ATE462710T1 - Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiert - Google Patents
Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiertInfo
- Publication number
- ATE462710T1 ATE462710T1 AT03791618T AT03791618T ATE462710T1 AT E462710 T1 ATE462710 T1 AT E462710T1 AT 03791618 T AT03791618 T AT 03791618T AT 03791618 T AT03791618 T AT 03791618T AT E462710 T1 ATE462710 T1 AT E462710T1
- Authority
- AT
- Austria
- Prior art keywords
- disease
- crohn
- fibrostenosis
- fibrostenosing
- nod2
- Prior art date
Links
- 208000011231 Crohn disease Diseases 0.000 title abstract 6
- 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 title abstract 5
- 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000035772 mutation Effects 0.000 title 1
- 108700028369 Alleles Proteins 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 108700002045 Nod2 Signaling Adaptor Proteins 0.000 abstract 2
- 101150083031 Nod2 gene Proteins 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40739102P | 2002-08-30 | 2002-08-30 | |
| US10/356,736 US20040053263A1 (en) | 2002-08-30 | 2003-01-30 | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| PCT/US2003/023926 WO2004020968A2 (en) | 2002-08-30 | 2003-07-30 | Mutations in nod2 are associated with fibrostenosing disease in patients with crohn’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462710T1 true ATE462710T1 (de) | 2010-04-15 |
Family
ID=31981139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03791618T ATE462710T1 (de) | 2002-08-30 | 2003-07-30 | Mutationen in nod2 sind bei patienten mit morbus crohn mit fibrostenosebildung assoziiert |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040053263A1 (de) |
| EP (1) | EP1556405B1 (de) |
| JP (2) | JP4606877B2 (de) |
| AT (1) | ATE462710T1 (de) |
| AU (1) | AU2003263834A1 (de) |
| DE (1) | DE60331941D1 (de) |
| WO (1) | WO2004020968A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828132B2 (en) * | 2001-03-01 | 2004-12-07 | Ultra Biotech Limited | Biological fertilizer compositions comprising garbage |
| US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
| US7662569B2 (en) * | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
| EP1692519B1 (de) * | 2003-12-03 | 2010-06-02 | Glycominds Ltd. | Diagnostikverfahren mittels messungen der antiglykan-antikörper-spiegeln |
| US7592150B2 (en) * | 2003-12-03 | 2009-09-22 | Glycominds, Ltd | Method for diagnosing diseases based on levels of anti-glycan antibodies |
| US20060205022A1 (en) * | 2003-12-03 | 2006-09-14 | Nir Dotan | Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease |
| US7803535B2 (en) * | 2004-03-27 | 2010-09-28 | Hanns-Georg Klein | Polymorphisms in the NOD2/CARD15 gene |
| WO2005115135A2 (en) * | 2004-04-09 | 2005-12-08 | The Regents Of The University Of California | Mouse model of crohn’s disease and a method to develop specific therapeutics |
| US11268149B2 (en) | 2004-12-08 | 2022-03-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| CA2589746A1 (en) * | 2004-12-08 | 2006-06-15 | Cedars-Sinai Medical Center | Methods for diagnosis and treatment of crohn's disease |
| US10544459B2 (en) * | 2004-12-08 | 2020-01-28 | Cedars-Sinai Medical Center | Methods of using genetic variants for the diagnosis and treatment of inflammatory bowel disease |
| US12110555B2 (en) | 2004-12-08 | 2024-10-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| WO2008109782A2 (en) * | 2007-03-06 | 2008-09-12 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
| EP2049691A4 (de) * | 2006-07-26 | 2010-06-16 | Genizon Biosciences Inc | Suszeptibilitätsgen für morbus crohn |
| US20080131887A1 (en) | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
| GB2444410B (en) * | 2006-11-30 | 2011-08-24 | Navigenics Inc | Genetic analysis systems and methods |
| US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
| US20100190162A1 (en) * | 2007-02-26 | 2010-07-29 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
| WO2008137762A2 (en) * | 2007-05-04 | 2008-11-13 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
| WO2008116150A2 (en) | 2007-03-21 | 2008-09-25 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease |
| WO2008134569A2 (en) * | 2007-04-26 | 2008-11-06 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
| US20110136255A1 (en) * | 2007-11-30 | 2011-06-09 | Nir Dotan | Composition and method for prediction of complicated disease course in crohn's disease |
| WO2009143278A2 (en) * | 2008-05-20 | 2009-11-26 | Cedars-Sinai Medical Center | Methods of diagnosing and characterizing cannabinoid signaling in crohn's disease |
| US20110177969A1 (en) * | 2008-10-01 | 2011-07-21 | Cedars-Sinai Medical Center | The role of il17rd and the il23-1l17 pathway in crohn's disease |
| US20110189685A1 (en) * | 2008-10-22 | 2011-08-04 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
| WO2010120814A1 (en) | 2009-04-14 | 2010-10-21 | Prometheus Laboratories Inc. | Inflammatory bowel disease prognostics |
