ATE464056T1 - Verfahren zur aktivierung von nkt-zellen - Google Patents

Verfahren zur aktivierung von nkt-zellen

Info

Publication number: ATE464056T1
Authority: AT; Austria
Prior art keywords: nkt cell; activation; nkt cells; cell; activating
Prior art date: 2004-09-03

Application number

AT05810863T

Other languages

English (en)

Inventor

Albert Bendelac

Dapeng Zhou

Luc Teyton

Paul Savage

Original Assignee

Univ Chicago

Scripps Research Inst

Univ Brigham Young

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-03

Filing date

2005-09-02

Publication date

2010-04-15

2005-09-02 Application filed by Univ Chicago, Scripps Research Inst, Univ Brigham Young filed Critical Univ Chicago

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE464056T1 publication Critical patent/ATE464056T1/de

Links

230000004913 activation Effects 0.000 title 1
210000000581 natural killer T-cell Anatomy 0.000 abstract 6
JMENXJYBCQFIRK-KRJDXUSZSA-N N-hexacosanoylisoglobotriaosyl ceramide Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@@H](CO)O1 JMENXJYBCQFIRK-KRJDXUSZSA-N 0.000 abstract 2
230000003213 activating effect Effects 0.000 abstract 2
102000004127 Cytokines Human genes 0.000 abstract 1
108090000695 Cytokines Proteins 0.000 abstract 1
239000002458 cell surface marker Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Cell Biology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Oncology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT05810863T 2004-09-03 2005-09-02 Verfahren zur aktivierung von nkt-zellen ATE464056T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60694104P	2004-09-03	2004-09-03
PCT/US2005/031407 WO2006029010A2 (en)	2004-09-03	2005-09-02	Methods of activating nkt cells

Publications (1)

Publication Number	Publication Date
ATE464056T1 true ATE464056T1 (de)	2010-04-15

Family

ID=35945148

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05810863T ATE464056T1 (de)	2004-09-03	2005-09-02	Verfahren zur aktivierung von nkt-zellen

Country Status (10)

Country	Link
US (2)	US7998739B2 (de)
EP (1)	EP1786439B1 (de)
JP (1)	JP5005541B2 (de)
AT (1)	ATE464056T1 (de)
AU (1)	AU2005282684B9 (de)
CA (1)	CA2578052C (de)
DE (1)	DE602005020643D1 (de)
DK (1)	DK1786439T3 (de)
ES (1)	ES2344740T3 (de)
WO (1)	WO2006029010A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7645873B2 (en)	2003-03-20	2010-01-12	The Scripps Research Institute	6″-amino-6″-deoxygalactosylceramides
DK1786439T3 (da) *	2004-09-03	2010-07-12	Univ Chicago	Fremgangsmåder til aktivering af NKT-celler
DK1848813T3 (da)	2005-01-28	2013-07-15	Univ Brigham Young	Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
WO2007118234A2 (en)	2006-04-07	2007-10-18	The Scripps Research Institute	Modified -galactosyl ceramides for staining and stimulating natural killer t cells
AU2007269299B2 (en) *	2006-06-30	2013-01-17	Brigham Young University	Adjuvants and methods of use
WO2008133983A1 (en) *	2007-04-25	2008-11-06	Immurx, Inc.	Adjuvant combinations of nkt activator, cd40 agonist, and optional antigen, the use through inducing synergistic cellular immunity
US8916164B2 (en) *	2007-08-29	2014-12-23	Abivax	Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (de) *	2007-11-07	2009-05-13	Wittycell	NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel
EP2060252A1 (de)	2007-11-19	2009-05-20	Wittycell	Neue Formulierung von Galactosylceramid-Derivaten
BRPI0820960B8 (pt)	2007-12-05	2021-05-25	Abivax	composição, composição farmacêutica, e uso da composição
US9220767B2 (en) *	2008-10-08	2015-12-29	Abivax	Vaccine composition for use against influenza
US9623083B2 (en)	2011-08-30	2017-04-18	Cornell University	Method to screen for an activator of adipose-resident NK cells
GB201506642D0 (en)	2015-04-20	2015-06-03	Ucl Business Plc	T cell receptor
GB201617716D0 (en)	2016-10-19	2016-11-30	Ucl Business Plc	Cell
GB201617714D0 (en)	2016-10-19	2016-11-30	Ucl Business Plc	T Cell receptor
AU2018227801B2 (en) *	2017-02-28	2024-02-22	Research Institute At Nationwide Children's Hospital	PM21 particles to improve bone marrow homing of NK cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1520583B1 (de)	1997-04-10	2009-01-28	Kyowa Hakko Kirin Co., Ltd.	NKT-Zellenaktivatoren, die Alpha-Glycosylceramide enthalten
AU2002327338A1 (en) *	2001-07-25	2003-02-17	New York University	Use of glycosylceramides as adjuvants for vaccines against infections and cancer
WO2003105769A2 (en) *	2002-06-13	2003-12-24	New York University	Synthetic c-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
DK1786439T3 (da) *	2004-09-03	2010-07-12	Univ Chicago	Fremgangsmåder til aktivering af NKT-celler

2005
- 2005-09-02 DK DK05810863.0T patent/DK1786439T3/da active
- 2005-09-02 US US11/218,906 patent/US7998739B2/en not_active Expired - Fee Related
- 2005-09-02 DE DE602005020643T patent/DE602005020643D1/de not_active Expired - Lifetime
- 2005-09-02 CA CA2578052A patent/CA2578052C/en not_active Expired - Fee Related
- 2005-09-02 ES ES05810863T patent/ES2344740T3/es not_active Expired - Lifetime
- 2005-09-02 JP JP2007530414A patent/JP5005541B2/ja not_active Expired - Fee Related
- 2005-09-02 AT AT05810863T patent/ATE464056T1/de not_active IP Right Cessation
- 2005-09-02 EP EP05810863A patent/EP1786439B1/de not_active Expired - Lifetime
- 2005-09-02 AU AU2005282684A patent/AU2005282684B9/en not_active Ceased
- 2005-09-02 WO PCT/US2005/031407 patent/WO2006029010A2/en not_active Ceased
2010
- 2010-10-11 US US12/901,971 patent/US20110082106A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1786439A2 (de)	2007-05-23
CA2578052C (en)	2013-08-13
CA2578052A1 (en)	2006-03-16
US7998739B2 (en)	2011-08-16
AU2005282684A1 (en)	2006-03-16
JP2008512093A (ja)	2008-04-24
AU2005282684B2 (en)	2011-03-10
EP1786439B1 (de)	2010-04-14
DK1786439T3 (da)	2010-07-12
AU2005282684B9 (en)	2011-07-07
ES2344740T3 (es)	2010-09-06
US20060073118A1 (en)	2006-04-06
US20110082106A1 (en)	2011-04-07
DE602005020643D1 (de)	2010-05-27
JP5005541B2 (ja)	2012-08-22
WO2006029010A3 (en)	2006-09-08
WO2006029010A2 (en)	2006-03-16

Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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