ATE466107T1 - Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe - Google Patents
Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probeInfo
- Publication number
- ATE466107T1 ATE466107T1 AT05767727T AT05767727T ATE466107T1 AT E466107 T1 ATE466107 T1 AT E466107T1 AT 05767727 T AT05767727 T AT 05767727T AT 05767727 T AT05767727 T AT 05767727T AT E466107 T1 ATE466107 T1 AT E466107T1
- Authority
- AT
- Austria
- Prior art keywords
- capture
- nucleic acid
- hairpin
- methods
- sample
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58542104P | 2004-07-01 | 2004-07-01 | |
| PCT/US2005/023555 WO2006007567A2 (en) | 2004-07-01 | 2005-06-29 | Methods and compositions to detect nucleic acids in a biological sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466107T1 true ATE466107T1 (de) | 2010-05-15 |
Family
ID=35457287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05767727T ATE466107T1 (de) | 2004-07-01 | 2005-06-29 | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8034554B2 (de) |
| EP (1) | EP1778867B1 (de) |
| JP (1) | JP5020818B2 (de) |
| AT (1) | ATE466107T1 (de) |
| AU (2) | AU2005262357B2 (de) |
| CA (1) | CA2572472C (de) |
| DE (1) | DE602005020943D1 (de) |
| DK (1) | DK1778867T3 (de) |
| WO (1) | WO2006007567A2 (de) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006007567A2 (en) | 2004-07-01 | 2006-01-19 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
| DE602005022759D1 (de) * | 2004-12-08 | 2010-09-16 | Gen Probe Inc | Nukleinsäuredetektion aus verschiedenen typen des humanen papillomavirus |
| US7993853B2 (en) * | 2005-05-06 | 2011-08-09 | Gen-Probe Incorporated | Methods of nucleic acid target capture |
| US8632970B2 (en) * | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
| WO2007035685A2 (en) * | 2005-09-16 | 2007-03-29 | Primera Biosystems, Inc. | Compositions and methods for purifying nucleic acids |
| AU2006304721B2 (en) | 2005-10-17 | 2012-01-19 | Gen-Probe Incorporated | Compositions and methods to detect Legionella pneumophila nucleic acid |
| JP5777269B2 (ja) | 2006-02-13 | 2015-09-09 | フリューダイム カナダ インコーポレイテッド | 元素分析によって実施される遺伝子発現アッセイ |
| CA2651946A1 (en) * | 2006-05-12 | 2007-11-22 | Gen-Probe Incorporated | Compositions and methods to detect enterococci nucleic acid |
| DE602007012045D1 (de) | 2006-06-06 | 2011-03-03 | Gen Probe Inc | Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren |
| WO2008052774A2 (en) * | 2006-10-31 | 2008-05-08 | Noxxon Pharma Ag | Methods for detection of a single- or double-stranded nucleic acid molecule |
| AU2014200826B2 (en) * | 2006-11-06 | 2016-01-14 | Clondiag Gmbh | Assays |
| CN101553306B (zh) * | 2006-11-06 | 2013-04-03 | 科隆迪亚戈有限公司 | 使用结合元件用于分析的装置和方法 |
| AU2016202243B2 (en) * | 2006-11-06 | 2017-12-14 | Clondiag Gmbh | Assays |
| WO2008080029A2 (en) | 2006-12-21 | 2008-07-03 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| EP1978111B1 (de) | 2007-04-02 | 2013-03-27 | Gen-Probe Incorporated | Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa |
| WO2009013321A2 (en) | 2007-07-23 | 2009-01-29 | Clondiag Gmbh | Assays |
| US20090162845A1 (en) * | 2007-12-20 | 2009-06-25 | Elazar Rabbani | Affinity tag nucleic acid and protein compositions, and processes for using same |
| EP2235214B1 (de) * | 2007-12-26 | 2014-07-09 | Gen Probe Inc | Zusammensetzungen und verfahren für den nachweis von candida albicans-nukleinsäure |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| EP2806037B1 (de) | 2008-05-13 | 2016-09-21 | Gen-Probe Incorporated | Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen |
| CA2723917A1 (en) * | 2008-05-30 | 2009-12-30 | Gen-Probe Incorporated | Compositions, kits and related methods for the detection and/or monitoring of salmonella |
| WO2010009398A1 (en) * | 2008-07-18 | 2010-01-21 | Xenomics, Inc. | Methods for pcr-based detection of "ultra short" nucleic acid sequences |
| AU2009324884B2 (en) * | 2008-11-25 | 2013-10-03 | Gen-Probe Incorporated | Compositions and methods for detecting small RNAs, and uses thereof |
| EP2389449B1 (de) | 2008-12-30 | 2015-02-18 | Gen-Probe Incorporated | Zusammensetzungen, kits und damit verbundene verfahren zum nachweis und/oder überwachen von listerien |
| EP2446057B1 (de) | 2009-06-23 | 2014-11-19 | Gen-Probe Incorporated | Zusammensetzungen und verfahren für den nukleinsäurenachweis aus mollicutes |
| CA2766391C (en) | 2009-07-01 | 2021-04-20 | Gen-Probe Incorporated | Methods and compositions for multiplex nucleic acid amplification |
| WO2011026139A1 (en) | 2009-08-31 | 2011-03-03 | Gen-Probe Incorporated | Dengue virus assay |
| EP3604558B1 (de) | 2010-02-17 | 2022-10-12 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von atopobium-vaginae-nukleinsäure |
| EP3587593B1 (de) | 2010-04-21 | 2023-09-27 | Gen-Probe Incorporated | Zusammensetzungen, verfahren und kits für den nachweis von nukleinsäuren des herpes-simplex-virus |
| WO2012030856A2 (en) | 2010-08-30 | 2012-03-08 | Gen-Probe Incorporated | Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus |
| EP2616555B1 (de) * | 2010-09-16 | 2017-11-08 | Gen-Probe Incorporated | Über l-nukleotidenden immobilisierbare fängersonden |
| EP3438289A1 (de) | 2010-10-04 | 2019-02-06 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren |
| AU2011323478B2 (en) | 2010-11-01 | 2015-09-10 | Gen-Probe Incorporated | Integrated capture and amplification of target nucleic acid for sequencing |
| USRE49975E1 (en) | 2011-03-10 | 2024-05-21 | Gen-Probe Incorporated | Methods and compositions for the selection and optimization of oligonucleotide tag sequences |
| EP3604559A1 (de) | 2011-04-25 | 2020-02-05 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure |
| CA3113828A1 (en) | 2011-07-15 | 2013-01-24 | Gen-Probe Incorporated | Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays |
| EP4219741A3 (de) | 2011-09-06 | 2023-08-23 | Gen-Probe Incorporated | Geschlossene nukleinsäurestrukturen |
| EP3255155B1 (de) | 2011-09-08 | 2019-04-24 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure |
| US9175337B2 (en) | 2011-09-21 | 2015-11-03 | Gen-Probe Incorporated | Methods for amplifying nucleic acid using tag-mediated displacement |
| WO2013049135A1 (en) | 2011-09-26 | 2013-04-04 | Gen-Probe Incorporated | Algorithms for sequence determinations |
| DE102011120550B4 (de) | 2011-12-05 | 2013-11-07 | Gen-Probe Prodesse, Inc. | Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren |
| EP2809807B1 (de) * | 2012-02-01 | 2019-04-10 | Gen-Probe Incorporated | Asymmetrische hairpin-target-capture-oligomere |
| US11098375B2 (en) | 2012-02-24 | 2021-08-24 | Gen-Probe Prodesse, Inc. | Detection of Shiga toxin genes in bacteria |
| JP6196611B2 (ja) * | 2012-03-05 | 2017-09-13 | 日本碍子株式会社 | 標的核酸の検出方法 |
| AU2013205110B2 (en) | 2012-04-24 | 2016-10-13 | Gen-Probe Incorporated | Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids |
| AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
| CN104755630B (zh) | 2012-08-30 | 2019-01-11 | 简·探针公司 | 多阶段核酸扩增 |
| AU2013205122B2 (en) | 2012-10-11 | 2016-11-10 | Gen-Probe Incorporated | Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid |
| AU2013205090B2 (en) | 2012-12-07 | 2016-07-28 | Gen-Probe Incorporated | Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid |
| JP6441893B2 (ja) * | 2013-03-19 | 2018-12-19 | ディレクティド・ジェノミクス・エル・エル・シー | 標的配列の濃縮 |
| WO2015023892A1 (en) | 2013-08-14 | 2015-02-19 | Gen-Probe Incorporated | Compositions and methods for detecting hev nucleic acid |
| AU2014384731B2 (en) | 2014-02-28 | 2017-12-14 | Gen-Probe Incorporated | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| GB2528344B (en) | 2014-02-28 | 2018-10-31 | Gen Probe Inc | Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde |
| GB2555995B (en) | 2014-10-20 | 2019-06-26 | Gen Probe Inc | Red blood cell lysis solution |
| US10865433B2 (en) | 2015-01-09 | 2020-12-15 | Gen-Probe Incorporated | Reaction mixtures for diagnosing bacterial vaginosis |
| US20160258938A1 (en) * | 2015-03-04 | 2016-09-08 | Headway Technologies, Inc. | Method of detecting an analyte in a sample |
| WO2016149357A1 (en) | 2015-03-16 | 2016-09-22 | Gen-Probe Incorporated | Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis |
| EP3400309B1 (de) | 2016-01-04 | 2025-03-19 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von candida-spezies |
| US12104206B2 (en) | 2016-02-11 | 2024-10-01 | Htg Molecular Diagnostics, Inc. | Method of direct target sequencing using nuclease protection |
| JP6584986B2 (ja) * | 2016-03-18 | 2019-10-02 | 株式会社東芝 | 核酸検出方法 |
| CA3021914C (en) | 2016-04-27 | 2024-04-30 | Gen-Probe Incorporated | Blood cell lysis reagent |
| EP3469103B1 (de) | 2016-06-10 | 2021-10-06 | Gen-Probe Incorporated | Zusammensetzungen und verfahren für den nachweis von zikavirus-nukleinsäure |
| CA3040907A1 (en) | 2016-10-19 | 2018-04-26 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying hepatitis c virus |
| CN110088302B (zh) | 2016-11-21 | 2025-02-25 | 简·探针公司 | 用于检测或定量乙型肝炎病毒的组合物和方法 |
| AU2018237578B2 (en) | 2017-03-24 | 2024-03-07 | Gen-Probe Incorporated | Compositions and methods for detecting or quantifying Parainfluenza virus |
| WO2018183124A1 (en) | 2017-03-25 | 2018-10-04 | Gen-Probe Incorporated | Compositions, methods and kits to detect adenovirus, metapneumovirus and/or rhinovirus nucleic acids |
| CA3062075C (en) | 2017-05-11 | 2024-04-02 | Gen-Probe Incorporated | Compositions and methods for isolating target nucleic acids |
| WO2018226798A1 (en) | 2017-06-07 | 2018-12-13 | Gen-Probe Incorporated | Detecting babesia species nucleic acid in a sample |
| WO2018227182A2 (en) * | 2017-06-09 | 2018-12-13 | University Of Houston System | Force-modulated hybridization for visualizing nucleic acid length and function |
| WO2019032809A1 (en) | 2017-08-11 | 2019-02-14 | Gen-Probe Incorporated | COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS |
| WO2019099629A1 (en) | 2017-11-17 | 2019-05-23 | Gen-Probe Incorporated | COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID |
| US11662281B2 (en) | 2017-12-13 | 2023-05-30 | Gen-Probe Incorporated | Compositions and methods for biological sample processing |
| EP3724354A1 (de) | 2017-12-15 | 2020-10-21 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von toxigenem clostridium difficile |
| EP3749781B1 (de) | 2018-02-06 | 2024-10-02 | Gen-Probe Incorporated | Dunkelrote farbstoffsondenformulierungen |
| CN120099195A (zh) | 2018-06-13 | 2025-06-06 | 简·探针公司 | 用于检测b群链球菌核酸的组合物和方法 |
| EP3830302B1 (de) | 2018-08-01 | 2022-10-05 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von nukleinsäuren des epstein-barr-virus |
| EP3841224A1 (de) | 2018-08-21 | 2021-06-30 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zur amplifikation, detektion oder quantifizierung von menschlichem cytomegalovirus |
| EP3841222A1 (de) | 2018-08-24 | 2021-06-30 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von bakterieller nukleinsäure und zur diagnose von bakterieller vaginose |
| CN109337956B (zh) * | 2018-09-07 | 2022-08-19 | 上海思路迪生物医学科技有限公司 | 基于ngs技术富集多基因茎环探针设计方法及试剂盒 |
| CN113195743A (zh) | 2018-10-22 | 2021-07-30 | 简·探针公司 | 扩增,检测或定量人类多瘤病毒bk病毒的组合物和方法 |
| TW202030333A (zh) | 2018-12-20 | 2020-08-16 | 美商簡 探針公司 | 用於檢測瘧原蟲物種核酸之組成物及方法 |
| AU2020210753A1 (en) | 2019-01-25 | 2021-09-02 | Gen-Probe Incorporated | Detection of drug-resistant mycoplasma genitalium |
| EP4389916A3 (de) | 2019-03-22 | 2024-10-16 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von gruppe-a-streptococcus |
| WO2020256378A1 (ko) * | 2019-06-17 | 2020-12-24 | 강릉원주대학교산학협력단 | 핵산 검출 방법 |
| EP3994284A1 (de) | 2019-07-03 | 2022-05-11 | Gen-Probe Incorporated | Trichomonas vaginalis oligonukleotide zur verwendung bei der bestimmung der anwesenheit in einer probe |
| CN114728263A (zh) | 2019-11-14 | 2022-07-08 | 简·探针公司 | 用于捕获靶核酸的组合物和方法 |
| AU2021230341C1 (en) | 2020-03-04 | 2026-03-26 | Gen-Probe Incorporated | Compositions and methods for detecting SARS-CoV-2 nucleic acid |
| WO2021224873A1 (en) | 2020-05-07 | 2021-11-11 | Grifols Diagnostic Solutions Inc. | Methods and compositions for detecting sars-cov-2 nucleic acid |
| WO2022197634A1 (en) | 2021-03-15 | 2022-09-22 | Gen-Probe Incorporated | Compositions and methods for biological sample processing |
| CA3218222A1 (en) | 2021-05-14 | 2022-11-17 | Gen-Probe Incorporated | Compositions and methods for detecting human adenovirus nucleic acid |
| EP4363610B1 (de) | 2021-07-01 | 2025-08-06 | Gen-Probe Incorporated | Enzymformulierungen und reaktionsmischungen zur nukleinsäureamplifikation |
| EP4377481A1 (de) | 2021-07-27 | 2024-06-05 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von gastrointestinalen pathogenen |
| CN114250224B (zh) * | 2021-12-16 | 2024-02-27 | 福建和瑞基因科技有限公司 | 一种用于提取或检测样本中小分子rna的核酸组合物及其试剂盒和方法 |
| CN114107446A (zh) * | 2021-12-16 | 2022-03-01 | 福建和瑞基因科技有限公司 | 一种核酸的检测试剂盒及其检测方法 |
| WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
| WO2024081776A1 (en) | 2022-10-13 | 2024-04-18 | Gen-Probe Incorporated | Cellularity control for nucleic acid assays |
| US20240124931A1 (en) * | 2022-10-15 | 2024-04-18 | Renato Rozental | Material and method for diagnosis of traumatic brain injury |
| AU2023408044A1 (en) | 2022-12-19 | 2025-07-31 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal pathogens |
| WO2024161179A1 (en) | 2023-01-31 | 2024-08-08 | Mobidiag Oy | Compositions and methods for detecting stx nucleic acids |
| EP4680772A1 (de) | 2023-03-16 | 2026-01-21 | Gen-Probe Incorporated | Zusammensetzungen und verfahren zum nachweis von gastrointestinalen parasiten |
| EP4455304A1 (de) | 2023-04-28 | 2024-10-30 | Mobidiag Oy | Kontrollen für nukleinsäureamplifikationsverfahren |
| EP4455303A1 (de) | 2023-04-28 | 2024-10-30 | Mobidiag Oy | Kontrollen für nukleinsäureamplifikationsverfahren |
| EP4454758A1 (de) | 2023-04-28 | 2024-10-30 | Mobidiag Oy | Kontrollen für nukleinsäureamplifikationsverfahren |
| WO2026050332A1 (en) | 2024-08-29 | 2026-03-05 | Gen-Probe Incorporated | Methods and compositions for amplifying and/or detecting rotavirus nucleic acids |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4174384A (en) * | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| CA1190838A (en) | 1981-07-17 | 1985-07-23 | Cavit Akin | Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer |
| FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
| US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
| US6221581B1 (en) * | 1984-04-27 | 2001-04-24 | Enzo Diagnostics, Inc. | Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions |
| CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
| US5288609A (en) * | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US5268266A (en) * | 1984-05-07 | 1993-12-07 | Genetics Institute, Inc. | Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences |
| US4766062A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
| US4824776A (en) * | 1985-07-25 | 1989-04-25 | Molecular Biosystems, Inc. | Method for increasing the sensitivity of nucleic acid hybridization assays |
| US4725536A (en) * | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
| US4752566A (en) * | 1985-12-17 | 1988-06-21 | Genetics Institute, Inc. | Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide |
| US4818680A (en) * | 1985-12-18 | 1989-04-04 | Mary Collins | Method and kit involving displacement and rehybridization of labeled polynucleotide |
| CA1273552A (en) | 1985-12-23 | 1990-09-04 | Michael J. Heller | Fluorescent stokes shift probes for polynucleotide hybridization assays |
| US5714380A (en) * | 1986-10-23 | 1998-02-03 | Amoco Corporation | Closed vessel for isolating target molecules and for performing amplification |
| ZA877772B (en) * | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
| US5283174A (en) * | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5118801A (en) * | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| ATE142272T1 (de) * | 1989-01-19 | 1996-09-15 | Behringwerke Ag | Nukleinsäure-amplifikation unter verwendung eines einzelprimers |
| ATE118824T1 (de) * | 1989-03-10 | 1995-03-15 | Amoco Corp | Immobilisierte oligonukleotidsonden und ihre verwendungen. |
| EP0481999B1 (de) * | 1989-03-10 | 1997-07-23 | VYSIS, Inc. | Interferenzverhinderung mit affinitätseinfangschemas |
| US5589335A (en) * | 1989-04-05 | 1996-12-31 | Amoco Corporation | Hybridization promotion reagents |
| DE69032847T2 (de) * | 1989-06-30 | 1999-05-12 | Chiron Corp., Emeryville, Calif. | Hydrophobe Nukleinsäure-Sonde |
| US5439793A (en) * | 1990-07-19 | 1995-08-08 | Syntex (U.S.A.) Inc. | Method for producing a polynucleotide having an intramolecularly base-paired structure |
| US5849481A (en) * | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| WO1992015708A1 (en) * | 1991-02-27 | 1992-09-17 | Amoco Corporation | Methods for improving the sensitivity of hybridization assays |
| US5445933A (en) * | 1992-09-15 | 1995-08-29 | Boehringer Mannheim Corporation | Strand displacement assay and complex useful therefor |
| EP0601889A2 (de) * | 1992-12-10 | 1994-06-15 | Maine Medical Center Research Institute | Nukleinsäure-Sonden |
| US6576419B1 (en) * | 1993-07-23 | 2003-06-10 | University Of Utah Research Foundation | Assay procedure using fluorogenic tracers |
| CA2105364A1 (en) * | 1993-09-01 | 1995-03-02 | Eric T. Kool | Stem-loop oligonucleotides containing parallel and antiparallel binding domains |
| US6156501A (en) * | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US6129828A (en) * | 1996-09-06 | 2000-10-10 | Nanogen, Inc. | Apparatus and methods for active biological sample preparation |
| US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5861273A (en) | 1993-12-21 | 1999-01-19 | Celtrix Phamraceuticals, Inc. | Chromosomal expression of heterologous genes in bacterial cells |
| US5631148A (en) * | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| AU2604995A (en) * | 1994-06-01 | 1995-12-21 | Hybridon, Inc. | Branched oligonucleotides as pathogen-inhibitory agents |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| US5770365A (en) * | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
| US5914230A (en) * | 1995-12-22 | 1999-06-22 | Dade Behring Inc. | Homogeneous amplification and detection of nucleic acids |
| WO1997039008A1 (en) * | 1996-04-12 | 1997-10-23 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
| US20030054376A1 (en) * | 1997-07-07 | 2003-03-20 | Mullis Kary Banks | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
| ATE339514T1 (de) * | 1996-07-16 | 2006-10-15 | Gen Probe Inc | Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm) |
| US5965363A (en) * | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| ES2271994T3 (es) * | 1997-05-02 | 2007-04-16 | Gen-Probe Incorporated | Hibridacion en dos pasos y captura de un polinucleotido. |
| US6534273B2 (en) * | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
| EP1025120B1 (de) * | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Sich auf "pna molecular beacons" beziehende verfahren, testsätze und zusammensetzungen |
| CA2333253C (en) | 1998-07-02 | 2010-09-07 | Gen-Probe Incorporated | Molecular torches |
| US6399302B1 (en) * | 1998-08-21 | 2002-06-04 | University Of Virginia Patent Foundation | Signal generating oligonucleotide-based biosensor |
| ATE253075T1 (de) * | 1998-08-27 | 2003-11-15 | Bayer Ag | Oligomerreinigung durch selektion mittels zweier enden |
| EP1147204A1 (de) * | 1999-01-28 | 2001-10-24 | Medical College Of Georgia Research Institute, Inc. | Zusammensetzung und verfahren zur in vivo und in vitro abschwächung der genexpression mittels dobbelsträngigem rna |
| AU5282300A (en) * | 1999-05-24 | 2000-12-12 | Public Health Research Institute Of The City Of New York, Inc., The | High specificity hairpin antisense oligonucleotides |
| US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
| WO2001094625A2 (en) * | 2000-06-06 | 2001-12-13 | Tm Bioscience Corporation | Capture moieties for nucleic acids and uses thereof |
| US6451588B1 (en) * | 2000-06-30 | 2002-09-17 | Pe Corporation (Ny) | Multipartite high-affinity nucleic acid probes |
| US6596490B2 (en) * | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| EP1366191A2 (de) * | 2000-12-11 | 2003-12-03 | Alexion Pharmaceuticals, Inc. | 'nested' haarnadelförmige oligonukleotide zur amplifizierung von nukleinsäure |
| USH2220H1 (en) | 2001-08-10 | 2008-07-01 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| US7371580B2 (en) * | 2001-08-24 | 2008-05-13 | Agilent Technologies, Inc. | Use of unstructured nucleic acids in assaying nucleic acid molecules |
| US7214780B2 (en) * | 2001-11-02 | 2007-05-08 | Gen-Probe Incorporated | Probes, compositions and kits for determining the presence of Mycoplasma pneuomoniae in a test sample |
| JPWO2003100095A1 (ja) * | 2002-05-08 | 2005-09-22 | アークレイ株式会社 | 標的核酸の検出法 |
| US7851150B2 (en) * | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
| EP1604172B1 (de) * | 2003-03-07 | 2009-06-17 | The University of Medicine and Dentistry of New Jersey | Optisch dekodierbare mikroträger, arrays und verfahren |
| CA2542232A1 (en) * | 2003-06-09 | 2005-01-20 | Alnylam Pharmaceuticals, Inc. | Method for treating neurodegenerative disease by inhibiting alpha-synuclein |
| US20050037362A1 (en) | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
| WO2006007567A2 (en) | 2004-07-01 | 2006-01-19 | Gen-Probe Incorporated | Methods and compositions to detect nucleic acids in a biological sample |
| US20060292616A1 (en) * | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
-
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- 2005-06-29 JP JP2007520409A patent/JP5020818B2/ja not_active Expired - Fee Related
- 2005-06-29 DE DE602005020943T patent/DE602005020943D1/de not_active Expired - Lifetime
- 2005-06-29 US US11/173,915 patent/US8034554B2/en not_active Expired - Fee Related
- 2005-06-29 EP EP05767727A patent/EP1778867B1/de not_active Expired - Lifetime
- 2005-06-29 CA CA2572472A patent/CA2572472C/en not_active Expired - Lifetime
- 2005-06-29 AT AT05767727T patent/ATE466107T1/de not_active IP Right Cessation
- 2005-06-29 AU AU2005262357A patent/AU2005262357B2/en not_active Ceased
- 2005-06-29 DK DK05767727.0T patent/DK1778867T3/da active
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| Publication number | Publication date |
|---|---|
| US20060068417A1 (en) | 2006-03-30 |
| AU2009238261B2 (en) | 2011-11-17 |
| CA2572472A1 (en) | 2006-01-19 |
| EP1778867A2 (de) | 2007-05-02 |
| DK1778867T3 (da) | 2010-08-02 |
| US8460869B2 (en) | 2013-06-11 |
| WO2006007567A2 (en) | 2006-01-19 |
| EP1778867B1 (de) | 2010-04-28 |
| AU2005262357A1 (en) | 2006-01-19 |
| US8034554B2 (en) | 2011-10-11 |
| JP2008504842A (ja) | 2008-02-21 |
| DE602005020943D1 (de) | 2010-06-10 |
| CA2572472C (en) | 2013-08-13 |
| JP5020818B2 (ja) | 2012-09-05 |
| AU2009238261A1 (en) | 2009-12-03 |
| AU2005262357B2 (en) | 2009-10-29 |
| US20120231551A1 (en) | 2012-09-13 |
| US8551766B2 (en) | 2013-10-08 |
| WO2006007567A3 (en) | 2006-03-30 |
| US20110250599A1 (en) | 2011-10-13 |
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