| WO2011060098A1 (en) | 2009-11-10 | 2011-05-19 | Prometheus Laboratories Inc. | Methods for predicting post-surgery risk associated with ileal pouch-anal anastomosis |
| WO2011088306A1 (en) * | 2010-01-15 | 2011-07-21 | Cedars-Sinai Medical Center | Methods of using genetic variants to diagnose crohn's disease |
| NZ609363A (en) | 2010-10-18 | 2015-04-24 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
| CA2827609A1 (en) | 2011-02-17 | 2012-11-15 | Nestec S.A. | Assays for detecting autoantibodies to anti-tnf.alpha. drugs |
| JP2014515599A (ja) * | 2011-03-25 | 2014-07-03 | セダーズ−シナイ メディカル センター | 炎症性腸疾患における腸の肉芽腫および低骨密度を診断および処置する方法 |
| AU2012253422B2 (en) | 2011-05-10 | 2015-08-13 | Société des Produits Nestlé S.A. | Methods of disease activity profiling for personalized therapy management |
| JP2015502740A (ja) | 2011-10-21 | 2015-01-29 | ネステク ソシエテ アノニム | 炎症性腸疾患の診断を改善するための方法 |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| EP4286517A3 (de) | 2013-04-04 | 2024-03-13 | President and Fellows of Harvard College | Therapeutische verwendungen einer genomänderung mit crispr-/cas-systemen |
| EP3022295A4 (de) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signatur des tl1a (tnfsf15)-signalweges |
| AU2016243583B2 (en) | 2015-03-27 | 2022-03-10 | President And Fellows Of Harvard College | Modified T cells and methods of making and using the same |
| KR20240095481A (ko) | 2016-03-17 | 2024-06-25 | 세다르스-신나이 메디칼 센터 | Rnaset2를 통한 염증성 장 질환의 진단 방법 |
| WO2018195129A1 (en) | 2017-04-17 | 2018-10-25 | University Of Maryland, College Park | Embryonic cell cultures and methods of using the same |
| WO2020139748A1 (en) * | 2018-12-28 | 2020-07-02 | Cedars-Sinai Medical Center | Methods of treating inflammatory bowel diseases that target ripk2 |
| CN115087455A (zh) * | 2019-11-12 | 2022-09-20 | 奥查德疗法(欧洲)有限公司 | 用于治疗或预防克罗恩病的组合物和方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3157053B2 (ja) * | 1992-09-16 | 2001-04-16 | ティーディーケイ株式会社 | Ｄｎａ作用物質の結合様式特定方法 |
| DK0615129T3 (da) * | 1993-03-10 | 2000-08-07 | Cedars Sinai Medical Center | Fremgangsmåder til selektiv påvisning af perinukleært anti-neutrophilt cytoplasmatisk antistof fra ulcerativ colitis eller |
| US5830675A (en) * | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
| US5691151A (en) * | 1994-10-07 | 1997-11-25 | Regents Of University Of California | Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca |
| US5916748A (en) * | 1996-04-12 | 1999-06-29 | Cedars-Sinai Medical Center | Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis |
| AU2438397A (en) * | 1996-04-12 | 1997-11-07 | Cedars-Sinai Medical Center | Methods of determining the risk of pouchitis development |
| US5874233A (en) * | 1996-04-12 | 1999-02-23 | Cedars-Sinai Medical Center | Methods of diagnosing a clinical subtype of Crohn's disease with features of ulcerative colitis |
| US6074835A (en) * | 1996-04-12 | 2000-06-13 | Regents Of The Univ. Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 |
| US5968741A (en) * | 1997-04-11 | 1999-10-19 | Cedars-Sinai Medical Center | Methods of diagnosing a medically resistant clinical subtype of ulcerative colitis |
| US6514700B1 (en) * | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
| JP2001269196A (ja) * | 2000-03-24 | 2001-10-02 | Hamamatsu Photonics Kk | 被検体核酸の定量方法、および被検体核酸の分子数の計数方法 |
| US7138237B1 (en) * | 2000-05-19 | 2006-11-21 | Cedars-Sinai Medical Center | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen |
| US20030092019A1 (en) * | 2001-01-09 | 2003-05-15 | Millennium Pharmaceuticals, Inc. | Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia |
| US20040053263A1 (en) * | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
-
2003
- 2003-01-30 US US10/356,736 patent/US20040053263A1/en not_active Abandoned
- 2003-07-30 EP EP03791618A patent/EP1556405B1/de not_active Expired - Lifetime
- 2003-07-30 WO PCT/US2003/023926 patent/WO2004020968A2/en not_active Ceased
- 2003-07-30 AU AU2003263834A patent/AU2003263834A1/en not_active Abandoned
- 2003-07-30 JP JP2004532837A patent/JP4606877B2/ja not_active Expired - Fee Related
- 2003-07-30 AT AT03791618T patent/ATE462710T1/de not_active IP Right Cessation
- 2003-07-30 US US10/526,256 patent/US7790370B2/en not_active Expired - Lifetime
- 2003-07-30 DE DE60331941T patent/DE60331941D1/de not_active Expired - Lifetime
-
2010
- 2010-08-02 JP JP2010174021A patent/JP2011015686A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20070072180A1 (en) | 2007-03-29 |
| US7790370B2 (en) | 2010-09-07 |
| US20040053263A1 (en) | 2004-03-18 |
| WO2004020968A2 (en) | 2004-03-11 |
| EP1556405B1 (de) | 2010-03-31 |
| JP2011015686A (ja) | 2011-01-27 |
| AU2003263834A1 (en) | 2004-03-19 |
| WO2004020968A3 (en) | 2004-08-26 |
| JP4606877B2 (ja) | 2011-01-05 |
| EP1556405A2 (de) | 2005-07-27 |
| JP2006500016A (ja) | 2006-01-05 |
| AU2003263834A8 (en) | 2004-03-19 |
| DE60331941D1 (de) | 2010-05-12 |
| EP1556405A4 (de) | 2007-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |