ATE458818T1 - Tet repressor basierte transkriptionale regulatorische proteine - Google Patents

Tet repressor basierte transkriptionale regulatorische proteine

Info

Publication number: ATE458818T1
Authority: AT; Austria
Prior art keywords: tetracycline; transcriptional regulatory; regulatory proteins; tet repressor; based transcriptional
Prior art date: 1999-06-07

Application number

AT00938973T

Other languages

English (en)

Inventor

Wolfgang Hillen

Hermann Bujard

Stefanie Urlinger

Original Assignee

Tet Systems Holding Gmbh & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-07

Filing date

2000-06-05

Publication date

2010-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22479925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE458818(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-06-05 Application filed by Tet Systems Holding Gmbh & Co filed Critical Tet Systems Holding Gmbh & Co

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458818T1 publication Critical patent/ATE458818T1/de

Links

230000002103 transcriptional effect Effects 0.000 title abstract 3
108091006104 gene-regulatory proteins Proteins 0.000 title 1
102000034356 gene-regulatory proteins Human genes 0.000 title 1
108700020534 tetracycline resistance-encoding transposon repressor Proteins 0.000 title 1
239000004098 Tetracycline Substances 0.000 abstract 4
229960002180 tetracycline Drugs 0.000 abstract 4
229930101283 tetracycline Natural products 0.000 abstract 4
235000019364 tetracycline Nutrition 0.000 abstract 4
150000003522 tetracyclines Chemical class 0.000 abstract 4
108091023040 Transcription factor Proteins 0.000 abstract 3
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 2
102000040945 Transcription factor Human genes 0.000 abstract 2
229960003722 doxycycline Drugs 0.000 abstract 2
102000037865 fusion proteins Human genes 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
230000006698 induction Effects 0.000 abstract 1
108091006106 transcriptional activators Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT00938973T 1999-06-07 2000-06-05 Tet repressor basierte transkriptionale regulatorische proteine ATE458818T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13798699P	1999-06-07	1999-06-07
PCT/IB2000/000886 WO2000075347A2 (en)	1999-06-07	2000-06-05	Tet repressor-based transcriptional regulatory proteins

Publications (1)

Publication Number	Publication Date
ATE458818T1 true ATE458818T1 (de)	2010-03-15

Family

ID=22479925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00938973T ATE458818T1 (de)	1999-06-07	2000-06-05	Tet repressor basierte transkriptionale regulatorische proteine

Country Status (8)

Country	Link
US (1)	US7541446B2 (de)
EP (1)	EP1200607B1 (de)
JP (1)	JP4836375B2 (de)
AT (1)	ATE458818T1 (de)
AU (1)	AU783233B2 (de)
CA (1)	CA2376665C (de)
DE (1)	DE60043889D1 (de)
WO (1)	WO2000075347A2 (de)

Families Citing this family (46)

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US20030186281A1 (en) *	2001-12-21	2003-10-02	Wolfgang Hillen	Modified tetracycline repressor protein compositions and methods of use
US8507277B2 (en)	2003-10-24	2013-08-13	Gencia Corporation	Nonviral vectors for delivering polynucleotides
US8133733B2 (en)	2003-10-24	2012-03-13	Gencia Corporation	Nonviral vectors for delivering polynucleotides to target tissues
WO2005056752A2 (en)	2003-10-24	2005-06-23	Gencia Corporation	Methods and compositions for delivering polynucleotides
US8062891B2 (en)	2003-10-24	2011-11-22	Gencia Corporation	Nonviral vectors for delivering polynucleotides to plants
US20090123468A1 (en)	2003-10-24	2009-05-14	Gencia Corporation	Transducible polypeptides for modifying metabolism
EP1797186B1 (de) *	2004-10-04	2016-05-25	National Research Council Of Canada	Expressionssystem, dessen komponenten und verwendungsverfahren
US7935788B2 (en) *	2004-10-04	2011-05-03	National Research Council Of Canada	Reverse cumate repressor mutant
US9068969B2 (en) *	2004-12-28	2015-06-30	Ptc Therapeutics, Inc.	Cell based methods and systems for the identification of RNA regulatory sequences and compounds that modulate their functions
JP4944781B2 (ja)	2005-09-15	2012-06-06	独立行政法人科学技術振興機構	テトラサイクリン系抗生物質によるタンパク質分解制御法
USRE49583E1 (en)	2005-11-17	2023-07-18	Tet Systems Gmbh & Co. Kg	Inducible expression systems
CA2652347A1 (en)	2006-05-15	2007-11-22	Paratek Pharmaceuticals, Inc.	Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
PT2043662E (pt) *	2006-07-26	2015-11-25	Intrexon Corp	Métodos e composições para tratamento de doença
EP2135945B1 (de) *	2007-03-14	2014-04-23	Japan Science and Technology Agency	Verfahren zur doppelten regulation von transkription/abbau für ein protein mittels antibiotikum
US20080235746A1 (en)	2007-03-20	2008-09-25	Michael James Peters	Methods and apparatus for content delivery and replacement in a network
DK2352833T3 (da)	2008-10-01	2013-04-22	Tet Systems Gmbh & Co Kg	Tetracyclin inducerbar transkriptionskontrolsekvens
EP2364322A1 (de)	2008-10-28	2011-09-14	Pioneer Hi-Bred International Inc.	Sulfonylharnstoffreaktive repressorproteine
US9866609B2 (en)	2009-06-08	2018-01-09	Time Warner Cable Enterprises Llc	Methods and apparatus for premises content distribution
US20110287936A1 (en) *	2010-04-23	2011-11-24	E.I. Dupont De Nemours And Company	Gene switch compositions and methods of use
US9127283B2 (en)	2010-11-24	2015-09-08	Clontech Laboratories, Inc.	Inducible expression system transcription modulators comprising a distributed protein transduction domain and methods for using the same
WO2012103256A2 (en) *	2011-01-26	2012-08-02	Clontech Laboratories, Inc.	Enhanced protein transduction
WO2012156535A1 (en)	2011-05-19	2012-11-22	Fundación Progreso Y Salud	Highly inducible dual-promoter lentiviral tet-on system
JP6362543B2 (ja)	2012-02-23	2018-07-25	ジュノセラピューティクスゲーエムベーハー	細胞および他の複雑な生物学的材料のクロマトグラフィーによる単離
EP3344757A1 (de)	2015-09-04	2018-07-11	Universita' Degli Studi Di Padova	Verfahren zur erzeugung von somatischen stammzellen
HK1258932A1 (zh)	2015-10-22	2019-11-22	Juno Therapeutics Gmbh	用於转导的方法、反应剂盒、反应剂和设备
CN108474791B (zh)	2015-10-22	2022-07-08	朱诺治疗学有限公司	培养细胞的方法及用于该方法的试剂盒和设备
CN116217657A (zh)	2016-05-27	2023-06-06	辛赛克斯公司	蛋白质界面
US10687115B2 (en)	2016-06-01	2020-06-16	Time Warner Cable Enterprises Llc	Cloud-based digital content recorder apparatus and methods
US10129593B2 (en)	2017-03-14	2018-11-13	Charter Communications Operating, Llc	Time-based dynamic secondary content placement calls in time-shifted content
MA49288A (fr)	2017-04-27	2020-03-04	Juno Therapeutics Gmbh	Reactifs particulaires oligomères et leurs méthodes d'utilisation
WO2019104244A1 (en)	2017-11-22	2019-05-31	Synthex, Inc.	Peptides for inhibiting rad51
US10939142B2 (en)	2018-02-27	2021-03-02	Charter Communications Operating, Llc	Apparatus and methods for content storage, distribution and security within a content distribution network
EP3856226B1 (de)	2018-09-28	2026-02-18	President and Fellows of Harvard College	Zelluläre umprogrammierung zur umkehrung der alterung und zur förderung der organ- und geweberegeneration
EP3856260A1 (de)	2018-09-28	2021-08-04	President and Fellows of Harvard College	Mutante reverse tetracyclin-transaktivatoren zur expression von genen
US12274733B2 (en)	2018-09-28	2025-04-15	President And Fellows Of Harvard College	Cellular reprogramming to reverse aging and promote organ and tissue regeneration
EP3874024A1 (de)	2018-10-31	2021-09-08	Juno Therapeutics GmbH	Verfahren zur selektion und stimulation von zellen und vorrichtung dafür
GB202003109D0 (en) *	2020-03-04	2020-04-15	Univ Bristol	Gene therapy
CN113584083A (zh)	2020-04-30	2021-11-02	深圳市深研生物科技有限公司	用于逆转录病毒载体的生产细胞和包装细胞及其制备方法
CN113699147B (zh)	2020-05-22	2023-06-09	深圳市深研生物科技有限公司	基于四环素和Cumate的共调控序列
US11566262B2 (en)	2021-03-24	2023-01-31	Dna Twopointo Inc.	Tetracycline-inducible expression systems
CN114134160B (zh) *	2021-12-04	2024-01-09	安徽大学	一种四环素调控蛋白突变体基因及其在调控基因表达和环境检测中的应用
US12252518B2 (en)	2023-01-06	2025-03-18	Life Biosciences, Inc.	Methods of treating non-arteritic anterior ischemic optic neuropathy
WO2025155923A1 (en)	2024-01-17	2025-07-24	The Broad Institute, Inc.	Aav capsid modifications that enable improved cns-wide gene delivery through interactions with the transferrin receptor
WO2025160155A1 (en)	2024-01-22	2025-07-31	The Broad Institute, Inc.	Epigenetic targeting of prion diseases
WO2025217174A1 (en)	2024-04-08	2025-10-16	The Broad Institute, Inc.	Aav capsid modifications that enable improved cns-wide gene delivery through interactions with carbonic anhydrase iv
WO2025217163A2 (en)	2024-04-08	2025-10-16	The Broad Institute, Inc.	Novel aav capsids binding to human cd59

