ATE465269T1 - Verbessertes biotransformationsverfahren unter verwendung von transaminase - Google Patents

Verbessertes biotransformationsverfahren unter verwendung von transaminase

Info

Publication number
ATE465269T1
ATE465269T1 AT98923497T AT98923497T ATE465269T1 AT E465269 T1 ATE465269 T1 AT E465269T1 AT 98923497 T AT98923497 T AT 98923497T AT 98923497 T AT98923497 T AT 98923497T AT E465269 T1 ATE465269 T1 AT E465269T1
Authority
AT
Austria
Prior art keywords
transaminase
amino acid
biotransformation process
pyruvate
produce
Prior art date
Application number
AT98923497T
Other languages
English (en)
Inventor
Ian Fotheringham
Original Assignee
Chemtura Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemtura Corp filed Critical Chemtura Corp
Application granted granted Critical
Publication of ATE465269T1 publication Critical patent/ATE465269T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01006—Acetolactate synthase (2.2.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT98923497T 1997-05-19 1998-05-19 Verbessertes biotransformationsverfahren unter verwendung von transaminase ATE465269T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/858,111 US6197558B1 (en) 1997-05-19 1997-05-19 Transaminase biotransformation process
PCT/US1998/010169 WO1998053088A1 (en) 1997-05-19 1998-05-19 Improved transaminase biotransformation process

Publications (1)

Publication Number Publication Date
ATE465269T1 true ATE465269T1 (de) 2010-05-15

Family

ID=25327508

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98923497T ATE465269T1 (de) 1997-05-19 1998-05-19 Verbessertes biotransformationsverfahren unter verwendung von transaminase

Country Status (8)

Country Link
US (1) US6197558B1 (de)
EP (1) EP0983372B1 (de)
JP (1) JP4108766B2 (de)
AT (1) ATE465269T1 (de)
AU (1) AU7578298A (de)
CA (1) CA2290065A1 (de)
DE (1) DE69841626D1 (de)
WO (1) WO1998053088A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023609A1 (en) * 1998-10-19 2000-04-27 Nsc Technologies Llc Transaminase biotransformation process employing glutamic acid
DE19919848A1 (de) * 1999-04-30 2000-11-02 Aventis Cropscience Gmbh Verfahren zur Herstellung von L-Phosphinothricin durch enzymatische Transaminierung mit Aspartat
US6457398B1 (en) * 2001-07-03 2002-10-01 Man Tat Wong Method and device for automatically turning and displaying music sheets
AU2002328982A1 (en) * 2001-08-03 2003-02-24 Basf Aktiengesellschaft Improved method and composition for determining resistance to an acetohydroxyacid synthase inhibitor
US20050009151A1 (en) * 2003-07-10 2005-01-13 Pharmacia Corporation Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
EP1818411A1 (de) * 2006-02-13 2007-08-15 Lonza AG Verfahren zur Herstellung von optisch aktiven chiralen Aminen
EP2022852B8 (de) 2006-05-29 2017-08-23 Kaneka Corporation Verfahren zur herstellung einer optisch aktiven aminverbindung, rekombinanter vektor und den vektor tragende transformante
CN1986777B (zh) * 2006-07-11 2010-09-08 湖北大学 活体催化工程菌及利用α-酮酸生产L型非天然疏水性氨基酸的方法
EP2132322A4 (de) * 2007-03-02 2013-02-20 Richmond Chemical Corp Verfahren zur erhöhung der ausbeute und verbesserung der reinigung von produkten aus transaminasereaktionen
CN104651381A (zh) 2008-01-03 2015-05-27 巴斯夫酶有限责任公司 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法
HUE052297T2 (hu) 2009-01-08 2021-04-28 Codexis Inc Transzamináz polipeptidek
WO2011005477A1 (en) 2009-06-22 2011-01-13 Codexis, Inc. Transaminase reactions
WO2011100265A2 (en) 2010-02-10 2011-08-18 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
HUE038434T2 (hu) 2010-06-17 2018-10-29 Codexis Inc Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez
KR20120098235A (ko) * 2011-02-28 2012-09-05 이화여자대학교 산학협력단 비천연 아미노산 생산 균주 및 이를 이용한 비천연 아미노산의 제조 방법
SG11201504752YA (en) 2012-12-21 2015-07-30 Codexis Inc Engineered biocatalysts and methods for synthesizing chiral amines
US9617573B2 (en) 2013-02-28 2017-04-11 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
EP3638688A4 (de) 2017-06-14 2021-07-07 Codexis, Inc. Manipulierte transaminase-polypeptide für industrielle biokatalyse
JP7601774B2 (ja) 2018-10-04 2024-12-17 アンナ・ユニバーシティ シトラマル酸、シトラコン酸又は２－オキソ酪酸からのｌ－２－アミノ酪酸の生成
CA3126671A1 (en) 2019-01-15 2020-07-23 Codexis, Inc. Engineered transaminase polypeptides
EP4133064A4 (de) 2020-04-10 2024-07-24 Codexis, Inc. Gentechnisch hergestellte transaminasepolypeptide
EP4217502A4 (de) 2020-09-28 2024-12-11 Codexis, Inc. Manipulierte biokatalysatoren und verfahren zur synthese chiraler amine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518692A (en) 1983-09-01 1985-05-21 Genetics Institute, Inc. Production of L-amino acids by transamination
US4826766A (en) 1985-09-23 1989-05-02 Genetics Institute, Inc. Production of amino acids using coupled aminotransferases
US4880738A (en) 1986-06-13 1989-11-14 Genetics Institute, Inc. Production of amino acids using coupled enzyme systems
US5316943A (en) * 1988-06-14 1994-05-31 Kidman Gene E Racemic conversion of using a transaminase
ATE171214T1 (de) * 1991-02-22 1998-10-15 Unilever Nv Verfahren zur herstellung einer alpha- acetomilchsäure

Also Published As

Publication number Publication date
JP4108766B2 (ja) 2008-06-25
DE69841626D1 (de) 2010-06-02
EP0983372A1 (de) 2000-03-08
CA2290065A1 (en) 1998-11-26
US6197558B1 (en) 2001-03-06
WO1998053088A1 (en) 1998-11-26
AU7578298A (en) 1998-12-11
JP2002514921A (ja) 2002-05-21
EP0983372B1 (de) 2010-04-21

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