ATE462973T1 - Diagnose und prävention der krebszellinvasion - Google Patents
Diagnose und prävention der krebszellinvasionInfo
- Publication number
- ATE462973T1 ATE462973T1 AT03763885T AT03763885T ATE462973T1 AT E462973 T1 ATE462973 T1 AT E462973T1 AT 03763885 T AT03763885 T AT 03763885T AT 03763885 T AT03763885 T AT 03763885T AT E462973 T1 ATE462973 T1 AT E462973T1
- Authority
- AT
- Austria
- Prior art keywords
- prevention
- cancer cell
- cell invasion
- diagnosis
- malignant disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02015944A EP1382969A1 (de) | 2002-07-17 | 2002-07-17 | Diagnose und Behandlung der Invasion von Krebszellen |
| PCT/EP2003/007786 WO2004008147A2 (en) | 2002-07-17 | 2003-07-17 | Diagnosis and prevention of cancer cell invasion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462973T1 true ATE462973T1 (de) | 2010-04-15 |
Family
ID=29762643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03763885T ATE462973T1 (de) | 2002-07-17 | 2003-07-17 | Diagnose und prävention der krebszellinvasion |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8277802B2 (de) |
| EP (4) | EP1382969A1 (de) |
| JP (2) | JP5419316B2 (de) |
| CN (2) | CN102349997A (de) |
| AT (1) | ATE462973T1 (de) |
| AU (2) | AU2003250984B2 (de) |
| CA (1) | CA2493111C (de) |
| DE (1) | DE60331921D1 (de) |
| DK (1) | DK1530724T3 (de) |
| ES (1) | ES2343950T3 (de) |
| WO (1) | WO2004008147A2 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7374886B2 (en) | 1999-04-09 | 2008-05-20 | Rigshospitalet | Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer |
| EP1171771B1 (de) | 1999-04-09 | 2005-06-29 | Rigshospitalet | Gewebeinhibitor der matrix-metalproteinase typ 1 (timp-1) als krebsmarker |
| EP1563094A4 (de) * | 2002-10-29 | 2007-04-25 | Rigel Pharmaceuticals Inc | Modulatoren der angiogenese und tumorigenese |
| EP1899482A2 (de) * | 2005-04-07 | 2008-03-19 | Novartis Vaccines and Diagnostics, Inc. | Ddr2 in der diagnose, dem nachweis und der behandlung von krebs |
| IN2014DN10515A (de) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| EP2114983B8 (de) | 2007-02-07 | 2015-02-18 | The Regents of the University of Colorado, A Body Corporate | Axl-tyrosinkinasehemmer sowie verfahren zu ihrer herstellung und verwendung |
| US20100255004A1 (en) * | 2007-04-13 | 2010-10-07 | Dana Farber Cancer Institute | Receptor tyrosine kinase profiling |
| ES2529790T3 (es) | 2007-04-13 | 2015-02-25 | Dana-Farber Cancer Institute, Inc. | Métodos de tratamiento de cáncer resistente a agentes terapéuticos de ERBB |
| WO2009005813A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| DK3059246T3 (en) | 2007-09-26 | 2018-10-01 | Chugai Pharmaceutical Co Ltd | Modified constant region of an antibody |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| AU2008317404B2 (en) * | 2007-10-19 | 2014-12-18 | Cell Signaling Technology, Inc. | Cancer classification and methods of use |
| CN101939336B (zh) * | 2007-11-12 | 2014-05-14 | U3制药有限公司 | Axl抗体 |
| TW200936160A (en) * | 2007-11-15 | 2009-09-01 | Chugai Pharmaceutical Co Ltd | Monoclonal antibodies that bind to anexelekto and uses thereof |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| US20120230991A1 (en) * | 2008-07-29 | 2012-09-13 | Douglas Kim Graham | Methods and compounds for enhancing anti-cancer therapy |
| SG174356A1 (en) * | 2009-03-13 | 2011-10-28 | Bergen Teknologioverforing As | Methods using axl as a biomarker of epithelial-to-mesnchymal transition |
| JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2409991B1 (de) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Variante einer konstanten antikörperregion |
| MX2011011825A (es) * | 2009-05-11 | 2011-12-06 | U3 Pharma Gmbh | Anticuerpos humanizados para axl. |
| EP2270053A1 (de) * | 2009-05-11 | 2011-01-05 | U3 Pharma GmbH | Humanisierte AXL-Antikörper |
| CN102459344A (zh) * | 2009-05-15 | 2012-05-16 | 中外制药株式会社 | 抗axl抗体 |
| AR077595A1 (es) | 2009-07-27 | 2011-09-07 | Genentech Inc | Tratamientos de combinacion |
| WO2011014872A2 (en) * | 2009-07-31 | 2011-02-03 | The Johns Hopkins University | Compositions and methods for diagnosing, treating or preventing neoplasias |
| US9074192B2 (en) | 2010-01-22 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL signaling in anti-metastatic therapy |
| CA2786149C (en) * | 2010-01-22 | 2019-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of axl signaling in anti-metastatic therapy |
| WO2011159980A1 (en) | 2010-06-18 | 2011-12-22 | Genentech, Inc. | Anti-axl antibodies and methods of use |
| EP2606364A4 (de) * | 2010-08-19 | 2014-04-16 | Howard Florey Inst | Tam-rezeptoren und tam-rezeptorliganden in der erfassung und modulation neuropathologischer krankheiten |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| US20130295578A1 (en) * | 2011-01-10 | 2013-11-07 | Trustees Of Dartmouth College | Methods for screening for drug resistance in cancer treatment |
| WO2012175692A1 (en) * | 2011-06-22 | 2012-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-axl antibodies and uses thereof |
| JP6033293B2 (ja) | 2011-06-22 | 2016-11-30 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル)Inserm(Institut National Dela Sante Et De La Recherche Medicale) | 抗Axl抗体及びその使用 |
| US9879061B2 (en) | 2011-12-15 | 2018-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis |
| US9499856B2 (en) | 2012-04-02 | 2016-11-22 | The Board Institute, Inc. | DDR2 mutations in squamous cell lung cancer |
| PT2931265T (pt) | 2012-12-14 | 2018-04-16 | Univ Leland Stanford Junior | Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática |
| JP5875054B2 (ja) * | 2013-02-13 | 2016-03-02 | 国立大学法人 東京大学 | がんの検査方法及び検査用キット |
| JP6195716B2 (ja) * | 2013-02-15 | 2017-09-13 | 富士レビオ株式会社 | 抗癌剤耐性診断マーカー |
| WO2015080047A1 (ja) | 2013-11-27 | 2015-06-04 | 株式会社カネカ | 細胞培養培地及びそれを用いた培養方法 |
| GB201322034D0 (en) | 2013-12-12 | 2014-01-29 | Almac Diagnostics Ltd | Prostate cancer classification |
| CA2935266C (en) * | 2014-01-03 | 2022-02-01 | Blanchette Rockefeller Neurosciences Institute | Convergence of aggregation rate with validated peripheral diagnostics for alzheimer's disease |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| JP2017205021A (ja) * | 2014-09-26 | 2017-11-24 | Jsr株式会社 | 初代癌細胞のスフェロイド作製方法、スフェロイド、スクリーニング方法、及び、診断方法 |
| US10137173B2 (en) | 2014-10-20 | 2018-11-27 | Aravive Biologics, Inc. | Antiviral activity of Gas6 inhibitor |
| AU2015366213B2 (en) | 2014-12-18 | 2021-10-07 | Bergenbio Asa | Anti-Axl antagonistic antibodies |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
| KR102606938B1 (ko) | 2016-04-15 | 2023-11-29 | 바이오아트라, 인코퍼레이티드 | 항 Axl항체 및 이의 면역접합체와 이것들의 용도 |
| EP3455261B1 (de) | 2016-05-13 | 2022-08-03 | BioAtla, Inc. | Anti-ror2-antikörper, antikörperfragmente, deren immunkonjugate und verwendungen davon |
| GB201610902D0 (en) | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
| US12187801B2 (en) | 2017-01-18 | 2025-01-07 | Exuma Biotech Corp. | Chimeric antigen receptors against AXL or ROR2 and methods of use thereof |
| KR102357045B1 (ko) | 2017-03-31 | 2022-01-28 | 뉴로디아그노스틱스 엘엘씨 | 알츠하이머 질환에 대한 림프구-기반 형태계측 시험 |
| WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| JP7029745B2 (ja) * | 2017-12-05 | 2022-03-04 | 国立大学法人金沢大学 | 膠芽腫マーカー及びその使用 |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| CN115916344A (zh) | 2020-04-08 | 2023-04-04 | 卑尔根生物股份公司 | 用于抗病毒疗法的axl抑制剂 |
| GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| DE4110405A1 (de) * | 1991-03-28 | 1992-10-01 | Birchmeier Walter Prof Dr | Verfahren zum nachweis der differenzierung und der invasivitaet von karzinomzellen |
| US5468634A (en) * | 1991-06-24 | 1995-11-21 | The University Of North Carolina At Chapel Hill | Axl oncogene |
| US5538861A (en) * | 1994-07-29 | 1996-07-23 | Amgen Inc. | DNA encoding a stimulating factor for the axl receptor |
| ES2315435T3 (es) | 1996-08-12 | 2009-04-01 | Celgene Corporation | Nuevos agentes inmunoterapeuticos y su uso para la reduccion de los niveles de citoquinas. |
| WO2000076309A2 (en) * | 1999-06-10 | 2000-12-21 | D.Collen Research Foundation Vzw | Non-human transgenic animals deficient in gas6 function and their use |
| US7442776B2 (en) * | 1999-10-08 | 2008-10-28 | Young David S F | Cancerous disease modifying antibodies |
| AU1339701A (en) * | 1999-10-22 | 2001-05-08 | Lifespan Biosciences, Inc. | Anti-cancer nucleic acid and protein targets |
| US20020068709A1 (en) * | 1999-12-23 | 2002-06-06 | Henrik Orum | Therapeutic uses of LNA-modified oligonucleotides |
| WO2001078778A1 (en) * | 2000-04-13 | 2001-10-25 | Vlaams Interuniversitair Instituut Voor Biotechnologie (Vib) | USE OF INHIBITION OF A Gas6 FUNCTION OR OF A Gas6 RECEPTOR FOR PREVENTING AND TREATING A CARDIOVASCULAR DISEASE |
| AU2002234799A1 (en) | 2000-12-08 | 2002-06-18 | Ipsogen | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| EP2003196A3 (de) * | 2003-06-09 | 2009-01-07 | The Regents of the University of Michigan | Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs |
-
2002
- 2002-07-17 EP EP02015944A patent/EP1382969A1/de not_active Withdrawn
-
2003
- 2003-07-17 JP JP2004520662A patent/JP5419316B2/ja not_active Expired - Fee Related
- 2003-07-17 CA CA2493111A patent/CA2493111C/en not_active Expired - Fee Related
- 2003-07-17 EP EP10185315A patent/EP2267454A3/de not_active Ceased
- 2003-07-17 DE DE60331921T patent/DE60331921D1/de not_active Expired - Lifetime
- 2003-07-17 US US10/521,410 patent/US8277802B2/en not_active Expired - Fee Related
- 2003-07-17 DK DK03763885.5T patent/DK1530724T3/da active
- 2003-07-17 EP EP10157827A patent/EP2228654A3/de not_active Withdrawn
- 2003-07-17 AU AU2003250984A patent/AU2003250984B2/en not_active Ceased
- 2003-07-17 ES ES03763885T patent/ES2343950T3/es not_active Expired - Lifetime
- 2003-07-17 EP EP03763885A patent/EP1530724B1/de not_active Expired - Lifetime
- 2003-07-17 CN CN2011103284459A patent/CN102349997A/zh active Pending
- 2003-07-17 AT AT03763885T patent/ATE462973T1/de not_active IP Right Cessation
- 2003-07-17 WO PCT/EP2003/007786 patent/WO2004008147A2/en not_active Ceased
- 2003-07-17 CN CNA03816955XA patent/CN1739030A/zh active Pending
-
2009
- 2009-12-22 AU AU2009251103A patent/AU2009251103B2/en not_active Ceased
-
2010
- 2010-08-02 JP JP2010173646A patent/JP2011024580A/ja active Pending
-
2012
- 2012-08-31 US US13/600,505 patent/US20130084300A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009251103B2 (en) | 2013-09-05 |
| DK1530724T3 (da) | 2010-08-02 |
| JP2011024580A (ja) | 2011-02-10 |
| JP2005532805A (ja) | 2005-11-04 |
| US20050186571A1 (en) | 2005-08-25 |
| US20130084300A1 (en) | 2013-04-04 |
| WO2004008147A3 (en) | 2004-05-27 |
| EP1530724A2 (de) | 2005-05-18 |
| EP2267454A3 (de) | 2011-03-30 |
| EP1382969A1 (de) | 2004-01-21 |
| CN102349997A (zh) | 2012-02-15 |
| AU2009251103A1 (en) | 2010-01-21 |
| EP1530724B1 (de) | 2010-03-31 |
| JP5419316B2 (ja) | 2014-02-19 |
| EP2228654A2 (de) | 2010-09-15 |
| AU2003250984A1 (en) | 2004-02-02 |
| US8277802B2 (en) | 2012-10-02 |
| CA2493111A1 (en) | 2004-01-22 |
| CN1739030A (zh) | 2006-02-22 |
| CA2493111C (en) | 2016-07-05 |
| EP2228654A3 (de) | 2011-01-05 |
| AU2003250984B2 (en) | 2009-10-08 |
| ES2343950T3 (es) | 2010-08-13 |
| DE60331921D1 (de) | 2010-05-12 |
| WO2004008147A2 (en) | 2004-01-22 |
| EP2267454A2 (de) | 2010-12-29 |
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