ATE468339T1 - Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung - Google Patents

Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung

Info

Publication number: ATE468339T1
Authority: AT; Austria
Prior art keywords: nrarb; substituted; nrac; alkyl; substituent
Prior art date: 2001-12-20

Application number

AT02805644T

Other languages

English (en)

Inventor

Arlindo Castelhano

Bryan Mckibben

Arno Steinig

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-20

Filing date

2002-12-20

Publication date

2010-06-15

2002-12-20 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2010-06-15 Application granted granted Critical

2010-06-15 Publication of ATE468339T1 publication Critical patent/ATE468339T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
KDOPAZIWBAHVJB-UHFFFAOYSA-N 5h-pyrrolo[3,2-d]pyrimidine Chemical compound C1=NC=C2NC=CC2=N1 KDOPAZIWBAHVJB-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
229910003827 NRaRb Inorganic materials 0.000 abstract 9
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
-1 dihydroxy Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002393 azetidinyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000004885 piperazines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT02805644T 2001-12-20 2002-12-20 Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung ATE468339T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34344301P	2001-12-20	2001-12-20
PCT/US2002/040890 WO2003053361A2 (en)	2001-12-20	2002-12-20	PYRROLOPYRIMIDINE A2b SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE

Publications (1)

Publication Number	Publication Date
ATE468339T1 true ATE468339T1 (de)	2010-06-15

Family

ID=42828977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02805644T ATE468339T1 (de)	2001-12-20	2002-12-20	Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung

Country Status (11)

Country	Link
EP (1)	EP1467995B1 (de)
JP (1)	JP4607457B2 (de)
KR (1)	KR100960827B1 (de)
AT (1)	ATE468339T1 (de)
AU (1)	AU2002366801B8 (de)
BR (1)	BR0215279A (de)
CA (1)	CA2470044C (de)
DK (1)	DK1467995T3 (de)
EA (1)	EA012926B1 (de)
MX (1)	MXPA04005861A (de)
WO (1)	WO2003053361A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4611524B2 (ja)	1998-06-02	2011-01-12	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	ピロロ［２，３ｄ］ピリミジン組成物およびその使用
US6680324B2 (en)	2000-12-01	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
DK1450811T3 (da)	2001-11-30	2010-02-15	Osi Pharm Inc	Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
CN1620294A (zh)	2001-12-20	2005-05-25	Osi药物公司	嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
TW200403058A (en) *	2002-04-19	2004-03-01	Bristol Myers Squibb Co	Heterocyclo inhibitors of potassium channel function
EP1479680A1 (de) *	2003-05-19	2004-11-24	Aventis Pharma Deutschland GmbH	Azaindole-Derivative als Faktor Xa Hemmer
AU2004280559A1 (en) *	2003-09-19	2005-04-21	Sri International	Methods and apparatuses for producing metallic compositions via reduction of metal halides
JPWO2005037269A1 (ja) *	2003-10-21	2006-12-28	住友製薬株式会社	新規ピペリジン誘導体
GB0412467D0 (en) *	2004-06-04	2004-07-07	Astrazeneca Ab	Chemical compounds
GB0503646D0 (en) *	2005-02-22	2005-03-30	Novartis Ag	Organic compounds
EP2392571A3 (de)	2005-07-29	2012-03-14	F. Hoffmann-La Roche AG	Indol-3-yl-Carbonyl-Piperidin- und Piperazinderivate
GB0519879D0 (en)	2005-09-30	2005-11-09	Astrazeneca Ab	Chemical process
GB0718432D0 (en) *	2007-09-21	2007-10-31	Vernalis R&D Ltd	New chemical compounds
GB0718434D0 (en) *	2007-09-21	2007-10-31	Vernalis R&D Ltd	New chemical compounds
JP5460690B2 (ja)	2008-03-26	2014-04-02	アドヴィナス・セラピューティックス・リミテッド	アデノシンレセプターアンタゴニストとしてのヘテロ環化合物
AU2010222289B2 (en)	2009-03-13	2013-07-11	Advinus Therapeutics Private Limited	Substituted fused pyrimidine compounds
US8324250B2 (en) *	2009-03-19	2012-12-04	Hoffmann-La Roche Inc.	Piperidine derivatives as NK3 receptor antagonists
EP2499142B1 (de)	2009-11-09	2016-09-21	Advinus Therapeutics Limited	Substituierte kondensierte pyrimidinverbindungen, ihre herstellung und ihre verwendung
CN103261200B (zh)	2010-09-13	2016-03-30	阿迪维纳斯疗法有限公司	作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途
MX338327B (es) *	2010-10-25	2016-04-12	G1 Therapeutics Inc	Inhibidores de cdk.
US20120115878A1 (en)	2010-11-10	2012-05-10	John Vincent Calienni	Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
US9701689B2 (en)	2012-11-30	2017-07-11	Kyowa Hakko Kirin Co., Ltd.	Substituted pyridines and pyridazines as CCR10 receptor inhibitors
KR20160065957A (ko) *	2013-10-07	2016-06-09	바이엘 파마 악티엔게젤샤프트	시클릭 티에노우라실-카르복스아미드 및 그의 용도
MX2021008094A (es)	2019-01-11	2021-09-21	Omeros Corp	Metodos y composiciones para el tratamiento del cancer.
US12390468B2 (en)	2019-01-23	2025-08-19	Novartis Ag	Crystalline forms of a succinate salt of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide
WO2025037229A1 (en) *	2023-08-14	2025-02-20	Novartis Ag	Compounds and compositions for modulating the activity of erk

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4611524B2 (ja) *	1998-06-02	2011-01-12	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	ピロロ［２，３ｄ］ピリミジン組成物およびその使用
HK1050319B (en) *	1999-12-02	2007-04-04	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine a1, a2a, and a3 receptor and uses thereof

2002
- 2002-12-20 EA EA200400829A patent/EA012926B1/ru not_active IP Right Cessation
- 2002-12-20 CA CA2470044A patent/CA2470044C/en not_active Expired - Fee Related
- 2002-12-20 AT AT02805644T patent/ATE468339T1/de not_active IP Right Cessation
- 2002-12-20 EP EP02805644A patent/EP1467995B1/de not_active Expired - Lifetime
- 2002-12-20 MX MXPA04005861A patent/MXPA04005861A/es active IP Right Grant
- 2002-12-20 WO PCT/US2002/040890 patent/WO2003053361A2/en not_active Ceased
- 2002-12-20 AU AU2002366801A patent/AU2002366801B8/en not_active Ceased
- 2002-12-20 KR KR1020047009796A patent/KR100960827B1/ko not_active Expired - Fee Related
- 2002-12-20 BR BR0215279-7A patent/BR0215279A/pt active Search and Examination
- 2002-12-20 DK DK02805644.8T patent/DK1467995T3/da active
- 2002-12-20 JP JP2003554121A patent/JP4607457B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2005525305A (ja)	2005-08-25
WO2003053361A2 (en)	2003-07-03
AU2002366801B2 (en)	2009-04-23
AU2002366801B8 (en)	2009-05-21
EA200400829A1 (ru)	2005-08-25
KR20040068966A (ko)	2004-08-02
AU2002366801A1 (en)	2003-07-09
EP1467995B1 (de)	2010-05-19
JP4607457B2 (ja)	2011-01-05
KR100960827B1 (ko)	2010-06-08
EA012926B1 (ru)	2010-02-26
CA2470044C (en)	2010-12-14
CA2470044A1 (en)	2003-07-03
EP1467995A2 (de)	2004-10-20
MXPA04005861A (es)	2004-10-29
WO2003053361A3 (en)	2003-12-24
HK1070647A1 (en)	2005-06-24
EP1467995A4 (de)	2005-12-07
DK1467995T3 (da)	2010-09-20
BR0215279A (pt)	2005-05-10

Legal Events

Date	Code	Title	Description
2010-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE468339T1 (de)	2010-06-15	Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung
ATE540933T1 (de)	2012-01-15	Pyrimidinverbindungen als interleukin-12 (il-12) inhibitoren
CO5590960A2 (es)	2005-12-30	Derivados de azaindolilalquilamina como ligandos de 5- hidroxitriptamina-6
CO5590921A2 (es)	2005-12-30	Compuestos de tienopirimidina y usos de los mismos
TR200402300T4 (tr)	2004-12-21	İmidazopirimidin türevleri ve triazolopirimidin türevleri.
PE20030808A1 (es)	2003-09-22	Derivados triciclicos heterociclicos como antagonistas receptores de trombina
RU98119523A (ru)	2000-10-20	Соединения пиперазина и пиперидина
ES2572332T3 (es)	2016-05-31	2,6-metano-3-benzazocinas sustituidas en posición 8 y morfinanos sustituidos en posición 3 como ligandos de receptores opioides
AR025975A1 (es)	2002-12-26	Compuestos quimicos.
PT1278728E (pt)	2004-10-29	Derivados de pirrolidina e de piperidina e sua utilizacao no tratamento de disturbios neurodegenerativos
CY1109479T1 (el)	2014-08-13	Παραγωγα κιναζολινης
DE60127845D1 (de)	2007-05-24	Benzylidenthiazolidindione und ihre verwendung als antimykotische mittel
EA200400748A1 (ru)	2004-12-30	Агонисты рецепторов, активируемых пероксисомным пролифератором
SE0100903D0 (sv)	2001-03-15	Compounds
CO5640091A2 (es)	2006-05-31	Antagonista de un receptor sensible al calcio
EA200301100A1 (ru)	2004-06-24	Новые фталазиноны
DE60027700D1 (de)	2006-06-08	Bicyclische verbindungen und ihre verwendung als integrinrezeptorliganden
NZ508910A (en)	2003-01-31	Di-substituted piperazine or piperidine derivatives useful as muscarinic antagonists
PE20020486A1 (es)	2002-06-14	Compuestos triciclicos como inhibidores de la farnesil proteino transferasa
MY128442A (en)	2007-02-28	Diphenyl ether compounds useful in therapy
EP0639275A1 (de)	1995-02-22	Neue gabaa-rezeptorsubtypen und verfahren zum screening von arzneimittelverbindungen unter verwendung von an gabaa-rezeptorsubtypen bindende imidazochinoxaline und pyrrolopyrimidine.
DE60229054D1 (de)	2008-11-06	Synthese von zyklopentadien derivaten
DE60327922D1 (de)	2009-07-23	Harnstoff-linker verbindungen und ihre verwendung als ppar regulatoren
AR042355A1 (es)	2005-06-15	Compuestos de 2 - aminopirimidina y metodos de obtencion
CO5690604A2 (es)	2006-10-31	Derivados de [6,7-dihidro-5h-imidazo[1.2-alfa]imidazol-3- sulfonilamino]-propionamida