ATE467678T1 - Produktion von poxviren mit adhärenten oder nicht adhärenten vogelzellinien - Google Patents
Produktion von poxviren mit adhärenten oder nicht adhärenten vogelzellinienInfo
- Publication number
- ATE467678T1 ATE467678T1 AT04744255T AT04744255T ATE467678T1 AT E467678 T1 ATE467678 T1 AT E467678T1 AT 04744255 T AT04744255 T AT 04744255T AT 04744255 T AT04744255 T AT 04744255T AT E467678 T1 ATE467678 T1 AT E467678T1
- Authority
- AT
- Austria
- Prior art keywords
- adherent
- poxviruses
- production
- cell lines
- bird cell
- Prior art date
Links
- 230000001464 adherent effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 241000271566 Aves Species 0.000 abstract 1
- 241000700618 Vaccinia virus Species 0.000 abstract 1
- 239000007640 basal medium Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24151—Methods of production or purification of viral material
- C12N2710/24152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291813A EP1500699A1 (de) | 2003-07-22 | 2003-07-22 | Herstellung von Vacciniaviren mit Hilfe adhärenter oder nicht adhärenter Vogelzelllinien |
| FR0314389 | 2003-12-09 | ||
| PCT/IB2004/002621 WO2005007840A1 (en) | 2003-07-22 | 2004-07-22 | Production of poxviruses with adherent or non adherent avian cell lines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE467678T1 true ATE467678T1 (de) | 2010-05-15 |
Family
ID=34081825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04744255T ATE467678T1 (de) | 2003-07-22 | 2004-07-22 | Produktion von poxviren mit adhärenten oder nicht adhärenten vogelzellinien |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7432101B2 (de) |
| EP (2) | EP1646715B1 (de) |
| JP (2) | JP4787156B2 (de) |
| KR (1) | KR101121971B1 (de) |
| AT (1) | ATE467678T1 (de) |
| AU (1) | AU2004257939B2 (de) |
| CA (1) | CA2531565C (de) |
| DE (1) | DE602004027141D1 (de) |
| DK (1) | DK1646715T3 (de) |
| ES (1) | ES2345820T3 (de) |
| PL (1) | PL1646715T3 (de) |
| PT (1) | PT1646715E (de) |
| SI (1) | SI1646715T1 (de) |
| WO (1) | WO2005007840A1 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| FR2836924B1 (fr) * | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| AU2003264144C1 (en) * | 2002-09-05 | 2009-12-17 | Bavarian Nordic A/S | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions |
| KR101121971B1 (ko) * | 2003-07-22 | 2012-03-09 | 비바리스 | 부착성 또는 비부착성 조류 세포주를 이용한폭스바이러스의 생산 |
| EP1528101A1 (de) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalisierte Vogel-Zelllinien für die Produktion von Viren |
| FR2884255B1 (fr) * | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| AU2011253998B2 (en) * | 2005-04-11 | 2014-04-24 | Valneva | Process of manufacturing viral vaccines in suspension avian embryonic derived stem cell lines |
| FR2898909A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Combinaison de marqueurs de cellules aviaires |
| WO2007135133A1 (en) * | 2006-05-19 | 2007-11-29 | Vivalis | Avian cell lines derived from primordial germ cells useful for the production of substances of interest |
| RU2489486C2 (ru) | 2006-06-20 | 2013-08-10 | Трансжене С.А. | Процесс получения поксвирусов и композиции поксвирусов |
| WO2008017704A1 (en) * | 2006-08-09 | 2008-02-14 | Vivalis | Method of production of transgenic avian using embryonic stem cells |
| EP2129764B1 (de) * | 2007-03-05 | 2018-10-10 | Terumo BCT, Inc. | Zellexpansionssystem und anwendungsverfahren |
| EP1985305A1 (de) | 2007-04-24 | 2008-10-29 | Vivalis | Aus Entenembryonen gewonnene Stammzellkulturen zur Herstellung von Impfstoffen gegen Viren |
| BRPI0811787B1 (pt) | 2007-07-03 | 2018-10-09 | Transgene Sa | usos de uma célula imortalizada e processo para imortalizar uma célula aviária |
| US8357531B2 (en) | 2007-07-03 | 2013-01-22 | Transgene S.A. | Immortalized avian cell lines |
| PL214884B1 (pl) * | 2008-09-29 | 2013-09-30 | Inst Immunologii I Terapii Doswiadczalnej Pan | Test ELISA do wykrywania w surowicy bydlecej przeciwcial przeciwko antygenowi powierzchniowemu gp51 BLV |
| EP2379598B1 (de) | 2009-01-19 | 2015-03-11 | Innate Pharma | Anti-kir3d-antikörper |
| WO2010089339A1 (en) * | 2009-02-06 | 2010-08-12 | Glaxosmithkline Biologicals S.A. | Purification of virus or viral antigens by density gradient ultracentrifugation |
| SG176554A1 (en) | 2009-05-12 | 2012-01-30 | Transgene Sa | Method for orthopoxvirus production and purification |
| CA2802430C (en) | 2010-07-20 | 2021-07-20 | Bavarian Nordic A/S | Method for harvesting poxvirus |
| CA3150342A1 (en) * | 2010-09-07 | 2012-03-15 | Technion Research & Development Foundation Limited | Novel methods and culture media for culturing pluripotent stem cells |
| US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| EP2660316A1 (de) | 2012-05-02 | 2013-11-06 | Helmholtz-Zentrum für Infektionsforschung GmbH | Vogelzelllinie und deren Verwendung bei der Herstellung eines Proteins |
| US20140255447A1 (en) * | 2013-03-05 | 2014-09-11 | Biomune Company | Production of avian embryo cells |
| EP3068867B1 (de) | 2013-11-16 | 2018-04-18 | Terumo BCT, Inc. | Zellenexpansion in einem bioreaktor |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US10077421B2 (en) | 2014-04-24 | 2018-09-18 | Terumo Bct, Inc. | Measuring flow rate |
| EP3198006B1 (de) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Geplante fütterung |
| US10517943B2 (en) | 2014-12-01 | 2019-12-31 | Transgene S.A. | Stable liquid vaccinia virus formulations |
| WO2016088243A1 (ja) * | 2014-12-05 | 2016-06-09 | 株式会社ニコン | 判定装置、観察システム、観察方法、そのプログラム、細胞の製造方法、および細胞 |
| CA2975432A1 (en) | 2015-02-13 | 2016-08-18 | Transgene Sa | Immunotherapeutic vaccine and antibody combination therapy |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| WO2018069316A2 (en) | 2016-10-10 | 2018-04-19 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| CA3062549A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| EP3624851A1 (de) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stabile virushaltige zusammensetzung |
| KR20240113607A (ko) | 2017-06-21 | 2024-07-22 | 트랜스진 | 개인 맞춤형 백신 |
| CN112384627A (zh) | 2018-05-30 | 2021-02-19 | 生物医学研究所 | 通过利用内源激活诱导性胞嘧啶脱氨酶改造b淋巴细胞 |
| EP3847246A1 (de) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Pockenviruszusammensetzungen mit verbesserter lagerung |
| BR112021009793A2 (pt) | 2018-11-23 | 2021-08-17 | Valneva Se | produtos alimentícios que compreendem células-tronco aviárias |
| MX2021006115A (es) | 2019-01-17 | 2021-07-07 | Boehringer Ingelheim Animal Health Usa Inc | Medio libre de suero para produccion de vacuna aviar y usos del mismo. |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| WO2021261892A1 (ko) * | 2020-06-22 | 2021-12-30 | 코오롱생명과학 주식회사 | 부유세포를 이용한 백시니아 바이러스의 대량생산방법 |
| KR20230038496A (ko) | 2020-07-13 | 2023-03-20 | 트랜스진 | 면역 억제의 치료 |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5340740A (en) | 1992-05-15 | 1994-08-23 | North Carolina State University | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process |
| FR2726003B1 (fr) | 1994-10-21 | 2002-10-18 | Agronomique Inst Nat Rech | Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires |
| US5989805A (en) | 1995-10-27 | 1999-11-23 | Board Of Trustees Operating Michigan State University | Immortal avian cell line to grow avian and animal viruses to produce vaccines |
| US5672485A (en) | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
| PT841392E (pt) | 1996-11-12 | 2004-11-30 | Univ Auburn | Vacina viva atenuada de neospora |
| EP1481409B1 (de) * | 2002-02-19 | 2005-12-07 | Cellergy Ltd | Elektrochemischer kondensator und dessen herstellung |
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| AU2003296974A1 (en) * | 2002-12-13 | 2004-07-14 | Aventis Pasteur, Inc. | Production of alvac on avian embryonic stem cells |
| KR101121971B1 (ko) * | 2003-07-22 | 2012-03-09 | 비바리스 | 부착성 또는 비부착성 조류 세포주를 이용한폭스바이러스의 생산 |
| EP1528101A1 (de) * | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalisierte Vogel-Zelllinien für die Produktion von Viren |
-
2004
- 2004-07-22 KR KR1020067001289A patent/KR101121971B1/ko not_active Expired - Fee Related
- 2004-07-22 AU AU2004257939A patent/AU2004257939B2/en not_active Ceased
- 2004-07-22 DE DE602004027141T patent/DE602004027141D1/de not_active Expired - Lifetime
- 2004-07-22 JP JP2006520937A patent/JP4787156B2/ja not_active Expired - Fee Related
- 2004-07-22 ES ES04744255T patent/ES2345820T3/es not_active Expired - Lifetime
- 2004-07-22 AT AT04744255T patent/ATE467678T1/de active
- 2004-07-22 PT PT04744255T patent/PT1646715E/pt unknown
- 2004-07-22 PL PL04744255T patent/PL1646715T3/pl unknown
- 2004-07-22 DK DK04744255.3T patent/DK1646715T3/da active
- 2004-07-22 US US10/565,281 patent/US7432101B2/en not_active Expired - Fee Related
- 2004-07-22 EP EP04744255A patent/EP1646715B1/de not_active Expired - Lifetime
- 2004-07-22 CA CA2531565A patent/CA2531565C/en not_active Expired - Fee Related
- 2004-07-22 WO PCT/IB2004/002621 patent/WO2005007840A1/en not_active Ceased
- 2004-07-22 SI SI200431453T patent/SI1646715T1/sl unknown
- 2004-07-22 EP EP09174819A patent/EP2143788A1/de not_active Withdrawn
-
2008
- 2008-10-01 US US12/243,437 patent/US7771980B2/en not_active Expired - Fee Related
-
2009
- 2009-11-03 US US12/611,806 patent/US20100111999A1/en not_active Abandoned
-
2011
- 2011-05-27 JP JP2011118610A patent/JP5416169B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5416169B2 (ja) | 2014-02-12 |
| DK1646715T3 (da) | 2010-08-16 |
| US20060233834A1 (en) | 2006-10-19 |
| CA2531565C (en) | 2014-02-11 |
| HK1091229A1 (en) | 2007-01-12 |
| ES2345820T3 (es) | 2010-10-04 |
| AU2004257939A1 (en) | 2005-01-27 |
| KR101121971B1 (ko) | 2012-03-09 |
| EP1646715B1 (de) | 2010-05-12 |
| JP2011224009A (ja) | 2011-11-10 |
| PL1646715T3 (pl) | 2010-10-29 |
| PT1646715E (pt) | 2010-08-09 |
| KR20060057577A (ko) | 2006-05-26 |
| US20100111999A1 (en) | 2010-05-06 |
| AU2004257939B2 (en) | 2008-06-05 |
| SI1646715T1 (sl) | 2010-09-30 |
| JP2006527995A (ja) | 2006-12-14 |
| CA2531565A1 (en) | 2005-01-27 |
| WO2005007840A1 (en) | 2005-01-27 |
| EP1646715A1 (de) | 2006-04-19 |
| US20090239286A1 (en) | 2009-09-24 |
| US7432101B2 (en) | 2008-10-07 |
| JP4787156B2 (ja) | 2011-10-05 |
| DE602004027141D1 (de) | 2010-06-24 |
| EP2143788A1 (de) | 2010-01-13 |
| US7771980B2 (en) | 2010-08-10 |
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