ATE459647T1 - Humane il-18 substitutionsmutanten und deren konjugate - Google Patents
Humane il-18 substitutionsmutanten und deren konjugateInfo
- Publication number
- ATE459647T1 ATE459647T1 AT04759472T AT04759472T ATE459647T1 AT E459647 T1 ATE459647 T1 AT E459647T1 AT 04759472 T AT04759472 T AT 04759472T AT 04759472 T AT04759472 T AT 04759472T AT E459647 T1 ATE459647 T1 AT E459647T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- human
- substitution mutants
- mutants
- substitution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46294703P | 2003-04-15 | 2003-04-15 | |
| PCT/US2004/011309 WO2004091517A2 (en) | 2003-04-15 | 2004-04-13 | Conjugates comprising human il-18 and substitution mutants thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459647T1 true ATE459647T1 (de) | 2010-03-15 |
Family
ID=33300018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759472T ATE459647T1 (de) | 2003-04-15 | 2004-04-13 | Humane il-18 substitutionsmutanten und deren konjugate |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7311902B2 (de) |
| EP (2) | EP2261244A3 (de) |
| JP (2) | JP4753867B2 (de) |
| AR (1) | AR044024A1 (de) |
| AT (1) | ATE459647T1 (de) |
| DE (1) | DE602004025799D1 (de) |
| ES (1) | ES2340494T3 (de) |
| TW (1) | TW200510454A (de) |
| WO (1) | WO2004091517A2 (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295450B1 (de) | 2000-09-29 | 2015-01-28 | Merck Sharp & Dohme Corp. | Pegyliertes interleukin 10 |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| WO2005075648A1 (en) * | 2004-01-28 | 2005-08-18 | Gifu University | Interleukin-18 mutant proteins |
| EP2059253A4 (de) * | 2006-09-14 | 2011-09-14 | Univ Pennsylvania | Modulation regulatorischer t-zellen mittels human-il-18 |
| CA2663300C (en) * | 2006-09-15 | 2014-10-07 | Creabilis Therapeutics S.P.A. | Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1 |
| EP2066336B1 (de) | 2006-09-28 | 2012-09-19 | Merck Sharp & Dohme Corp. | Verwendung von pegyliertem il-10 zur krebsbehandlung |
| PE20090190A1 (es) * | 2007-03-23 | 2009-03-22 | Smithkline Beecham Corp | Combinacion de anticuerpos anti-cd20 y polipeptidos de il-18 |
| US8865875B2 (en) | 2007-08-22 | 2014-10-21 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions |
| US8168165B2 (en) * | 2008-12-23 | 2012-05-01 | Abbott Laboratories | Alkylated interleukin-18 compositions |
| CN102341412B (zh) | 2009-03-05 | 2018-01-05 | 梅达雷克斯有限责任公司 | 特异于cadm1 的全人抗体 |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| CN102507824B (zh) * | 2011-11-01 | 2013-10-09 | 北京三元基因工程有限公司 | 聚乙二醇修饰蛋白质的修饰位点分析方法 |
| HUE033704T2 (en) | 2012-02-13 | 2017-12-28 | Bristol Myers Squibb Co | Enediyne compounds, conjugates thereof, and uses and methods therefor |
| LT2956173T (lt) | 2013-02-14 | 2017-06-26 | Bristol-Myers Squibb Company | Tubulizino junginiai, gavimo ir panaudojimo būdai |
| MX2015014438A (es) | 2013-04-18 | 2016-05-18 | Armo Biosciences Inc | Metodos de uso de interleucina-10 para tratar enfermedades y trastornos. |
| EP3010527B1 (de) | 2013-06-17 | 2018-08-08 | Armo Biosciences, Inc. | Verfahren zur beurteilung der proteinidentität und -stabilität |
| CN105658232A (zh) | 2013-08-30 | 2016-06-08 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素-10治疗疾病和病症的方法 |
| CN120242030A (zh) | 2013-11-11 | 2025-07-04 | 阿尔莫生物科技股份有限公司 | 将白细胞介素-10用于治疗疾病和病症的方法 |
| WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| WO2016060996A2 (en) | 2014-10-14 | 2016-04-21 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
| AU2015336101A1 (en) | 2014-10-22 | 2017-04-20 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| BR112017014937A2 (pt) | 2015-01-14 | 2018-03-13 | Bristol-Myers Squibb Company | dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US20160361415A1 (en) | 2015-05-28 | 2016-12-15 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
| KR20180038553A (ko) | 2015-08-25 | 2018-04-16 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| CN109641911B (zh) | 2016-08-19 | 2023-02-21 | 百时美施贵宝公司 | seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法 |
| US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
| US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
| US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
| US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
| US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
| US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
| IL272635B2 (en) * | 2017-09-06 | 2024-02-01 | Univ Yale | Variants of interleukin-18 and methods of use |
| JP7404252B2 (ja) * | 2017-11-08 | 2023-12-25 | ヤフェイ シャンハイ バイオロジー メディスン サイエンス アンド テクノロジー カンパニー リミテッド | 生体分子のコンジュゲートおよびその使用 |
| WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
| US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
| CN111378026A (zh) * | 2018-12-27 | 2020-07-07 | 天津键凯科技有限公司 | 一种制备结合位点可控的peg化生物分子的方法 |
| JP7686563B2 (ja) * | 2019-02-08 | 2025-06-02 | ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド | 皮膚、毛髪、爪および／または粘膜の処置および／またはケアに有用な化合物 |
| US12029778B2 (en) | 2019-05-13 | 2024-07-09 | Yale University | Interleukin-18 mimics and methods of use |
| WO2021141986A1 (en) * | 2020-01-07 | 2021-07-15 | St. Jude Children's Research Hospital, Inc. | Chimeric gmcsf-il18 receptor |
| CA3189327A1 (en) * | 2020-08-19 | 2022-02-24 | Vijaya Raghavan PATTABIRAMAN | Modified il-18 polypeptides and uses thereof |
| JP2023550545A (ja) * | 2020-11-02 | 2023-12-01 | シムハ・アイエル－１８・インコーポレイテッド | インターロイキン－１８バリアントおよび使用の方法 |
| JP7812094B2 (ja) * | 2021-02-10 | 2026-02-09 | 国立大学法人 長崎大学 | 新規ヒトインターロイキン－１８変異体及びその用途 |
| JP7849832B2 (ja) | 2021-08-06 | 2026-04-22 | 国立大学法人 長崎大学 | がんの治療剤 |
| WO2023118497A1 (en) * | 2021-12-22 | 2023-06-29 | Pieris Pharmaceuticals Gmbh | Novel il-18 variants |
| WO2023161857A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | Bifunctional cytokine compositions |
| CA3244053A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | MODIFIED IL-18 POLYPEPTIDES |
| AU2023226512A1 (en) | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Immune antigen specific il-18 immunocytokines and uses thereof |
| AU2023226005A1 (en) * | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Activatable il-18 polypeptides |
| US20260092093A1 (en) * | 2022-09-06 | 2026-04-02 | TJ Biopharma (Shanghai) Co., Ltd. | Il-18 variant polypeptides |
| WO2024102587A2 (en) * | 2022-11-11 | 2024-05-16 | Mural Oncology, Inc. | Interleukin 18 variants |
| CN116083572A (zh) * | 2022-11-25 | 2023-05-09 | 广州希灵生物科技有限公司 | 一种检测il18基因启动子甲基化生物标志物的引物的应用 |
| US20250186594A1 (en) | 2023-08-23 | 2025-06-12 | Bright Peak Therapeutics Ag | Il-18 polypeptides modified with polymers |
| WO2025041101A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| WO2025041102A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Targeted immune activation with il-18 immunocytokines |
| US12134635B1 (en) | 2023-12-29 | 2024-11-05 | Sonnet BioTherapeutics, Inc. | Interleukin 18 (IL-18) variants and fusion proteins comprising same |
| WO2025188694A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Tricyclic tlr7 agonists and uses thereof |
| WO2025188693A1 (en) | 2024-03-05 | 2025-09-12 | Bristol-Myers Squibb Company | Bicyclic tlr7 agonists and uses thereof |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2026069134A1 (en) | 2024-09-26 | 2026-04-02 | Bright Peak Therapeutics Ag | Human therapy with il-18 immunocytokines |
| WO2026083296A1 (en) | 2024-10-16 | 2026-04-23 | Bright Peak Therapeutics Ag | Trispecific compositions comprising il-18, vegf binding domains, and pd-1 binding domains |
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| US604630A (en) | 1898-05-24 | Avilliam | ||
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-
2004
- 2004-04-13 EP EP10152172A patent/EP2261244A3/de not_active Withdrawn
- 2004-04-13 ES ES04759472T patent/ES2340494T3/es not_active Expired - Lifetime
- 2004-04-13 EP EP04759472A patent/EP1613274B1/de not_active Expired - Lifetime
- 2004-04-13 WO PCT/US2004/011309 patent/WO2004091517A2/en not_active Ceased
- 2004-04-13 DE DE602004025799T patent/DE602004025799D1/de not_active Expired - Lifetime
- 2004-04-13 TW TW093110162A patent/TW200510454A/zh unknown
- 2004-04-13 AT AT04759472T patent/ATE459647T1/de not_active IP Right Cessation
- 2004-04-13 JP JP2006509956A patent/JP4753867B2/ja not_active Expired - Lifetime
- 2004-04-14 US US10/823,964 patent/US7311902B2/en not_active Expired - Lifetime
- 2004-04-15 AR ARP040101274A patent/AR044024A1/es unknown
-
2007
- 2007-12-21 US US11/962,811 patent/US7736639B2/en not_active Expired - Lifetime
-
2011
- 2011-01-21 JP JP2011010984A patent/JP2011105737A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2340494T3 (es) | 2010-06-04 |
| WO2004091517A2 (en) | 2004-10-28 |
| WO2004091517A3 (en) | 2006-07-27 |
| DE602004025799D1 (de) | 2010-04-15 |
| EP1613274A4 (de) | 2008-04-16 |
| JP2011105737A (ja) | 2011-06-02 |
| US20080206189A1 (en) | 2008-08-28 |
| EP1613274A2 (de) | 2006-01-11 |
| EP2261244A3 (de) | 2011-02-23 |
| JP2007526207A (ja) | 2007-09-13 |
| US7736639B2 (en) | 2010-06-15 |
| JP4753867B2 (ja) | 2011-08-24 |
| TW200510454A (en) | 2005-03-16 |
| US20050008615A1 (en) | 2005-01-13 |
| EP2261244A2 (de) | 2010-12-15 |
| EP1613274B1 (de) | 2010-03-03 |
| AR044024A1 (es) | 2005-08-24 |
| US7311902B2 (en) | 2007-12-25 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |