ATE469240T1 - Verfahren zum nachweis geringer konzentrationen eines zielbakteriums unter verwendung von phagen zur infizierung von zielbakterienzellen - Google Patents

Verfahren zum nachweis geringer konzentrationen eines zielbakteriums unter verwendung von phagen zur infizierung von zielbakterienzellen

Info

Publication number
ATE469240T1
ATE469240T1 AT03726259T AT03726259T ATE469240T1 AT E469240 T1 ATE469240 T1 AT E469240T1 AT 03726259 T AT03726259 T AT 03726259T AT 03726259 T AT03726259 T AT 03726259T AT E469240 T1 ATE469240 T1 AT E469240T1
Authority
AT
Austria
Prior art keywords
target
bacteria
bacteriophage
bacterial cells
low concentrations
Prior art date
Application number
AT03726259T
Other languages
English (en)
Inventor
Angelo Madonna
Kent Voorhees
Jon Rees
Original Assignee
Colorado School Of Mines
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colorado School Of Mines filed Critical Colorado School Of Mines
Application granted granted Critical
Publication of ATE469240T1 publication Critical patent/ATE469240T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT03726259T 2002-04-12 2003-04-10 Verfahren zum nachweis geringer konzentrationen eines zielbakteriums unter verwendung von phagen zur infizierung von zielbakterienzellen ATE469240T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31918402P 2002-04-12 2002-04-12
PCT/US2003/011253 WO2003087772A2 (en) 2002-04-12 2003-04-10 Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells

Publications (1)

Publication Number Publication Date
ATE469240T1 true ATE469240T1 (de) 2010-06-15

Family

ID=29250416

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726259T ATE469240T1 (de) 2002-04-12 2003-04-10 Verfahren zum nachweis geringer konzentrationen eines zielbakteriums unter verwendung von phagen zur infizierung von zielbakterienzellen

Country Status (9)

Country Link
US (3) US7166425B2 (de)
EP (1) EP1540018B1 (de)
JP (2) JP4490112B2 (de)
AT (1) ATE469240T1 (de)
AU (1) AU2003228505B2 (de)
CA (1) CA2482173C (de)
DE (1) DE60332740D1 (de)
ES (1) ES2346424T3 (de)
WO (1) WO2003087772A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US20020192676A1 (en) * 2001-06-18 2002-12-19 Madonna Angelo J. Method for determining if a type of bacteria is present in a mixture
US20050003346A1 (en) * 2002-04-12 2005-01-06 Colorado School Of Mines Apparatus and method for detecting microscopic living organisms using bacteriophage
ATE469240T1 (de) * 2002-04-12 2010-06-15 Colorado School Of Mines Verfahren zum nachweis geringer konzentrationen eines zielbakteriums unter verwendung von phagen zur infizierung von zielbakterienzellen
US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
CA2501648A1 (en) * 2002-10-15 2004-04-29 Regents Of The University Of Minnesota Assays to detect or quantify bacterial or viral pathogens and contaminants
WO2005001475A2 (en) * 2003-04-10 2005-01-06 Kent Voorhees Apparatus and method for detecting microscopic living organisms using bacteriophage
WO2005047882A2 (en) 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8007725B2 (en) 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having valve system
US20050250096A1 (en) * 2004-02-13 2005-11-10 Microphage, Incorporated Microorganism detection using bacteriophage amplification
WO2008157384A2 (en) 2007-06-15 2008-12-24 Microphage Incorporated Method of detection of microorganisms with enhanced bacteriophage amplification
US20090286225A1 (en) * 2004-02-13 2009-11-19 Microphagetm Incorporated Method and apparatus for bacteriophage-based diagnostic assays
EP1789572A2 (de) * 2004-06-07 2007-05-30 Microphage, Incorporated Nachweis von mikroorganismen mittels bakteriophagenamplifikation
WO2006092629A1 (en) * 2005-03-04 2006-09-08 Blaze Venture Technologies Limited Method and device for bacterial sampling
FR2883296B1 (fr) * 2005-03-15 2007-05-18 Nicolas Bara Procede et dispositif permettant d'isoler les microorganismes
US20110097702A1 (en) * 2005-03-31 2011-04-28 Voorhees Kent J Methods and compositions for in situ detection of microorganisms on a surface
WO2006105504A1 (en) * 2005-03-31 2006-10-05 Microphage Incorporated Apparatus and method for detecting microorganisms using flagged bacteriophage
CA2622439A1 (en) * 2005-09-15 2007-03-29 Microphage Incorporated Method and apparatus for identification of microorganisms using bacteriophage
US20070178450A1 (en) * 2006-01-27 2007-08-02 Microphage (Tm) Incorporation Method and apparatus for determining level of microorganisms using bacteriophage
US20070292397A1 (en) * 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
WO2008063838A2 (en) * 2006-10-31 2008-05-29 Microphage Incorporated Method and apparatus for enhanced bacteriophage-based diagnostic assays by selective inhibition of potential cross-reactive organisms
EP2140018B1 (de) 2007-04-04 2012-08-01 Guild Associates, Inc. Biologisches detektionssystem und -verfahren
US8697434B2 (en) 2008-01-11 2014-04-15 Colorado School Of Mines Detection of phage amplification by SERS nanoparticles
US9441204B2 (en) 2008-04-03 2016-09-13 Colorado School Of Mines Compositions and methods for detecting Yersinia pestis bacteria
WO2010092958A1 (ja) * 2009-02-10 2010-08-19 株式会社日立ハイテクノロジーズ 質量分析技術を用いた免疫分析方法および免疫分析システム
US20110183314A1 (en) * 2010-01-26 2011-07-28 Microphage Incorporated Bacteriophage-based microorganism diagnostic assay using speed or acceleration of bacteriophage reproduction
CN102762980B (zh) * 2010-03-03 2015-11-25 株式会社日立高新技术 分析装置
GB201011152D0 (en) 2010-07-02 2010-08-18 Microsens Medtech Ltd Capture of micro-organisms
FR2980213B1 (fr) * 2011-09-16 2013-09-06 Biomerieux Sa Procede de caracterisation de bacteries, par detection de proteines non-structurales de bacteriophages
US10519483B2 (en) 2012-02-21 2019-12-31 Laboratory Corporation Of America Holdings Methods and systems for rapid detection of microorganisms using infectious agents
US9482668B2 (en) * 2012-02-21 2016-11-01 Laboratory Corporation Of America Holdings Methods and systems for the detection of bacteria
US10662459B2 (en) 2012-03-23 2020-05-26 Laboratory Corporation Of America Holdings Biologic machines for the detection of biomolecules
AU2013267976B2 (en) * 2012-05-29 2016-06-02 Biodesix, Inc. Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
BR112015023108A8 (pt) 2013-03-13 2018-01-23 Geneweave Biosciences Inc sistema de acondicionamento de célula bacteriana, método para acondicionamento de uma molécula de ácido nucléico repórter, composição, método para detectar uma presença ou uma ausência de uma célula bacteriana em uma amostra, vetor, método para detectar um transcrito alvo em uma célula, método para detectar a presença de uma célula bacteriana em uma amostra e kit.
EP3022314B1 (de) 2013-07-15 2021-05-19 President and Fellows of Harvard College Assays für antimikrobielle wirkung und anwendungen davon
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
CN104865186B (zh) * 2015-05-29 2017-08-25 重庆大学 便携式致病菌快速检测方法
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
NL1042018B1 (en) * 2016-08-26 2018-03-06 Bacsassin B V Patent Bacteria Detection and Elimination according to SID
JP2019049455A (ja) * 2017-09-08 2019-03-28 東芝テック株式会社 試料調製装置及び試料調製方法
WO2019215273A1 (en) 2018-05-09 2019-11-14 F. Hoffmann-La Roche Ag Devices and methods for determining particle concentration in a sample
MX2021015900A (es) 2019-06-21 2022-02-03 Laboratory Corp America Holdings Metodos para producir bacteriofagos mutantes para la deteccion de listeria.
US11739363B2 (en) 2019-08-26 2023-08-29 Laboratory Corporation Of America Holdings Devices and methods for detecting microorganisms using recombinant reproduction-deficient indicator bacteriophage
BR112022004479A2 (pt) 2019-09-11 2022-05-31 Laboratory Corp America Holdings Métodos e sistemas para a rápida detecção de microrganismos usando agentes infecciosas recombinantes para expressar uma subunidade indicadora
CN113325063B (zh) * 2021-05-19 2024-05-03 宁波大学 胶体金免疫层析试纸检测结果的验证装置及方法

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839175A (en) * 1973-06-28 1974-10-01 Owens Illinois Inc Electrodeposition of enzymes
US4104126A (en) * 1976-01-29 1978-08-01 Nichols Institute Of Endocrinology, Inc. Non-isotopic substrate assay employing bacteriolysis products
DE3317415A1 (de) * 1983-05-13 1984-11-15 Kernforschungsanlage Jülich GmbH, 5170 Jülich Kammer zur behandlung von zellen im elektrischen feld
EP0175761A4 (de) 1984-03-19 1986-09-24 Marius Constantin Teodorescu Bakteriophagen als erkennungs- und nachweisagenzien.
US4797363A (en) * 1984-03-19 1989-01-10 Board Of Trustees, University Of Illinois Bacteriophages as recognition and identification agents
CA1277931C (en) 1984-06-05 1990-12-18 Shimon Ulitzur Detection and/or identification of microorganisms in a test sample usingbioluminescence or other exogenous genetically-introduced marker
US4861709A (en) * 1985-05-31 1989-08-29 Technicon Research A.G. Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
FR2590675B1 (fr) * 1985-11-27 1990-10-12 Transia Melange d'anticorps specifiques des bacteriophages de bacteries lactiques et ses applications a la detection et a la neutralisation desdits bacteriophages
US5085982A (en) * 1986-06-12 1992-02-04 City Of Hope Method of detecting specific substances by selective growth of living cells
EP0298094A1 (de) 1986-12-01 1989-01-11 McDONNELL DOUGLAS CORPORATION Verfahren zur identifizierung von salmonella
US5620845A (en) * 1988-06-06 1997-04-15 Ampcor, Inc. Immunoassay diagnostic kit
EP0430987B1 (de) 1988-08-02 1993-11-18 London Biotechnology Limited Ein verstärkungs-testverfahren für hydrolase-enzyme
US5126024A (en) * 1989-12-19 1992-06-30 Colorado School Of Mines Apparatus and method for concentrating microorganisms from a liquid medium on an electrode by electrodeposition
JPH05219994A (ja) 1990-01-24 1993-08-31 Amoco Corp シグナル産生部分およびその使用法
US5135870A (en) * 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
US5168037A (en) * 1990-08-02 1992-12-01 Phyllis Entis Method for the preparation of a labelled virus without the inactivation of viral binding sites and method of assay utilizing said labelled virus
GB9017443D0 (en) * 1990-08-09 1990-09-26 Amersham Int Plc Reporter bacteria for rapid microbial detection
US5101105A (en) * 1990-11-02 1992-03-31 Univeristy Of Maryland, Baltimore County Neutralization/chemical reionization tandem mass spectrometry method and apparatus therefor
GB2255561B (en) 1991-04-20 1995-06-21 Agricultural & Food Res Lysins from bacteriophages
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
US6300061B1 (en) * 1992-02-07 2001-10-09 Albert Einstein College Of Medicine Of Yeshiva University Mycobacterial species-specific reporter mycobacteriophages
AU3776493A (en) 1992-02-28 1993-09-13 Paul W. Judkins Method and diagnostic kit for determination of bacteria
US5888725A (en) * 1992-09-22 1999-03-30 The Secretary Of State For The Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Method for identifying target bacteria
GB9220027D0 (en) * 1992-09-22 1992-11-04 Mini Agriculture & Fisheries Method and kits for detection of bacteria
US5469369A (en) * 1992-11-02 1995-11-21 The United States Of America As Represented By The Secretary Of The Navy Smart sensor system and method using a surface acoustic wave vapor sensor array and pattern recognition for selective trace organic vapor detection
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US5679510A (en) * 1993-04-27 1997-10-21 Hybridon, Inc. Quantitative detection of specific nucleic acid sequences using lambdoid bacteriophages linked by oligonucleotides to solid support
DE4314998A1 (de) * 1993-05-06 1994-11-10 Max Delbrueck Centrum Monoklonale Antikörper gegen filamentöse Phagen, ihre Herstellung und Verwendung zum Nachweis und zur Isolierung der Phagen
GB9317139D0 (en) 1993-08-18 1993-10-06 Miniser For Agriculture Fisher Method and test kits for detection of bacteriophage
US5443987A (en) 1993-09-02 1995-08-22 Decicco; Benedict T. Detection system for microbial contamination in health-care products
US5550062A (en) * 1993-10-27 1996-08-27 Microsensor Systems, Inc. Method and apparatus for chemical detection by pyrolysis
US5658747A (en) 1994-05-10 1997-08-19 Biocontrol System, Inc. Compositions and methods for control of reactivity between diagnostic reagents and microorganisms
US5824507A (en) 1994-05-20 1998-10-20 Genelabs Technologies, Inc. Hepatitis G virus and molecular cloning thereof
US5498528A (en) 1994-06-10 1996-03-12 King; Wing Detection of helicobacter pylori
CA2130072C (en) * 1994-08-12 2003-02-18 John W. Cherwonogrodzky Method of detecting a pathogen using a virus
US5656424A (en) * 1995-02-15 1997-08-12 Albert Einstein College Of Medicine, A Division Of Yeshiva University Identification of mycobacterium tuberculosis complex species
US5476768A (en) * 1995-03-10 1995-12-19 Becton, Dickinson And Company Mycobacteriophage DSGA specific for the mycobacterium tuberculosis complex
DE19517940A1 (de) * 1995-05-18 1996-11-21 Merck Patent Gmbh Nachweis von Listerien mittels rekombinanter Bakteriophagen
US5874226A (en) 1995-05-22 1999-02-23 H. Lee Browne In situ immunodetection of antigens
US6316266B1 (en) * 1995-06-07 2001-11-13 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US6093541A (en) * 1995-06-07 2000-07-25 Arizona State University Board Of Regents Mass spectrometer having a derivatized sample presentation apparatus
GB9525661D0 (en) * 1995-12-15 1996-02-14 Biotec Diagnostics Limited Method
US6461833B1 (en) * 1995-12-15 2002-10-08 Biotec Laboratories Limited Method to detect bacteria
US5859375A (en) * 1996-04-03 1999-01-12 Barringer Research Limited Apparatus for and method of collecting trace samples for analysis
US6177266B1 (en) * 1996-04-29 2001-01-23 The United States Of America As Represented By The Secretary Of The Army Rapid identification of bacteria by mass spectrometry
WO1998008944A1 (fr) 1996-08-26 1998-03-05 Bio Venture Bank Co., Ltd. Nouveau bacteriophage et procede de criblage associe, nouvelles matieres biobactericides preparees avec ledit bacteriophage et reactif utilise pour detecter celui-ci
US6322783B1 (en) * 1996-08-26 2001-11-27 Seishi Takahashi Bacteriophages, method for screening same and bactericidal compositions using same, and detection kits using same
US5789174A (en) * 1996-10-11 1998-08-04 Universite Laval Detection of periodontal pathogens including bacteroides forsythus, porphyromonas gingivalis, prevotilla intermedia and prevotella nigrescens
US5710005A (en) * 1996-10-29 1998-01-20 Biocode, Inc. Analyte detection with a gradient lateral flow device
US7153651B1 (en) 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
US5958675A (en) * 1997-04-18 1999-09-28 3M Innovative Properties Company Method for detecting bacteria using bacteriophage, contrast-coloring dye and precipitable dye
IT1291913B1 (it) * 1997-05-22 1999-01-21 Angeletti P Ist Richerche Bio Metodo che prevede l'uso di batteriofagi per la rivelazione della presenza di molecole di interesse in campioni biologici
TW552304B (en) * 1997-08-08 2003-09-11 Food Industry Res & Dev Inst Rapid identification of microorganisms
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
US6037118A (en) * 1998-05-14 2000-03-14 University Of Maryland Baltimore County Viral characterization by direct detection of capsid proteins
EP1086378B1 (de) * 1998-06-04 2005-11-09 Microsens Biophage Limited Analytisches verfahren unter verwendung von multipelviren-markierung
US6183950B1 (en) * 1998-07-31 2001-02-06 Colorado School Of Mines Method and apparatus for detecting viruses using primary and secondary biomarkers
BR9912876A (pt) 1998-08-14 2001-05-08 Biocontrol Systems Inc Composições, fórmulas, dispositivos e processos de controle da especificidade e da inclusividade de microorganismos contendo epìtopos antigênicos intimamente relacionados
DE60014987T2 (de) * 1999-02-22 2005-11-10 Matsushita Electric Industrial Co., Ltd., Kadoma Verfahren zum Nachweis von Bakterien
US6482632B1 (en) 1999-03-29 2002-11-19 Council Of Scientic And Industrial Research Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof
US6580068B1 (en) * 1999-07-09 2003-06-17 Sandia Corporation Method and apparatus for time dispersive spectroscopy
AU781090B2 (en) * 1999-07-30 2005-05-05 Biomerieux S.A. Detection and identification of bacterial strains
US6737266B1 (en) 1999-10-01 2004-05-18 3M Innovative Properties Company Devices and methods for microorganism detection
WO2001025758A1 (en) 1999-10-06 2001-04-12 Surromed, Inc. Surface enhanced spectroscopy-active composite nanoparticles
DE19957542C2 (de) * 1999-11-30 2002-01-10 Infineon Technologies Ag Alternierende Phasenmaske
US6436661B1 (en) * 2000-04-13 2002-08-20 3M Innovative Properties Company Bacteria and bacteriophage detection using immobilized enzyme substrates
US6799119B1 (en) * 2000-05-15 2004-09-28 Colorado School Of Mines Method for detection of biological related materials using biomarkers
GB0017121D0 (en) 2000-07-13 2000-08-30 Blackburn Juliet Convertible seating and bedding apparatus
US6528325B1 (en) * 2000-10-13 2003-03-04 Dexall Biomedical Labs, Inc. Method for the visual detection of specific antibodies in human serum by the use of lateral flow assays
US6514778B2 (en) 2001-01-31 2003-02-04 United Microelectronics Corp. Method for measuring effective gate channel length during C-V method
WO2002061117A1 (de) 2001-02-01 2002-08-08 Profos Ag Nachweis und identifikation von bakteriengruppen
CN1141318C (zh) * 2001-02-28 2004-03-10 中国医学科学院血液学研究所 人促血液血管细胞生成素及其制造方法
US20020192676A1 (en) * 2001-06-18 2002-12-19 Madonna Angelo J. Method for determining if a type of bacteria is present in a mixture
JP4426286B2 (ja) 2001-07-10 2010-03-03 テバ ファーマシューティカル インダストリーズ リミティド ０次、０次−二相性、上昇型又は下降型薬物放出のための薬物送達システム
WO2003035889A2 (en) 2001-07-13 2003-05-01 Investigen, Inc. Compositions and methods for bacteria detection
US6544729B2 (en) * 2001-07-20 2003-04-08 University Of Tennessee Bioluminescent biosensor device
JP4554206B2 (ja) 2001-09-27 2010-09-29 ガンガゲン インコーポレーティッド 無力化した全菌体免疫原性細菌組成物
US7034113B2 (en) 2002-02-22 2006-04-25 Paradigm Diagnostics, Llc Bacteriocin-metal complexes in the detection of pathogens and other biological analytes
ATE469240T1 (de) 2002-04-12 2010-06-15 Colorado School Of Mines Verfahren zum nachweis geringer konzentrationen eines zielbakteriums unter verwendung von phagen zur infizierung von zielbakterienzellen
US20050003346A1 (en) * 2002-04-12 2005-01-06 Colorado School Of Mines Apparatus and method for detecting microscopic living organisms using bacteriophage
US8216780B2 (en) 2002-04-12 2012-07-10 Microphage (Tm) Incorporated Method for enhanced sensitivity in bacteriophage-based diagnostic assays
US20040002126A1 (en) 2002-06-28 2004-01-01 Michel Houde Method, device and system for detecting the presence of microorganisms
US20050208475A1 (en) 2002-09-16 2005-09-22 Eric Best Process and apparatus comprising episcopic differential contrast (EDIC) microscopy plus epifluorescence microscopy (EF) for the detection or identification of biological materials on surfaces
CA2501648A1 (en) * 2002-10-15 2004-04-29 Regents Of The University Of Minnesota Assays to detect or quantify bacterial or viral pathogens and contaminants
US7282349B2 (en) 2003-12-16 2007-10-16 Kimberly-Clark Worldwide, Inc. Solvatochromatic bacterial detection
US20050250096A1 (en) 2004-02-13 2005-11-10 Microphage, Incorporated Microorganism detection using bacteriophage amplification
US20090286225A1 (en) 2004-02-13 2009-11-19 Microphagetm Incorporated Method and apparatus for bacteriophage-based diagnostic assays
US20050255043A1 (en) 2004-04-09 2005-11-17 Hnatowich Donald J Bacteriophage imaging of inflammation
WO2006014687A1 (en) 2004-07-20 2006-02-09 Medtronic, Inc. Switched power using telemetry in an implantable medical device
WO2006105504A1 (en) * 2005-03-31 2006-10-05 Microphage Incorporated Apparatus and method for detecting microorganisms using flagged bacteriophage
US20070178450A1 (en) * 2006-01-27 2007-08-02 Microphage (Tm) Incorporation Method and apparatus for determining level of microorganisms using bacteriophage
US8697434B2 (en) 2008-01-11 2014-04-15 Colorado School Of Mines Detection of phage amplification by SERS nanoparticles
US7674602B2 (en) 2008-02-20 2010-03-09 The Clorox Company Method for detecting a plurality of catalase positive microorganisms
US9441204B2 (en) 2008-04-03 2016-09-13 Colorado School Of Mines Compositions and methods for detecting Yersinia pestis bacteria

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JP2010088456A (ja) 2010-04-22
WO2003087772A3 (en) 2005-04-21
ES2346424T3 (es) 2010-10-15
EP1540018B1 (de) 2010-05-26
US20040224359A1 (en) 2004-11-11
HK1082525A1 (en) 2006-06-09
DE60332740D1 (de) 2010-07-08
AU2003228505B2 (en) 2009-01-08
US20070275370A1 (en) 2007-11-29
WO2003087772A2 (en) 2003-10-23
EP1540018A4 (de) 2006-05-24
US7972773B2 (en) 2011-07-05
CA2482173A1 (en) 2003-10-23
US7166425B2 (en) 2007-01-23
EP1540018A2 (de) 2005-06-15
JP4490112B2 (ja) 2010-06-23
CA2482173C (en) 2012-10-23
AU2003228505A1 (en) 2003-10-27
JP2005524394A (ja) 2005-08-18

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