ATE471316T1 - Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolin - Google Patents

Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolin

Info

Publication number
ATE471316T1
ATE471316T1 AT05736074T AT05736074T ATE471316T1 AT E471316 T1 ATE471316 T1 AT E471316T1 AT 05736074 T AT05736074 T AT 05736074T AT 05736074 T AT05736074 T AT 05736074T AT E471316 T1 ATE471316 T1 AT E471316T1
Authority
AT
Austria
Prior art keywords
methoxyquinoline
chlorphenyl
bromine
synthesis method
diastereoselective synthesis
Prior art date
Application number
AT05736074T
Other languages
English (en)
Inventor
Walter Filliers
Rudy Broeckx
Patrick Angibaud
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE471316T1 publication Critical patent/ATE471316T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05736074T 2004-05-03 2005-04-28 Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolin ATE471316T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076321 2004-05-03
PCT/EP2005/051932 WO2005105783A1 (en) 2004-05-03 2005-04-28 Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline

Publications (1)

Publication Number Publication Date
ATE471316T1 true ATE471316T1 (de) 2010-07-15

Family

ID=34965002

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05736074T ATE471316T1 (de) 2004-05-03 2005-04-28 Diastereoselektives syntheseverfahren mit 6-brom- 4-(3-chlorphenyl)-2-methoxychinolin

Country Status (10)

Country Link
US (1) US7572916B2 (de)
EP (1) EP1756085B1 (de)
JP (1) JP4917022B2 (de)
CN (1) CN100567291C (de)
AT (1) ATE471316T1 (de)
AU (1) AU2005238222B2 (de)
CA (1) CA2563806C (de)
DE (1) DE602005021878D1 (de)
ES (1) ES2346986T3 (de)
WO (1) WO2005105783A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ593090A (en) 2008-11-13 2013-06-28 Link Medicine Corp Azaquinolinone derivatives and uses thereof
SMT202100712T1 (it) 2015-08-17 2022-01-10 Kura Oncology Inc Metodi di trattamento di pazienti di cancro con inibitori di farnesil trasferasi
TW201818965A (zh) 2016-11-03 2018-06-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶（ｆａｒｎｅｓｙｌ ｔｒａｎｓｆｅｒａｓｅ）抑制劑治療癌症病患之方法
AU2019270163A1 (en) 2018-05-18 2020-12-03 Kura Oncology, Inc. Synthesis of tipifarnib

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK283335B6 (sk) * 1995-12-08 2003-06-03 Janssen Pharmaceutica N. V. (Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
WO2001051127A1 (en) * 2000-01-12 2001-07-19 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2001051126A1 (en) * 2000-01-12 2001-07-19 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
HN2000000266A (es) * 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
WO2002020015A1 (en) * 2000-09-05 2002-03-14 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
BRPI0208075B8 (pt) 2001-03-12 2021-05-25 Janssen Pharmaceutica Nv processo para a preparação de compostos de imidazol
AU2002254375A1 (en) * 2001-03-30 2002-10-15 Merck And Co., Inc. Inhibitors of prenyl-protein transferase
AU2003274759A1 (en) * 2002-10-28 2004-05-13 Chugai Seiyaku Kabushiki Kaisha Benzofuran compounds having antitumor activity
WO2004076446A1 (ja) * 2003-02-27 2004-09-10 Chugai Seiyaku Kabushiki Kaisha ベンゾチオフェン誘導体
EP1758885B1 (de) * 2004-05-03 2008-06-18 Janssen Pharmaceutica N.V. Diastereoselektive addition von lithiiertem n-methylimidazol an sulfinimine

Also Published As

Publication number Publication date
EP1756085A1 (de) 2007-02-28
JP2007536334A (ja) 2007-12-13
JP4917022B2 (ja) 2012-04-18
EP1756085B1 (de) 2010-06-16
CA2563806A1 (en) 2005-11-10
US7572916B2 (en) 2009-08-11
AU2005238222A1 (en) 2005-11-10
US20070293680A1 (en) 2007-12-20
ES2346986T3 (es) 2010-10-22
HK1101398A1 (en) 2007-10-18
CN100567291C (zh) 2009-12-09
CA2563806C (en) 2012-11-20
AU2005238222B2 (en) 2010-10-28
WO2005105783A1 (en) 2005-11-10
CN1946710A (zh) 2007-04-11
DE602005021878D1 (de) 2010-07-29

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