ATE469547T1 - Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist - Google Patents

Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist

Info

Publication number
ATE469547T1
ATE469547T1 AT01914893T AT01914893T ATE469547T1 AT E469547 T1 ATE469547 T1 AT E469547T1 AT 01914893 T AT01914893 T AT 01914893T AT 01914893 T AT01914893 T AT 01914893T AT E469547 T1 ATE469547 T1 AT E469547T1
Authority
AT
Austria
Prior art keywords
human
agents
virus
animal model
infectable
Prior art date
Application number
AT01914893T
Other languages
English (en)
Inventor
Norman M Kneteman
Lorne D Tyrrell
David F Mercer
Original Assignee
Kmt Hepatech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kmt Hepatech Inc filed Critical Kmt Hepatech Inc
Application granted granted Critical
Publication of ATE469547T1 publication Critical patent/ATE469547T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT01914893T 2000-03-17 2001-03-16 Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist ATE469547T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/528,120 US6509514B1 (en) 2000-03-17 2000-03-17 Chimeric animal model susceptible to human hepatitis C virus infection
PCT/CA2001/000350 WO2001067854A1 (en) 2000-03-17 2001-03-16 Chimeric animal model susceptible to human hepatitis c virus infection

Publications (1)

Publication Number Publication Date
ATE469547T1 true ATE469547T1 (de) 2010-06-15

Family

ID=24104337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914893T ATE469547T1 (de) 2000-03-17 2001-03-16 Chimäres tiermodell, das mit dem menschlichen hepatitis c virus infizierbar ist

Country Status (13)

Country Link
US (6) US6509514B1 (de)
EP (1) EP1265480B1 (de)
JP (2) JP4059672B2 (de)
KR (1) KR100656795B1 (de)
AT (1) ATE469547T1 (de)
AU (2) AU2001242163B2 (de)
CA (1) CA2402117C (de)
DE (1) DE60142281D1 (de)
DK (1) DK1265480T3 (de)
ES (1) ES2346636T3 (de)
IL (2) IL151621A0 (de)
NZ (1) NZ521119A (de)
WO (1) WO2001067854A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995299B2 (en) * 1999-11-02 2006-02-07 University Of Connecticut Propagation of human hepatocytes in non-human animals
US6509514B1 (en) * 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection
JPWO2002028174A1 (ja) * 2000-10-03 2004-02-12 財団法人 東京都医学研究機構 Ｃ型肝炎ウイルス感染方法
US20030096316A1 (en) * 2001-11-21 2003-05-22 Ingmar Wester Use of apolipoprotein B as a single marker for evaluation of the risk or cardiovascular disease
EP1496110B1 (de) * 2002-03-25 2012-05-09 Hiroshima Industrial Promotion Organization Verfahren zur vermehrung menschlicher hepatozyten und verfahren zur gewinnung menschlicher hepatozyten
EP1552740A1 (de) * 2004-01-09 2005-07-13 Institut Pasteur Chimaeres Mausmodell enthaltend humane Hepatocyten - Anwendung zum Screening von Verbindungen
AU2005277463A1 (en) * 2004-08-20 2006-03-02 Kmt Hepatech, Inc. Malarial animal model having a chimeric human liver
JP4854509B2 (ja) * 2004-08-20 2012-01-18 積水メディカル株式会社 薬物のヒトにおける肝代謝及び肝機能を予測する方法
ATE514708T1 (de) 2004-08-27 2011-07-15 Chrontech Pharma Ab Transgene mausmodelle des hepatitis c virus (hcv) sowie identifizierung von hcv therapeutika
WO2006054755A1 (ja) * 2004-11-16 2006-05-26 Hiroshima Industrial Promotion Organization 医薬候補物質のスクリーニング方法
US20060148080A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Methods for supporting and producing human cells and tissues in non-human mammal hosts
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
JP2009501546A (ja) * 2005-07-18 2009-01-22 ノバルティス アーゲー Ｈｃｖ複製についての小動物モデル
WO2008151283A1 (en) * 2007-06-05 2008-12-11 Oregon Health & Science University Method of expanding human hepatocytes in vivo
US9173383B2 (en) * 2008-02-21 2015-11-03 The University Of North Carolina At Chapel Hill Recombinant non-human mammalian model for hepatitis infection and immunopathogenesis
CN101550425B (zh) * 2008-03-31 2011-03-30 北京大学 一种可调控的肝损伤动物模型的制作方法及其专用载体
JP5710097B2 (ja) * 2008-07-10 2015-04-30 株式会社バイオマーカーサイエンス 動脈硬化改善・予防効果の評価方法、物質のスクリーニング方法、並びに、マーカーとしての使用
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
CN101748123B (zh) * 2008-11-27 2012-11-07 北京大学 可调控肝损伤动物模型的制作方法及其专用dna片段
CN102281758B (zh) * 2009-01-16 2014-12-10 公益财团法人实验动物中央研究所 移植了人肝细胞的小鼠
JP5841322B2 (ja) 2010-04-22 2016-01-13 オレゴン ヘルス アンド サイエンス ユニバーシティ フマリルアセト酢酸ヒドロラーゼ（ｆａｈ）欠損性ブタおよびその使用
WO2012048170A2 (en) 2010-10-06 2012-04-12 Massachusetts Institute Of Technology Humanized animals via tissue engineering and uses therefor
WO2013032918A1 (en) 2011-08-26 2013-03-07 Yecuris Corporation Fumarylacetoacetate hydrolase (fah)-deficient and immunodeficient rats and uses thereof
JP5950235B2 (ja) 2011-09-30 2016-07-13 公立大学法人横浜市立大学 肝細胞の分化誘導方法、ヒト化肝臓キメラ非ヒト動物の作製方法
JP5883265B2 (ja) * 2011-10-13 2016-03-09 株式会社フェニックスバイオ ヒト肝細胞を担持するキメラ非ヒト動物
US20150007357A1 (en) * 2011-12-06 2015-01-01 Massachusetts Institute Of Technology Use Of Humanized Mice To Determine Toxicity
CA2868292A1 (en) * 2012-03-27 2013-10-03 National University Corporation Kumamoto University Immunodeficient mouse with humanized liver
JP5976380B2 (ja) * 2012-04-27 2016-08-23 公益財団法人東京都医学総合研究所 ウロキナーゼ型プラスミノーゲンアクチベータートランスジェニックマウス
CA2878404A1 (en) 2012-07-10 2014-01-16 The Trustees Of The University Of Pennsylvania Biomaterials for enhanced implant-host integration
CN103088106A (zh) * 2013-01-25 2013-05-08 中国水产科学研究院淡水渔业研究中心 用鱼原代肝细胞损伤模型筛选鱼类保肝药物的方法
WO2015073222A1 (en) 2013-11-01 2015-05-21 Oregon Health & Science University Normalization of the enterohepatic circulation in animals with a chimeric humanized liver
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
US11338065B2 (en) 2015-10-08 2022-05-24 Massachusetts Institute Of Technology In situ expansion of engineered devices for regeneration
CN106047870B (zh) * 2016-06-16 2019-01-08 中国医学科学院医学生物学研究所 树鼩mhc-drb1*1101基因序列及其应用
CN114875066A (zh) 2016-06-27 2022-08-09 贝勒医学院 具有缺陷性p450氧化还原酶的人肝嵌合非人动物及其使用方法
US11530388B2 (en) 2017-02-14 2022-12-20 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of engineering human induced pluripotent stem cells to produce liver tissue
US12070021B2 (en) * 2017-09-25 2024-08-27 National University Of Singapore Chimeric mouse comprising stably transplanted bat cells
KR102362814B1 (ko) 2020-06-04 2022-02-15 한국생명공학연구원 인간 간세포 이식용 동물모델 및 이를 이용한 항바이러스제 스크리닝 방법

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476996A (en) * 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5994617A (en) * 1988-09-19 1999-11-30 Hsc Research Development Corporation Engraftment of immune-deficient mice with human cells
DK0438053T3 (da) 1990-01-15 1999-11-22 Yeda Res & Dev Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr
US5849288A (en) 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5652373A (en) 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US5858328A (en) 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5849987A (en) 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5804160A (en) 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5408038A (en) 1991-10-09 1995-04-18 The Scripps Research Institute Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides
US5866757A (en) 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
IL106368A0 (en) 1992-07-24 1993-11-15 Univ Pennsylvania Non-native liver generation in an animal with impaired native liver function,by cell implantation
CA2161798C (en) 1993-05-17 2005-04-05 Yair Reisner Animal model for hepatitis virus infection
US6107027A (en) 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
US5980886A (en) * 1994-12-14 1999-11-09 University Of Washington Recombinant vectors for reconstitution of liver
WO1996039810A1 (en) 1995-06-07 1996-12-19 Novartis Ag Human hepatocellular tissue in chimeric immunocompromised animals
DE69734557T2 (de) * 1996-03-15 2006-07-27 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Sprühvorrichtung zum aufbringen von gewebeklebstoff
GB9705744D0 (en) 1997-03-20 1997-05-07 Davies Alison M Methods for selecting cells and their uses
US6034297A (en) * 1997-09-26 2000-03-07 Cedars-Sinai Medical Center In vivo, animal model for expression of hepatitis C virus
EP1062512A4 (de) 1998-03-10 2001-12-12 Univ California Verfahren und hilfsmittel zum identifizieren von verbindungen, die atherosklerose modulieren indem sie ldl-proteoglykanbindungen beeinflussen
WO2000017338A1 (en) 1998-09-18 2000-03-30 Albert Einstein College Of Medicine Of Yeshiva University Upa/rag-2 mouse with mammalian repopulating hepatocytes for infection by hepadnaviruses
US6864402B1 (en) 1998-09-18 2005-03-08 Albert Einstein College Of Medicine Of Yeshiva University Chronic hepatitis virus infection and clonal hepatocellular carcinoma in mouse repopulated livers
US6249089B1 (en) * 1998-10-09 2001-06-19 Frederick Bruwer Intelligent electrical device comprising microchip
AU6092900A (en) 1999-07-14 2001-02-05 Board Of Trustees Of The Leland Stanford Junior University Animals comprising human hepatocellular tissue
US6525242B1 (en) 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6509514B1 (en) 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection

Also Published As

Publication number Publication date
CA2402117C (en) 2012-01-17
KR20030027883A (ko) 2003-04-07
JP4436389B2 (ja) 2010-03-24
US6509514B1 (en) 2003-01-21
JP2003526348A (ja) 2003-09-09
IL151621A (en) 2006-06-11
DK1265480T3 (da) 2010-09-20
AU2001242163B2 (en) 2005-06-23
US20110167507A1 (en) 2011-07-07
US20120309032A1 (en) 2012-12-06
US20090151012A1 (en) 2009-06-11
US7498479B2 (en) 2009-03-03
EP1265480A1 (de) 2002-12-18
ES2346636T3 (es) 2010-10-19
US20070107069A1 (en) 2007-05-10
IL151621A0 (en) 2003-04-10
DE60142281D1 (de) 2010-07-15
NZ521119A (en) 2004-03-26
KR100656795B1 (ko) 2006-12-12
JP2008022853A (ja) 2008-02-07
US8445745B2 (en) 2013-05-21
US8212106B2 (en) 2012-07-03
AU4216301A (en) 2001-09-24
EP1265480B1 (de) 2010-06-02
WO2001067854A1 (en) 2001-09-20
US20030115616A1 (en) 2003-06-19
US7161057B2 (en) 2007-01-09
JP4059672B2 (ja) 2008-03-12
CA2402117A1 (en) 2001-09-20
US7781642B2 (en) 2010-08-24

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