ATE461184T1 - Synthese von polyoxygenierten stickstoffsystemen, bei der man enamine von 1,3-dioxan-5-onen und nitroolefine miteinander umsetzt - Google Patents
Synthese von polyoxygenierten stickstoffsystemen, bei der man enamine von 1,3-dioxan-5-onen und nitroolefine miteinander umsetztInfo
- Publication number
- ATE461184T1 ATE461184T1 AT05769869T AT05769869T ATE461184T1 AT E461184 T1 ATE461184 T1 AT E461184T1 AT 05769869 T AT05769869 T AT 05769869T AT 05769869 T AT05769869 T AT 05769869T AT E461184 T1 ATE461184 T1 AT E461184T1
- Authority
- AT
- Austria
- Prior art keywords
- nitroolefins
- enamines
- dioxan
- systems
- synthesis
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 6
- 150000002081 enamines Chemical class 0.000 title abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 3
- GYRVFISXYPPJBT-UHFFFAOYSA-N 1,3-dioxan-5-one Chemical class O=C1COCOC1 GYRVFISXYPPJBT-UHFFFAOYSA-N 0.000 abstract 2
- 239000000370 acceptor Substances 0.000 abstract 2
- 238000000137 annealing Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- VREZDOWOLGNDPW-ALTGWBOUSA-N Pancratistatin Chemical compound C1=C2[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)[C@@H]3NC(=O)C2=C(O)C2=C1OCO2 VREZDOWOLGNDPW-ALTGWBOUSA-N 0.000 abstract 1
- VREZDOWOLGNDPW-MYVCAWNPSA-N Pancratistatin Natural products O=C1N[C@H]2[C@H](O)[C@H](O)[C@H](O)[C@H](O)[C@@H]2c2c1c(O)c1OCOc1c2 VREZDOWOLGNDPW-MYVCAWNPSA-N 0.000 abstract 1
- 238000007259 addition reaction Methods 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- VREZDOWOLGNDPW-UHFFFAOYSA-N pancratistatine Natural products C1=C2C3C(O)C(O)C(O)C(O)C3NC(=O)C2=C(O)C2=C1OCO2 VREZDOWOLGNDPW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 abstract 1
- 229950010357 tetrodotoxin Drugs 0.000 abstract 1
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000000844 transformation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200401547A ES2245603B2 (es) | 2004-06-25 | 2004-06-25 | Sintesis de sistemas nitrogenados polioxigenados mediante reacciones de enaminas de 1,3-dioxan-5-onas con nitroolefinas. |
| PCT/ES2005/000374 WO2006003227A1 (es) | 2004-06-25 | 2005-06-20 | Síntesis de sistemas nitrogenados polioxigenados mediante reacciones de enaminaas de 1,3-dioxan-5-onas con nitroolefinas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461184T1 true ATE461184T1 (de) | 2010-04-15 |
Family
ID=35614430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05769869T ATE461184T1 (de) | 2004-06-25 | 2005-06-20 | Synthese von polyoxygenierten stickstoffsystemen, bei der man enamine von 1,3-dioxan-5-onen und nitroolefine miteinander umsetzt |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080045523A1 (de) |
| EP (1) | EP1783123B1 (de) |
| CN (1) | CN101006071A (de) |
| AT (1) | ATE461184T1 (de) |
| CA (1) | CA2575048A1 (de) |
| DE (1) | DE602005020026D1 (de) |
| ES (1) | ES2245603B2 (de) |
| WO (1) | WO2006003227A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1956024A1 (de) * | 2007-02-12 | 2008-08-13 | Laboratorios del Dr. Esteve S.A. | 1-Azaspiro[3.5]nonan-2-ona-5,7-Karbolakton- und 5,7-geschützte-1-azaspiro[3.5]nonan-2-ona-Derivate und ihre Verwendung als Zwischenprodukte bei der Synthese von TTX |
| WO2009026961A1 (en) * | 2007-08-30 | 2009-03-05 | Universidad De Santiago De Compostela | Processes for the preparation of pancratistatin and pancratistatin analogues |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5777137A (en) * | 1995-11-01 | 1998-07-07 | University Of Florida | Pancratistatins and processes for their production |
-
2004
- 2004-06-25 ES ES200401547A patent/ES2245603B2/es not_active Expired - Fee Related
-
2005
- 2005-06-20 US US11/572,707 patent/US20080045523A1/en not_active Abandoned
- 2005-06-20 CN CNA2005800281146A patent/CN101006071A/zh active Pending
- 2005-06-20 AT AT05769869T patent/ATE461184T1/de not_active IP Right Cessation
- 2005-06-20 CA CA002575048A patent/CA2575048A1/en not_active Abandoned
- 2005-06-20 WO PCT/ES2005/000374 patent/WO2006003227A1/es not_active Ceased
- 2005-06-20 EP EP05769869A patent/EP1783123B1/de not_active Expired - Lifetime
- 2005-06-20 DE DE602005020026T patent/DE602005020026D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20080045523A1 (en) | 2008-02-21 |
| ES2245603A1 (es) | 2006-01-01 |
| DE602005020026D1 (de) | 2010-04-29 |
| WO2006003227A1 (es) | 2006-01-12 |
| EP1783123A1 (de) | 2007-05-09 |
| CA2575048A1 (en) | 2006-01-12 |
| ES2245603B2 (es) | 2006-07-01 |
| CN101006071A (zh) | 2007-07-25 |
| EP1783123B1 (de) | 2010-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |