ATE469230T1 - Bakterien mit verkleinertem genom - Google Patents
Bakterien mit verkleinertem genomInfo
- Publication number
- ATE469230T1 ATE469230T1 AT03733830T AT03733830T ATE469230T1 AT E469230 T1 ATE469230 T1 AT E469230T1 AT 03733830 T AT03733830 T AT 03733830T AT 03733830 T AT03733830 T AT 03733830T AT E469230 T1 ATE469230 T1 AT E469230T1
- Authority
- AT
- Austria
- Prior art keywords
- genome
- bacterium
- methods
- present
- smaller
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/08—Reducing the nucleic acid content
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/057,582 US6989265B2 (en) | 2002-01-23 | 2002-01-23 | Bacteria with reduced genome |
| PCT/US2003/001800 WO2003070880A2 (en) | 2002-01-23 | 2003-01-22 | Bacteria with reduced genome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE469230T1 true ATE469230T1 (de) | 2010-06-15 |
Family
ID=22011493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03733830T ATE469230T1 (de) | 2002-01-23 | 2003-01-22 | Bakterien mit verkleinertem genom |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6989265B2 (de) |
| EP (1) | EP1483367B1 (de) |
| JP (2) | JP4658478B2 (de) |
| KR (1) | KR100967592B1 (de) |
| CN (2) | CN103540543B (de) |
| AT (1) | ATE469230T1 (de) |
| AU (2) | AU2003239116B8 (de) |
| BR (2) | BRPI0307125A2 (de) |
| CA (1) | CA2473922C (de) |
| DE (1) | DE60332708D1 (de) |
| IL (2) | IL162911A0 (de) |
| IS (1) | IS7355A (de) |
| MX (1) | MX264365B (de) |
| NO (1) | NO330918B1 (de) |
| NZ (1) | NZ534010A (de) |
| SG (1) | SG155052A1 (de) |
| WO (1) | WO2003070880A2 (de) |
| ZA (1) | ZA200405509B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989265B2 (en) * | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
| US8765408B2 (en) | 2002-01-23 | 2014-07-01 | Wisconsin Alumni Research Foundation | Prophage element-free bacteria |
| US8039243B2 (en) * | 2002-01-23 | 2011-10-18 | Wisconsin Alumni Research Foundation | Insertion sequence-free bacteria |
| US8119365B2 (en) * | 2002-01-23 | 2012-02-21 | Wisconsin Alumni Research Foundation | Insertion sequence-free bacteria |
| US20060270043A1 (en) * | 2002-01-23 | 2006-11-30 | Blattner Frederick R | Bacteria with reduced genome |
| US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
| AU2005222788A1 (en) * | 2004-02-27 | 2005-09-29 | President And Fellows Of Harvard College | Polynucleotide synthesis |
| WO2005087940A1 (en) * | 2004-03-11 | 2005-09-22 | Wisconsin Alumni Research Foundation | Genetically altered microorganisms with modified metabolism |
| KR100585450B1 (ko) * | 2004-09-02 | 2006-06-07 | 한국과학기술원 | 유전자 결실을 위한 선형 dna 단편, 이를 이용하여생물막 형성이 억제된 대장균 변이주 및 이의 제조 방법 |
| US20080009041A1 (en) * | 2004-11-26 | 2008-01-10 | Hiroshi Mizoguchi | Industrially Useful Microorganism |
| WO2007005053A1 (en) * | 2005-06-30 | 2007-01-11 | Codon Devices, Inc. | Hierarchical assembly methods for genome engineering |
| EP2543726B1 (de) * | 2005-08-20 | 2018-10-03 | Scarab Genomics, LLC | E. coli mit reduziertem Genom |
| MX297190B (en) | 2005-09-08 | 2012-03-16 | Scarab Genomics Llc | Oxygen-regulated microorganisms |
| DE102006004871A1 (de) * | 2006-02-02 | 2007-08-09 | Wacker Chemie Ag | Mikroorganismenstamm zur Produktion von rekombinanten Proteinen |
| DE602007007612D1 (de) * | 2006-04-22 | 2010-08-19 | Scarab Genomics Llc | Verfahren und zusammensetzungen zur herstellung rekombinanter proteine unter verwendung eines gens für trna |
| EP2049668A2 (de) | 2006-08-03 | 2009-04-22 | Wisconsin Alumni Research Foundation | Vektorensysteme |
| US20110165680A1 (en) * | 2008-09-12 | 2011-07-07 | Scarab Genomics, Llc | Clean genome bactofection |
| US20120093865A2 (en) | 2009-02-12 | 2012-04-19 | Scarab Genomics Llc | Compositions comprising reduced genome bacteria for use in treatment of sepsis |
| JP2013511277A (ja) | 2009-11-18 | 2013-04-04 | ミリアント・コーポレイション | 化学物質の効率的な生産のための微生物の改変 |
| WO2011080505A2 (en) | 2009-12-28 | 2011-07-07 | Bigdna Ltd | Method of growing phage for commercial use |
| US10224182B2 (en) | 2011-10-17 | 2019-03-05 | Novellus Systems, Inc. | Mechanical suppression of parasitic plasma in substrate processing chamber |
| JP6151704B2 (ja) * | 2011-10-20 | 2017-06-21 | スカラブ ゲノミクス, エルエルシー | 遺伝的安定性が向上したゲノム縮小化細菌 |
| EP2825663B1 (de) | 2012-03-13 | 2019-08-07 | Board of Trustees of the University of Arkansas | Auf separatom basierte proteinexpressions- und -reinigungsplattform |
| US9484233B2 (en) | 2012-04-13 | 2016-11-01 | Novellus Systems, Inc. | Carousel reactor for multi-station, sequential processing systems |
| KR20150084033A (ko) * | 2012-11-06 | 2015-07-21 | 아두로 바이오테크, 인코포레이티드 | 조건적으로 약독화된 박테리아 종 그리고 이의 제조 방법 및 이의 용도 |
| US9449795B2 (en) | 2013-02-28 | 2016-09-20 | Novellus Systems, Inc. | Ceramic showerhead with embedded RF electrode for capacitively coupled plasma reactor |
| WO2015009760A1 (en) | 2013-07-15 | 2015-01-22 | Donald Danforth Plant Science Center | Enhanced oil production and stress tolerance in plants |
| US9822371B2 (en) | 2013-09-17 | 2017-11-21 | The Board Of Trustees Of The University Of Arkansas | E. coli separatome-based protein expression and purification platform |
| WO2015073720A1 (en) | 2013-11-14 | 2015-05-21 | Scarab Genomics, Llc | Bacteria with improved metabolic capacity |
| WO2015134402A1 (en) * | 2014-03-03 | 2015-09-11 | Scarab Genomics, Llc | Enhanced production of recombinant crm197 in e. coli |
| CA2957921A1 (en) | 2014-07-22 | 2016-01-28 | Nmc, Inc. | Improved carbon fixation systems in plants and algae |
| WO2016161305A1 (en) | 2015-04-02 | 2016-10-06 | Scarab Genomics, Llc | Materials and methods for extended continuous flow fermentation of reduced genome bacteria |
| JP7296386B2 (ja) | 2017-09-05 | 2023-06-22 | スカラブ ゲノミクス, エルエルシー | 組換えタンパク質の発現を改善するための方法および組成物 |
| CN112680393B (zh) * | 2021-01-15 | 2023-04-07 | 江南大学 | 一种能提高生产效率的无菌毛大肠杆菌的构建及应用 |
| CN114410564B (zh) * | 2022-04-02 | 2022-07-19 | 中国农业大学 | 一种用于5-氨基乙酰丙酸生产的菌株及生产方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US647216A (en) | 1899-10-18 | 1900-04-10 | Charles N Perkins | Nozzle-holder. |
| EP0177343B1 (de) | 1984-10-05 | 1992-07-22 | Genentech, Inc. | DNA, Zellkulturen und Verfahren zur Sekretion von heterologen Proteinen und periplasmische Proteinrückgewinnung |
| US4981797A (en) | 1985-08-08 | 1991-01-01 | Life Technologies, Inc. | Process of producing highly transformable cells and cells produced thereby |
| US4851348A (en) | 1986-07-16 | 1989-07-25 | Cold Spring Harbor Laboratory | Biologically pure escherichia coli cell line which is a deoR- mutant and which is more transformation efficient with foreign plasmids than deoR+ escherichia coli cell lines, processes for obtaining these cell lines, methods of use |
| ATE122391T1 (de) * | 1987-01-30 | 1995-05-15 | Harvard College | Periplasmische protease-mutanten von escherichia coli. |
| JP2676511B2 (ja) | 1987-03-23 | 1997-11-17 | 株式会社日立製作所 | 酢酸を指標とした培養方法及びその装置 |
| US5578464A (en) * | 1989-10-31 | 1996-11-26 | Schering Corporation | E. coli secretory strains |
| US5474896A (en) * | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5747662A (en) * | 1995-03-01 | 1998-05-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| EP0798380A3 (de) * | 1996-03-28 | 1998-04-29 | Mitsui Toatsu Chemicals, Inc. | Verfahren zur Herstellung sekretischer Proteinprodukten |
| FR2750704B1 (fr) * | 1996-07-04 | 1998-09-25 | Rhone Poulenc Rorer Sa | Procede de production d'adn therapeutique |
| JP2003524368A (ja) * | 1997-08-26 | 2003-08-19 | アリアド ジーン セラピューティクス インコーポレイテッド | ニ量化ドメイン、三量化ドメインまたは四量化ドメインおよび補足的非相同転写活性化ドメイン、転写抑制ドメイン、dna結合ドメインまたはリガンド結合ドメインを含む融合蛋白 |
| US6015709A (en) * | 1997-08-26 | 2000-01-18 | Ariad Pharmaceuticals, Inc. | Transcriptional activators, and compositions and uses related thereto |
| US6509156B1 (en) * | 1997-12-05 | 2003-01-21 | Europaisches Laboratorium Fur Molekularoiologie (Embl) | DNA cloning method relying on the E. coli recE/recT recombination system |
| US6022952A (en) * | 1998-04-01 | 2000-02-08 | University Of Alberta | Compositions and methods for protein secretion |
| JP2000333684A (ja) * | 1999-05-26 | 2000-12-05 | Novo Nordisk As | グルコースイソメラーゼ活性を有するポリペプチド及びそれをコードする核酸 |
| AU1206801A (en) | 1999-10-13 | 2001-04-23 | University Of Georgia Research Foundation, Inc., The | High yield protein expression system and methods |
| DK1311661T3 (da) | 2000-08-14 | 2012-11-26 | Us Gov Health & Human Serv | Forøget homolog rekombination medieret ved lambda-rekombinationsproteiner |
| AU2002347677A1 (en) | 2001-12-05 | 2003-06-17 | Dsm Biotech Gmbh | Process for the production of an aromatic amino acid metabolite or derivative thereof |
| US6989265B2 (en) | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
| US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
| WO2005087940A1 (en) | 2004-03-11 | 2005-09-22 | Wisconsin Alumni Research Foundation | Genetically altered microorganisms with modified metabolism |
-
2002
- 2002-01-23 US US10/057,582 patent/US6989265B2/en not_active Expired - Lifetime
-
2003
- 2003-01-22 MX MXPA04006942 patent/MX264365B/es active IP Right Grant
- 2003-01-22 CA CA2473922A patent/CA2473922C/en not_active Expired - Lifetime
- 2003-01-22 AT AT03733830T patent/ATE469230T1/de not_active IP Right Cessation
- 2003-01-22 EP EP03733830A patent/EP1483367B1/de not_active Expired - Lifetime
- 2003-01-22 AU AU2003239116A patent/AU2003239116B8/en not_active Expired
- 2003-01-22 JP JP2003569773A patent/JP4658478B2/ja not_active Expired - Lifetime
- 2003-01-22 BR BRPI0307125A patent/BRPI0307125A2/pt active IP Right Grant
- 2003-01-22 DE DE60332708T patent/DE60332708D1/de not_active Expired - Lifetime
- 2003-01-22 KR KR1020047011334A patent/KR100967592B1/ko not_active Expired - Lifetime
- 2003-01-22 WO PCT/US2003/001800 patent/WO2003070880A2/en not_active Ceased
- 2003-01-22 IL IL16291103A patent/IL162911A0/xx unknown
- 2003-01-22 NZ NZ534010A patent/NZ534010A/en not_active IP Right Cessation
- 2003-01-22 CN CN201310363511.5A patent/CN103540543B/zh not_active Expired - Lifetime
- 2003-01-22 SG SG200702708-9A patent/SG155052A1/en unknown
- 2003-01-22 CN CN03802545.0A patent/CN1620497B/zh not_active Expired - Lifetime
- 2003-01-22 BR BRPI0307125-1A patent/BRPI0307125B1/pt unknown
-
2004
- 2004-07-12 ZA ZA2004/05509A patent/ZA200405509B/en unknown
- 2004-07-20 IS IS7355A patent/IS7355A/is unknown
- 2004-08-19 NO NO20043465A patent/NO330918B1/no not_active IP Right Cessation
-
2005
- 2005-07-01 US US11/173,900 patent/US8043842B2/en not_active Expired - Fee Related
-
2008
- 2008-06-30 AU AU2008202865A patent/AU2008202865A1/en not_active Abandoned
- 2008-11-18 IL IL195374A patent/IL195374A/en active IP Right Grant
-
2010
- 2010-09-21 JP JP2010210443A patent/JP5255030B2/ja not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |