ATE458746T1 - Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs - Google Patents

Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs

Info

Publication number: ATE458746T1
Authority: AT; Austria
Prior art keywords: cancer chemotherapeutics; melphalan; melphalan derivatives; derivatives; alkylating
Prior art date: 2000-06-13

Application number

AT01938945T

Other languages

English (en)

Inventor

Rolf Lewensohn

Joakim Gullbo

Rolf Larsson

Hans Ehrsson

Kristina Luthman

Original Assignee

Oncopeptides Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-13

Filing date

2001-06-11

Publication date

2010-03-15

2001-06-11 Application filed by Oncopeptides Ab filed Critical Oncopeptides Ab

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458746T1 publication Critical patent/ATE458746T1/de

Links

SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical class OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title abstract 2
230000001093 anti-cancer Effects 0.000 title 1
230000002152 alkylating effect Effects 0.000 abstract 2
150000003862 amino acid derivatives Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000000711 cancerogenic effect Effects 0.000 abstract 1
231100000315 carcinogenic Toxicity 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01938945T 2000-06-13 2001-06-11 Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs ATE458746T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US21122700P	2000-06-13	2000-06-13
SE0002202A SE0002202D0 (sv)	2000-06-13	2000-06-13	New peptides
PCT/SE2001/001318 WO2001096367A1 (en)	2000-06-13	2001-06-11	Melphalan derivatives and their use as cancer chemotherapeutic drugs

Publications (1)

Publication Number	Publication Date
ATE458746T1 true ATE458746T1 (de)	2010-03-15

Family

ID=20280067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01938945T ATE458746T1 (de)	2000-06-13	2001-06-11	Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs

Country Status (10)

Country	Link
EP (1)	EP1290011B1 (de)
JP (1)	JP4798930B2 (de)
AT (1)	ATE458746T1 (de)
AU (1)	AU2001264515A1 (de)
CA (1)	CA2408501C (de)
DK (1)	DK1290011T3 (de)
ES (1)	ES2341702T3 (de)
PT (1)	PT1290011E (de)
SE (1)	SE0002202D0 (de)
WO (1)	WO2001096367A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1374907A3 (de) *	2002-06-24	2004-01-07	Ghanem Elias c/o Institut Jules Bordet Ghanem	Arzneimittel Transport und Abgabesystem
DE10239832A1 (de) *	2002-08-29	2004-03-18	Lipal Biochemicals AG c/o University of Zurich	Sarcolysyl-Derivate und Verfahren zu deren Herstellung
WO2011011865A1 (en) *	2009-07-29	2011-02-03	3R Valo, S.E.C.	Anticancer agents based on amino acid derivatives
WO2011078782A1 (en) *	2009-12-22	2011-06-30	Oncopeptides Ab	A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer
SMT202000447T1 (it) *	2011-04-28	2020-09-10	Oncopeptides Ab	Preparazione liofilizzata di dipeptidi citotossici
KR102122429B1 (ko) *	2011-04-28	2020-06-12	온코펩타이드즈 아베	세포독성 디펩티드의 동결건조 제제
ES2768268T3 (es) *	2012-10-26	2020-06-22	Oncopeptides Ab	Preparaciones liofilizadas de melfalán flufenamida
BR112015009280B1 (pt)	2012-10-26	2022-05-31	Oncopeptides Ab	Preparação farmacêutica liofilizada de melfalana flufenamida, composição e kit de combinação de partes
GB201507903D0 (en) *	2015-05-08	2015-06-24	Oncopeptides Ab	Process for preparation of nitrogen mustard derivatives
GB201521217D0 (en)	2015-12-01	2016-01-13	Oncopeptides Ab	Dosage regimens
CN108864251B (zh) *	2018-06-30	2022-06-14	大连理工大学	一类氨肽酶n激活的药物前体化合物及其制备方法和应用
CA3116198A1 (en) *	2018-10-18	2020-04-23	Oncopeptides Ab	Compounds containing deuterium
WO2020201542A1 (en)	2019-04-03	2020-10-08	Oncopeptides Ab	Treatment of al amyloidosis with melflufen
GB201905477D0 (en)	2019-04-17	2019-05-29	Oncopeptides Ab	Novel formulations
WO2021053185A1 (en)	2019-09-20	2021-03-25	Oncopeptides Ab	Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
WO2022167087A1 (en) *	2021-02-05	2022-08-11	Oncopeptides Ab	Peptidase enhanced cytotoxic dipeptides
EP4083052A1 (de)	2021-04-29	2022-11-02	BKmdcl AB	Peptidkonjugate von melphalan zur behandlung von krebs
WO2022253894A1 (en)	2021-06-01	2022-12-08	Synthon B.V.	Process for making melflufen or a salt thereof
GB202109896D0 (en)	2021-07-08	2021-08-25	Oncopeptides Ab	Novel treatments
GB202109894D0 (en)	2021-07-08	2021-08-25	Oncopeptides Ab	Novel treatments
US20240307480A1 (en)	2021-07-08	2024-09-19	Oncopeptides Ab	Melflufen for use in the treatment of multiple myeloma
GB202109895D0 (en)	2021-07-08	2021-08-25	Oncopeptides Ab	Novel treatments
GB202204171D0 (en)	2022-03-24	2022-05-11	Oncopeptides Ab	Novel formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB750155A (en)	1953-03-17	1956-06-13	Nat Res Dev	Substituted alanines

2000
- 2000-06-13 SE SE0002202A patent/SE0002202D0/xx unknown
2001
- 2001-06-11 CA CA2408501A patent/CA2408501C/en not_active Expired - Lifetime
- 2001-06-11 EP EP01938945A patent/EP1290011B1/de not_active Expired - Lifetime
- 2001-06-11 AT AT01938945T patent/ATE458746T1/de not_active IP Right Cessation
- 2001-06-11 PT PT01938945T patent/PT1290011E/pt unknown
- 2001-06-11 AU AU2001264515A patent/AU2001264515A1/en not_active Abandoned
- 2001-06-11 WO PCT/SE2001/001318 patent/WO2001096367A1/en not_active Ceased
- 2001-06-11 DK DK01938945.1T patent/DK1290011T3/da active
- 2001-06-11 JP JP2002510508A patent/JP4798930B2/ja not_active Expired - Lifetime
- 2001-06-11 ES ES01938945T patent/ES2341702T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SE0002202D0 (sv)	2000-06-13
ES2341702T3 (es)	2010-06-25
CA2408501C (en)	2011-01-18
EP1290011B1 (de)	2010-02-24
WO2001096367A1 (en)	2001-12-20
AU2001264515A1 (en)	2001-12-24
DK1290011T3 (da)	2010-06-07
CA2408501A1 (en)	2001-12-20
JP2004503564A (ja)	2004-02-05
PT1290011E (pt)	2010-05-11
JP4798930B2 (ja)	2011-10-19
EP1290011A1 (de)	2003-03-12

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Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties