ATE471982T1 - BIOLOGICAL VARIABILITY OF ASTHMA-ASSOCIATED FACTOR 2 AAF2 (IL-9 RECEPTOR) USEFUL FOR THE TREATMENT AND DIAGNOSIS OF ATOPIC ALLERGIES SUCH AS ASTHMA AND ASTHMA-LIKE DISEASES - Google Patents

BIOLOGICAL VARIABILITY OF ASTHMA-ASSOCIATED FACTOR 2 AAF2 (IL-9 RECEPTOR) USEFUL FOR THE TREATMENT AND DIAGNOSIS OF ATOPIC ALLERGIES SUCH AS ASTHMA AND ASTHMA-LIKE DISEASES

Info

Publication number
ATE471982T1
ATE471982T1 AT04013403T AT04013403T ATE471982T1 AT E471982 T1 ATE471982 T1 AT E471982T1 AT 04013403 T AT04013403 T AT 04013403T AT 04013403 T AT04013403 T AT 04013403T AT E471982 T1 ATE471982 T1 AT E471982T1
Authority
AT
Austria
Prior art keywords
asthma
aaf2
diagnosis
treatment
atopic
Prior art date
Application number
AT04013403T
Other languages
German (de)
Inventor
Roy Levitt
Luigi Grasso
Nicholas Nicolaides
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Application granted granted Critical
Publication of ATE471982T1 publication Critical patent/ATE471982T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor (2). One embodiment of the invention is a variant of AAF2, wherein codon 173 is deleted resulting in the loss of glutamine 173 from the mature protein precursor. This single amino acid deletion results in a non-functional AAF2 protein and therefore the presence of this phenotype should be associated with less evidence of atopic asthma. Correspondingly, the lack of susceptibility to an asthmatic, atopic phenotype is characterized by the loss of glutamine at codon 173. The invention includes isolated DNA molecules which are variants of the wild type sequence as well as the proteins encoded by such DNA and the use of such DNA molecules and expressed protein in the diagnosis and treatment of atopic asthma.
AT04013403T 1996-12-02 1997-12-02 BIOLOGICAL VARIABILITY OF ASTHMA-ASSOCIATED FACTOR 2 AAF2 (IL-9 RECEPTOR) USEFUL FOR THE TREATMENT AND DIAGNOSIS OF ATOPIC ALLERGIES SUCH AS ASTHMA AND ASTHMA-LIKE DISEASES ATE471982T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3222496P 1996-12-02 1996-12-02
US98087297A 1997-12-01 1997-12-01

Publications (1)

Publication Number Publication Date
ATE471982T1 true ATE471982T1 (en) 2010-07-15

Family

ID=26708147

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04013403T ATE471982T1 (en) 1996-12-02 1997-12-02 BIOLOGICAL VARIABILITY OF ASTHMA-ASSOCIATED FACTOR 2 AAF2 (IL-9 RECEPTOR) USEFUL FOR THE TREATMENT AND DIAGNOSIS OF ATOPIC ALLERGIES SUCH AS ASTHMA AND ASTHMA-LIKE DISEASES

Country Status (8)

Country Link
EP (1) EP0942979A2 (en)
JP (2) JP4552076B2 (en)
AT (1) ATE471982T1 (en)
AU (1) AU746595B2 (en)
CA (1) CA2271952C (en)
DE (1) DE69739920D1 (en)
ES (1) ES2347962T3 (en)
PT (1) PT1471144E (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119040500B (en) * 2024-07-18 2026-04-17 中国农业科学院作物科学研究所 SNP molecular marker related to soybean seed oil content, protein content and hundred-grain weight and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2241329A3 (en) * 1995-08-24 2011-03-09 Ligand Pharmaceuticals Incorporated Anti-interleukin-9 antibody or anti-interleukin-9 receptor antibody for treating bronchial hyper-responsiveness

Also Published As

Publication number Publication date
AU5689198A (en) 1998-06-29
AU746595B2 (en) 2002-05-02
JP2009159976A (en) 2009-07-23
PT1471144E (en) 2010-08-17
CA2271952C (en) 2010-04-06
CA2271952A1 (en) 1998-06-11
EP0942979A2 (en) 1999-09-22
ES2347962T3 (en) 2010-11-26
DE69739920D1 (en) 2010-08-05
JP2002514911A (en) 2002-05-21
JP4552076B2 (en) 2010-09-29

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