ATE471144T1 - Intranasale verabreichung von schnell wirkendem insulin - Google Patents

Intranasale verabreichung von schnell wirkendem insulin

Info

Publication number: ATE471144T1
Authority: AT; Austria
Prior art keywords: rapid; intranasal administration; acting insulin; insulin; human insulin
Prior art date: 2005-10-20

Application number

AT06826368T

Other languages

English (en)

Inventor

Steven Quay

Annemarie Cohen

Henry Costantino

Shu-Chih Chen Quay

Anthony SILENO

Mary Kleppe

Original Assignee

Mdrna Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-20

Filing date

2006-10-20

Publication date

2010-07-15

2006-10-20 Application filed by Mdrna Inc filed Critical Mdrna Inc

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE471144T1 publication Critical patent/ATE471144T1/de

Links

229940123452 Rapid-acting insulin Drugs 0.000 title 1
108010026951 Short-Acting Insulin Proteins 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
102000007469 Actins Human genes 0.000 abstract 1
108010085238 Actins Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Inorganic Chemistry (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT06826368T 2005-10-20 2006-10-20 Intranasale verabreichung von schnell wirkendem insulin ATE471144T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US72887705P	2005-10-20	2005-10-20
US77872406P	2006-03-03	2006-03-03
US80690406P	2006-07-10	2006-07-10
US82152506P	2006-08-04	2006-08-04
US82587606P	2006-09-15	2006-09-15
PCT/US2006/041081 WO2007047948A2 (en)	2005-10-20	2006-10-20	Intranasal administration of rapid acting insulin

Publications (1)

Publication Number	Publication Date
ATE471144T1 true ATE471144T1 (de)	2010-07-15

Family

ID=37898816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06826368T ATE471144T1 (de)	2005-10-20	2006-10-20	Intranasale verabreichung von schnell wirkendem insulin

Country Status (10)

Country	Link
US (1)	US20100210506A1 (de)
EP (1)	EP1951198B1 (de)
JP (1)	JP2009512709A (de)
KR (1)	KR20080064171A (de)
AT (1)	ATE471144T1 (de)
AU (1)	AU2006304757A1 (de)
CA (1)	CA2626357A1 (de)
DE (1)	DE602006014990D1 (de)
IL (1)	IL190838A0 (de)
WO (1)	WO2007047948A2 (de)

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EP1969004B1 (de)	2005-12-28	2011-08-10	Novo Nordisk A/S	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
CN101541830A (zh)	2006-09-22	2009-09-23	诺沃-诺迪斯克有限公司	蛋白酶抗性的胰岛素类似物
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JP2010525033A (ja) *	2007-04-30	2010-07-22	ノボ・ノルデイスク・エー／エス	高濃縮のインスリン溶液及び組成物
EP2514406A1 (de) *	2007-06-01	2012-10-24	Novo Nordisk A/S	Spontan dispergierbare Vorkonzentrate mit einem Peptidwirkstoff in einem festen oder halbfesten Träger
AU2008257505B2 (en) *	2007-06-01	2013-05-16	Novo Nordisk A/S	Stable non-aqueous pharmaceutical compositions
CN101970477B (zh)	2008-03-14	2014-12-31	诺沃-诺迪斯克有限公司	蛋白酶稳定的胰岛素类似物
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
TWI394580B (zh) *	2008-04-28	2013-05-01	Halozyme Inc	超快起作用胰島素組成物
EP3685837A1 (de) *	2008-09-04	2020-07-29	Amylin Pharmaceuticals, LLC	Formulierungen mit verzögerter freisetzung unter verwendung nichtwässriger träger
CN102202683A (zh)	2008-10-30	2011-09-28	诺沃-诺迪斯克有限公司	用少于每日一次的注射频率注射胰岛素来治疗糖尿病
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
US10525214B2 (en)	2010-01-12	2020-01-07	Dance Biopharm Inc.	Preservative-free single dose inhaler system
US9545488B2 (en)	2010-01-12	2017-01-17	Dance Biopharm Inc.	Preservative-free single dose inhaler systems
US9180261B2 (en)	2010-01-12	2015-11-10	Dance Biopharm Inc.	Preservative free insulin formulations and systems and methods for aerosolizing
US10842951B2 (en)	2010-01-12	2020-11-24	Aerami Therapeutics, Inc.	Liquid insulin formulations and methods relating thereto
US8950394B2 (en)	2010-01-12	2015-02-10	Dance Biopharm Inc.	Preservative-free single dose inhaler systems
US20130269684A1 (en)	2012-04-16	2013-10-17	Dance Pharmaceuticals, Inc.	Methods and systems for supplying aerosolization devices with liquid medicaments
US20120035103A1 (en) *	2010-01-29	2012-02-09	Pillion Dennis J	Method for administration of insulin and pharmaceutical composition thereof
WO2012051116A1 (en) *	2010-10-12	2012-04-19	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
US8658676B2 (en)	2010-10-12	2014-02-25	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
WO2012065996A1 (en) *	2010-11-15	2012-05-24	Sanofi-Aventis Deutschland Gmbh	PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND MALTOSYL-ß-CYCLODEXTRIN
WO2012066086A1 (en) *	2010-11-17	2012-05-24	Sanofi-Aventis Deutschland Gmbh	PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SULFOBUTYL ETHER 7-ß-CYCLODEXTRIN
US9993529B2 (en)	2011-06-17	2018-06-12	Halozyme, Inc.	Stable formulations of a hyaluronan-degrading enzyme
EP2720712B1 (de) *	2011-06-17	2016-03-02	Halozyme, Inc.	Stabile formulierungen eines hyaluronan-abbauenden enzyms
CN104168911A (zh) *	2012-01-20	2014-11-26	卡斯西部储备大学	谷氨酸-稳定的胰岛素类似物
EP2836508B1 (de)	2012-04-11	2016-06-29	Novo Nordisk A/S	Insulinformulierungen
EP2991672A1 (de)	2013-04-30	2016-03-09	Novo Nordisk A/S	Neuartiges verabreichungsschema
CA2926701A1 (en)	2013-10-07	2015-04-16	Novo Nordisk A/S	Novel derivative of an insulin analogue
US10857313B2 (en)	2014-07-01	2020-12-08	Aerami Therapeutics, Inc.	Liquid nebulization systems and methods
US10471222B2 (en)	2014-07-01	2019-11-12	Dance Biopharm Inc.	Aerosolization system with flow restrictor and feedback device
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EP3261648B1 (de)	2015-02-25	2023-12-06	Aerami Therapeutics, Inc.	Flüssige insulinformulierungen und verfahren dafür
WO2017180708A1 (en)	2016-04-12	2017-10-19	Cell and Molecular Tissue Engineering, LLC	Systems, methods and products for minimizing tissue reactions and tissue injury at an infusion site
GB201607918D0 (en) *	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
EP4265296A3 (de)	2016-09-29	2023-12-20	Arecor Limited	Pharmazeutische zubereitung enthaltend einer insulinverbindung
ES2886837T3 (es)	2016-12-16	2021-12-21	Novo Nordisk As	Composiciones farmacéuticas que contienen insulina
EP3773474B1 (de)	2018-04-04	2026-01-07	Arecor Limited	Medizinisches infusionspumpensystem zur abgabe einer insulinverbindung
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
CN114096269B (zh)	2019-07-12	2024-06-11	诺和诺德股份有限公司	高浓度胰岛素制剂
JP2023501385A (ja) *	2019-11-08	2023-01-18	ユニバーシティオブピッツバーグ－オブザコモンウェルスシステムオブハイヤーエデュケイション	抗微生物ペプチドを含む組成物
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2006
- 2006-10-20 WO PCT/US2006/041081 patent/WO2007047948A2/en not_active Ceased
- 2006-10-20 KR KR1020087011970A patent/KR20080064171A/ko not_active Ceased
- 2006-10-20 EP EP06826368A patent/EP1951198B1/de not_active Not-in-force
- 2006-10-20 AU AU2006304757A patent/AU2006304757A1/en not_active Abandoned
- 2006-10-20 JP JP2008536832A patent/JP2009512709A/ja active Pending
- 2006-10-20 US US12/672,478 patent/US20100210506A1/en not_active Abandoned
- 2006-10-20 CA CA002626357A patent/CA2626357A1/en not_active Abandoned
- 2006-10-20 DE DE602006014990T patent/DE602006014990D1/de active Active
- 2006-10-20 AT AT06826368T patent/ATE471144T1/de not_active IP Right Cessation
2008
- 2008-04-14 IL IL190838A patent/IL190838A0/en unknown

Also Published As

Publication number	Publication date
JP2009512709A (ja)	2009-03-26
EP1951198B1 (de)	2010-06-16
US20100210506A1 (en)	2010-08-19
WO2007047948A3 (en)	2007-10-11
WO2007047948A2 (en)	2007-04-26
DE602006014990D1 (de)	2010-07-29
EP1951198A2 (de)	2008-08-06
IL190838A0 (en)	2008-11-03
CA2626357A1 (en)	2007-04-26
KR20080064171A (ko)	2008-07-08
AU2006304757A1 (en)	2007-04-26

Legal Events

Date	Code	Title	Description
2010-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602006014990D1 (de)	2010-07-29	Intranasale verabreichung von schnell wirkendem insulin
AR059350A1 (es)	2008-03-26	Formulacion farmaceutica para aerosoles con dos o mas principios activos y al menos una sustancia tensioactiva
BR112022013150A2 (pt)	2023-02-28	Derivado da insulina
DE60332629D1 (de)	2010-07-01	Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yi)aminderivate
MY149623A (en)	2013-09-13	Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation
HRP20060147B1 (hr)	2014-02-14	Terapijski sustav s kontroliranim otpuštanjem za nazalnu primjenu
NO20080220L (no)	2008-04-21	Formuleringer med hoy medikament belastning og doseringsformer
MX2009007742A (es)	2009-07-27	Formulaciones farmaceuticas multi-fasicas de farmacos pobremente solubles en agua para una biodisponibilidad oral de variabilidad alimentada/en ayunas reducida y mejorada.
EA200802012A1 (ru)	2009-04-28	Фармацевтические препараты в форме раствора для дозирующих ингаляторов под давлением
WO2007123945A3 (en)	2009-05-07	Mechanical single dose intrapulmonary drug delivery devices
CY1111159T1 (el)	2015-06-11	Πυκνα διαλυματα μεθοτρεξατης
ATE418324T1 (de)	2009-01-15	Mucoadhäsive xyloglucan-haltige formulierung für medizinprodukte und pharmazeutische darreichungsformen
NZ594618A (en)	2014-01-31	Transdermal pharmaceutical preparations
HN2008000964A (es)	2013-03-11	Enmascaramiento del sabor de polvos
NO20062051L (no)	2006-07-25	Farmasoytisk virkestoffinneholdende formulering med belegg
EP1919288A4 (de)	2009-12-16	Famotidin- und ibuprofenhaltige arzneimittel und ihre verabreichung
BR112012030641A2 (pt)	2016-08-16	métodos e composições para terapia farmacêutica oral
CY1109537T1 (el)	2014-08-13	Πεπτιδια και παραγωγα πεπτιδιου, παρασκευη αυτων καθως επισης χρηση αυτων για την παρασκευη θεραπευτικως η/και προληπτικως δραστικης φαρμακευτικης συνθεσης
CY1107819T1 (el)	2013-06-19	Φαρμακευτικη διαμορφωση της ολανζαπινης
AR049518A1 (es)	2006-08-09	Composicion farmaceutica que comprende un agente siliconado y dos principios activos solubilizados
GB2446341A (en)	2008-08-06	Method and system for transdermal drug delivery
ES2325291A1 (es)	2009-08-31	"uso de un extracto de silybum marianum"
WO2008041116A3 (en)	2009-03-12	Formulations of active principles incorporated in slns suitable for transdermal administration
TR200601092T1 (tr)	2006-08-21	İrbesartan etkin maddesi içeren yeni oral farmasötik formülasyonlar.
IL179177A (en)	2013-05-30	A pharmaceutical product including acyclovir and delivery compound, dosage unit, use of acyclovir in the preparation of the pharmaceutical product, use of the pharmaceutical product in the preparation of a drug and a method for the preparation of the pharmaceutical product