ATE462417T1 - Microemulsionen als feste dosisformen zur oralen verabreichung - Google Patents

Microemulsionen als feste dosisformen zur oralen verabreichung

Info

Publication number
ATE462417T1
ATE462417T1 AT99941159T AT99941159T ATE462417T1 AT E462417 T1 ATE462417 T1 AT E462417T1 AT 99941159 T AT99941159 T AT 99941159T AT 99941159 T AT99941159 T AT 99941159T AT E462417 T1 ATE462417 T1 AT E462417T1
Authority
AT
Austria
Prior art keywords
drug
microemulsion
microemulsions
oral administration
dose forms
Prior art date
Application number
AT99941159T
Other languages
English (en)
Inventor
S Pather
Sangeeta Gupte
Rajendra Khankari
John Hontz
Ramya Kumbale
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Application granted granted Critical
Publication of ATE462417T1 publication Critical patent/ATE462417T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99941159T 1998-08-13 1999-08-13 Microemulsionen als feste dosisformen zur oralen verabreichung ATE462417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9634798P 1998-08-13 1998-08-13
PCT/US1999/018552 WO2000009093A1 (en) 1998-08-13 1999-08-13 Microemulsions as solid dosage forms for oral administration

Publications (1)

Publication Number Publication Date
ATE462417T1 true ATE462417T1 (de) 2010-04-15

Family

ID=22256941

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941159T ATE462417T1 (de) 1998-08-13 1999-08-13 Microemulsionen als feste dosisformen zur oralen verabreichung

Country Status (9)

