ATE459622T1 - Tropanverbindungen - Google Patents

Tropanverbindungen

Info

Publication number: ATE459622T1
Authority: AT; Austria
Prior art keywords: tropane compounds; tropane; compounds; formula; methods
Prior art date: 2007-10-25

Application number

AT08832769T

Other languages

English (en)

Inventor

Kenneth D Rice

Naing Aay

Arlyn Arcalas

Tae-Gon Baik

Charles M Blazey

Owen Joseph Bowles

Chris A Buhr

Joerg Bussenius

Simona Costanzo

Jeffry Kimo Curtis

Steven Charles Defina

Larisa Dubenko

Abigail R Kennedy

Angie Inyoung Kim

Katherine Lara

Sunghoon Ma

Jean-Claire Limun Manalo

Csaba J Peto

Tsze H Tsang

Longcheng Wang

Neel Kumar Anand

Original Assignee

Exelixis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-25

Filing date

2008-10-27

Publication date

2010-03-15

2008-10-27 Application filed by Exelixis Inc filed Critical Exelixis Inc

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE459622T1 publication Critical patent/ATE459622T1/de

Links

XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical class C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biotechnology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)

AT08832769T 2007-10-25 2008-10-27 Tropanverbindungen ATE459622T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68707P	2007-10-25	2007-10-25
PCT/US2008/012221 WO2009055077A1 (en)	2007-10-25	2008-10-27	Tropane compounds

Publications (1)

Publication Number	Publication Date
ATE459622T1 true ATE459622T1 (de)	2010-03-15

Family

ID=40287869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08832769T ATE459622T1 (de)	2007-10-25	2008-10-27	Tropanverbindungen

Country Status (26)

Country	Link
US (1)	US8012956B2 (de)
EP (1)	EP2074120B1 (de)
JP (2)	JP5476307B2 (de)
KR (1)	KR101578792B1 (de)
CN (1)	CN101910168B (de)
AT (1)	ATE459622T1 (de)
AU (1)	AU2008317262B2 (de)
BR (1)	BRPI0818893B8 (de)
CA (1)	CA2703477C (de)
CO (1)	CO6321232A2 (de)
CY (1)	CY1110648T1 (de)
DE (1)	DE602008000754D1 (de)
DK (1)	DK2074120T3 (de)
EA (1)	EA018999B1 (de)
ES (1)	ES2342348T3 (de)
HR (1)	HRP20100292T1 (de)
IL (1)	IL205202A0 (de)
MX (1)	MX2010004493A (de)
NZ (1)	NZ585137A (de)
PL (1)	PL2074120T3 (de)
PT (1)	PT2074120E (de)
RS (1)	RS51346B (de)
SG (1)	SG2012079653A (de)
SI (1)	SI2074120T1 (de)
WO (1)	WO2009055077A1 (de)
ZA (1)	ZA201002987B (de)

Families Citing this family (26)

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EP2231666B1 (de) *	2007-12-12	2015-07-29	Rigel Pharmaceuticals, Inc.	Carbonsäureamid-, Sulfonamid- und Aminverbindungen gegen Stoffwechselerkrankungen
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
UY32940A (es)	2009-10-27	2011-05-31	Bayer Cropscience Ag	Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
KR20130018845A (ko)	2010-04-05	2013-02-25	시오노기세야쿠 가부시키가이샤	카테콜기를 갖는 세펨 화합물
US20140080810A1 (en)	2010-11-15	2014-03-20	Exelixis, Inc.	Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
EP2740474A1 (de)	2012-12-05	2014-06-11	Instituto Europeo di Oncologia S.r.l.	Cyclopropylaminderivate als Hemmer von Histon-Demethylase-KDM1A
US20150352086A1 (en) *	2013-01-07	2015-12-10	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Heat shock protein (hsp) inhibition and monitoring effectiveness thereof
AU2014308991B2 (en)	2013-08-21	2019-02-14	Janssen Biopharma, Inc.	Antiviral compounds
CA2931088A1 (en) *	2013-11-18	2015-05-21	Del Mar Pharmaceuticals	Hplc analysis of impurities in dianhydrogalactitol
EP2949648A1 (de)	2014-05-30	2015-12-02	IEO - Istituto Europeo di Oncologia Srl	Cyclopropylaminderivate als Histondemethylaseinhibitoren
WO2015181380A1 (en)	2014-05-30	2015-12-03	Ieo - Istituto Europeo Di Oncologia S.R.L.	Cyclopropylamine compounds as histone demethylase inhibitors
TW201625243A (zh)	2014-10-14	2016-07-16	艾克塞里克斯公司	用於治療黑素瘤之藥物組合
CN108136055A (zh) *	2015-07-16	2018-06-08	阿库鲁制药公司	用连接有标记、细胞毒或免疫调节基团的slc6a3配体检测与治疗肾细胞癌
WO2018155260A1 (ja) *	2017-02-23	2018-08-30	株式会社Ihi	Ｏｈラジカル検出プローブ、ｏｈラジカル測定装置、および、ｏｈラジカル測定方法
CN108164529B (zh) *	2017-12-25	2020-04-24	三峡大学	一种小分子抑制剂sld9059及其在制药中的应用
EP3737677B1 (de)	2018-01-10	2021-11-03	Allinky Biopharma	Tetrahydroisquinolin verbindungen
WO2020206608A1 (en)	2019-04-09	2020-10-15	Ranok Therapeutics (Hangzhou) Co., Ltd.	Methods and compositions for targeted protein degradation
CN111825702A (zh) *	2019-04-22	2020-10-27	成都科岭源医药技术有限公司	一种氮杂*并吲唑类衍生物及其制备方法和用途
CN110698395B (zh) *	2019-10-22	2021-05-25	杭州百诚医药科技股份有限公司	一种托吡司特的中间体的制备方法
CN112920078A (zh) *	2019-12-05	2021-06-08	武汉珈汇精化科技有限公司	一种制备4-氰基苯甲酸甲酯的方法和一种制备4-氰基苯甲酸的方法
TW202136238A (zh) *	2020-01-06	2021-10-01	大陸商廣東東陽光藥業有限公司	RORγt抑制劑及其製備方法和用途
MX2023004373A (es) *	2020-10-14	2023-07-07	Ranok Therapeutics Hangzhou Co Ltd	Metodos y composiciones para la degradacion dirigida de proteinas.
CN114591192B (zh) *	2020-12-04	2024-06-21	江西仰立新材料有限公司	一种n-环丙甲基苯胺类化合物的制备方法
US20240083910A1 (en) *	2020-12-18	2024-03-14	Merck Sharp & Dohme Llc	Amido-substituted pyridyl compounds and methods of use thereof for the treatment of herpesviruses
CN112707809B (zh) *	2020-12-30	2023-08-29	丽珠集团新北江制药股份有限公司	一种制备噁唑啉杀虫剂氟雷拉纳中间体的方法
KR20240027076A (ko) *	2021-07-26	2024-02-29	조에티스 서비시즈 엘엘씨	세로토닌 5-ht2b 억제 화합물

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EP0101641A3 (de)	1982-07-22	1984-03-28	Beecham Group Plc	Sulphonylamino-aza-bicycloalkyl-Derivate
FR2738569B1 (fr)	1995-09-12	1997-11-28	Pf Medicament	Nouveaux derives naphtamide de 3 beta-amino azabicyclo octane ou nonane, leur procede de preparation, leur utilisation a titre de medicament antipsychotique
MY117098A (en)	1996-01-15	2004-05-31	Janssen Pharmaceutica Nv	Angiogenesis inhibiting pyridazinamines
HUP0202001A2 (hu) *	2002-06-14	2005-08-29	Sanofi-Aventis	DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
DE602004021921D1 (de)	2003-05-28	2009-08-20	Theravance Inc	Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
BRPI0411608A (pt)	2003-06-24	2006-08-08	Neurosearch As	derivado de 8-aza-biciclo [3.2.1] octano, composição farmacêutica, uso do composto, e, método de tratamento, prevenção ou alìvio de uma doença, um distúrbio ou uma condição de um organismo animal vivo
GB0323236D0 (en) *	2003-10-03	2003-11-05	Pfizer Ltd	Chemical compounds
KR100777885B1 (ko) *	2003-10-03	2007-11-28	화이자 인코포레이티드	Ｈｉｖ 및 염증 치료를 위한 ｃｃｒ5 수용체 길항제 활성을갖는 이미다조피리딘 치환된 트로판 유도체
AU2005228289B2 (en) *	2004-03-31	2008-01-10	Nippon Soda Co., Ltd.	Cyclic amine compound and pest control agent
FR2873693B1 (fr) *	2004-07-29	2006-09-15	Sanofi Synthelabo	Derives d'amino-tropane, leur preparation et leur application en therapeutique
EP1838705A2 (de)	2005-01-13	2007-10-03	Neurosearch A/S	3,8-substituierte 8-aza-bicyclo [3.2.1] octanderivate und deren verwendung als monoamin-neurotransmitter-wiederaufnahmeinhibitoren
CN102127078A (zh) *	2005-07-14	2011-07-20	安斯泰来制药株式会社	Janus激酶3的杂环类抑制剂
MY141762A (en) *	2005-10-06	2010-06-30	Nippon Soda Co	Cross-linked cyclic amine compounds and agents for pest control
US7994094B2 (en) *	2006-09-01	2011-08-09	Otsuka Agritechno Co., Ltd.	N-pyridylpiperidine compound, method for producing the same, and pest control agent

2008
- 2008-10-27 SG SG2012079653A patent/SG2012079653A/en unknown
- 2008-10-27 DK DK08832769.7T patent/DK2074120T3/da active
- 2008-10-27 CA CA2703477A patent/CA2703477C/en active Active
- 2008-10-27 MX MX2010004493A patent/MX2010004493A/es active IP Right Grant
- 2008-10-27 US US12/290,159 patent/US8012956B2/en active Active
- 2008-10-27 WO PCT/US2008/012221 patent/WO2009055077A1/en not_active Ceased
- 2008-10-27 CN CN200880122860.5A patent/CN101910168B/zh not_active Expired - Fee Related
- 2008-10-27 NZ NZ585137A patent/NZ585137A/en not_active IP Right Cessation
- 2008-10-27 AU AU2008317262A patent/AU2008317262B2/en not_active Ceased
- 2008-10-27 ES ES08832769T patent/ES2342348T3/es active Active
- 2008-10-27 KR KR1020107011444A patent/KR101578792B1/ko not_active Expired - Fee Related
- 2008-10-27 SI SI200830024T patent/SI2074120T1/sl unknown
- 2008-10-27 JP JP2010531069A patent/JP5476307B2/ja not_active Expired - Fee Related
- 2008-10-27 HR HR20100292T patent/HRP20100292T1/hr unknown
- 2008-10-27 BR BRPI0818893A patent/BRPI0818893B8/pt not_active IP Right Cessation
- 2008-10-27 DE DE602008000754T patent/DE602008000754D1/de active Active
- 2008-10-27 RS RSP-2010/0220A patent/RS51346B/sr unknown
- 2008-10-27 PL PL08832769T patent/PL2074120T3/pl unknown
- 2008-10-27 PT PT08832769T patent/PT2074120E/pt unknown
- 2008-10-27 AT AT08832769T patent/ATE459622T1/de active
- 2008-10-27 EA EA201070519A patent/EA018999B1/ru not_active IP Right Cessation
- 2008-10-27 EP EP08832769A patent/EP2074120B1/de active Active
2010
- 2010-04-19 IL IL205202A patent/IL205202A0/en active IP Right Grant
- 2010-04-29 ZA ZA2010/02987A patent/ZA201002987B/en unknown
- 2010-05-24 CO CO10061824A patent/CO6321232A2/es not_active Application Discontinuation
- 2010-06-01 CY CY20101100483T patent/CY1110648T1/el unknown
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BRPI0818893B8 (pt)	2021-05-25
EA201070519A1 (ru)	2010-12-30
ES2342348T3 (es)	2010-07-05
CO6321232A2 (es)	2011-09-20
HK1129390A1 (en)	2009-11-27
PT2074120E (pt)	2010-06-15
SI2074120T1 (sl)	2010-06-30
BRPI0818893B1 (pt)	2021-02-02
DK2074120T3 (da)	2010-06-14
IL205202A0 (en)	2010-12-30
EP2074120A1 (de)	2009-07-01
AU2008317262A1 (en)	2009-04-30
BRPI0818893A2 (pt)	2015-05-05
JP5476307B2 (ja)	2014-04-23
EP2074120B1 (de)	2010-03-03
CY1110648T1 (el)	2015-06-10
PL2074120T3 (pl)	2010-08-31
CN101910168B (zh)	2014-07-30
CA2703477C (en)	2016-10-11
KR20100090782A (ko)	2010-08-17
US8012956B2 (en)	2011-09-06
WO2009055077A1 (en)	2009-04-30
DE602008000754D1 (de)	2010-04-15
EA018999B1 (ru)	2013-12-30
JP2014070077A (ja)	2014-04-21
MX2010004493A (es)	2010-06-11
HRP20100292T1 (hr)	2010-06-30
JP2011500815A (ja)	2011-01-06
US20090163471A1 (en)	2009-06-25
CN101910168A (zh)	2010-12-08
AU2008317262B2 (en)	2013-12-19
JP5745021B2 (ja)	2015-07-08
RS51346B (sr)	2011-02-28
SG2012079653A (en)	2014-05-29
ZA201002987B (en)	2011-02-23
KR101578792B1 (ko)	2015-12-21
CA2703477A1 (en)	2009-04-30
NZ585137A (en)	2012-07-27

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