ATE469912T1 - Gegenionenaustauschverfahren für peptide - Google Patents

Gegenionenaustauschverfahren für peptide

Info

Publication number
ATE469912T1
ATE469912T1 AT05811089T AT05811089T ATE469912T1 AT E469912 T1 ATE469912 T1 AT E469912T1 AT 05811089 T AT05811089 T AT 05811089T AT 05811089 T AT05811089 T AT 05811089T AT E469912 T1 ATE469912 T1 AT E469912T1
Authority
AT
Austria
Prior art keywords
peptides
exchange process
peptide
column
counterion exchange
Prior art date
Application number
AT05811089T
Other languages
English (en)
Inventor
Avi Tovi
Chaim Eidelman
Shimon Shushan
Shai Elster
Hagi Alon
Alexander Ivchenko
Gabriel-Marcus Butilca
Gil Zaoui
Original Assignee
Novetide Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novetide Ltd filed Critical Novetide Ltd
Application granted granted Critical
Publication of ATE469912T1 publication Critical patent/ATE469912T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05811089T 2004-10-04 2005-10-04 Gegenionenaustauschverfahren für peptide ATE469912T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61601004P 2004-10-04 2004-10-04
US63052804P 2004-11-22 2004-11-22
PCT/US2005/035868 WO2006041945A2 (en) 2004-10-04 2005-10-04 A counterion exchange process for peptides

Publications (1)

Publication Number Publication Date
ATE469912T1 true ATE469912T1 (de) 2010-06-15

Family

ID=36096369

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05811089T ATE469912T1 (de) 2004-10-04 2005-10-04 Gegenionenaustauschverfahren für peptide

Country Status (10)

Country Link
US (1) US20060148699A1 (de)
EP (2) EP1709065B1 (de)
JP (1) JP2007513192A (de)
AT (1) ATE469912T1 (de)
CA (1) CA2582083A1 (de)
DE (1) DE602005021614D1 (de)
DK (1) DK1709065T3 (de)
ES (1) ES2344657T3 (de)
IL (1) IL182157A0 (de)
WO (1) WO2006041945A2 (de)

Families Citing this family (30)

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NL2000126C2 (nl) * 2005-07-15 2008-01-29 Solvay Werkwijze voor de vervaardiging van eptifibatide.
EP2057183A2 (de) * 2007-03-01 2009-05-13 Novetide Ltd. Peptide von hoher reinheit
CN101790535A (zh) * 2007-06-29 2010-07-28 隆萨股份公司 制备普兰林肽的方法
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
EP2062909A1 (de) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Herstellung von Peptiden und Reinigungsverfahren
RU2461564C2 (ru) * 2008-02-06 2012-09-20 Байокон Лимитид Способ очистки циклического или нециклического пептида
CN101314613B (zh) * 2008-05-08 2012-04-25 吉尔生化（上海）有限公司 一种阿托西班的固相合成方法
WO2009150657A1 (en) * 2008-06-09 2009-12-17 Natco Pharma Limited Improved process for preparation of eptifibatide by fmoc solid phase synthesis
CN101463080B (zh) * 2009-01-09 2011-09-14 深圳翰宇药业股份有限公司 一种纯化奈西利肽的方法
CN101696236B (zh) * 2009-02-11 2012-02-15 海南中和药业有限公司 一种固相合成阿托西班方法
WO2010119450A2 (en) 2009-04-06 2010-10-21 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
WO2011011342A1 (en) * 2009-07-20 2011-01-27 Mallinckrodt Inc. Synthesis of desmopressin
PL2464655T3 (pl) * 2009-08-11 2017-08-31 Biocon Limited Procesy chromatograficzne
CN101787071B (zh) * 2010-02-26 2012-11-07 深圳翰宇药业股份有限公司 一种伐普肽的纯化方法
CN101780267A (zh) * 2010-03-12 2010-07-21 深圳翰宇药业股份有限公司 一种抗血小板凝集的制剂及其制备方法
RU2441018C1 (ru) * 2010-09-28 2012-01-27 Закрытое Акционерное Общество "Фарм-Синтез" Способ хроматографической очистки октреотида
CN102146121A (zh) * 2010-11-19 2011-08-10 深圳市健元医药科技有限公司 一种含有oxt拮抗剂药物的生产工艺
RU2494105C2 (ru) * 2010-12-29 2013-09-27 Общество с ограниченной ответственностью "Химфармресурс" Способ получения циклического пептида
US9388212B2 (en) 2013-02-21 2016-07-12 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
CN102875663B (zh) * 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 利西拉来的纯化方法
JP6382488B2 (ja) * 2013-02-21 2018-08-29 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． 側鎖結合を介する固相ペプチド合成
CN103965291B (zh) * 2014-05-27 2016-09-21 上海第一生化药业有限公司 奥曲肽、奥曲肽醋酸盐的制备方法
CN106699847B (zh) * 2017-01-04 2020-08-14 陕西慧康生物科技有限责任公司 一种低成本纯化六胜肽的方法
JP6707576B2 (ja) * 2018-04-03 2020-06-10 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． 側鎖結合を介する固相ペプチド合成
HUE057693T2 (hu) 2018-04-06 2022-05-28 Univ Pennsylvania Fokozott oldhatóságú és javított farmakokinetikai tulajdonságú kompsztatin analógok
WO2020170185A1 (en) * 2019-02-21 2020-08-27 Dr. Reddy’S Laboratories Limited Substantially pure lanreotide or its salt & process thereof
CN109942686B (zh) * 2019-05-06 2021-06-25 上海上药第一生化药业有限公司 一种加压素乙酰化杂质的精制方法
CN109929011B (zh) * 2019-05-06 2021-04-06 上海上药第一生化药业有限公司 一种加压素[5-Asp]杂质的精制方法
KR20220054598A (ko) * 2019-07-26 2022-05-03 알레그로 파마슈티칼스, 엘엘씨 비삼출성 황반변성 및 기타 안질환 치료용 펩티드
WO2024112250A1 (en) * 2022-11-23 2024-05-30 Polypeptide Laboratories Holding (Ppl) Ab Method of preparing vasopressin

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US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
CY1327A (en) * 1979-11-27 1986-06-27 Sandoz Ag Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
GB8813160D0 (en) * 1988-06-03 1988-07-06 Soc D Etudes Prod Chimique Therapeutic methods
EP0710243B1 (de) * 1993-06-29 2000-06-14 Ferring B.V. Synthese zyklischer peptide
WO1995033769A1 (de) * 1994-06-02 1995-12-14 Boehringer Mannheim Gmbh Verfahren zur herstellung von cardiodilatin-fragmenten, hochgereinigte cardiodilatin-fragmente und zwischenprodukte zu deren herstellung
US5889146A (en) * 1997-11-26 1999-03-30 Institute Of Nuclear Energy Research Method for synthesis of bifunctional chelating agents-peptides
CN1242062C (zh) * 1998-07-10 2006-02-15 赛欧斯公司 生产等电点高于8或低于5的多肽的方法
PL205149B1 (pl) * 2000-02-22 2010-03-31 Serono Lab Sposób przygotowania rekombinowanej hCG
HRP20020651B1 (en) * 2000-02-22 2011-01-31 Laboratoires Serono Sa Purified lh
DK1511761T3 (da) * 2003-04-07 2006-11-27 Novetide Ltd Fremgangsmåde til fremstilling af cykliske peptider
ME01063B (me) * 2004-04-08 2012-10-20 Millennium Pharm Inc Postupak za dobijanje eptifibatida i odgovarajućih intermedijernih jedinjenja

Also Published As

Publication number Publication date
WO2006041945A2 (en) 2006-04-20
WO2006041945A3 (en) 2006-08-24
EP2163558A3 (de) 2010-10-27
EP1709065A2 (de) 2006-10-11
CA2582083A1 (en) 2006-04-20
EP1709065B1 (de) 2010-06-02
JP2007513192A (ja) 2007-05-24
DK1709065T3 (da) 2010-08-23
IL182157A0 (en) 2007-07-24
DE602005021614D1 (de) 2010-07-15
ES2344657T3 (es) 2010-09-02
EP2163558A2 (de) 2010-03-17
US20060148699A1 (en) 2006-07-06

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