Country Link
US (1) US6280770B1 (de)
EP (2) EP2127642A3 (de)
JP (1) JP4815053B2 (de)
AT (1) ATE462417T1 (de)
AU (1) AU5486899A (de)
CA (1) CA2339991C (de)
DE (1) DE69942205D1 (de)
ES (1) ES2341510T3 (de)
WO (1) WO2000009093A1 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US6793934B1 (en) 1999-12-08 2004-09-21 Shire Laboratories, Inc. Solid oral dosage form
AUPQ573300A0 (en) 2000-02-21 2000-03-16 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
WO2002024170A1 (en) * 2000-09-19 2002-03-28 Cima Labs Inc. Pharmaceutical compositions for rectal and vaginal administration
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
JP5684440B2 (ja) * 2001-02-23 2015-03-11 シーマ・ラブス、インコーポレイテッド 組成物および固形製剤
US6692771B2 (en) * 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
OA12625A (en) * 2001-06-22 2006-06-12 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drug.
US20030068356A1 (en) 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
ITMI20011756A1 (it) * 2001-08-09 2003-02-09 Remedia S R L Composizione farmaceutica comprendente una microemulsione doppia acqua/olio/acqua incorporata in un supporto solido
US20030124196A1 (en) * 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
JP2005515996A (ja) * 2001-12-03 2005-06-02 ノバセア インコーポレイティッド 活性型ビタミンｄ化合物を含む薬学的組成物
ITMI20012694A1 (it) * 2001-12-19 2003-06-19 Remedia S R L Composizione farmaceutica comprendente una microemulsione doppia olio/acqua/olio incorporata in un supporto solido
DE60320940D1 (de) 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
ITMI20021392A1 (it) * 2002-06-25 2003-12-29 Nicox Sa Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita'
CN100515388C (zh) * 2002-06-26 2009-07-22 金拓 难溶药物快速溶出固体剂型
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
FR2851918B1 (fr) * 2003-03-06 2006-06-16 Poudre impregnee ameliorant la biodisponibilite et/ou la solubilite et procede de fabrication
BRPI0413277A (pt) 2003-08-04 2006-10-10 Pfizer Prod Inc composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
EP1715853A4 (de) * 2004-02-17 2012-07-18 Transcept Pharmaceuticals Inc Zusammensetzungen zur abgabe von hypnotika im bereich der mundschleimhäute und verwendungsverfahren davon
US20050220866A1 (en) * 2004-04-02 2005-10-06 Dr. Reddy's Laboratories Limited Novel capsule formulations of etoposide for oral use
US20050238675A1 (en) * 2004-04-26 2005-10-27 Wenjie Li Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
WO2006036614A2 (en) 2004-09-24 2006-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. A new class of surfactant-like materials comprising vitamin e tpgs and a water soluble polymer
US20090169583A1 (en) * 2005-02-08 2009-07-02 Pfizer, Inc. Solid Adsorbates of Hydrophobic Drugs
CA2604943C (en) 2005-04-15 2013-09-17 Clarus Therapeutics, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070123562A1 (en) * 2005-05-25 2007-05-31 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the-night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
JP5050322B2 (ja) * 2005-06-21 2012-10-17 三菱化学株式会社 含油固形物およびその製造方法
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US20100143481A1 (en) * 2006-11-08 2010-06-10 Dinesh Shenoy Method of preparing solid dosage forms of multi-phasic pharmaceutical compositions
WO2008091588A1 (en) 2007-01-22 2008-07-31 Targacept, Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
EP2162120B1 (de) 2007-06-04 2016-05-04 Bend Research, Inc Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer
US20090060993A1 (en) * 2007-09-04 2009-03-05 Joseph Schwarz Solid pharmaceutical composition for enhanced delivery of coenzyme q-10 and ubiquinones
WO2009073216A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer
EP2231169B1 (de) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
EP2111854A1 (de) 2008-04-22 2009-10-28 Lek Pharmaceuticals D.D. Selbstmikroemulgierende Systeme in Mikrokapseln mit Flüssigkern
EP2334302B1 (de) * 2008-09-09 2018-03-21 Cima Labs Inc Dosierungsformen für schwach ionisierbare wirkstoffe
WO2010077878A1 (en) * 2008-12-15 2010-07-08 Fleming And Company, Pharmaceuticals Rapidly dissolving vitamin formulation and methods of using the same
KR101004205B1 (ko) * 2008-12-17 2010-12-24 동아제약주식회사 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물
WO2010142456A1 (en) * 2009-06-11 2010-12-16 Photocure Asa Solid compositions comprising 5-aminolevulinic acid
ES2385240B1 (es) 2010-07-26 2013-09-23 Gp-Pharm, S.A. Cápsulas de principios activos farmacéuticos y ácidos grasos poliinsaturados para el tratamiento de enfermedades de la próstata.
US20120213855A1 (en) * 2011-02-17 2012-08-23 Cima Labs Inc. Dosage forms for weakly ionizable compounds
US20130004619A1 (en) * 2011-06-28 2013-01-03 Kemin Industries, Inc. Method of Forming Encapsulated Compositions with Enhanced Solubility and Stability
US20170325481A1 (en) * 2011-06-28 2017-11-16 Kemin Industries, Inc. Method of forming encapsulated compositions with enhanced solubility and stability
CN104755481A (zh) 2012-10-30 2015-07-01 尼克塔治疗公司 作为阿片激动剂的α-6-mPEG6-O-羟基可酮的固体盐形式以及其用途
CN113842362A (zh) 2012-11-14 2021-12-28 格雷斯公司 含有生物活性材料与无序无机氧化物的组合物
US20140179655A1 (en) 2012-12-20 2014-06-26 Solural Pharma ApS Solid oral dosage form of testosterone derivative
WO2014128564A2 (en) 2013-02-21 2014-08-28 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions of cetp inhibitors
US10245273B2 (en) 2013-12-26 2019-04-02 Clarus Therapeutics, Inc. Oral pharmaceutical products and methods of use combining testosterone esters with hypolipidemic agents
ES2851332T3 (es) * 2014-06-19 2021-09-06 Solural Pharma ApS Forma sólida de dosificación oral de compuestos lipofílicos
WO2016033430A1 (en) 2014-08-28 2016-03-03 Board Of Regents, The University Of Texas System Formulations of testosterone and methods of treatment therewith
RU2708254C2 (ru) 2015-05-28 2019-12-05 Др. Редди'С Лабораториз Лтд. Пероральная композиция целекоксиба для лечения боли
ITUA20164228A1 (it) * 2016-06-09 2017-12-09 Labomar S R L Formulazione a matrice grassa auto-emulsionante e gastro-resistente e relativo metodo di preparazione
US9950353B2 (en) * 2016-08-22 2018-04-24 Remediation Products, Inc. Bioremediation composition with time-release materials for removing energetic compounds from contaminated environments
US12090123B2 (en) 2017-10-10 2024-09-17 Douglas Pharmaceuticals Ltd. Extended release pharmaceutical formulation
US10441544B2 (en) 2017-10-10 2019-10-15 Douglas Pharmaceuticals, Ltd. Extended release pharmaceutical formulation
CN111630026A (zh) 2017-10-10 2020-09-04 道格拉斯制药有限公司 缓释药物制剂和治疗方法
US10869838B2 (en) 2017-10-10 2020-12-22 Douglas Pharmaceuticals, Ltd. Extended release pharmaceutical formulation
US11471415B2 (en) 2017-10-10 2022-10-18 Douglas Pharmaceuticals, Ltd. Extended release pharmaceutical formulation and methods of treatment
US11564933B2 (en) 2019-04-12 2023-01-31 Tolmar, Inc. Methods of treating testosterone deficiency
EP4041209A4 (de) 2019-10-11 2024-01-24 Pike Therapeutics, Inc. Transdermale zusammensetzungen mit cannabidiol (cbd) zur verwendung bei der behandlung von anfallsleiden
CN114681470A (zh) 2020-12-28 2022-07-01 雷迪博士实验室有限公司 治疗疼痛的方法
EP4271414A4 (de) 2020-12-31 2024-11-27 The Governing Council of the University of Toronto Vollständig verdünnbare, selbstmikroemulgierende abgabesysteme (smedds) für schwer wasserlösliche polare solute

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962384A (en) * 1972-04-10 1976-06-08 Hoffmann-La Roche Inc. Spray-drying technique for preparing agglomerated powders
CH586568A5 (de) * 1972-04-10 1977-04-15 Hoffmann La Roche
JPS5157813A (en) * 1974-11-14 1976-05-20 Sankyo Co Ll dooba mataha sonojudotaiseizaino seiho
SE421042B (sv) * 1976-06-29 1981-11-23 Kockums Chem Sett att minska den for en viss biologisk effekt erforderliga mengden biologiskt aktiv substans
US4360061A (en) 1980-04-03 1982-11-23 Exxon Research And Engineering Co. Oil recovery process using polymer microemulsion complexes
US4353806A (en) 1980-04-03 1982-10-12 Exxon Research And Engineering Company Polymer-microemulsion complexes for the enhanced recovery of oil
DE3224619A1 (de) 1981-07-14 1983-05-19 Freund Industrial Co., Ltd., Tokyo Orale pharmazeutische zusammensetzung
FR2594693B1 (fr) * 1986-02-24 1990-01-05 Farah Nabil Nouveaux procedes de preparation a partir d'emulsions seches de formes orales solides a liberation modifiee et retardee de leur principes actifs
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5688761A (en) 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
AU668509B2 (en) * 1991-04-19 1996-05-09 Affinity Biotech, Inc. Convertible microemulsion formulations
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
US5393527A (en) 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
US5435936A (en) 1993-09-01 1995-07-25 Colgate Palmolive Co. Nonaqueous liquid microemulsion compositions
ES2094688B1 (es) * 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
SE9503143D0 (sv) * 1995-09-12 1995-09-12 Astra Ab New preparation
US5800834A (en) 1996-06-10 1998-09-01 Spireas; Spiridon Liquisolid systems and methods of preparing same

Also Published As

Publication number Publication date
US6280770B1 (en) 2001-08-28
CA2339991A1 (en) 2000-02-24
EP1104290A4 (de) 2006-01-18
CA2339991C (en) 2007-01-02
EP2127642A2 (de) 2009-12-02
DE69942205D1 (de) 2010-05-12
JP2002522473A (ja) 2002-07-23
EP2127642A3 (de) 2010-02-24
ES2341510T3 (es) 2010-06-21
JP4815053B2 (ja) 2011-11-16
EP1104290B1 (de) 2010-03-31
WO2000009093A1 (en) 2000-02-24
EP1104290A1 (de) 2001-06-06
AU5486899A (en) 2000-03-06

Similar Documents

Publication Publication Date Title
ATE462417T1 (de) Microemulsionen als feste dosisformen zur oralen verabreichung
WO2005065069A3 (en) Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
ATE356612T1 (de) Orale, pharmazeutische darreichungsformen von flüssigen medikamenten mitverbesserter bioverfügbarkeit
UA41346C2 (uk) Фармацевтична композиція, яка містить флуоксетин або його сіль, таблетка на її основі, спосіб виробництва таблетки, яка диспергується
EP1685839B8 (de) Peroral zu verabreichende Arzneiform enthaltend eine Kombination von einem Opioid-Agonisten und einem Opioid- Antagonisten
SE9301171D0 (sv) Pharmaceutical composition containing lipophilic drugs
MXPA03011538A (es) Composicion medicinal que sustancialmente no causaria dano a la mucosa intestinal.
CY1109861T1 (el) Διαδερμικο θεραπευτικο συστημα για την ασθενεια του παρκινσον που προκαλει υψηλα επιπεδα πλασματος της ροτιγοτινης
IL114596A (en) Pharmaceutical compositions containing an active substance blended with a carrier process for preparation thereof and their use for preparation of inhalated drugs
EP2269613A3 (de) Feste orale Dosierungsform enthaltend eine Kombination von Glibenclamide und Metformine
FR11C0017I2 (fr) Utilisation de spinosad ou d'une formulation comprennant spinosad
IL121160A0 (en) Method compositions and kits for increasing the oral bioavailability of pharmaceutical agents
ATE292453T1 (de) Antivirale arznei
CA2353693A1 (en) Pharmaceutical composition containing citalopram
WO2003020214A3 (en) Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
JP2002542281A5 (de)
BG106234A (bg) Терапевтична употреба на мелатонин
CA2385755A1 (en) Prevention of colorectal cancer
DE3263832D1 (en) Gallium chloride, an anti-cancer drug
EA200500387A1 (ru) Композиции для ингаляции с высоким содержанием лекарственных веществ
NO307496B1 (no) Anvendelse av en <delta>-opioid antagonist for fremstilling av et antitussivt middel
GEP20043377B (en) Pharmaceutical Complex
HUP9900521A2 (hu) Eljárás nagyon kis dózisú hatóanyagok szilárd dózisformáinak előállítására
EA200101157A1 (ru) 14β-H-СТЕРОЛЫ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И ПРИМЕНЕНИЕ ЭТИХ ПРОИЗВОДНЫХ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ, РЕГУЛИРУЮЩИХ МЕЙОЗ
DE68907091D1 (de) Scleroglucan und wirkstoff enthaltende pharmazeutische tabletten und kapselgranulate.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties