ATE471144T1 - Intranasale verabreichung von schnell wirkendem insulin - Google Patents

Intranasale verabreichung von schnell wirkendem insulin

Info

Publication number: ATE471144T1
Authority: AT; Austria
Prior art keywords: rapid; intranasal administration; acting insulin; insulin; human insulin
Prior art date: 2005-10-20

Application number

AT06826368T

Other languages

English (en)

Inventor

Steven Quay

Annemarie Cohen

Henry Costantino

Shu-Chih Chen Quay

Anthony SILENO

Mary Kleppe

Original Assignee

Mdrna Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-20

Filing date

2006-10-20

Publication date

2010-07-15

2006-10-20 Application filed by Mdrna Inc filed Critical Mdrna Inc

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE471144T1 publication Critical patent/ATE471144T1/de

Links

229940123452 Rapid-acting insulin Drugs 0.000 title 1
108010026951 Short-Acting Insulin Proteins 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
102000007469 Actins Human genes 0.000 abstract 1
108010085238 Actins Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Otolaryngology (AREA)
Inorganic Chemistry (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT06826368T 2005-10-20 2006-10-20 Intranasale verabreichung von schnell wirkendem insulin ATE471144T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US72887705P	2005-10-20	2005-10-20
US77872406P	2006-03-03	2006-03-03
US80690406P	2006-07-10	2006-07-10
US82152506P	2006-08-04	2006-08-04
US82587606P	2006-09-15	2006-09-15
PCT/US2006/041081 WO2007047948A2 (en)	2005-10-20	2006-10-20	Intranasal administration of rapid acting insulin

Publications (1)

Publication Number	Publication Date
ATE471144T1 true ATE471144T1 (de)	2010-07-15

Family

ID=37898816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06826368T ATE471144T1 (de)	2005-10-20	2006-10-20	Intranasale verabreichung von schnell wirkendem insulin

Country Status (10)

Country	Link
US (1)	US20100210506A1 (de)
EP (1)	EP1951198B1 (de)
JP (1)	JP2009512709A (de)
KR (1)	KR20080064171A (de)
AT (1)	ATE471144T1 (de)
AU (1)	AU2006304757A1 (de)
CA (1)	CA2626357A1 (de)
DE (1)	DE602006014990D1 (de)
IL (1)	IL190838A0 (de)
WO (1)	WO2007047948A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7658721B2 (en)	2004-01-16	2010-02-09	Biodel Inc.	Sublingual drug delivery device
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
ES2371361T3 (es)	2005-12-28	2011-12-30	Novo Nordisk A/S	Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
RU2524150C2 (ru)	2006-09-22	2014-07-27	Ново Нордиск А/С	Аналоги инсулина, устойчивые к протеазам
JP5496082B2 (ja)	2007-04-30	2014-05-21	ノボ・ノルデイスク・エー／エス	タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP2010525033A (ja) *	2007-04-30	2010-07-22	ノボ・ノルデイスク・エー／エス	高濃縮のインスリン溶液及び組成物
US20110144010A1 (en) *	2007-06-01	2011-06-16	Novo Nordisk A/S	Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier
CN101677944A (zh) *	2007-06-01	2010-03-24	诺沃-诺迪斯克有限公司	稳定的非含水药物组合物
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
TWI394580B (zh)	2008-04-28	2013-05-01	Halozyme Inc	超快起作用胰島素組成物
SI2341905T2 (sl) *	2008-09-04	2024-02-29	Amylin Pharmaceuticals, Llc	Formulacije s podaljšanim sproščanjem z uporabo brezvodnih nosilcev
JP4959005B2 (ja)	2008-10-30	2012-06-20	ノボ・ノルデイスク・エー／エス	毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
US20130269684A1 (en)	2012-04-16	2013-10-17	Dance Pharmaceuticals, Inc.	Methods and systems for supplying aerosolization devices with liquid medicaments
US9545488B2 (en)	2010-01-12	2017-01-17	Dance Biopharm Inc.	Preservative-free single dose inhaler systems
US10525214B2 (en)	2010-01-12	2020-01-07	Dance Biopharm Inc.	Preservative-free single dose inhaler system
US8950394B2 (en)	2010-01-12	2015-02-10	Dance Biopharm Inc.	Preservative-free single dose inhaler systems
US10842951B2 (en)	2010-01-12	2020-11-24	Aerami Therapeutics, Inc.	Liquid insulin formulations and methods relating thereto
US9180261B2 (en) *	2010-01-12	2015-11-10	Dance Biopharm Inc.	Preservative free insulin formulations and systems and methods for aerosolizing
US20120035103A1 (en) *	2010-01-29	2012-02-09	Pillion Dennis J	Method for administration of insulin and pharmaceutical composition thereof
PL2627173T5 (pl) *	2010-10-12	2019-11-29	Chiesi Farm Spa	Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom
US8658676B2 (en)	2010-10-12	2014-02-25	The Medicines Company	Clevidipine emulsion formulations containing antimicrobial agents
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
WO2012065996A1 (en) *	2010-11-15	2012-05-24	Sanofi-Aventis Deutschland Gmbh	PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND MALTOSYL-ß-CYCLODEXTRIN
WO2012066086A1 (en) *	2010-11-17	2012-05-24	Sanofi-Aventis Deutschland Gmbh	PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SULFOBUTYL ETHER 7-ß-CYCLODEXTRIN
NZ618331A (en) *	2011-06-17	2016-04-29	Halozyme Inc	Stable formulations of a hyaluronan-degrading enzyme
US20130011378A1 (en) *	2011-06-17	2013-01-10	Tzung-Horng Yang	Stable formulations of a hyaluronan-degrading enzyme
EP2804621A4 (de) *	2012-01-20	2015-11-18	Univ Case Western Reserve	Glutaminsäurestabilisierte insulinanaloga
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
EP2991672A1 (de)	2013-04-30	2016-03-09	Novo Nordisk A/S	Neuartiges verabreichungsschema
JP6499184B2 (ja)	2013-10-07	2019-04-10	ノヴォノルディスクアー／エス	インスリン類似体の新規な誘導体
US11273271B2 (en)	2014-07-01	2022-03-15	Aerami Therapeutics, Inc.	Aerosolization system with flow restrictor and feedback device
US10471222B2 (en)	2014-07-01	2019-11-12	Dance Biopharm Inc.	Aerosolization system with flow restrictor and feedback device
US10857313B2 (en)	2014-07-01	2020-12-08	Aerami Therapeutics, Inc.	Liquid nebulization systems and methods
BR112017018060A2 (pt)	2015-02-25	2018-04-10	Dance Biopharm Inc	formulação de insulina, dose de unidade, e, método de tratar um indivíduo com diabetes melito.
WO2017180708A1 (en)	2016-04-12	2017-10-19	Cell and Molecular Tissue Engineering, LLC	Systems, methods and products for minimizing tissue reactions and tissue injury at an infusion site
GB201607918D0 (en) *	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
JP2019529506A (ja)	2016-09-29	2019-10-17	アレコルリミテッド	新規の製剤
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina
US12357562B2 (en)	2018-04-04	2025-07-15	Arecor Limited	Injection pen system for the delivery of an insulin compound
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
JP2023501385A (ja) *	2019-11-08	2023-01-18	ユニバーシティオブピッツバーグ－オブザコモンウェルスシステムオブハイヤーエデュケイション	抗微生物ペプチドを含む組成物
US11585042B2 (en)	2020-09-30	2023-02-21	Haier Us Appliance Solutions, Inc.	Dryer appliance with additive dispenser
US12371463B2 (en)	2021-04-20	2025-07-29	University of Pittsburgh—of the Commonwealth System of Higher Education	Methods and compositions for treatment of antibiotic-resistant bacterial infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4179337A (en) *	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
CA1291036C (en) *	1986-04-23	1991-10-22	Edwin I. Stoltz	Nasal administration of drugs
US4789660A (en) *	1987-09-10	1988-12-06	American Home Products Corporation	Insulin administration using methyl and propyl paraben
BE1006873A6 (nl) *	1993-03-26	1995-01-10	Merkus Franciscus W H M	Toedieningsformulering voor nasale insuline toediening.
US20010003739A1 (en) *	1993-06-24	2001-06-14	Astrazeneca Ab	Systemic administration of a therapeutic preparation
AR012894A1 (es) *	1997-06-13	2000-11-22	Lilly Co Eli	Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
SI1031347T1 (en) *	1999-01-27	2002-10-31	Idea Ag	Transnasal transport/immunisation with highly adaptable carriers
BRPI0412735A (pt) *	2003-07-18	2006-09-26	Baxter Int	métodos para a fabricação, uso e composição de partìculas esféricas pequenas preparadas mediante a separação de fase controlada
WO2008016729A1 (en) *	2006-08-04	2008-02-07	Nastech Pharmaceutical Company Inc.	Compositions for intranasal delivery of human insulin and uses thereof

2006
- 2006-10-20 JP JP2008536832A patent/JP2009512709A/ja active Pending
- 2006-10-20 DE DE602006014990T patent/DE602006014990D1/de active Active
- 2006-10-20 EP EP06826368A patent/EP1951198B1/de not_active Not-in-force
- 2006-10-20 KR KR1020087011970A patent/KR20080064171A/ko not_active Ceased
- 2006-10-20 WO PCT/US2006/041081 patent/WO2007047948A2/en not_active Ceased
- 2006-10-20 CA CA002626357A patent/CA2626357A1/en not_active Abandoned
- 2006-10-20 US US12/672,478 patent/US20100210506A1/en not_active Abandoned
- 2006-10-20 AU AU2006304757A patent/AU2006304757A1/en not_active Abandoned
- 2006-10-20 AT AT06826368T patent/ATE471144T1/de not_active IP Right Cessation
2008
- 2008-04-14 IL IL190838A patent/IL190838A0/en unknown

Also Published As

Publication number	Publication date
EP1951198A2 (de)	2008-08-06
WO2007047948A3 (en)	2007-10-11
US20100210506A1 (en)	2010-08-19
CA2626357A1 (en)	2007-04-26
JP2009512709A (ja)	2009-03-26
IL190838A0 (en)	2008-11-03
WO2007047948A2 (en)	2007-04-26
KR20080064171A (ko)	2008-07-08
DE602006014990D1 (de)	2010-07-29
EP1951198B1 (de)	2010-06-16
AU2006304757A1 (en)	2007-04-26

Legal Events

Date	Code	Title	Description
2010-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE471144T1 (de)	2010-07-15	Intranasale verabreichung von schnell wirkendem insulin
AR059350A1 (es)	2008-03-26	Formulacion farmaceutica para aerosoles con dos o mas principios activos y al menos una sustancia tensioactiva
DE60332629D1 (de)	2010-07-01	Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yi)aminderivate
BR112022013150A2 (pt)	2023-02-28	Derivado da insulina
MY149623A (en)	2013-09-13	Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation
EA200901112A1 (ru)	2010-02-26	Жидкие композиции, образующие дермальные пленки, для введения лекарственных препаратов в кожу
HRP20060147B1 (hr)	2014-02-14	Terapijski sustav s kontroliranim otpuštanjem za nazalnu primjenu
NO20080220L (no)	2008-04-21	Formuleringer med hoy medikament belastning og doseringsformer
MX2009007742A (es)	2009-07-27	Formulaciones farmaceuticas multi-fasicas de farmacos pobremente solubles en agua para una biodisponibilidad oral de variabilidad alimentada/en ayunas reducida y mejorada.
EA200802012A1 (ru)	2009-04-28	Фармацевтические препараты в форме раствора для дозирующих ингаляторов под давлением
WO2007123945A3 (en)	2009-05-07	Mechanical single dose intrapulmonary drug delivery devices
CY1111159T1 (el)	2015-06-11	Πυκνα διαλυματα μεθοτρεξατης
NZ594618A (en)	2014-01-31	Transdermal pharmaceutical preparations
EP1919288A4 (de)	2009-12-16	Famotidin- und ibuprofenhaltige arzneimittel und ihre verabreichung
ATE549015T1 (de)	2012-03-15	Pharmazeutische wirkstoffhaltige formulierung mit überzug
BR112012030641A2 (pt)	2016-08-16	métodos e composições para terapia farmacêutica oral
ATE507818T1 (de)	2011-05-15	Orale verabreichung eines calcitonins
CY1109537T1 (el)	2014-08-13	Πεπτιδια και παραγωγα πεπτιδιου, παρασκευη αυτων καθως επισης χρηση αυτων για την παρασκευη θεραπευτικως η/και προληπτικως δραστικης φαρμακευτικης συνθεσης
CY1107819T1 (el)	2013-06-19	Φαρμακευτικη διαμορφωση της ολανζαπινης
GB2446341A (en)	2008-08-06	Method and system for transdermal drug delivery
ES2325291A1 (es)	2009-08-31	"uso de un extracto de silybum marianum"
WO2008041116A3 (en)	2009-03-12	Formulations of active principles incorporated in slns suitable for transdermal administration
TR200601092T1 (tr)	2006-08-21	İrbesartan etkin maddesi içeren yeni oral farmasötik formülasyonlar.
IL179177A (en)	2013-05-30	A pharmaceutical product including acyclovir and delivery compound, dosage unit, use of acyclovir in the preparation of the pharmaceutical product, use of the pharmaceutical product in the preparation of a drug and a method for the preparation of the pharmaceutical product
SE0203817D0 (sv)	2002-12-20	New composition