, und Derivate davon
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
WO2004067021A1 (en) 2003-01-24 2004-08-12 Gardella Thomas J Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ

Also Published As

Publication number Publication date
EP1133560B1 (de) 2010-02-17
US6417333B1 (en) 2002-07-09
US20050203012A1 (en) 2005-09-15
US20040176568A1 (en) 2004-09-09
DE69942035D1 (de) 2010-04-01
JP2002530111A (ja) 2002-09-17
JP4486258B2 (ja) 2010-06-23
EP1133560A1 (de) 2001-09-19
WO2000031266A1 (en) 2000-06-02
US7479478B2 (en) 2009-01-20
US6803213B2 (en) 2004-10-12
HK1040738A1 (en) 2002-06-21
AU1633200A (en) 2000-06-13

Similar Documents

Publication Publication Date Title
ATE458054T1 (de) Menschliches parathyroidhormon, modifikationen, herstellung und verwendung
ATE477020T1 (de) Prevention und verringerung von ischemia
DE69938064D1 (de) Aminoterminal modifizierte parathyroidhormon (pth) analoge
CA2120358A1 (en) Hormone analogs with multiple ctp extensions
DE69129226D1 (de) Glp-1-analoga verwendbar in der diabetesbehandlung
DE69433299D1 (de) Rekombinante spinnerseide analoge
CA2055963A1 (en) Chimeric fibroblast growth factor
ATE402957T1 (de) Analoge des menschlichen interferon-alpha mit niedriger toxizität
UA35636C2 (uk) Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців
MY123740A (en) Il-13 receptor polypeptide
DE59007517D1 (de) Neue proteine mit tnf-hemmender wirkung und ihre herstellung.
ATE162201T1 (de) Cnp-gen und vorläuferprotein aus schwein
MXPA02000465A (es) Derivados ciclopeptidicos como inhibidores de la integrina alfav beta6.
AU5963290A (en) Inhibition of the n-end rule pathway in living cells
ATE345139T1 (de) Karzinostatische wirkstoffe
ATE211391T1 (de) Verwendung von hmg proteinen zur herstellung von arzneimitteln mit zytotoxischer wirkung
DE3261304D1 (en) Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
NO975565L (no) Benstimulerende faktor
DE3751398D1 (de) Substrat-Peptide.
ES2171157T3 (es) Gen recombinante codificante para una proteina con actividad endoquitinasa.
BR0202157A (pt) Peptìdeo obtido de veneno escorpião para uso como agente hipotensivo
ATE432985T1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
TH26711A (th) " สิ่งที่คล้ายกันของปัจจัยหลั่งฮอโมนของการเจริญเติบโต "
ATE305478T1 (de) Topoisomerase-ii inhibitoren
CA2216704A1 (en) Novel peptides and remedy for bone diseases containing the same as active ingredient

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties