ATE465170T1 - Neue polypeptide und anti-hiv-arzneimittel, die diese enthalten - Google Patents

Neue polypeptide und anti-hiv-arzneimittel, die diese enthalten

Info

Publication number: ATE465170T1
Authority: AT; Austria
Prior art keywords: residue; citrulline; alanine; ornithine; lysine
Prior art date: 2000-09-05

Application number

AT01963414T

Other languages

English (en)

Inventor

Nobutaka Fujii

Original Assignee

Biokine Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-09-05

Filing date

2001-09-05

Publication date

2010-05-15

2001-09-05 Application filed by Biokine Therapeutics Ltd filed Critical Biokine Therapeutics Ltd

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE465170T1 publication Critical patent/ATE465170T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
239000002259 anti human immunodeficiency virus agent Substances 0.000 title 1
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 4
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 3
239000004472 Lysine Substances 0.000 abstract 3
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 3
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 3
229960002173 citrulline Drugs 0.000 abstract 3
235000013477 citrulline Nutrition 0.000 abstract 3
229960003646 lysine Drugs 0.000 abstract 3
239000004475 Arginine Substances 0.000 abstract 2
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 2
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 2
229960003121 arginine Drugs 0.000 abstract 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
229960003104 ornithine Drugs 0.000 abstract 2
NSHFIBIUHBWAOX-SFYZADRCSA-N (2s)-1-[(2r)-2,5-diaminopentanoyl]pyrrolidine-2-carboxylic acid Chemical group NCCC[C@@H](N)C(=O)N1CCC[C@H]1C(O)=O NSHFIBIUHBWAOX-SFYZADRCSA-N 0.000 abstract 1
AIXUQKMMBQJZCU-BDAKNGLRSA-N (2s)-1-[(2r)-2,6-diaminohexanoyl]pyrrolidine-2-carboxylic acid Chemical group NCCCC[C@@H](N)C(=O)N1CCC[C@H]1C(O)=O AIXUQKMMBQJZCU-BDAKNGLRSA-N 0.000 abstract 1
IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
-1 prolyl-D-ornithine Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/857—Fish; fish eggs; shell fish; crustacea

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Insects & Arthropods (AREA)
Virology (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT01963414T 2000-09-05 2001-09-05 Neue polypeptide und anti-hiv-arzneimittel, die diese enthalten ATE465170T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2000269296		2000-09-05
JP2001092306		2001-03-28
PCT/JP2001/007668 WO2002020561A1 (en)	2000-09-05	2001-09-05	Novel polypeptides and anti-hiv drugs containing the same

Publications (1)

Publication Number	Publication Date
ATE465170T1 true ATE465170T1 (de)	2010-05-15

Family

ID=26599311

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01963414T ATE465170T1 (de)	2000-09-05	2001-09-05	Neue polypeptide und anti-hiv-arzneimittel, die diese enthalten

Country Status (8)

Country	Link
US (2)	US7138488B2 (de)
EP (1)	EP1323730B1 (de)
JP (1)	JP4808363B2 (de)
AT (1)	ATE465170T1 (de)
AU (1)	AU2001284419A1 (de)
CA (1)	CA2421183C (de)
DE (1)	DE60136373D1 (de)
WO (1)	WO2002020561A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8435939B2 (en) *	2000-09-05	2013-05-07	Biokine Therapeutics Ltd.	Polypeptide anti-HIV agent containing the same
JP4781621B2 (ja) *	2002-08-27	2011-09-28	バイオカインセラピューティックスリミテッド	Ｃｘｃｒ４拮抗薬およびその用途
EP2426139B1 (de)	2002-08-27	2014-10-01	Biokine Therapeutics Ltd.	CXCR4-Antagonisten und Verwendung davon
EP1898943B1 (de) *	2005-05-25	2012-10-10	Hadasit Medical Research Services & Development Ltd.	Cxcr4-antagonisten für wundheilung und reepithelialisierung
EP3011961B1 (de)	2006-12-21	2020-11-11	Biokine Therapeutics LTD.	4f-benzoyl-tn14003 für die mobilisierung von hämotopoietischen vorläuferzellen im hinblick auf transplantation
US9427456B2 (en)	2009-06-14	2016-08-30	Biokine Therapeutics Ltd.	Peptide therapy for increasing platelet levels
WO2012095849A1 (en)	2011-01-10	2012-07-19	Biokine Therapeutics Ltd.	Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma
WO2013160895A1 (en)	2012-04-24	2013-10-31	Biokine Therapeutics Ltd.	Peptides and use thereof in the treatment of large cell lung cancer
CN105163749B (zh)	2013-03-24	2018-03-27	拜欧肯治疗有限公司	治疗骨髓性白血病的方法
EP3062809B1 (de)	2013-10-31	2020-07-08	Biokine Therapeutics Ltd.	Ein cxcr4 peptide inhibitor zur behandlung von akuter myeloischer leukämie mit einer flt3-mutation
JP2017506259A (ja)	2014-02-03	2017-03-02	イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドＹｉｓｓｕｍＲｅｓｅａｒｃｈＤｅｖｅｌｏｐｍｅｎｔＣｏｍｐａｎｙＯｆＴｈｅＨｅｂｒｅｗＵｎｉｖｅｒｓｉｔｙＯｆＪｅｒｕｓａｌｅｍＬｔｄ．	幹細胞を枯渇させるためのカゼインキナーゼｉ阻害剤の使用
MX2017016844A (es)	2015-07-16	2018-08-15	Biokine Therapeutics Ltd	Composiciones y procedimientos para tratar cancer.
WO2017021963A1 (en)	2015-08-03	2017-02-09	Biokine Therapeutics Ltd.	Cxcr4 binding agents for treatment of diseases
CA3014530A1 (en)	2016-02-23	2017-08-31	Biolinerx Ltd.	Methods of treating acute myeloid leukemia
WO2020065647A1 (en)	2018-09-25	2020-04-02	Biolinerx Ltd.	Methods of selecting treatment for cxcr4-associated cancer
WO2020079692A1 (en)	2018-10-17	2020-04-23	Biolinerx Ltd.	Treatment of metastatic pancreatic adenocarcinoma
US12268725B2 (en)	2020-12-30	2025-04-08	Biolinerx Ltd.	Composition of BL-8040
EP4271697A4 (de)	2020-12-30	2024-11-20	BioLineRx Ltd.	Verfahren zur herstellung von peptiden
WO2025224720A1 (en)	2024-04-24	2025-10-30	Biolinerx Ltd.	Methods of selecting treatment regimen against solid tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69416824T2 (de)	1993-10-14	1999-07-08	Seikagaku Corp., Tokio/Tokyo	Polypeptide und daraus hergestellte, gegen hiv wirksame substanzen
DE69914463T2 (de)	1998-03-13	2004-11-11	The University Of British Columbia, Vancouver	Therapeutische chemokine rezeptor antagonisten
AU2001236065A1 (en) *	2000-03-03	2001-09-12	Nobutaka Fujii	Antiviral compounds
EP2426139B1 (de)	2002-08-27	2014-10-01	Biokine Therapeutics Ltd.	CXCR4-Antagonisten und Verwendung davon

2001
- 2001-09-05 EP EP01963414A patent/EP1323730B1/de not_active Expired - Lifetime
- 2001-09-05 US US10/363,209 patent/US7138488B2/en not_active Expired - Lifetime
- 2001-09-05 CA CA2421183A patent/CA2421183C/en not_active Expired - Lifetime
- 2001-09-05 JP JP2002525180A patent/JP4808363B2/ja not_active Expired - Fee Related
- 2001-09-05 AU AU2001284419A patent/AU2001284419A1/en not_active Abandoned
- 2001-09-05 WO PCT/JP2001/007668 patent/WO2002020561A1/ja not_active Ceased
- 2001-09-05 DE DE60136373T patent/DE60136373D1/de not_active Expired - Lifetime
- 2001-09-05 AT AT01963414T patent/ATE465170T1/de not_active IP Right Cessation
2006
- 2006-08-01 US US11/497,225 patent/US7595298B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60136373D1 (de)	2008-12-11
WO2002020561A1 (en)	2002-03-14
CA2421183A1 (en)	2003-03-04
EP1323730B1 (de)	2010-04-21
US7138488B2 (en)	2006-11-21
US7595298B2 (en)	2009-09-29
US20060264605A1 (en)	2006-11-23
JP4808363B2 (ja)	2011-11-02
AU2001284419A1 (en)	2002-03-22
CA2421183C (en)	2015-06-16
EP1323730A4 (de)	2005-01-05
US20040116655A1 (en)	2004-06-17
JPWO2002020561A1 (ja)	2004-01-15
EP1323730A1 (de)	2003-07-02

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60136373D1 (de)	2008-12-11	Neue polypeptide und anti-hiv-arzneimittel, die diese enthalten
RU95112539A (ru)	1997-06-27	Новый полипептид и фармацевтическая композиция против вич-инфекции
Büllesbach et al.	2000	The relaxin receptor-binding site geometry suggests a novel gripping mode of interaction
WO2000012542A3 (en)	2000-06-29	Cytotoxic lactoferrin derivatives modified by bulky or lipophilic moieties
ES8802161A1 (es)	1988-04-01	Procedimiento para la obtencion de peptidos
DE69429176D1 (en)	2002-01-03	Protegrine
ATE213499T1 (de)	2002-03-15	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
DE60144561D1 (de)	2011-06-16	N- und/oder c-terminal mit kurzen geladenen peptidsequenzen modifizierte peptide
WO2002048180A3 (de)	2003-01-30	Peptide und/oder proteine sowie verwendung desselben zur herstellung eines therapeutischen und/oder präventiven arzneimittels
GR3014915T3 (en)	1995-05-31	Novel polypeptides with affinity to lipopolysaccharides and their uses.
CA2334941A1 (en)	2000-02-24	Tnf-derived peptides for use in treating oedema
ATE143024T1 (de)	1996-10-15	Aminoacyl und oligopeptidylderivate von allopurinol mit immunostimulierender wirkung und diese enthaltende pharmazeutische zubereitungen
WO2001027136A3 (fr)	2001-12-13	Peptides ayant une activite de stimulation de la reponse immunitaire et de regeneration tissulaire
DE69329899D1 (de)	2001-03-08	Behandlung von tropikalischer spastischer Paresis mit Peptide T
ATE3416T1 (de)	1983-06-15	Pharmakologisch aktive peptide und diese enthaltende arzneimittel.
GR3020507T3 (en)	1996-10-31	New peptide derivatives, process to prepare them and their use as medicaments
AU2676399A (en)	1999-08-30	Novel cystine knot protein and materials and methods for making it
ATE46173T1 (de)	1989-09-15	Pharmakologisch aktive peptide.
ES416516A1 (es)	1976-03-01	Un procedimiento para la preparacion de nonapeptidos.
JPH0160003B2 (de)	1989-12-20
TH21704A (th)	1996-11-13	เพพไทด์ชนิดใหม่ที่มีผลปรับภูมิคุ้มกัน
ATE207496T1 (de)	2001-11-15	Neue peptide und nootroper wirkstoff