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US5464758A (en) *	1993-06-14	1995-11-07	Gossen; Manfred	Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US6004941A (en) *	1993-06-14	1999-12-21	Basf Aktiengesellschaft	Methods for regulating gene expression
US5589362A (en) *	1993-06-14	1996-12-31	Basf Aktiengesellschaft	Tetracycline regulated transcriptional modulators with altered DNA binding specificities
CA2165162C (en) *	1993-06-14	2000-05-23	Hermann Bujard	Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5866755A (en) *	1993-06-14	1999-02-02	Basf Aktiengellschaft	Animals transgenic for a tetracycline-regulated transcriptional inhibitor
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US6087166A (en) *	1997-07-03	2000-07-11	Basf Aktiengesellschaft	Transcriptional activators with graded transactivation potential
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DE19851415B4 (de)	1998-11-07	2010-11-04	Wolfgang Hillen	Mutanter Transaktivator

2000
- 2000-06-05 AT AT00938973T patent/ATE458818T1/de not_active IP Right Cessation
- 2000-06-05 DE DE60043889T patent/DE60043889D1/de not_active Expired - Fee Related
- 2000-06-05 JP JP2001501629A patent/JP4836375B2/ja not_active Expired - Lifetime
- 2000-06-05 AU AU54191/00A patent/AU783233B2/en not_active Expired
- 2000-06-05 CA CA2376665A patent/CA2376665C/en not_active Expired - Lifetime
- 2000-06-05 EP EP00938973A patent/EP1200607B1/de not_active Expired - Lifetime
- 2000-06-05 WO PCT/IB2000/000886 patent/WO2000075347A2/en not_active Ceased
2003
- 2003-06-05 US US10/456,395 patent/US7541446B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU783233B2 (en)	2005-10-06
AU5419100A (en)	2000-12-28
JP4836375B2 (ja)	2011-12-14
WO2000075347A3 (en)	2002-01-10
US7541446B2 (en)	2009-06-02
CA2376665A1 (en)	2000-12-14
WO2000075347A2 (en)	2000-12-14
EP1200607A2 (de)	2002-05-02
EP1200607B1 (de)	2010-02-24
DE60043889D1 (en)	2010-04-08
CA2376665C (en)	2014-02-25
JP2003515314A (ja)	2003-05-07
US20030208783A1 (en)	2003-11-06

Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60043889D1 (en)	2010-04-08	Tet repressor basierte transkriptionale regulatorische proteine
ATE280160T1 (de)	2004-11-15	Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität
ATE311363T1 (de)	2005-12-15	Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
ATE238790T1 (de)	2003-05-15	Verwendung von pramipexole als neuroschutzmittel
ES2191208T3 (es)	2003-09-01	Oxiimino-pregnano-carbolactonas.
PT1165115E (pt)	2003-10-31	Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2
DK1187632T3 (da)	2009-04-06	Behandling med anti-ErbB2-antistoffer
CR6540A (es)	2008-09-17	Trifluorobutenos nematicidas
ATE355079T1 (de)	2006-03-15	Behandlung von prostata-krebs mit anti-erbb2 antikörpern
ITMI931780A1 (it)	1995-02-05	Tropil 7-azaindolil-3-carbossiamidi
DE59803538D1 (de)	2002-05-02	Wässerige dispersionen enthaltend polyurethane mit carbodiimidgruppen
ATE305034T1 (de)	2005-10-15	Transkriptionsmodulatoren tetracyklin-regulierte
DK0929565T3 (da)	2002-09-09	Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf
DE69609864D1 (de)	2000-09-21	Steroidnitritesterderivate und ihre verwendung als entzündungshemmende medikamente
ES2088128T3 (es)	1996-08-01	Aminosulfonilureas inhibidoras de acat.
DK0670890T3 (da)	1997-12-15	Bioreaktor med immobiliserede mælkesyrebakterier og anvendelsen deraf
DE60231137D1 (de)	2009-03-26	Reca-negativ und rhab-negativ mikroorganismus
DK0652964T3 (da)	2006-05-08	Promotor af K. lactis transaldolasegenet og anvendelse heraf
TR199700761A2 (xx)	1998-02-21	Ksanten ve akridin t�revleri ve bunlar�n kullan�m�.
ATE249230T1 (de)	2003-09-15	Selektion und verwendung von milchsäurebakterienstämmen, die die nicht- spezifische immunität modulieren können
DE69631500D1 (de)	2004-03-18	Inhibitor des Hepatozytwachstumsfaktoraktivators
ATE247649T1 (de)	2003-09-15	Disubstituierte biphenyloxazoline
ATE148105T1 (de)	1997-02-15	Succinoylaminohydroxyäthylaminosulfamidsäureder vate und ihre verwendung als retrovirale proteasehemmer
ATE309337T1 (de)	2005-11-15	Kombination von genen zur regulierung der blühinduktion bei nutz- und zierpflanzen
DE69020520D1 (de)	1995-08-03	2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase.