ATE464056T1 - Verfahren zur aktivierung von nkt-zellen - Google Patents

Verfahren zur aktivierung von nkt-zellen

Info

Publication number: ATE464056T1
Authority: AT; Austria
Prior art keywords: nkt cell; activation; nkt cells; cell; activating
Prior art date: 2004-09-03

Application number

AT05810863T

Other languages

English (en)

Inventor

Albert Bendelac

Dapeng Zhou

Luc Teyton

Paul Savage

Original Assignee

Univ Chicago

Scripps Research Inst

Univ Brigham Young

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-03

Filing date

2005-09-02

Publication date

2010-04-15

2005-09-02 Application filed by Univ Chicago, Scripps Research Inst, Univ Brigham Young filed Critical Univ Chicago

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE464056T1 publication Critical patent/ATE464056T1/de

Links

230000004913 activation Effects 0.000 title 1
210000000581 natural killer T-cell Anatomy 0.000 abstract 6
JMENXJYBCQFIRK-KRJDXUSZSA-N N-hexacosanoylisoglobotriaosyl ceramide Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@@H](CO)O1 JMENXJYBCQFIRK-KRJDXUSZSA-N 0.000 abstract 2
230000003213 activating effect Effects 0.000 abstract 2
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
239000002458 cell surface marker Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Oncology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT05810863T 2004-09-03 2005-09-02 Verfahren zur aktivierung von nkt-zellen ATE464056T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60694104P	2004-09-03	2004-09-03
PCT/US2005/031407 WO2006029010A2 (en)	2004-09-03	2005-09-02	Methods of activating nkt cells

Publications (1)

Publication Number	Publication Date
ATE464056T1 true ATE464056T1 (de)	2010-04-15

Family

ID=35945148

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05810863T ATE464056T1 (de)	2004-09-03	2005-09-02	Verfahren zur aktivierung von nkt-zellen

Country Status (10)

Country	Link
US (2)	US7998739B2 (de)
EP (1)	EP1786439B1 (de)
JP (1)	JP5005541B2 (de)
AT (1)	ATE464056T1 (de)
AU (1)	AU2005282684B9 (de)
CA (1)	CA2578052C (de)
DE (1)	DE602005020643D1 (de)
DK (1)	DK1786439T3 (de)
ES (1)	ES2344740T3 (de)
WO (1)	WO2006029010A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7645873B2 (en)	2003-03-20	2010-01-12	The Scripps Research Institute	6″-amino-6″-deoxygalactosylceramides
CA2578052C (en) *	2004-09-03	2013-08-13	The University Of Chicago	Methods of activating nkt cells
PT1848813E (pt)	2005-01-28	2013-07-15	Scripps Research Inst	Activação de glicolípidos bacterianos de células nkt restritas ao cd1d
DK2056842T3 (da)	2006-04-07	2013-01-14	Univ Chicago	Modificeret galactosylceramid til behandling af cancerøse sygdomme
EP2040541B1 (de) *	2006-06-30	2016-03-23	The Scripps Research Institute	Hilfsstoffe und verwendungsverfahren
JP5331100B2 (ja)	2007-04-25	2013-10-30	イミュアールエックス・インコーポレーテッド	Ｎｋｔアクチベータ、ｃｄ４０アゴニスト、及び任意選択的に抗原を含んでなるアジュバント組合せと、細胞性免疫において相乗的な増強を誘導するためのその使用
US8916164B2 (en) *	2007-08-29	2014-12-23	Abivax	Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (de)	2007-11-07	2009-05-13	Wittycell	NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel
EP2060252A1 (de)	2007-11-19	2009-05-20	Wittycell	Neue Formulierung von Galactosylceramid-Derivaten
RU2537188C2 (ru) *	2007-12-05	2014-12-27	Виттисель	Композиции и способы для усиления имунного ответа на антигены
JP5809560B2 (ja) *	2008-10-08	2015-11-11	アビヴァックス	インフルエンザに対して使用するためのワクチン組成物
WO2013033283A1 (en) *	2011-08-30	2013-03-07	Cornell University	Improving systemic glucose tolerance in type-2 diabetes
GB201506642D0 (en)	2015-04-20	2015-06-03	Ucl Business Plc	T cell receptor
GB201617714D0 (en)	2016-10-19	2016-11-30	Ucl Business Plc	T Cell receptor
GB201617716D0 (en)	2016-10-19	2016-11-30	Ucl Business Plc	Cell
IL309689B1 (en) *	2017-02-28	2026-02-01	Univ Central Florida Res Found Inc	PM21 particles to enhance NK cell migration to the bone marrow

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3495740B2 (ja) *	1997-04-10	2004-02-09	麒麟麦酒株式会社	α−グリコシルセラミドを含有するＮＫＴ細胞活性化剤
EP1434859A2 (de)	2001-07-25	2004-07-07	New York University	Verwendung von glycosylceramiden als adjuvantien für vakzine gegen infektionen und krebs
AU2003251518B2 (en)	2002-06-13	2009-07-02	New York University	Synthetic C-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
CA2578052C (en) *	2004-09-03	2013-08-13	The University Of Chicago	Methods of activating nkt cells

2005
- 2005-09-02 CA CA2578052A patent/CA2578052C/en not_active Expired - Fee Related
- 2005-09-02 ES ES05810863T patent/ES2344740T3/es not_active Expired - Lifetime
- 2005-09-02 DE DE602005020643T patent/DE602005020643D1/de not_active Expired - Lifetime
- 2005-09-02 EP EP05810863A patent/EP1786439B1/de not_active Expired - Lifetime
- 2005-09-02 JP JP2007530414A patent/JP5005541B2/ja not_active Expired - Fee Related
- 2005-09-02 WO PCT/US2005/031407 patent/WO2006029010A2/en not_active Ceased
- 2005-09-02 US US11/218,906 patent/US7998739B2/en not_active Expired - Fee Related
- 2005-09-02 DK DK05810863.0T patent/DK1786439T3/da active
- 2005-09-02 AU AU2005282684A patent/AU2005282684B9/en not_active Ceased
- 2005-09-02 AT AT05810863T patent/ATE464056T1/de not_active IP Right Cessation
2010
- 2010-10-11 US US12/901,971 patent/US20110082106A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2005282684B2 (en)	2011-03-10
WO2006029010A3 (en)	2006-09-08
DE602005020643D1 (de)	2010-05-27
EP1786439A2 (de)	2007-05-23
ES2344740T3 (es)	2010-09-06
US20060073118A1 (en)	2006-04-06
CA2578052C (en)	2013-08-13
CA2578052A1 (en)	2006-03-16
EP1786439B1 (de)	2010-04-14
JP5005541B2 (ja)	2012-08-22
AU2005282684B9 (en)	2011-07-07
WO2006029010A2 (en)	2006-03-16
JP2008512093A (ja)	2008-04-24
DK1786439T3 (da)	2010-07-12
US7998739B2 (en)	2011-08-16
US20110082106A1 (en)	2011-04-07
AU2005282684A1 (en)	2006-03-16

Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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