ATE469547T1 - Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist - Google Patents

Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist

Info

Publication number
ATE469547T1
ATE469547T1 AT01914893T AT01914893T ATE469547T1 AT E469547 T1 ATE469547 T1 AT E469547T1 AT 01914893 T AT01914893 T AT 01914893T AT 01914893 T AT01914893 T AT 01914893T AT E469547 T1 ATE469547 T1 AT E469547T1
Authority
AT
Austria
Prior art keywords
human
agents
virus
animal model
infectable
Prior art date
Application number
AT01914893T
Other languages
English (en)
Inventor
Norman M Kneteman
Lorne D Tyrrell
David F Mercer
Original Assignee
Kmt Hepatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kmt Hepatech Inc filed Critical Kmt Hepatech Inc
Application granted granted Critical
Publication of ATE469547T1 publication Critical patent/ATE469547T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01914893T 2000-03-17 2001-03-16 Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist ATE469547T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/528,120 US6509514B1 (en) 2000-03-17 2000-03-17 Chimeric animal model susceptible to human hepatitis C virus infection
PCT/CA2001/000350 WO2001067854A1 (en) 2000-03-17 2001-03-16 Chimeric animal model susceptible to human hepatitis c virus infection

Publications (1)

Publication Number Publication Date
ATE469547T1 true ATE469547T1 (de) 2010-06-15

Family

ID=24104337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914893T ATE469547T1 (de) 2000-03-17 2001-03-16 Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist

Country Status (13)

Country Link
US (6) US6509514B1 (de)
EP (1) EP1265480B1 (de)
JP (2) JP4059672B2 (de)
KR (1) KR100656795B1 (de)
AT (1) ATE469547T1 (de)
AU (2) AU4216301A (de)
CA (1) CA2402117C (de)
DE (1) DE60142281D1 (de)
DK (1) DK1265480T3 (de)
ES (1) ES2346636T3 (de)
IL (2) IL151621A0 (de)
NZ (1) NZ521119A (de)
WO (1) WO2001067854A1 (de)

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JP4854509B2 (ja) * 2004-08-20 2012-01-18 積水メディカル株式会社 薬物のヒトにおける肝代謝及び肝機能を予測する方法
US7566812B2 (en) 2004-08-27 2009-07-28 Tripep Ab Transgenic mouse models of hepatitis C virus (HCV) and identification of HCV therapeutics
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WO2009105244A1 (en) * 2008-02-21 2009-08-27 The University Of North Carolina At Chapel Hill Recombiant non-human mammalian model for hepatitis infection and immunopathogenesis
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US9186128B2 (en) * 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
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JP5841322B2 (ja) 2010-04-22 2016-01-13 オレゴン ヘルス アンド サイエンス ユニバーシティ フマリルアセト酢酸ヒドロラーゼ（ｆａｈ）欠損性ブタおよびその使用
WO2012048170A2 (en) 2010-10-06 2012-04-12 Massachusetts Institute Of Technology Humanized animals via tissue engineering and uses therefor
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US9532554B2 (en) 2011-09-30 2017-01-03 Public University Corporation Yokohama City University Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver
JP5883265B2 (ja) * 2011-10-13 2016-03-09 株式会社フェニックスバイオ ヒト肝細胞を担持するキメラ非ヒト動物
WO2013086019A1 (en) * 2011-12-06 2013-06-13 Massachusetts Institute Of Technology Use of humanized mice to determine toxicity
WO2013145331A1 (ja) * 2012-03-27 2013-10-03 株式会社トランスジェニック ヒト化マウス
JP5976380B2 (ja) 2012-04-27 2016-08-23 公益財団法人東京都医学総合研究所 ウロキナーゼ型プラスミノーゲンアクチベータートランスジェニックマウス
EP2872155A4 (de) 2012-07-10 2016-07-13 Univ Pennsylvania Biomaterialien für verbesserte implantat-host-integration
CN103088106A (zh) * 2013-01-25 2013-05-08 中国水产科学研究院淡水渔业研究中心 用鱼原代肝细胞损伤模型筛选鱼类保肝药物的方法
US9566315B2 (en) 2013-11-01 2017-02-14 Oregon Health & Science University Normalization of the enterohepatic circulation in animals with a chimeric humanized liver
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
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US12070021B2 (en) * 2017-09-25 2024-08-27 National University Of Singapore Chimeric mouse comprising stably transplanted bat cells
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Also Published As

Publication number Publication date
IL151621A (en) 2006-06-11
JP4436389B2 (ja) 2010-03-24
ES2346636T3 (es) 2010-10-19
WO2001067854A1 (en) 2001-09-20
US20110167507A1 (en) 2011-07-07
JP4059672B2 (ja) 2008-03-12
US20030115616A1 (en) 2003-06-19
CA2402117C (en) 2012-01-17
US7498479B2 (en) 2009-03-03
EP1265480B1 (de) 2010-06-02
US6509514B1 (en) 2003-01-21
JP2008022853A (ja) 2008-02-07
DE60142281D1 (de) 2010-07-15
IL151621A0 (en) 2003-04-10
US20090151012A1 (en) 2009-06-11
US20120309032A1 (en) 2012-12-06
US7161057B2 (en) 2007-01-09
JP2003526348A (ja) 2003-09-09
US20070107069A1 (en) 2007-05-10
US8445745B2 (en) 2013-05-21
AU2001242163B2 (en) 2005-06-23
KR20030027883A (ko) 2003-04-07
KR100656795B1 (ko) 2006-12-12
US8212106B2 (en) 2012-07-03
CA2402117A1 (en) 2001-09-20
EP1265480A1 (de) 2002-12-18
US7781642B2 (en) 2010-08-24
NZ521119A (en) 2004-03-26
AU4216301A (en) 2001-09-24
DK1265480T3 (da) 2010-09-20

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